JP2004519459A5 - - Google Patents
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- Publication number
- JP2004519459A5 JP2004519459A5 JP2002557400A JP2002557400A JP2004519459A5 JP 2004519459 A5 JP2004519459 A5 JP 2004519459A5 JP 2002557400 A JP2002557400 A JP 2002557400A JP 2002557400 A JP2002557400 A JP 2002557400A JP 2004519459 A5 JP2004519459 A5 JP 2004519459A5
- Authority
- JP
- Japan
- Prior art keywords
- helicobacter pylori
- binding
- group
- oligosaccharide
- nac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000027455 binding Effects 0.000 claims description 32
- 150000002482 oligosaccharides Polymers 0.000 claims description 27
- 241000590002 Helicobacter pylori Species 0.000 claims description 26
- 229940037467 helicobacter pylori Drugs 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 20
- 229930186217 Glycolipid Natural products 0.000 claims description 9
- 229920001542 oligosaccharide Polymers 0.000 claims description 8
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims description 6
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims description 5
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims description 5
- -1 lactosyl residue Chemical group 0.000 claims description 4
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 108010037833 Bacterial Adhesins Proteins 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 238000000159 protein binding assay Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 15
- 235000013350 formula milk Nutrition 0.000 claims 11
- 125000006850 spacer group Chemical group 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical class NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 150000002772 monosaccharides Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 claims 1
- 208000012895 Gastric disease Diseases 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000016222 Pancreatic disease Diseases 0.000 claims 1
- 208000031845 Pernicious anaemia Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 208000034972 Sudden Infant Death Diseases 0.000 claims 1
- 206010042440 Sudden infant death syndrome Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 150000001408 amides Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 201000005000 autoimmune gastritis Diseases 0.000 claims 1
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 125000002519 galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 claims 1
- 201000006585 gastric adenocarcinoma Diseases 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 125000003563 glycoside group Chemical group 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 125000003198 secondary alcohol group Chemical group 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 150000002339 glycosphingolipids Chemical class 0.000 description 29
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 6
- ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical group CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 3
- 238000000211 autoradiogram Methods 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 238000010306 acid treatment Methods 0.000 description 2
- 150000001450 anions Chemical group 0.000 description 2
- 238000000376 autoradiography Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 108010005965 endoglycoceramidase Proteins 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 238000002143 fast-atom bombardment mass spectrum Methods 0.000 description 2
- 210000001156 gastric mucosa Anatomy 0.000 description 2
- 210000003714 granulocyte Anatomy 0.000 description 2
- 150000002402 hexoses Chemical class 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- HOMYIYLRRDTKAA-UHFFFAOYSA-N 2-hydroxy-N-[3-hydroxy-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]hexadecanamide Chemical compound CCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=CCCCCCCCCC)COC1OC(CO)C(O)C(O)C1O HOMYIYLRRDTKAA-UHFFFAOYSA-N 0.000 description 1
- 241001672700 Erycina crista-galli Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical group CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- WPIHMWBQRSAMDE-YCZTVTEBSA-N beta-D-galactosyl-(1->4)-beta-D-galactosyl-N-(pentacosanoyl)sphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)\C=C\CCCCCCCCCCCCC WPIHMWBQRSAMDE-YCZTVTEBSA-N 0.000 description 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 150000002298 globosides Chemical class 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000000350 glycoloyl group Chemical group O=C([*])C([H])([H])O[H] 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 238000012900 molecular simulation Methods 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 125000005630 sialyl group Chemical group 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000002992 thymic effect Effects 0.000 description 1
- 150000004043 trisaccharides Chemical group 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- HFQKBOPMAOTAIR-TZSVBWBLSA-N α-d-galactosyl-(1->4)-β-d-galactosyl-(1->4)-β-d-glucosylceramide Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(C)=O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 HFQKBOPMAOTAIR-TZSVBWBLSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20010118A FI20010118L (fi) | 2001-01-19 | 2001-01-19 | Uudet helicobacter pylori reseptorit ja niiden käyttö |
| PCT/FI2002/000043 WO2002056893A1 (en) | 2001-01-19 | 2002-01-18 | Novel receptors for $i(helicobacter pylori) and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004519459A JP2004519459A (ja) | 2004-07-02 |
| JP2004519459A5 true JP2004519459A5 (enExample) | 2010-06-24 |
Family
ID=8560066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557400A Pending JP2004519459A (ja) | 2001-01-19 | 2002-01-18 | ヘリコバクターピロリに対する新規受容体およびその用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20040096465A1 (enExample) |
| EP (1) | EP1359922A1 (enExample) |
| JP (1) | JP2004519459A (enExample) |
| KR (1) | KR100886777B1 (enExample) |
| CN (1) | CN100455290C (enExample) |
| AU (1) | AU2002229792B2 (enExample) |
| CA (1) | CA2434350A1 (enExample) |
| CZ (1) | CZ20031914A3 (enExample) |
| EE (1) | EE200300339A (enExample) |
| FI (1) | FI20010118L (enExample) |
| HU (1) | HUP0302790A3 (enExample) |
| IL (1) | IL156992A0 (enExample) |
| NO (1) | NO20033270L (enExample) |
| NZ (1) | NZ526906A (enExample) |
| PL (1) | PL363617A1 (enExample) |
| RU (1) | RU2306140C2 (enExample) |
| SK (1) | SK10042003A3 (enExample) |
| WO (1) | WO2002056893A1 (enExample) |
| ZA (1) | ZA200305155B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904581D0 (sv) * | 1999-12-15 | 1999-12-15 | A & Science Invest Ab | A novel helicobacter pylori-binding substance and use thereof |
| FI20011671A7 (fi) | 2001-08-20 | 2003-02-21 | Carbion Oy | Tuumorispesifiset oligosakkaridisekvenssit ja niiden käyttö |
| US20050220819A1 (en) * | 2002-01-18 | 2005-10-06 | Biotie Therapies Oyj | Novel binding epitopes for helicobacter pylori and use thereof |
| EP1531832B1 (en) * | 2002-06-28 | 2009-04-15 | Glykos Finland Oy | Therapeutic compositions for use in prophylaxis or treatment of diarrheas |
| FI20021989A0 (fi) * | 2002-11-06 | 2002-11-06 | Halina Miller-Podraza | Korkean affiniteetin Helicobacter pylori-reseptorit ja niiden käyttö |
| WO2004065400A1 (en) * | 2003-01-20 | 2004-08-05 | Glykos Finland Oy | Novel binding epitopes for helicobacter pylori and use thereof |
| JP5035787B2 (ja) * | 2005-10-04 | 2012-09-26 | 焼津水産化学工業株式会社 | α−１、４結合型Ｎ−アセチルグルコサミン含有Ｏ−グリカン型糖鎖の分泌促進剤並びにこれを含有するヘリコバクターピロリ菌を原因とする病態の治療予防剤 |
| JP5140246B2 (ja) * | 2006-03-15 | 2013-02-06 | 公益財団法人野口研究所 | Ｎ−アセチルグルコサミンの誘導体を含有するピロリ菌増殖抑制剤 |
| JP5014018B2 (ja) * | 2006-10-18 | 2012-08-29 | 旭化成ケミカルズ株式会社 | ピロリ菌の抑制剤または静菌剤 |
| US8075674B2 (en) | 2006-11-30 | 2011-12-13 | Donaldson Company, Inc. | Filter apparatus with pulse cleaning and methods for pulse cleaning filters |
| US20100233198A1 (en) * | 2007-11-08 | 2010-09-16 | Nestec S.A. | Use of oligosaccharides containing n-acetyllactosamine for maturation of immune responses in neonates |
| EP2060257A1 (en) | 2007-11-08 | 2009-05-20 | Nestec S.A. | Prevention and treatment of secondary infections following viral infection |
| AU2013237497B2 (en) * | 2012-03-19 | 2016-05-12 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Carbohydrate-glycolipid conjugate vaccines |
| AU2013338153B2 (en) * | 2012-10-29 | 2018-06-21 | The Board Of Trustees Of The University Of Arkansas | Novel mucosal adjuvants and delivery systems |
| CN112023037A (zh) * | 2020-09-09 | 2020-12-04 | 四川大学 | 一种聚糖在制备对Hp感染的预防和治疗产品中的应用、产品及制备方法 |
| CN112285338B (zh) * | 2020-10-20 | 2023-04-28 | 四川大学华西医院 | 一种copd诊断试剂盒 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU561067B2 (en) | 1982-03-22 | 1987-04-30 | Biocarb Ab | Anti-bacterial composition containing an oligosaccharide |
| SE8203925D0 (sv) * | 1982-06-23 | 1982-06-23 | Svenska Sockerfabriks Ab | New and novel glycosides, glycoconjugates and processes for their preparation |
| DK17685D0 (da) * | 1985-01-14 | 1985-01-14 | Hans Goeran Magnusson | Glycosidderivater |
| US5217715A (en) * | 1988-08-01 | 1993-06-08 | The United States Of America As Represented By The Department Of Health And Human Services | Carbohydrate receptor for bacteria and method for use thereof |
| KR960022566A (ko) * | 1994-12-30 | 1996-07-18 | 김충환 | 신규한 아미노올리고당 유도체 및 그의 제조방법 |
| US5736533A (en) * | 1995-06-07 | 1998-04-07 | Neose Technologies, Inc. | Bacterial inhibition with an oligosaccharide compound |
| JPH1045602A (ja) * | 1996-07-31 | 1998-02-17 | Motoyasu Murakami | ヘリコバクター・ピロリ接着阻害剤またはインターロイキン−８産生阻害剤 |
| SE9904581D0 (sv) * | 1999-12-15 | 1999-12-15 | A & Science Invest Ab | A novel helicobacter pylori-binding substance and use thereof |
-
2001
- 2001-01-19 FI FI20010118A patent/FI20010118L/fi unknown
-
2002
- 2002-01-18 EP EP02710901A patent/EP1359922A1/en not_active Withdrawn
- 2002-01-18 PL PL02363617A patent/PL363617A1/xx not_active Application Discontinuation
- 2002-01-18 CN CNB028057538A patent/CN100455290C/zh not_active Expired - Fee Related
- 2002-01-18 CZ CZ20031914A patent/CZ20031914A3/cs unknown
- 2002-01-18 HU HU0302790A patent/HUP0302790A3/hu unknown
- 2002-01-18 RU RU2003125370/15A patent/RU2306140C2/ru not_active IP Right Cessation
- 2002-01-18 NZ NZ526906A patent/NZ526906A/en unknown
- 2002-01-18 AU AU2002229792A patent/AU2002229792B2/en not_active Ceased
- 2002-01-18 KR KR1020037009587A patent/KR100886777B1/ko not_active Expired - Fee Related
- 2002-01-18 JP JP2002557400A patent/JP2004519459A/ja active Pending
- 2002-01-18 SK SK1004-2003A patent/SK10042003A3/sk not_active Application Discontinuation
- 2002-01-18 IL IL15699202A patent/IL156992A0/xx unknown
- 2002-01-18 EE EEP200300339A patent/EE200300339A/xx unknown
- 2002-01-18 WO PCT/FI2002/000043 patent/WO2002056893A1/en not_active Ceased
- 2002-01-18 CA CA002434350A patent/CA2434350A1/en not_active Abandoned
- 2002-01-18 ZA ZA200305155A patent/ZA200305155B/xx unknown
- 2002-01-18 US US10/466,415 patent/US20040096465A1/en not_active Abandoned
-
2003
- 2003-07-18 NO NO20033270A patent/NO20033270L/no not_active Application Discontinuation
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