JP2004520267A5 - - Google Patents
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- Publication number
- JP2004520267A5 JP2004520267A5 JP2002518950A JP2002518950A JP2004520267A5 JP 2004520267 A5 JP2004520267 A5 JP 2004520267A5 JP 2002518950 A JP2002518950 A JP 2002518950A JP 2002518950 A JP2002518950 A JP 2002518950A JP 2004520267 A5 JP2004520267 A5 JP 2004520267A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- composition
- cancer
- angiogenesis
- branched alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 26
- 239000000203 mixture Substances 0.000 description 16
- 230000033115 angiogenesis Effects 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 208000035475 disorder Diseases 0.000 description 12
- 125000000623 heterocyclic group Chemical group 0.000 description 12
- 125000003118 aryl group Chemical group 0.000 description 6
- 125000003107 substituted aryl group Chemical group 0.000 description 6
- LSBDFXRDZJMBSC-UHFFFAOYSA-N Amide-Phenylacetic acid Natural products NC(=O)CC1=CC=CC=C1 LSBDFXRDZJMBSC-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- ALDSXDRDRWDASQ-UHFFFAOYSA-N 2-(3-benzoylphenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 ALDSXDRDRWDASQ-UHFFFAOYSA-N 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- -1 3-benzoylphenyl Chemical group 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- XAARRDGAECXQPW-UHFFFAOYSA-N 2-[2-amino-3-(4-fluorobenzoyl)phenyl]acetamide Chemical group NC(=O)CC1=CC=CC(C(=O)C=2C=CC(F)=CC=2)=C1N XAARRDGAECXQPW-UHFFFAOYSA-N 0.000 description 2
- 206010005003 Bladder cancer Diseases 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- 206010055665 Corneal neovascularisation Diseases 0.000 description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 description 2
- 208000010412 Glaucoma Diseases 0.000 description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 2
- 206010060862 Prostate cancer Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 201000002154 Pterygium Diseases 0.000 description 2
- 206010038389 Renal cancer Diseases 0.000 description 2
- 208000017442 Retinal disease Diseases 0.000 description 2
- 206010038923 Retinopathy Diseases 0.000 description 2
- 206010038933 Retinopathy of prematurity Diseases 0.000 description 2
- 206010038935 Retinopathy sickle cell Diseases 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 2
- 208000029742 colonic neoplasm Diseases 0.000 description 2
- 201000000159 corneal neovascularization Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 206010017758 gastric cancer Diseases 0.000 description 2
- 229940113601 irrigation solution Drugs 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 201000010982 kidney cancer Diseases 0.000 description 2
- 201000007270 liver cancer Diseases 0.000 description 2
- 201000004514 liver lymphoma Diseases 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- 201000010997 liver sarcoma Diseases 0.000 description 2
- 201000005202 lung cancer Diseases 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- 208000002780 macular degeneration Diseases 0.000 description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 201000003142 neovascular glaucoma Diseases 0.000 description 2
- 201000002528 pancreatic cancer Diseases 0.000 description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 description 2
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 description 2
- 201000011549 stomach cancer Diseases 0.000 description 2
- 201000005112 urinary bladder cancer Diseases 0.000 description 2
- QYWOBAQCODTFCM-UHFFFAOYSA-N 2-[2-amino-3-(4-chlorobenzoyl)phenyl]acetamide Chemical compound NC(=O)CC1=CC=CC(C(=O)C=2C=CC(Cl)=CC=2)=C1N QYWOBAQCODTFCM-UHFFFAOYSA-N 0.000 description 1
- YVKSMFUEDUPYIF-UHFFFAOYSA-N 3-oxo-2,3-diphenylpropanoic acid Chemical compound C=1C=CC=CC=1C(C(=O)O)C(=O)C1=CC=CC=C1 YVKSMFUEDUPYIF-UHFFFAOYSA-N 0.000 description 1
- 125000000242 4-chlorobenzoyl group Chemical group ClC1=CC=C(C(=O)*)C=C1 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22513300P | 2000-08-14 | 2000-08-14 | |
| US60/225,133 | 2000-08-14 | ||
| PCT/US2001/025318 WO2002013804A2 (en) | 2000-08-14 | 2001-08-13 | Method of treating angiogenesis-related disorders using benzoyl phenylacetic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012158552A Division JP2012193214A (ja) | 2000-08-14 | 2012-07-17 | ベンゾイルフェニル酢酸を使用して、血管形成関連障害を処置するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004520267A JP2004520267A (ja) | 2004-07-08 |
| JP2004520267A5 true JP2004520267A5 (https=) | 2008-08-14 |
| JP5586117B2 JP5586117B2 (ja) | 2014-09-10 |
Family
ID=22843668
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002518950A Expired - Fee Related JP5586117B2 (ja) | 2000-08-14 | 2001-08-13 | ベンゾイルフェニル酢酸を使用して、血管形成関連障害を処置するための方法 |
| JP2012158552A Pending JP2012193214A (ja) | 2000-08-14 | 2012-07-17 | ベンゾイルフェニル酢酸を使用して、血管形成関連障害を処置するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012158552A Pending JP2012193214A (ja) | 2000-08-14 | 2012-07-17 | ベンゾイルフェニル酢酸を使用して、血管形成関連障害を処置するための方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20020037929A1 (https=) |
| EP (1) | EP1309323B1 (https=) |
| JP (2) | JP5586117B2 (https=) |
| KR (1) | KR20030017653A (https=) |
| CN (1) | CN1447688A (https=) |
| AR (1) | AR030345A1 (https=) |
| AT (1) | ATE345123T1 (https=) |
| AU (2) | AU2001283337B2 (https=) |
| BR (1) | BR0113204A (https=) |
| CA (1) | CA2417282C (https=) |
| DE (1) | DE60124560T2 (https=) |
| DK (1) | DK1309323T3 (https=) |
| ES (1) | ES2275710T3 (https=) |
| MX (1) | MXPA03001057A (https=) |
| PL (1) | PL366220A1 (https=) |
| PT (1) | PT1309323E (https=) |
| WO (1) | WO2002013804A2 (https=) |
| ZA (1) | ZA200300782B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0309747A (pt) * | 2002-05-03 | 2005-04-26 | Alcon Inc | Método para o tratamento de distúrbios vasculares mediados pelo fator de crescimento vascular endotelial |
| KR20050043923A (ko) * | 2002-09-16 | 2005-05-11 | 알콘 매뉴팩츄어링, 리미티드 | 혈관신생 치료를 위한 ｐｄｅ-ⅳ 저해제의 용도 |
| JP2006512318A (ja) * | 2002-11-12 | 2006-04-13 | アルコン，インコーポレイテッド | 眼の血管新生もしくは水腫状の疾患および障害を処置するためのヒストンデアセチラーゼインヒビター |
| PT1586316E (pt) | 2003-01-21 | 2008-05-28 | Senju Pharma Co | Preparação líquida aquosa contendo ácido 2-amino-3-(4- bromobenzoil)fenilacético |
| US7879905B2 (en) * | 2004-11-09 | 2011-02-01 | Alcon, Inc. | 5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses |
| TWI358290B (en) | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| FR2909876A1 (fr) * | 2006-12-19 | 2008-06-20 | Galderma Res & Dev S N C Snc | Utilisation du nepafenac ou ses derives pour le traitement de desordres dermatologiques |
| US20100292289A1 (en) * | 2007-11-30 | 2010-11-18 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with novel amides |
| RU2010138799A (ru) * | 2008-02-21 | 2012-03-27 | Иста Фармасьютикалз (Us) | Офтальмологические нестероидные противовоспалительные средства в качестве адъювантов |
| US8962686B2 (en) * | 2010-04-28 | 2015-02-24 | The Chinese University Of Hong Kong | Method and medication for prevention and treatment of ocular hypertension and glaucoma |
| US9630909B2 (en) | 2013-06-27 | 2017-04-25 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE400966B (sv) * | 1975-08-13 | 1978-04-17 | Robins Co Inc A H | Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror |
| US4313949A (en) * | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
| ZA805476B (en) * | 1979-09-26 | 1981-11-25 | Robins Co Inc A H | 2-amino-3-benzoyl-phenylacetamides and cyclic homologues |
| US4254146A (en) * | 1979-10-18 | 1981-03-03 | A. H. Robins Company, Inc. | 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| DE3026402A1 (de) * | 1980-07-11 | 1982-02-04 | Syntex Corp., Palo Alto, Calif. | Die verwendung analgetischer und nicht-hormonaler, entzuendungshemmender mittel bei der behandlung von mikrovaskulaeren erkrankungen |
| US4503073A (en) * | 1981-01-07 | 1985-03-05 | A. H. Robins Company, Incorporated | 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids |
| IL64724A0 (en) * | 1981-02-17 | 1982-03-31 | Robins Co Inc A H | 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them |
| US4568695A (en) * | 1983-12-07 | 1986-02-04 | A. H. Robins Company, Incorporated | 2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor |
| US4683242A (en) * | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
| CA1325382C (en) * | 1988-01-27 | 1993-12-21 | Takahiro Ogawa | Locally administrable therapeutic composition for inflammatory disease |
| US5475034A (en) * | 1994-06-06 | 1995-12-12 | Alcon Laboratories, Inc. | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
| US5811446A (en) * | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
| US6207700B1 (en) * | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
| ATE283013T1 (de) * | 1999-10-21 | 2004-12-15 | Alcon Inc | Medikamentenzuführvorrichtung |
| US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
| WO2001035181A1 (en) * | 1999-11-11 | 2001-05-17 | Wireless Methods Ltd. | Remote switching and actuation of electrical devices |
-
2001
- 2001-08-10 AR ARP010103846A patent/AR030345A1/es not_active Application Discontinuation
- 2001-08-13 EP EP01962132A patent/EP1309323B1/en not_active Expired - Lifetime
- 2001-08-13 ES ES01962132T patent/ES2275710T3/es not_active Expired - Lifetime
- 2001-08-13 MX MXPA03001057A patent/MXPA03001057A/es active IP Right Grant
- 2001-08-13 US US09/929,381 patent/US20020037929A1/en not_active Abandoned
- 2001-08-13 AU AU2001283337A patent/AU2001283337B2/en not_active Ceased
- 2001-08-13 AT AT01962132T patent/ATE345123T1/de active
- 2001-08-13 KR KR10-2003-7001087A patent/KR20030017653A/ko not_active Ceased
- 2001-08-13 CA CA002417282A patent/CA2417282C/en not_active Expired - Fee Related
- 2001-08-13 JP JP2002518950A patent/JP5586117B2/ja not_active Expired - Fee Related
- 2001-08-13 BR BRPI0113204-0A patent/BR0113204A/pt not_active Application Discontinuation
- 2001-08-13 DE DE60124560T patent/DE60124560T2/de not_active Expired - Lifetime
- 2001-08-13 PL PL01366220A patent/PL366220A1/xx not_active Application Discontinuation
- 2001-08-13 DK DK01962132T patent/DK1309323T3/da active
- 2001-08-13 CN CN01814168A patent/CN1447688A/zh active Pending
- 2001-08-13 WO PCT/US2001/025318 patent/WO2002013804A2/en not_active Ceased
- 2001-08-13 PT PT01962132T patent/PT1309323E/pt unknown
- 2001-08-13 AU AU8333701A patent/AU8333701A/xx active Pending
-
2003
- 2003-01-29 ZA ZA200300782A patent/ZA200300782B/en unknown
-
2012
- 2012-07-17 JP JP2012158552A patent/JP2012193214A/ja active Pending
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