JP2004527509A5 - - Google Patents
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- Publication number
- JP2004527509A5 JP2004527509A5 JP2002571919A JP2002571919A JP2004527509A5 JP 2004527509 A5 JP2004527509 A5 JP 2004527509A5 JP 2002571919 A JP2002571919 A JP 2002571919A JP 2002571919 A JP2002571919 A JP 2002571919A JP 2004527509 A5 JP2004527509 A5 JP 2004527509A5
- Authority
- JP
- Japan
- Prior art keywords
- nad
- och
- composition
- compound
- catalyst precursor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 10
- 239000012018 catalyst precursor Substances 0.000 claims 7
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 6
- -1 1- (8-acryloyloxy-3,6-dioxaoctanoyl) -carbamoylpyridinium bromide salt Chemical compound 0.000 claims 5
- 230000003592 biomimetic effect Effects 0.000 claims 5
- 239000010948 rhodium Substances 0.000 claims 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 4
- 102000004316 Oxidoreductases Human genes 0.000 claims 4
- 108090000854 Oxidoreductases Proteins 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052703 rhodium Inorganic materials 0.000 claims 3
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical group [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims 3
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 2
- 229930024421 Adenine Natural products 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 2
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 2
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 229960000643 adenine Drugs 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 239000003638 chemical reducing agent Substances 0.000 claims 2
- 229910017052 cobalt Inorganic materials 0.000 claims 2
- 239000010941 cobalt Substances 0.000 claims 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- 229910052741 iridium Inorganic materials 0.000 claims 2
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims 2
- 229910052759 nickel Inorganic materials 0.000 claims 2
- 238000007128 oxidoreductase reaction Methods 0.000 claims 2
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 2
- 229920000573 polyethylene Polymers 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 229910052707 ruthenium Inorganic materials 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical group [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000004678 hydrides Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000033116 oxidation-reduction process Effects 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000012279 sodium borohydride Substances 0.000 claims 1
- 229910000033 sodium borohydride Inorganic materials 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
- 150000008648 triflates Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/805,726 US6716596B2 (en) | 2001-03-12 | 2001-03-12 | Agents for replacement of NAD+/NADH system in enzymatic reactions |
| PCT/US2002/007444 WO2002072869A2 (en) | 2001-03-12 | 2002-03-11 | Novel agents for replacement of nad+/nadh system in enzymatic ractions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527509A JP2004527509A (ja) | 2004-09-09 |
| JP2004527509A5 true JP2004527509A5 (https=) | 2005-07-07 |
Family
ID=25192354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571919A Withdrawn JP2004527509A (ja) | 2001-03-12 | 2002-03-11 | 酵素反応におけるｎａｄ＋／ｎａｄｈ系の代替物としての新規物質 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6716596B2 (https=) |
| EP (1) | EP1373552A4 (https=) |
| JP (1) | JP2004527509A (https=) |
| AU (1) | AU2002255706A1 (https=) |
| WO (1) | WO2002072869A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070014833A1 (en) * | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| US20060229265A1 (en) * | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| US20060292099A1 (en) * | 2005-05-25 | 2006-12-28 | Michael Milburn | Treatment of eye disorders with sirtuin modulators |
| KR101039753B1 (ko) | 2008-07-24 | 2011-06-09 | 한국과학기술원 | 금속 나노입자를 이용한 옥시도리덕타제 보조인자의전기화학적 재생방법 |
| EP2668161B1 (en) * | 2011-01-26 | 2014-11-26 | Roche Diagniostics GmbH | Method and substances for preparation of n-substituted pyridinium compounds |
| EP2503003A1 (en) | 2011-03-24 | 2012-09-26 | Volker Sieber | Synthetic pathway for the production of alcohols or amines |
| DK3005461T3 (en) | 2013-06-05 | 2018-10-15 | Tianjin Inst Ind Biotechnology Cas | COMPLETE OXIDATION OF SUGARS FOR ELECTRICITY USING CELL-FREE SYNTHETIC ENZYMATIC ROADS |
| WO2019209187A1 (en) * | 2018-04-25 | 2019-10-31 | Vidyasirimedhi Institute Of Science And Technology | A luciferase reporter system and an assay for gene expression profiling using the same |
| CN116655528B (zh) * | 2023-04-28 | 2025-12-02 | 宁波百思佳医药科技有限公司 | 一种氯化1-甲基烟酰铵的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2930087A1 (de) * | 1979-07-25 | 1981-02-26 | Biotechnolog Forschung Gmbh | Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden alpha -hydroxycarbonsaeuren |
| US5866434A (en) * | 1994-12-08 | 1999-02-02 | Meso Scale Technology | Graphitic nanotubes in luminescence assays |
| US5801006A (en) * | 1997-02-04 | 1998-09-01 | Specialty Assays, Inc. | Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites |
-
2001
- 2001-03-12 US US09/805,726 patent/US6716596B2/en not_active Expired - Fee Related
-
2002
- 2002-03-11 WO PCT/US2002/007444 patent/WO2002072869A2/en not_active Ceased
- 2002-03-11 EP EP02725121A patent/EP1373552A4/en not_active Withdrawn
- 2002-03-11 JP JP2002571919A patent/JP2004527509A/ja not_active Withdrawn
- 2002-03-11 AU AU2002255706A patent/AU2002255706A1/en not_active Abandoned
-
2003
- 2003-12-06 US US10/729,627 patent/US20040235084A1/en not_active Abandoned
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