JP2004531478A5 - - Google Patents
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- Publication number
- JP2004531478A5 JP2004531478A5 JP2002562732A JP2002562732A JP2004531478A5 JP 2004531478 A5 JP2004531478 A5 JP 2004531478A5 JP 2002562732 A JP2002562732 A JP 2002562732A JP 2002562732 A JP2002562732 A JP 2002562732A JP 2004531478 A5 JP2004531478 A5 JP 2004531478A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salts
- pharmaceutical compositions
- salts including
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- -1 ethylenedioxyphenyl Chemical group 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 3
- 230000005907 cancer growth Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 150000002339 glycosphingolipids Chemical class 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 150000003408 sphingolipids Chemical class 0.000 claims 3
- 150000003512 tertiary amines Chemical class 0.000 claims 3
- 230000005747 tumor angiogenesis Effects 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002723 alicyclic group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 0 C[N+](C1C=C*(*)C=C1)[O-] Chemical compound C[N+](C1C=C*(*)C=C1)[O-] 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26094801P | 2001-01-10 | 2001-01-10 | |
| US26219601P | 2001-01-17 | 2001-01-17 | |
| PCT/US2002/000808 WO2002062777A2 (en) | 2001-01-10 | 2002-01-10 | Amino ceramide-like compounds and therapeutic methods of use |
| CA002454456A CA2454456A1 (en) | 2001-01-10 | 2003-12-24 | Amino ceramide-like compounds and therapeutic methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004531478A JP2004531478A (ja) | 2004-10-14 |
| JP2004531478A5 true JP2004531478A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
Family
ID=34841311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002562732A Pending JP2004531478A (ja) | 2001-01-10 | 2002-01-10 | アミノセラミド様化合物および治療目的での使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7335681B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1358172B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2004531478A (cg-RX-API-DMAC7.html) |
| BR (1) | BR0206400A (cg-RX-API-DMAC7.html) |
| CA (2) | CA2434028C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002062777A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0206400A (pt) | 2001-01-10 | 2005-01-18 | Univ Michigan | Compostos de amino ceramidas e seus usos em métodos terapêuticos |
| DK2067775T3 (da) | 2001-07-16 | 2012-07-16 | Genzyme Corp | N-acylsphingosinglucosyltransferase-inhibitor |
| US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
| US6916802B2 (en) | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| EP1811991B1 (en) | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis |
| US8153666B2 (en) | 2005-01-26 | 2012-04-10 | Allergan, Inc. | Compounds having analgesic and/or immunostimulant activity |
| PT2032134E (pt) | 2006-05-09 | 2015-10-07 | Genzyme Corp | Métodos de tratamento da doença do fígado gorduroso |
| US9314466B2 (en) | 2007-03-06 | 2016-04-19 | Allergan, Inc. | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| EP2594565B1 (en) | 2007-05-31 | 2018-10-24 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| BRPI0823522A2 (pt) | 2007-10-05 | 2014-01-07 | Genzyme Corp | Uso de um composto derivado de ceramida |
| GB2466912B (en) | 2007-11-29 | 2012-01-04 | Hospital For Sick Children | Compositions and methods for treating lysosomal disorders |
| US8741967B2 (en) | 2007-12-12 | 2014-06-03 | Children's Hospital & Research Center At Oakland | Use of unsaturated sphingosine compounds as chemotherapeutic agents for the treatment of cancer |
| WO2009132082A2 (en) * | 2008-04-22 | 2009-10-29 | Medical College Of Georgia Research Institute, Inc. | Immunogenic compositions containing ceramide and methods of use thereof |
| EP2320886B1 (en) | 2008-07-28 | 2017-06-28 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| CA2738768C (en) | 2008-10-03 | 2017-10-31 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| EP2411526A4 (en) * | 2009-03-27 | 2012-09-19 | Zacharon Pharmaceuticals Inc | MODULATORS OF GANGLIOSID BIOSYNTHESIS |
| NZ625712A (en) | 2009-11-27 | 2016-02-26 | Genzyme Corp | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| EP2583107A2 (en) * | 2010-06-20 | 2013-04-24 | Zora Biosciences OY | Lipidomic biomarkers for identification of high-risk coronary artery disease patients |
| WO2021214771A1 (en) * | 2020-04-23 | 2021-10-28 | The Israel Institute of Biological Research (IIBR) | Glucosylceramide synthase inhibitors for prevention and treatment of viral diseases |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE197672T1 (de) * | 1993-08-13 | 2000-12-15 | Seikagaku Kogyo Co Ltd | Arzneimittel gegen nervöse erkrankungen |
| JP3850437B2 (ja) * | 1994-06-10 | 2006-11-29 | 生化学工業株式会社 | ２−アシルアミノプロパノール化合物及び医薬組成物 |
| WO1997010817A1 (en) * | 1995-09-20 | 1997-03-27 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US6255336B1 (en) * | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US6890949B1 (en) * | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| WO2001004108A1 (en) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20030073680A1 (en) * | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| NO965193L (no) * | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
| US5972928A (en) * | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
| JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| DE69935720T2 (de) | 1998-07-27 | 2007-12-27 | The Johns Hopkins University | Diamino-propanol-verbindungen zur behandlung von ischaemien |
| US7148251B2 (en) * | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| BR0206400A (pt) | 2001-01-10 | 2005-01-18 | Univ Michigan | Compostos de amino ceramidas e seus usos em métodos terapêuticos |
| US20040260099A1 (en) | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20020198240A1 (en) * | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
| DK2067775T3 (da) | 2001-07-16 | 2012-07-16 | Genzyme Corp | N-acylsphingosinglucosyltransferase-inhibitor |
| US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| US20060217560A1 (en) | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
-
2002
- 2002-01-10 BR BR0206400-6A patent/BR0206400A/pt not_active Application Discontinuation
- 2002-01-10 JP JP2002562732A patent/JP2004531478A/ja active Pending
- 2002-01-10 EP EP02718827A patent/EP1358172B1/en not_active Expired - Lifetime
- 2002-01-10 CA CA2434028A patent/CA2434028C/en not_active Expired - Lifetime
- 2002-01-10 WO PCT/US2002/000808 patent/WO2002062777A2/en not_active Ceased
-
2003
- 2003-12-24 CA CA002454456A patent/CA2454456A1/en not_active Abandoned
-
2006
- 2006-09-15 US US11/522,063 patent/US7335681B2/en not_active Expired - Lifetime