|
US6372250B1
(en)
*
|
2000-04-25 |
2002-04-16 |
The Regents Of The University Of California |
Non-invasive gene targeting to the brain
|
|
US20030027331A1
(en)
*
|
2000-11-30 |
2003-02-06 |
Yan Wen Liang |
Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same
|
|
WO2002082904A2
(en)
|
2001-04-13 |
2002-10-24 |
The Trustees Of The University Of Pennsylvania |
Method of treating or retarding the development of blindness
|
|
US7265208B2
(en)
*
|
2001-05-01 |
2007-09-04 |
The Regents Of The University Of California |
Fusion molecules and treatment of IgE-mediated allergic diseases
|
|
RU2294192C2
(ru)
*
|
2001-05-30 |
2007-02-27 |
Дзе Скриппс Рисерч Инститьют |
Система доставки нуклеиновых кислот
|
|
US20040096880A1
(en)
*
|
2001-08-07 |
2004-05-20 |
Kmiec Eric B. |
Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation
|
|
WO2003013437A2
(en)
*
|
2001-08-07 |
2003-02-20 |
University Of Delaware |
Compositions and methods for the prevention and treatment of huntington's disease
|
|
EP1495120B1
(en)
*
|
2002-04-18 |
2012-10-10 |
Acuity Pharmaceuticals, Inc |
Means and methods for the specific modulation of target genes in the eye
|
|
EP1506286B1
(en)
|
2002-05-24 |
2014-03-19 |
Merck Sharp & Dohme Corp. |
Neutralizing human anti-igfr antibody
|
|
WO2004009022A2
(en)
*
|
2002-07-18 |
2004-01-29 |
The General Hospital Corp. |
Method for augmenting vision in persons suffering from photoreceptor cell degeneration
|
|
US7148342B2
(en)
|
2002-07-24 |
2006-12-12 |
The Trustees Of The University Of Pennyslvania |
Compositions and methods for sirna inhibition of angiogenesis
|
|
US7605249B2
(en)
|
2002-11-26 |
2009-10-20 |
Medtronic, Inc. |
Treatment of neurodegenerative disease through intracranial delivery of siRNA
|
|
US7618948B2
(en)
*
|
2002-11-26 |
2009-11-17 |
Medtronic, Inc. |
Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
|
|
US7829694B2
(en)
|
2002-11-26 |
2010-11-09 |
Medtronic, Inc. |
Treatment of neurodegenerative disease through intracranial delivery of siRNA
|
|
US7388079B2
(en)
*
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
US7994149B2
(en)
|
2003-02-03 |
2011-08-09 |
Medtronic, Inc. |
Method for treatment of Huntington's disease through intracranial delivery of sirna
|
|
US7732591B2
(en)
*
|
2003-11-25 |
2010-06-08 |
Medtronic, Inc. |
Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna
|
|
EP1947116B1
(en)
|
2003-02-10 |
2017-06-21 |
2-BBB Medicines B.V. |
Differentially expressed nucleic acids in the blood-brain barrier under inflammatory conditions
|
|
DK1633327T3
(da)
*
|
2003-06-04 |
2010-11-15 |
Univ Georgetown |
Fremgangsmåde til forbedring af stabilitet og opbevaringslevetid af liposomkomplekser
|
|
US20060263783A1
(en)
*
|
2003-07-03 |
2006-11-23 |
Podhajcer Osvaldo L |
Methods and systems for diagnosis of non-central nervous system (cns) diseases in cns samples
|
|
US20050042298A1
(en)
*
|
2003-08-20 |
2005-02-24 |
Pardridge William M. |
Immunonanoparticles
|
|
US20050074506A1
(en)
*
|
2003-10-02 |
2005-04-07 |
Brainsgate Ltd. |
Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
|
|
US7326567B2
(en)
|
2003-11-12 |
2008-02-05 |
Schering Corporation |
Plasmid system for multigene expression
|
|
US20050147664A1
(en)
*
|
2003-11-13 |
2005-07-07 |
Elan Pharma International Ltd. |
Compositions comprising antibodies and methods of using the same for targeting nanoparticulate active agent delivery
|
|
TW200526684A
(en)
*
|
2003-11-21 |
2005-08-16 |
Schering Corp |
Anti-IGFR1 antibody therapeutic combinations
|
|
WO2005080410A1
(en)
*
|
2004-02-20 |
2005-09-01 |
Genesis Research And Development Corporation Limited |
Targeted delivery of rna interference molecules for the treatment of ige-mediated disorders
|
|
US20050202075A1
(en)
*
|
2004-03-12 |
2005-09-15 |
Pardridge William M. |
Delivery of genes encoding short hairpin RNA using receptor-specific nanocontainers
|
|
US20050208090A1
(en)
*
|
2004-03-18 |
2005-09-22 |
Medtronic, Inc. |
Methods and systems for treatment of neurological diseases of the central nervous system
|
|
JP2008503590A
(ja)
*
|
2004-06-21 |
2008-02-07 |
メドトロニック・インコーポレーテッド |
組成物を細胞にデリバリーするための医学用システム及び方法
|
|
EP1799660A2
(en)
*
|
2004-09-17 |
2007-06-27 |
Comentis, Inc. |
Amino-containing compounds which inhibit memapsin 2 beta-secretase activity and methods of use thereof
|
|
AU2005286844A1
(en)
*
|
2004-09-17 |
2006-03-30 |
Comentis, Inc |
Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof
|
|
PT1828249E
(pt)
*
|
2004-12-03 |
2011-02-25 |
Schering Corp |
Biomarcadores para a pré-selecção de pacientes para terapêutica anti-igf1r
|
|
NZ562314A
(en)
*
|
2005-04-08 |
2010-02-26 |
Comentis Inc |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
JP4875064B2
(ja)
*
|
2005-04-15 |
2012-02-15 |
シェーリング コーポレイション |
癌を処置または予防するための方法および組成物
|
|
US20060253068A1
(en)
*
|
2005-04-20 |
2006-11-09 |
Van Bilsen Paul |
Use of biocompatible in-situ matrices for delivery of therapeutic cells to the heart
|
|
WO2006121960A2
(en)
*
|
2005-05-06 |
2006-11-16 |
Medtronic, Inc. |
Methods and sequences to suppress primate huntington gene expression
|
|
US7902352B2
(en)
*
|
2005-05-06 |
2011-03-08 |
Medtronic, Inc. |
Isolated nucleic acid duplex for reducing huntington gene expression
|
|
US9943481B2
(en)
*
|
2005-05-26 |
2018-04-17 |
Biorest Ltd. |
Compositions and methods using same for delivering agents into a target organ protected by a blood barrier
|
|
NZ564098A
(en)
*
|
2005-06-15 |
2010-04-30 |
Schering Corp |
Anti-IGF1R antibody formulations
|
|
US20080280843A1
(en)
*
|
2006-05-24 |
2008-11-13 |
Van Bilsen Paul |
Methods and kits for linking polymorphic sequences to expanded repeat mutations
|
|
US9133517B2
(en)
*
|
2005-06-28 |
2015-09-15 |
Medtronics, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
|
US20150182756A1
(en)
*
|
2005-08-05 |
2015-07-02 |
Gholam A. Peyman |
Methods to regulate polarization and enhance function of cells
|
|
US8741260B2
(en)
*
|
2005-10-07 |
2014-06-03 |
Armagen Technologies, Inc. |
Fusion proteins for delivery of GDNF to the CNS
|
|
US8124095B2
(en)
*
|
2005-10-07 |
2012-02-28 |
Armagen Technologies, Inc. |
Fusion proteins for delivery of erythropoietin to the CNS
|
|
US8053569B2
(en)
*
|
2005-10-07 |
2011-11-08 |
Armagen Technologies, Inc. |
Nucleic acids encoding and methods of producing fusion proteins
|
|
US20090130212A1
(en)
*
|
2006-05-15 |
2009-05-21 |
Physical Pharmaceutica, Llc |
Composition and improved method for preparation of small particles
|
|
US9273356B2
(en)
|
2006-05-24 |
2016-03-01 |
Medtronic, Inc. |
Methods and kits for linking polymorphic sequences to expanded repeat mutations
|
|
DK2029746T3
(da)
*
|
2006-06-12 |
2012-10-08 |
Exegenics Inc D B A Opko Health Inc |
Sammensætninger og fremgangsmåder til siRNA-hæmning af angiogenese
|
|
US20080039415A1
(en)
*
|
2006-08-11 |
2008-02-14 |
Gregory Robert Stewart |
Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
|
|
US8759297B2
(en)
*
|
2006-08-18 |
2014-06-24 |
Armagen Technologies, Inc. |
Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns
|
|
US7872118B2
(en)
*
|
2006-09-08 |
2011-01-18 |
Opko Ophthalmics, Llc |
siRNA and methods of manufacture
|
|
WO2008030604A2
(en)
|
2006-09-08 |
2008-03-13 |
Rhode Island Hospital |
Treatment, prevention, and reversal of alcohol-induced brain disease
|
|
US20080213349A1
(en)
*
|
2006-09-11 |
2008-09-04 |
Deepak Ramesh Thakker |
Liposome Complexes Containing Pharmaceutical Agents and Methods
|
|
US8821943B2
(en)
*
|
2006-09-12 |
2014-09-02 |
Board Of Regents Of The University Of Nebraska |
Methods and compositions for targeted delivery of therapeutic agents
|
|
US9375440B2
(en)
*
|
2006-11-03 |
2016-06-28 |
Medtronic, Inc. |
Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
|
|
US8324367B2
(en)
|
2006-11-03 |
2012-12-04 |
Medtronic, Inc. |
Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
|
|
US7988668B2
(en)
*
|
2006-11-21 |
2011-08-02 |
Medtronic, Inc. |
Microsyringe for pre-packaged delivery of pharmaceuticals
|
|
US7819842B2
(en)
*
|
2006-11-21 |
2010-10-26 |
Medtronic, Inc. |
Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites
|
|
WO2008070579A2
(en)
*
|
2006-12-01 |
2008-06-12 |
Loma Linda University Medical Center |
Inhibition of brain enzymes involved in cerebral amyloid angiopathy and macular degeneration
|
|
US20080171906A1
(en)
*
|
2007-01-16 |
2008-07-17 |
Everaerts Frank J L |
Tissue performance via hydrolysis and cross-linking
|
|
PL2308514T3
(pl)
|
2007-03-23 |
2013-11-29 |
To Bbb Holding B V |
Koniugaty do ukierunkowanego dostarczania leku poprzez barierę krew-mózg
|
|
EP2140004B1
(en)
*
|
2007-04-12 |
2022-01-12 |
The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin |
Genetic suppression and replacement
|
|
WO2008137066A1
(en)
*
|
2007-05-02 |
2008-11-13 |
The Board Of Regents Of The University Of Oklahoma |
Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases
|
|
US20100286145A1
(en)
*
|
2007-07-26 |
2010-11-11 |
Comentis, Inc. |
Isophthalamide derivatives inhibiting beta-secretase activity
|
|
AU2008282496B2
(en)
|
2007-07-27 |
2013-04-04 |
Armagen Technologies, Inc. |
Methods and compositions for increasing alpha-iduronidase activity in the CNS
|
|
WO2009038779A2
(en)
*
|
2007-09-19 |
2009-03-26 |
University Of Tennessee Research Foundation |
Methods and compositions for inhibiting undesirable cellular proliferation by targeted liposome delivery of active agents
|
|
JP5055432B2
(ja)
*
|
2007-09-24 |
2012-10-24 |
コメンティス,インコーポレーテッド |
治療のためのβ−セクレターゼ阻害剤としての(3−ヒドロキシ−4−アミノブタン−2−イル)−3−(2−チアゾール−2−イル−ピロリジン−1−カルボニル)ベンズアミド誘導体及び関連する化合物
|
|
US7973019B1
(en)
|
2007-10-03 |
2011-07-05 |
Alcon Research, Ltd. |
Transferrin/transferrin receptor-mediated siRNA delivery
|
|
AR069328A1
(es)
|
2007-11-15 |
2010-01-13 |
Alcon Mfg Ltd |
Liberacion de rna interferente corto o sirna, intermediada por receptor de lipoproteina de baja densidad
|
|
EP2274007B1
(en)
*
|
2008-03-10 |
2016-12-14 |
Cornell University |
Modulation of blood brain barrier permeability
|
|
CA2740316A1
(en)
|
2008-10-15 |
2010-04-22 |
Angiochem Inc. |
Conjugates of glp-1 agonists and uses thereof
|
|
AU2009322279A1
(en)
|
2008-12-04 |
2011-07-14 |
Opko Pharmaceuticals, Llc |
Compositions and methods for selective inhibition of pro-angiogenic VEGF isoforms
|
|
CA2748889A1
(en)
|
2009-03-18 |
2010-09-23 |
Armagen Technologies, Inc. |
Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins
|
|
AU2010229700A1
(en)
*
|
2009-03-26 |
2011-10-27 |
Northeastern University |
Ascorbate-linked nanosystems for brain delivery
|
|
US20120301463A1
(en)
|
2009-09-30 |
2012-11-29 |
President And Fellows Of Harvard College |
Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
|
|
AU2010305284A1
(en)
*
|
2009-10-06 |
2012-05-03 |
Angiochem Inc. |
Compositions and methods for the transport of therapeutic agents
|
|
EP2485761B1
(en)
|
2009-10-09 |
2019-02-27 |
Armagen, Inc. |
Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
|
|
LT2547364T
(lt)
|
2010-03-15 |
2017-03-27 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Peptidai, konjugatai ir vakcinos imunogeniškumo padidinimo būdas
|
|
EP2380595A1
(en)
|
2010-04-19 |
2011-10-26 |
Nlife Therapeutics S.L. |
Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
|
|
ES2486321T3
(es)
*
|
2010-06-18 |
2014-08-18 |
Xiberscience Gmbh |
Péptidos como agentes activos para estabilizar barreras biológicas
|
|
CA2818173C
(en)
|
2010-11-30 |
2022-05-03 |
Genentech, Inc. |
Low affinity blood brain barrier receptor antibodies and uses therefor
|
|
CN102008441B
(zh)
*
|
2010-12-01 |
2014-05-07 |
赵永祥 |
Endoglin抗体偶联的脂质体及其制备方法和应用
|
|
WO2012161677A1
(en)
|
2011-05-20 |
2012-11-29 |
Alcon Research, Ltd. |
TRANSFERRIN/TRANSFERRIN RECEPTOR-MEDIATED siRNA DELIVERY
|
|
AU2012346448B2
(en)
|
2011-12-02 |
2017-09-14 |
Armagen, Inc. |
Methods and compositions for increasing arylsulfatase A activity in the CNS
|
|
EP2804602B1
(en)
|
2012-01-20 |
2024-12-04 |
Del Mar Pharmaceuticals |
Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem cells including glioblastoma multforme and medulloblastoma
|
|
EP2872183B1
(en)
*
|
2012-07-11 |
2018-09-26 |
The Trustees Of The University Of Pennsylvania |
Aav-mediated gene therapy for rpgr x-linked retinal degeneration
|
|
JP2015526434A
(ja)
|
2012-08-14 |
2015-09-10 |
アンジオケム インコーポレーテッド |
ペプチド−デンドリマーコンジュゲート及びその使用
|
|
US20140120157A1
(en)
*
|
2012-09-19 |
2014-05-01 |
Georgetown University |
Targeted liposomes
|
|
US9468681B2
(en)
|
2013-03-01 |
2016-10-18 |
California Institute Of Technology |
Targeted nanoparticles
|
|
US9605260B2
(en)
|
2013-03-14 |
2017-03-28 |
Ibis Biosciences, Inc. |
Alteration of neuronal gene expression by synthetic piRNAs and by alteration of piRNA function
|
|
WO2014185964A1
(en)
|
2013-05-14 |
2014-11-20 |
California Institute Of Technology |
Method of delivering therapeutics and imaging agents by nanoparticles that cross the blood brain barrier
|
|
SG11201608303QA
(en)
|
2014-04-04 |
2016-11-29 |
Del Mar Pharmaceuticals |
Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
|
|
US10538589B2
(en)
|
2015-01-14 |
2020-01-21 |
Armagen Inc. |
Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
|
|
WO2016168197A1
(en)
*
|
2015-04-15 |
2016-10-20 |
Yale University |
Compositions for enhancing delivery of agents across the blood brain barrier and methods of use thereof
|
|
EP3307326B9
(en)
|
2015-06-15 |
2021-02-24 |
Angiochem Inc. |
Methods for the treatment of leptomeningeal carcinomatosis
|
|
ES2882255T3
(es)
|
2015-07-01 |
2021-12-01 |
California Inst Of Techn |
Sistemas de administración basados en polímeros de ácido múcico catiónicos
|
|
GB201806095D0
(en)
|
2018-04-13 |
2018-05-30 |
Ucl Business Plc |
Metabolisable pH sensitive polymersomes
|
|
WO2019241327A1
(en)
|
2018-06-13 |
2019-12-19 |
California Institute Of Technology |
Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
|
|
CN113646003A
(zh)
*
|
2019-01-07 |
2021-11-12 |
Ucl商业有限公司 |
多配体官能化的聚合物泡囊
|
|
WO2020193802A1
(en)
|
2019-03-28 |
2020-10-01 |
Fundación De La Comunidad Valenciana Centro De Investigación Príncipe Felipe |
Polymeric conjugates and uses thereof
|
|
WO2021222295A1
(en)
*
|
2020-04-27 |
2021-11-04 |
Aruna Bio, Inc. |
Binding agents and uses thereof for central nervous system delivery
|
|
TW202228792A
(zh)
|
2020-10-09 |
2022-08-01 |
殷漢生技股份有限公司 |
吸入用奈米載體製劑
|
|
WO2025110074A1
(ja)
*
|
2023-11-22 |
2025-05-30 |
ケミテラス株式会社 |
デアザフラビンのリポソーム製剤
|
|
WO2025160275A1
(en)
|
2024-01-24 |
2025-07-31 |
Arrowhead Pharmaceuticals, Inc. |
Anti-transferrin receptor antibodies, conjugates thereof, and uses thereof
|