JP2004524357A5 - - Google Patents
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- Publication number
- JP2004524357A5 JP2004524357A5 JP2002577011A JP2002577011A JP2004524357A5 JP 2004524357 A5 JP2004524357 A5 JP 2004524357A5 JP 2002577011 A JP2002577011 A JP 2002577011A JP 2002577011 A JP2002577011 A JP 2002577011A JP 2004524357 A5 JP2004524357 A5 JP 2004524357A5
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydro
- pyran
- hydroxymethyl
- pyrrolidin
- isobutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 6
- 208000015114 central nervous system disease Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- RCDRJCSOBMHAGQ-CHXUSJIQSA-N (4s)-1-[[2,3-dihydroxy-5-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl]-4-(2-methylpropyl)pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1CC1(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(CO)O1 RCDRJCSOBMHAGQ-CHXUSJIQSA-N 0.000 claims 2
- AZUXUOROLIYZMA-IEPCQTTFSA-N (4s)-4-(2-methylpropyl)-1-[(2,3,4,5-tetrahydroxyoxan-2-yl)methyl]pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1CC1(O)C(O)C(O)C(O)CO1 AZUXUOROLIYZMA-IEPCQTTFSA-N 0.000 claims 2
- BAZBIXRKAXNTCJ-IEPCQTTFSA-N (4s)-4-(2-methylpropyl)-1-[[2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl]pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1CC1(O)C(O)C(O)C(CO)O1 BAZBIXRKAXNTCJ-IEPCQTTFSA-N 0.000 claims 2
- XDWMEMJQXHTKBB-CHXUSJIQSA-N (4s)-4-(2-methylpropyl)-1-[[2,3,5-trihydroxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl]pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1CC1(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(O)CO1 XDWMEMJQXHTKBB-CHXUSJIQSA-N 0.000 claims 2
- BSKMCHXCKWARJQ-RZAKBIKASA-N (4s)-1-[3,4-dihydroxy-6-(hydroxymethyl)-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]-4-(2-methylpropyl)pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1C1C(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(CO)O1 BSKMCHXCKWARJQ-RZAKBIKASA-N 0.000 claims 1
- BQKWHOPNFGYFHX-LONARHHWSA-N (4s)-1-[3,4-dihydroxy-6-(hydroxymethyl)-5-[3,4,5-tris(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]-4-(2-methylpropyl)pyrrolidin-2-one Chemical compound O=C1C[C@H](CC(C)C)CN1C1C(O)C(O)C(OC2C(C(CO)C(CO)CO2)CO)C(CO)O1 BQKWHOPNFGYFHX-LONARHHWSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims 1
- 229960001233 pregabalin Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28017601P | 2001-03-30 | 2001-03-30 | |
| PCT/IB2002/000647 WO2002078747A2 (en) | 2001-03-30 | 2002-02-25 | Pregabalin lactose conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004524357A JP2004524357A (ja) | 2004-08-12 |
| JP2004524357A5 true JP2004524357A5 (https=) | 2005-12-22 |
Family
ID=23072002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002577011A Pending JP2004524357A (ja) | 2001-03-30 | 2002-02-25 | プレガバリンラクトース結合体 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7022678B2 (https=) |
| EP (1) | EP1377318A2 (https=) |
| JP (1) | JP2004524357A (https=) |
| KR (1) | KR20040008146A (https=) |
| CN (1) | CN1511043A (https=) |
| AP (1) | AP2003002873A0 (https=) |
| AR (1) | AR033024A1 (https=) |
| BG (1) | BG108193A (https=) |
| BR (1) | BR0208439A (https=) |
| CA (1) | CA2440468C (https=) |
| CZ (1) | CZ20032547A3 (https=) |
| DO (1) | DOP2002000356A (https=) |
| EA (1) | EA200300954A1 (https=) |
| EC (1) | ECSP034740A (https=) |
| EE (1) | EE200300480A (https=) |
| GT (1) | GT200200051A (https=) |
| HU (1) | HUP0303956A2 (https=) |
| IL (1) | IL157879A0 (https=) |
| IS (1) | IS6912A (https=) |
| MA (1) | MA27004A1 (https=) |
| MX (1) | MXPA03007437A (https=) |
| NO (1) | NO20034348D0 (https=) |
| OA (1) | OA12456A (https=) |
| PA (1) | PA8542101A1 (https=) |
| PE (1) | PE20021016A1 (https=) |
| PL (1) | PL369179A1 (https=) |
| SK (1) | SK11832003A3 (https=) |
| SV (1) | SV2003000928A (https=) |
| TN (1) | TNSN02038A1 (https=) |
| UY (1) | UY27233A1 (https=) |
| WO (1) | WO2002078747A2 (https=) |
| ZA (1) | ZA200306608B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| ES2398579T3 (es) * | 2005-09-19 | 2013-03-20 | Teva Pharmaceutical Industries Ltd | Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico |
| DE102007019071A1 (de) | 2007-04-23 | 2008-10-30 | Ratiopharm Gmbh | Stabilisierte pharmazeutische Zusammensetzung enthaltend Pregabalin |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| EP2297090A1 (en) * | 2008-06-23 | 2011-03-23 | Teva Pharmaceutical Industries Ltd. | Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester |
| WO2010115612A2 (en) | 2009-04-10 | 2010-10-14 | Synthon B.V. | Pregabalin compositions |
| WO2010150221A1 (en) | 2009-06-25 | 2010-12-29 | Wockhardt Research Centre | Taste masked pharmaceutical compositions of pregabalin |
| HU230031B1 (hu) * | 2010-03-01 | 2015-05-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Pregabalint és izomaltot tartalmazó stabilizált gyógyszerkészítmény |
| CN103494796B (zh) * | 2013-09-30 | 2016-01-20 | 浙江华义医药有限公司 | 普瑞巴林稳定的药物组合物及其制备方法 |
| CN104370986B (zh) * | 2014-10-28 | 2017-07-04 | 河南中烟工业有限责任公司 | 糖衍生物烟用增香保润剂Mal‑Pro、制备方法及其应用 |
| CN104311608B (zh) * | 2014-10-28 | 2016-10-05 | 河南中烟工业有限责任公司 | 亲水型烟草增香保润剂Mal-Hyp、制备方法及其应用 |
| CN105520918B (zh) * | 2015-12-31 | 2018-12-11 | 常州市阳光药业有限公司 | 普瑞巴林胶囊 |
| CN105434395B (zh) * | 2015-12-31 | 2018-12-11 | 常州市阳光药业有限公司 | 普瑞巴林胶囊及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| FR2781793B1 (fr) * | 1998-08-03 | 2001-07-20 | Prographarm Lab | Procede de fabrication de granules de gabapentine enrobes |
| EP1121114B1 (en) * | 1998-10-16 | 2007-01-10 | Warner-Lambert Company Llc | Use of gaba analogs for the manufacture of a medicament for the treatment of mania and bipolar disorders |
| CA2430298A1 (en) * | 2000-11-30 | 2002-06-06 | Banavara Lakshman Mylari | Combination of gaba agonists and sorbitol dehydrogenase inhibitors |
-
2002
- 2002-01-28 US US10/058,903 patent/US7022678B2/en not_active Expired - Fee Related
- 2002-02-25 CN CNA028067509A patent/CN1511043A/zh active Pending
- 2002-02-25 SK SK1183-2003A patent/SK11832003A3/sk not_active Application Discontinuation
- 2002-02-25 EP EP02702614A patent/EP1377318A2/en not_active Withdrawn
- 2002-02-25 EE EEP200300480A patent/EE200300480A/xx unknown
- 2002-02-25 MX MXPA03007437A patent/MXPA03007437A/es active IP Right Grant
- 2002-02-25 JP JP2002577011A patent/JP2004524357A/ja active Pending
- 2002-02-25 PL PL02369179A patent/PL369179A1/xx not_active Application Discontinuation
- 2002-02-25 CZ CZ20032547A patent/CZ20032547A3/cs unknown
- 2002-02-25 HU HU0303956A patent/HUP0303956A2/hu unknown
- 2002-02-25 EA EA200300954A patent/EA200300954A1/ru unknown
- 2002-02-25 CA CA002440468A patent/CA2440468C/en not_active Expired - Fee Related
- 2002-02-25 KR KR10-2003-7012714A patent/KR20040008146A/ko not_active Ceased
- 2002-02-25 IL IL15787902A patent/IL157879A0/xx unknown
- 2002-02-25 BR BR0208439-2A patent/BR0208439A/pt not_active IP Right Cessation
- 2002-02-25 WO PCT/IB2002/000647 patent/WO2002078747A2/en not_active Ceased
- 2002-02-25 OA OA1200300232A patent/OA12456A/en unknown
- 2002-02-25 AP APAP/P/2003/002873A patent/AP2003002873A0/en unknown
- 2002-03-07 DO DO2002000356A patent/DOP2002000356A/es unknown
- 2002-03-19 GT GT200200051A patent/GT200200051A/es unknown
- 2002-03-22 SV SV2002000928A patent/SV2003000928A/es not_active Application Discontinuation
- 2002-03-27 PA PA20028542101A patent/PA8542101A1/es unknown
- 2002-03-27 PE PE2002000252A patent/PE20021016A1/es not_active Application Discontinuation
- 2002-03-27 UY UY27233A patent/UY27233A1/es not_active Application Discontinuation
- 2002-03-27 AR ARP020101140A patent/AR033024A1/es unknown
- 2002-03-29 TN TNTNSN02038A patent/TNSN02038A1/fr unknown
-
2003
- 2003-08-14 IS IS6912A patent/IS6912A/is unknown
- 2003-08-21 EC EC2003004740A patent/ECSP034740A/es unknown
- 2003-08-25 ZA ZA200306608A patent/ZA200306608B/en unknown
- 2003-09-17 MA MA27315A patent/MA27004A1/fr unknown
- 2003-09-24 BG BG108193A patent/BG108193A/xx unknown
- 2003-09-29 NO NO20034348A patent/NO20034348D0/no not_active Application Discontinuation
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