JP2004532205A - 細胞への核酸分子の送達およびその評価方法 - Google Patents

細胞への核酸分子の送達およびその評価方法 Download PDF

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Publication number
JP2004532205A
JP2004532205A JP2002575020A JP2002575020A JP2004532205A JP 2004532205 A JP2004532205 A JP 2004532205A JP 2002575020 A JP2002575020 A JP 2002575020A JP 2002575020 A JP2002575020 A JP 2002575020A JP 2004532205 A JP2004532205 A JP 2004532205A
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Prior art keywords
cells
nucleic acid
cell
acid molecule
cationic
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JP2002575020A
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English (en)
Japanese (ja)
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JP2004532205A5 (fr
Inventor
ゲイリー・デジョン
サンドラ・ルイーズ・バンダービル
フォルカー・オーベルレ
ディルク・フークストラ
ジャン・ドレイヤー
パウル・ペーテル・タック
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クロモス・モレキユラー・システムズ・インコーポレーテツド
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Priority claimed from US09/815,981 external-priority patent/US6936469B2/en
Priority claimed from US09/815,979 external-priority patent/US7294511B2/en
Priority claimed from US10/086,745 external-priority patent/US20030186390A1/en
Application filed by クロモス・モレキユラー・システムズ・インコーポレーテツド filed Critical クロモス・モレキユラー・システムズ・インコーポレーテツド
Publication of JP2004532205A publication Critical patent/JP2004532205A/ja
Publication of JP2004532205A5 publication Critical patent/JP2004532205A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2002575020A 2001-03-22 2002-03-22 細胞への核酸分子の送達およびその評価方法 Pending JP2004532205A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/815,981 US6936469B2 (en) 2001-03-22 2001-03-22 Methods for delivering nucleic acid molecules into cells and assessment thereof
US09/815,979 US7294511B2 (en) 2001-03-22 2001-03-22 Methods for delivering nucleic acid molecules into cells and assessment thereof
US10/086,745 US20030186390A1 (en) 2001-03-22 2002-02-28 Methods for delivering nucleic acid molecules into cells and assessment thereof
PCT/US2002/009262 WO2002076508A1 (fr) 2001-03-22 2002-03-22 Techniques d'apport de molecules d'acides nucleiques dans des cellules et evaluation de cet apport

Publications (2)

Publication Number Publication Date
JP2004532205A true JP2004532205A (ja) 2004-10-21
JP2004532205A5 JP2004532205A5 (fr) 2005-12-22

Family

ID=27375461

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002575020A Pending JP2004532205A (ja) 2001-03-22 2002-03-22 細胞への核酸分子の送達およびその評価方法

Country Status (6)

Country Link
EP (1) EP1383541A4 (fr)
JP (1) JP2004532205A (fr)
CA (1) CA2441535C (fr)
IL (1) IL157703A0 (fr)
NZ (1) NZ527972A (fr)
WO (1) WO2002076508A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007284379A (ja) * 2006-04-17 2007-11-01 Keio Gijuku 細胞への薬剤導入方法および細胞への薬剤導入装置
JP2020510452A (ja) * 2016-11-22 2020-04-09 シーダーズ−サイナイ メディカル センター トランスフェクションおよび薬剤送達用の新規デバイス

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7294511B2 (en) 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
NZ528003A (en) 2001-05-30 2006-09-29 Chromos Molecular Systems Inc Platform artificial chromosome expression systems (ACes) containing single or multiple site-specific recombination sites
JP4676679B2 (ja) * 2003-04-02 2011-04-27 帝人株式会社 人工軟骨
CA3079874C (fr) 2004-10-22 2023-01-03 Revivicor, Inc. Ongules dotes de systemes immunitaires genetiquement modifies
WO2010051288A1 (fr) 2008-10-27 2010-05-06 Revivicor, Inc. Ongulés immunodéprimés
CN117357480B (zh) * 2023-12-08 2024-03-29 北京中科利华医药研究院有限公司 无针经皮注射用组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ253943A (en) * 1992-06-18 1997-01-29 Genpharm Int Transfering polynucleotides into eukaryotic cells using co-lipofection complexes of a cationic lipid and the polynucleotide
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
NL1000884C2 (nl) * 1995-07-25 1997-01-28 Univ Groningen Transportvehikels voor macromoleculen.
US6184037B1 (en) * 1996-05-17 2001-02-06 Genemedicine, Inc. Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell
US6074667A (en) * 1996-11-20 2000-06-13 Kinnunen; Paavo Liposomal transfection method
WO1999025385A1 (fr) * 1997-11-17 1999-05-27 Imarx Pharmaceutical Corp. Procede d'accroissement de la synthese d'acides nucleiques au moyen d'ultrasons
AU785026B2 (en) * 1998-12-04 2006-08-24 Genetronics, Inc. Facs assisted methods for introducing individual chromosomes into cells

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007284379A (ja) * 2006-04-17 2007-11-01 Keio Gijuku 細胞への薬剤導入方法および細胞への薬剤導入装置
JP2020510452A (ja) * 2016-11-22 2020-04-09 シーダーズ−サイナイ メディカル センター トランスフェクションおよび薬剤送達用の新規デバイス

Also Published As

Publication number Publication date
WO2002076508B1 (fr) 2002-12-12
EP1383541A1 (fr) 2004-01-28
WO2002076508A1 (fr) 2002-10-03
IL157703A0 (en) 2004-03-28
EP1383541A4 (fr) 2009-11-04
CA2441535A1 (fr) 2002-10-03
CA2441535C (fr) 2008-08-26
NZ527972A (en) 2006-04-28

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