JP2004514709A - ヒスタミンｈ１およびｈ３の二重アゴニストまたは二重アンタゴニストとしての置換イミダゾール - Google Patents
ヒスタミンｈ１およびｈ３の二重アゴニストまたは二重アンタゴニストとしての置換イミダゾール Download PDFInfo
- Publication number
- JP2004514709A JP2004514709A JP2002546511A JP2002546511A JP2004514709A JP 2004514709 A JP2004514709 A JP 2004514709A JP 2002546511 A JP2002546511 A JP 2002546511A JP 2002546511 A JP2002546511 A JP 2002546511A JP 2004514709 A JP2004514709 A JP 2004514709A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compounds
- allergy
- mmol
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*1c[n]cn1 Chemical compound C*1c[n]cn1 0.000 description 7
- QCBAZEKZFFMSNA-UHFFFAOYSA-N C(C1=CCCC=N1)N1CCNCC1 Chemical compound C(C1=CCCC=N1)N1CCNCC1 QCBAZEKZFFMSNA-UHFFFAOYSA-N 0.000 description 1
- UYLKLRQSKWLIRH-UHFFFAOYSA-N CC(C1C(C2)C2C(N)=CC1)c1ccccc1 Chemical compound CC(C1C(C2)C2C(N)=CC1)c1ccccc1 UYLKLRQSKWLIRH-UHFFFAOYSA-N 0.000 description 1
- HQYVYZOIYYQKBU-UHFFFAOYSA-N CCCCC1(CCN(C)CC1)C(OC)=O Chemical compound CCCCC1(CCN(C)CC1)C(OC)=O HQYVYZOIYYQKBU-UHFFFAOYSA-N 0.000 description 1
- RNVSSNFHWMOWRB-UHFFFAOYSA-N Clc1ccc(C(CN2CC(CCc3c[nH]cn3)CC2)c(cc2)ccc2Cl)cc1 Chemical compound Clc1ccc(C(CN2CC(CCc3c[nH]cn3)CC2)c(cc2)ccc2Cl)cc1 RNVSSNFHWMOWRB-UHFFFAOYSA-N 0.000 description 1
- MRXWUWJKAYYNEE-UHFFFAOYSA-N O=C(C(c(cc1)ccc1Cl)c(cc1)ccc1Cl)N1CC(CCc2c[nH]cn2)CC1 Chemical compound O=C(C(c(cc1)ccc1Cl)c(cc1)ccc1Cl)N1CC(CCc2c[nH]cn2)CC1 MRXWUWJKAYYNEE-UHFFFAOYSA-N 0.000 description 1
- WYAGFQSJWMFJLX-UHFFFAOYSA-N O=C(C(c1ccccc1)c1ccccc1)N1CCC(Cc2c[nH]cn2)CC1 Chemical compound O=C(C(c1ccccc1)c1ccccc1)N1CCC(Cc2c[nH]cn2)CC1 WYAGFQSJWMFJLX-UHFFFAOYSA-N 0.000 description 1
- RUJOSMNRFKUHKE-UHFFFAOYSA-N O=C(CC(c(cc1)ccc1Cl)c1ccccn1)N1CCC(Cc2c[nH]cn2)CC1 Chemical compound O=C(CC(c(cc1)ccc1Cl)c1ccccn1)N1CCC(Cc2c[nH]cn2)CC1 RUJOSMNRFKUHKE-UHFFFAOYSA-N 0.000 description 1
- DJVXWOROCWSLIX-UHFFFAOYSA-N OC(CC(c(cc1)ccc1Cl)c1ccccn1)N1CCNCC1 Chemical compound OC(CC(c(cc1)ccc1Cl)c1ccccn1)N1CCNCC1 DJVXWOROCWSLIX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23403900P | 2000-09-20 | 2000-09-20 | |
| PCT/US2001/029062 WO2002044141A2 (en) | 2000-09-20 | 2001-09-18 | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004514709A true JP2004514709A (ja) | 2004-05-20 |
| JP2004514709A5 JP2004514709A5 (enExample) | 2008-09-11 |
Family
ID=22879625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546511A Pending JP2004514709A (ja) | 2000-09-20 | 2001-09-18 | ヒスタミンｈ１およびｈ３の二重アゴニストまたは二重アンタゴニストとしての置換イミダゾール |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6762186B2 (enExample) |
| EP (1) | EP1318996B1 (enExample) |
| JP (1) | JP2004514709A (enExample) |
| CN (1) | CN1461304A (enExample) |
| AR (1) | AR032894A1 (enExample) |
| AT (1) | ATE283853T1 (enExample) |
| AU (1) | AU2002241459A1 (enExample) |
| CA (1) | CA2422729A1 (enExample) |
| DE (1) | DE60107586T2 (enExample) |
| ES (1) | ES2233708T3 (enExample) |
| HK (1) | HK1052182B (enExample) |
| MX (1) | MXPA03002446A (enExample) |
| TW (1) | TWI228127B (enExample) |
| WO (1) | WO2002044141A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1585731A2 (en) * | 2002-09-18 | 2005-10-19 | Eli Lilly And Company | Histamine h3 receptor antagonists, preparaton and therapeutic uses |
| US8063650B2 (en) | 2002-11-27 | 2011-11-22 | Rambus Inc. | Testing fuse configurations in semiconductor devices |
| US20050090527A1 (en) * | 2003-01-28 | 2005-04-28 | Schering Corporation | Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis |
| KR20060066070A (ko) | 2003-07-28 | 2006-06-15 | 스미스클라인 비참 코포레이션 | 에스트로겐 수용체의 조절제로서의 시클로알킬리덴 화합물 |
| TWI290140B (en) * | 2003-08-25 | 2007-11-21 | Schering Corp | 2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders |
| JP2009504637A (ja) * | 2005-08-08 | 2009-02-05 | アストラゼネカ・アクチエボラーグ | 治療薬 |
| CA2653497A1 (en) * | 2006-05-26 | 2007-12-06 | Neuromed Pharmaceuticals Ltd. | Heterocyclic compounds as calcium channel blockers |
| DE602007012308D1 (de) | 2006-12-22 | 2011-03-10 | Avexa Ltd | Bicyclische pyrimidinone und deren verwendung |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| CN110878069A (zh) * | 2019-12-09 | 2020-03-13 | 南京杰运医药科技有限公司 | 一种4-吗琳基-2-乙基哌嗪的制备方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63280081A (ja) * | 1987-04-24 | 1988-11-17 | シンテックス・ファーマシュティカルズ | 置換イミダゾリル−アルキル−ピペラジンおよび−ジアゼピン誘導体 |
| JPH04234359A (ja) * | 1990-07-26 | 1992-08-24 | Lab Del Dr Esteve Sa | １−ジフェニルメチルピペラジンの新規誘導体、それらの製法、及びそれらの医薬用途 |
| JPH0789956A (ja) * | 1990-01-15 | 1995-04-04 | Heumann Pharma Gmbh & Co | イミダゾリルプロピルグアニジン誘導体、その製造法及びそれを含有する医薬組成物 |
| US5869479A (en) * | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
| WO2000023438A1 (en) * | 1998-10-16 | 2000-04-27 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-h3 agonists or antagonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2586562B1 (fr) * | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
| GB8916947D0 (en) | 1989-07-25 | 1989-09-13 | Smith Kline French Lab | Medicaments |
| DK0448765T3 (da) | 1990-03-30 | 1994-09-19 | Heumann Pharma Gmbh & Co | Anvendelse af guanidinderivater til fremstilling af et lægemiddel med NPY-antagonistisk virkning |
| GB9115740D0 (en) | 1991-07-20 | 1991-09-04 | Smithkline Beecham Plc | Medicaments |
| CA2125964C (en) | 1991-12-18 | 2001-06-19 | Neng-Yang Shih | Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists |
| US5352707A (en) * | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
| HU213104B (en) * | 1992-06-17 | 1997-02-28 | Richter Gedeon Vegyeszet | Process for producing 4-methyl-2-imidazolinone derivatives and pharmaceutical compositions containing them |
| HUT74386A (en) | 1993-11-15 | 1996-12-30 | Schering Corp | Phenyl-alkyl imidazoles as h3-receptor antagonists and pharmaceutical compositions containing them |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| DK1019050T3 (da) | 1997-06-24 | 2002-07-08 | Novo Nordisk As | Anvendelse af somatostatinagonister og -antagonister til behandling af sygdomme i forbindelse med øjet |
-
2001
- 2001-09-18 AU AU2002241459A patent/AU2002241459A1/en not_active Abandoned
- 2001-09-18 AT AT01988119T patent/ATE283853T1/de not_active IP Right Cessation
- 2001-09-18 HK HK03104439.8A patent/HK1052182B/en not_active IP Right Cessation
- 2001-09-18 US US09/955,383 patent/US6762186B2/en not_active Expired - Fee Related
- 2001-09-18 AR ARP010104401A patent/AR032894A1/es unknown
- 2001-09-18 JP JP2002546511A patent/JP2004514709A/ja active Pending
- 2001-09-18 ES ES01988119T patent/ES2233708T3/es not_active Expired - Lifetime
- 2001-09-18 CN CN01815990A patent/CN1461304A/zh active Pending
- 2001-09-18 CA CA002422729A patent/CA2422729A1/en not_active Abandoned
- 2001-09-18 EP EP01988119A patent/EP1318996B1/en not_active Expired - Lifetime
- 2001-09-18 MX MXPA03002446A patent/MXPA03002446A/es active IP Right Grant
- 2001-09-18 DE DE60107586T patent/DE60107586T2/de not_active Expired - Lifetime
- 2001-09-18 WO PCT/US2001/029062 patent/WO2002044141A2/en not_active Ceased
- 2001-09-19 TW TW090123022A patent/TWI228127B/zh not_active IP Right Cessation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63280081A (ja) * | 1987-04-24 | 1988-11-17 | シンテックス・ファーマシュティカルズ | 置換イミダゾリル−アルキル−ピペラジンおよび−ジアゼピン誘導体 |
| JPH0789956A (ja) * | 1990-01-15 | 1995-04-04 | Heumann Pharma Gmbh & Co | イミダゾリルプロピルグアニジン誘導体、その製造法及びそれを含有する医薬組成物 |
| JPH04234359A (ja) * | 1990-07-26 | 1992-08-24 | Lab Del Dr Esteve Sa | １−ジフェニルメチルピペラジンの新規誘導体、それらの製法、及びそれらの医薬用途 |
| US5869479A (en) * | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
| WO2000023438A1 (en) * | 1998-10-16 | 2000-04-27 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-h3 agonists or antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| US6762186B2 (en) | 2004-07-13 |
| US20020082278A1 (en) | 2002-06-27 |
| CA2422729A1 (en) | 2002-06-06 |
| EP1318996B1 (en) | 2004-12-01 |
| WO2002044141A3 (en) | 2002-11-07 |
| HK1052182A1 (en) | 2003-09-05 |
| DE60107586D1 (de) | 2005-01-05 |
| EP1318996A2 (en) | 2003-06-18 |
| DE60107586T2 (de) | 2005-10-06 |
| ATE283853T1 (de) | 2004-12-15 |
| TWI228127B (en) | 2005-02-21 |
| AR032894A1 (es) | 2003-12-03 |
| MXPA03002446A (es) | 2003-06-19 |
| AU2002241459A1 (en) | 2002-06-11 |
| HK1052182B (en) | 2005-04-01 |
| WO2002044141A2 (en) | 2002-06-06 |
| ES2233708T3 (es) | 2005-06-16 |
| CN1461304A (zh) | 2003-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080715 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080715 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110826 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120203 |