JP2004532102A - 集中音響エネルギーを使用する薬剤粒子の生成 - Google Patents

集中音響エネルギーを使用する薬剤粒子の生成 Download PDF

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Publication number
JP2004532102A
JP2004532102A JP2002577117A JP2002577117A JP2004532102A JP 2004532102 A JP2004532102 A JP 2004532102A JP 2002577117 A JP2002577117 A JP 2002577117A JP 2002577117 A JP2002577117 A JP 2002577117A JP 2004532102 A JP2004532102 A JP 2004532102A
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solvent
reservoir
solution
acoustic
drug
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JP2002577117A
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Japanese (ja)
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JP2004532102A5 (cg-RX-API-DMAC7.html
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デイビッド スーン−フア リー,
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ピコリター インコーポレイテッド
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Publication of JP2004532102A publication Critical patent/JP2004532102A/ja
Publication of JP2004532102A5 publication Critical patent/JP2004532102A5/ja
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1688Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2002577117A 2001-03-30 2002-04-01 集中音響エネルギーを使用する薬剤粒子の生成 Pending JP2004532102A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/823,899 US6596206B2 (en) 2001-03-30 2001-03-30 Generation of pharmaceutical agent particles using focused acoustic energy
PCT/US2002/010266 WO2002078863A1 (en) 2001-03-30 2002-04-01 Generation of pharmaceutical agent particles using focused acoustic energy

Publications (2)

Publication Number Publication Date
JP2004532102A true JP2004532102A (ja) 2004-10-21
JP2004532102A5 JP2004532102A5 (cg-RX-API-DMAC7.html) 2005-12-22

Family

ID=25240048

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002577117A Pending JP2004532102A (ja) 2001-03-30 2002-04-01 集中音響エネルギーを使用する薬剤粒子の生成

Country Status (5)

Country Link
US (1) US6596206B2 (cg-RX-API-DMAC7.html)
EP (1) EP1379337B1 (cg-RX-API-DMAC7.html)
JP (1) JP2004532102A (cg-RX-API-DMAC7.html)
AT (1) ATE556788T1 (cg-RX-API-DMAC7.html)
WO (1) WO2002078863A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009119363A (ja) * 2007-11-14 2009-06-04 Nikkiso Co Ltd 微粒子化方法
JP2009535399A (ja) * 2006-05-04 2009-10-01 バイオ−シネクティクス インク. ナノスケールの活物質粒子の製造方法

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620351B2 (en) * 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
US6642061B2 (en) * 2000-09-25 2003-11-04 Picoliter Inc. Use of immiscible fluids in droplet ejection through application of focused acoustic energy
US6869551B2 (en) * 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US20050260273A1 (en) * 2001-06-07 2005-11-24 Chinea Vanessa I Applicatin of a bioactive agent in a solvent composition to produce a target particle morphology
US7354141B2 (en) * 2001-12-04 2008-04-08 Labcyte Inc. Acoustic assessment of characteristics of a fluid relevant to acoustic ejection
CN1668315A (zh) 2002-06-12 2005-09-14 梅瑟·格里斯海姆有限公司 使用含氙气体进行脑保护
EP1515731A1 (de) * 2002-06-12 2005-03-23 Air Liquide Deutschland GmbH Xenonhaltiges spasmolytikum
US7070260B2 (en) * 2003-01-09 2006-07-04 Labcyte Inc. Droplet dispensation from a reservoir with reduction in uncontrolled electrostatic charge
US7537803B2 (en) * 2003-04-08 2009-05-26 New Jersey Institute Of Technology Polymer coating/encapsulation of nanoparticles using a supercritical antisolvent process
CN1878602A (zh) * 2003-11-28 2006-12-13 三菱化学株式会社 有机化合物微粒的制造方法
KR100603974B1 (ko) * 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
US9682043B2 (en) * 2003-12-09 2017-06-20 Medcrystalforms, Llc Method of preparation of mixed phase co-crystals with active agents
US20060210443A1 (en) 2005-03-14 2006-09-21 Stearns Richard G Avoidance of bouncing and splashing in droplet-based fluid transport
US20070120281A1 (en) * 2005-11-08 2007-05-31 Boris Khusid Manufacture of fine particles and nano particles and coating thereof
US20100270695A1 (en) * 2006-09-05 2010-10-28 Maciej Radosz Processing Nanoparticles by Micellization of Blocky-Copolymers in Subcritical and Supercritical Solvents
US8389013B2 (en) * 2006-10-06 2013-03-05 Newsouth Innovations Pty Limited Process for producing particles via atomized rapid injection for solvent extraction
US8828445B2 (en) 2010-03-22 2014-09-09 Bio-Synectics Inc. Method for preparing nano-particles utilizing a saccharide anti-coagulant
CN102058996A (zh) * 2010-10-29 2011-05-18 华侨大学 非溶剂法改进超临界抗溶剂过程制备药物超细微粒的方法
US10105316B2 (en) 2012-07-05 2018-10-23 Arven llac Sanayi Ve Ticaret A.S. Inhalation compositions comprising muscarinic receptor antagonist
US10111957B2 (en) * 2012-07-05 2018-10-30 Arven Ilac Snayi ve Ticaret A.S. Inhalation compositions comprising glucose anhydrous
WO2014078258A1 (en) * 2012-11-16 2014-05-22 Merck Sharp & Dohme Corp. Process for making agglomerates using acoustic mixing technology
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
WO2019040346A1 (en) * 2017-08-25 2019-02-28 Merck Sharp & Dohme Corp. METHODS FOR PREPARING STORED AMORPHOUS MEDICATION FORMULATIONS USING ACOUSTIC FUSION
JP7503781B2 (ja) * 2018-07-30 2024-06-21 株式会社リコー 粒子の製造方法、並びに、それにより製造された粒子及び医薬

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308547A (en) 1978-04-13 1981-12-29 Recognition Equipment Incorporated Liquid drop emitter
US5041849A (en) 1989-12-26 1991-08-20 Xerox Corporation Multi-discrete-phase Fresnel acoustic lenses and their application to acoustic ink printing
US6063910A (en) 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
DK0863202T3 (da) * 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
US5874029A (en) 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
WO1997031691A1 (en) * 1996-03-01 1997-09-04 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
GB9828204D0 (en) 1998-12-21 1999-02-17 Smithkline Beecham Plc Process
TR200101891T2 (tr) 1999-01-29 2001-12-21 Bristol-Myers Squibb Company Sonik etkili jet kristalleşme aparat ve cihazı.
US6620351B2 (en) 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
GB0016002D0 (en) 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
US7121275B2 (en) 2000-12-18 2006-10-17 Xerox Corporation Method of using focused acoustic waves to deliver a pharmaceutical product
US8122880B2 (en) 2000-12-18 2012-02-28 Palo Alto Research Center Incorporated Inhaler that uses focused acoustic waves to deliver a pharmaceutical product
US6622720B2 (en) 2000-12-18 2003-09-23 Xerox Corporation Using capillary wave driven droplets to deliver a pharmaceutical product
KR20040040475A (ko) * 2001-09-28 2004-05-12 가부시키가이샤 디나벡크 겐큐쇼 에피토프 결합 β2m을 코드하는 포유동물 세포감염성 바이러스 벡터 및 그의 이용

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009535399A (ja) * 2006-05-04 2009-10-01 バイオ−シネクティクス インク. ナノスケールの活物質粒子の製造方法
JP4830019B2 (ja) * 2006-05-04 2011-12-07 バイオ−シネクティクス インク. ナノスケールの活物質粒子の製造方法
JP2009119363A (ja) * 2007-11-14 2009-06-04 Nikkiso Co Ltd 微粒子化方法

Also Published As

Publication number Publication date
ATE556788T1 (de) 2012-05-15
WO2002078863A1 (en) 2002-10-10
EP1379337B1 (en) 2012-05-09
US6596206B2 (en) 2003-07-22
EP1379337A1 (en) 2004-01-14
US20020142049A1 (en) 2002-10-03

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