JP2004518624A - Ｈｉｖ−１感染を阻害する組成物および方法 - Google Patents
Ｈｉｖ−１感染を阻害する組成物および方法 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- Peptides Or Proteins (AREA)
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| US66321900A | 2000-09-15 | 2000-09-15 | |
| PCT/US2001/002633 WO2001055439A1 (en) | 2000-01-28 | 2001-01-26 | Compositions and methods for inhibition of hiv-1 infection |
| US26673801P | 2001-02-06 | 2001-02-06 | |
| US09/912,824 US7138119B2 (en) | 2000-09-15 | 2001-07-25 | Compositions and methods for inhibition of HIV-1 infection |
| PCT/US2001/028756 WO2002022077A2 (en) | 2000-09-15 | 2001-09-14 | Compositions and methods for inhibition of hiv-1 infection |
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| JP2004518624A true JP2004518624A (ja) | 2004-06-24 |
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| AU (2) | AU9092501A (OSRAM) |
| CA (1) | CA2422275A1 (OSRAM) |
| WO (1) | WO2002022077A2 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012065055A3 (en) * | 2010-11-12 | 2012-07-12 | The Rockefeller University | Fusion proteins for hiv therapy |
| JP2017501986A (ja) * | 2013-12-02 | 2017-01-19 | アーロン ダイアモンド エイズ リサーチ センター | ネイティブな構成を有する二重特異性抗体を使用した細胞レセプターアンカリングによる改善されたｈｉｖ−１中和抗体の効力及び幅 |
| JP2019521639A (ja) * | 2015-11-21 | 2019-08-08 | フンダシオ プリバダ インスティトゥト デ レセルカ デラ シダ−カイサＦｕｎｄａｃｉｏ Ｐｒｉｖａｄａ Ｉｎｓｔｉｔｕｔ Ｄｅ Ｒｅｃｅｒｃａ Ｄｅ Ｌａ Ｓｉｄａ−Ｃａｉｘａ | 抗ウイルスおよび免疫調節の二重活性を有するｈｉｖ抗体誘導体 |
| JP2020519309A (ja) * | 2017-05-10 | 2020-07-02 | アルバジュナ・セラピューティクス・エセ・エレ | 高い二重のＨＩＶ抗ウイルス及び免疫調節活性を有するＦｃ融合タンパク質誘導体 |
| US12098187B2 (en) | 2013-12-02 | 2024-09-24 | The Trustees Of Columbia University In The City Of New York | Bispecific HIV-1-neutralizing antibodies |
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| US7858298B1 (en) | 1996-04-01 | 2010-12-28 | Progenics Pharmaceuticals Inc. | Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists |
| US6344545B1 (en) * | 1996-06-14 | 2002-02-05 | Progenics Pharmaceuticals, Inc. | Method for preventing HIV-1 infection of CD4+ cells |
| US20040086528A1 (en) * | 1996-06-14 | 2004-05-06 | Progenics Pharmaceuticals, Inc. | Uses of a chemokine receptor for inhibiting HIV-1 infection |
| US20040228869A1 (en) * | 1998-12-16 | 2004-11-18 | Progenics Pharmaceuticals, Inc. | Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto |
| SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US6548636B2 (en) * | 2000-02-29 | 2003-04-15 | Progenics Pharmaceuticals, Inc. | Sulfated CCR5 peptides for HIV-1 infection |
| US7138119B2 (en) | 2000-09-15 | 2006-11-21 | Progenics Pharmaceuticals, Inc. | Compositions and methods for inhibition of HIV-1 infection |
| US7060273B2 (en) | 2001-04-06 | 2006-06-13 | Progenics Pharmaceuticals, Inc. | Methods for inhibiting HIV-1 infection |
| US20020146415A1 (en) * | 2001-04-06 | 2002-10-10 | Olson William C. | Methods for inhibiting HIV-1 infection |
| US7122185B2 (en) * | 2002-02-22 | 2006-10-17 | Progenics Pharmaceuticals, Inc. | Anti-CCR5 antibody |
| CA2522690A1 (en) * | 2003-05-06 | 2004-11-25 | Syntonix Pharmaceuticals, Inc. | Inhibition of drug binding to serum albumin |
| ATE497783T1 (de) * | 2003-05-06 | 2011-02-15 | Syntonix Pharmaceuticals Inc | Gerinnungsfaktor vii-fc chimäre proteine zur behandlung von hämostatischen krankheiten |
| US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| FI20040704A0 (fi) * | 2004-05-21 | 2004-05-21 | Ari Hinkkanen | Replikatiivisen viruksen tai sen rekombinantin käyttö terapiassa |
| TW200720289A (en) | 2005-04-01 | 2007-06-01 | Hoffmann La Roche | Antibodies against CCR5 and uses thereof |
| JP2009514790A (ja) * | 2005-07-22 | 2009-04-09 | プロジェニクス・ファーマスーティカルズ・インコーポレイテッド | Ｈｉｖ−１−感染患者におけるウイルス負荷を減少させる方法 |
| CA2658474A1 (en) | 2006-08-17 | 2008-02-21 | F.Hoffmann-La Roche Ag | A conjugate of an antibody against ccr5 and an antifusogenic peptide |
| TW200817438A (en) * | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
| CA2664752A1 (en) | 2006-09-29 | 2008-04-03 | F. Hoffmann-La Roche Ag | Antibodies against ccr5 and uses thereof |
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| TWI745671B (zh) | 2013-03-15 | 2021-11-11 | 美商百歐維拉提夫治療公司 | 因子ｉｘ多肽調配物 |
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| NZ561465A (en) | 2002-02-22 | 2009-04-30 | Pdl Biopharma Inc | Anti-CCR5 antibody |
| US7122185B2 (en) * | 2002-02-22 | 2006-10-17 | Progenics Pharmaceuticals, Inc. | Anti-CCR5 antibody |
| AU2004251228B2 (en) * | 2003-05-16 | 2008-04-24 | University Of Maryland Biotechnology Institute | Compositions for down-regulation of CCR5 expression and methods of use therefor |
| US20050131042A1 (en) * | 2003-12-11 | 2005-06-16 | Flentge Charles A. | HIV protease inhibiting compounds |
| WO2005105841A2 (en) * | 2004-03-12 | 2005-11-10 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor (ccr5) hdgnr10 |
| JP2009514790A (ja) * | 2005-07-22 | 2009-04-09 | プロジェニクス・ファーマスーティカルズ・インコーポレイテッド | Ｈｉｖ−１−感染患者におけるウイルス負荷を減少させる方法 |
-
2001
- 2001-07-25 US US09/912,824 patent/US7138119B2/en not_active Expired - Lifetime
- 2001-09-14 AU AU9092501A patent/AU9092501A/xx active Pending
- 2001-09-14 AU AU2001290925A patent/AU2001290925C1/en not_active Expired
- 2001-09-14 CA CA002422275A patent/CA2422275A1/en not_active Abandoned
- 2001-09-14 EP EP01970984A patent/EP1322332A4/en not_active Withdrawn
- 2001-09-14 JP JP2002526332A patent/JP2004518624A/ja not_active Withdrawn
- 2001-09-14 WO PCT/US2001/028756 patent/WO2002022077A2/en not_active Ceased
-
2006
- 2006-09-12 US US11/520,556 patent/US7736649B2/en not_active Expired - Fee Related
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| WO2012065055A3 (en) * | 2010-11-12 | 2012-07-12 | The Rockefeller University | Fusion proteins for hiv therapy |
| US8637024B2 (en) | 2010-11-12 | 2014-01-28 | The Rockefeller University | Fusion antibodies for HIV therapy |
| JP2017501986A (ja) * | 2013-12-02 | 2017-01-19 | アーロン ダイアモンド エイズ リサーチ センター | ネイティブな構成を有する二重特異性抗体を使用した細胞レセプターアンカリングによる改善されたｈｉｖ−１中和抗体の効力及び幅 |
| JP2020002174A (ja) * | 2013-12-02 | 2020-01-09 | アーロン ダイアモンド エイズ リサーチ センター | 二重特異性ｈｉｖ−１中和抗体 |
| US12098187B2 (en) | 2013-12-02 | 2024-09-24 | The Trustees Of Columbia University In The City Of New York | Bispecific HIV-1-neutralizing antibodies |
| JP2019521639A (ja) * | 2015-11-21 | 2019-08-08 | フンダシオ プリバダ インスティトゥト デ レセルカ デラ シダ−カイサＦｕｎｄａｃｉｏ Ｐｒｉｖａｄａ Ｉｎｓｔｉｔｕｔ Ｄｅ Ｒｅｃｅｒｃａ Ｄｅ Ｌａ Ｓｉｄａ−Ｃａｉｘａ | 抗ウイルスおよび免疫調節の二重活性を有するｈｉｖ抗体誘導体 |
| JP2022008978A (ja) * | 2015-11-21 | 2022-01-14 | フンダシオ プリバダ インスティトゥト デ レセルカ デラ シダ－カイサ | 抗ウイルスおよび免疫調節の二重活性を有するｈｉｖ抗体誘導体 |
| JP6991138B2 (ja) | 2015-11-21 | 2022-02-03 | フンダシオ プリバダ インスティトゥト デ レセルカ デラ シダ－カイサ | 抗ウイルスおよび免疫調節の二重活性を有するｈｉｖ抗体誘導体 |
| US11866479B2 (en) | 2015-11-21 | 2024-01-09 | Fundació Privada Institute De Recera De La Sida-Caixa | HIV antibody derivatives with dual antiviral and immunomodulatory activities from CD4 and GP41 |
| JP2020519309A (ja) * | 2017-05-10 | 2020-07-02 | アルバジュナ・セラピューティクス・エセ・エレ | 高い二重のＨＩＶ抗ウイルス及び免疫調節活性を有するＦｃ融合タンパク質誘導体 |
| JP2023078339A (ja) * | 2017-05-10 | 2023-06-06 | アルバジュナ・セラピューティクス・エセ・エレ | 高い二重のＨＩＶ抗ウイルス及び免疫調節活性を有するＦｃ融合タンパク質誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20020106374A1 (en) | 2002-08-08 |
| EP1322332A2 (en) | 2003-07-02 |
| US7138119B2 (en) | 2006-11-21 |
| US20070020280A1 (en) | 2007-01-25 |
| AU9092501A (en) | 2002-03-26 |
| AU2001290925B2 (en) | 2006-07-13 |
| WO2002022077A2 (en) | 2002-03-21 |
| US7736649B2 (en) | 2010-06-15 |
| CA2422275A1 (en) | 2002-03-21 |
| WO2002022077A3 (en) | 2002-06-20 |
| AU2001290925C1 (en) | 2009-01-22 |
| EP1322332A4 (en) | 2006-06-21 |
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