JP2004511512A - 認識障害の治療のためのアセチルコリンエステラーゼ阻害薬およびｇａｂａａ反作用薬の組合せ使用 - Google Patents

認識障害の治療のためのアセチルコリンエステラーゼ阻害薬およびｇａｂａａ反作用薬の組合せ使用 Download PDF

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JP2004511512A
JP2004511512A JP2002535650A JP2002535650A JP2004511512A JP 2004511512 A JP2004511512 A JP 2004511512A JP 2002535650 A JP2002535650 A JP 2002535650A JP 2002535650 A JP2002535650 A JP 2002535650A JP 2004511512 A JP2004511512 A JP 2004511512A
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tetrahydro
naphthyridine
carboxamide
oxo
ethoxy
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JP2004511512A5 (enExample
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ビラロボス，アナベラ
カセラ，ジェイムズ　ビンセント
ラジャチャンドラン，ラバンヤ
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Neurogen Corp
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Neurogen Corp
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Organic Chemistry (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002535650A 2000-10-17 2001-10-15 認識障害の治療のためのアセチルコリンエステラーゼ阻害薬およびｇａｂａａ反作用薬の組合せ使用 Pending JP2004511512A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24114500P 2000-10-17 2000-10-17
PCT/IB2001/001934 WO2002032412A2 (en) 2000-10-17 2001-10-15 Combination use of acetylcholinesterase inhibitors and gabaa inverse agonists for the treatment of cognitive disorders

Publications (2)

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JP2004511512A true JP2004511512A (ja) 2004-04-15
JP2004511512A5 JP2004511512A5 (enExample) 2007-02-01

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JP2002535650A Pending JP2004511512A (ja) 2000-10-17 2001-10-15 認識障害の治療のためのアセチルコリンエステラーゼ阻害薬およびｇａｂａａ反作用薬の組合せ使用

Country Status (14)

Country Link
US (2) US20020151591A1 (enExample)
EP (1) EP1328294A2 (enExample)
JP (1) JP2004511512A (enExample)
KR (1) KR20030046509A (enExample)
AR (1) AR030893A1 (enExample)
AU (2) AU2001294117B2 (enExample)
CA (1) CA2426120A1 (enExample)
HU (1) HUP0302476A3 (enExample)
IL (1) IL155225A0 (enExample)
NZ (1) NZ525103A (enExample)
PE (1) PE20020473A1 (enExample)
UY (1) UY26970A1 (enExample)
WO (1) WO2002032412A2 (enExample)
ZA (1) ZA200302918B (enExample)

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US8299062B2 (en) * 2003-09-17 2012-10-30 Franklin Volvovitz Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction
EP1666066A4 (en) * 2003-09-19 2007-03-28 Eisai R&D Man Co Ltd DRUG AGAINST THE DOWN SYNDROME
TW200533371A (en) * 2004-04-15 2005-10-16 Dainippon Pharmaceutical Co Medicament comprising a combination of an acetylcholinesterase inhibitor and a 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1h)-one derivative
CA2566204A1 (en) * 2004-05-14 2005-12-01 The Johns Hopkins University Method for improving cognitive function by co-administration of a gabab receptor antagonist and an acetylcholinesterase inhibitor
JP2008509212A (ja) * 2004-08-09 2008-03-27 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 中枢神経系障害の治療のための新規なキノキサリノンノルエピネフリン再吸収阻害剤
CN100382802C (zh) * 2005-08-08 2008-04-23 赵德禄 治疗自主神经系统功能紊乱的药物
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AU2001294117B2 (en) 2006-07-27
PE20020473A1 (es) 2002-06-14
EP1328294A2 (en) 2003-07-23
HUP0302476A2 (hu) 2003-11-28
IL155225A0 (en) 2003-11-23
UY26970A1 (es) 2002-06-20
NZ525103A (en) 2004-12-24
AR030893A1 (es) 2003-09-03
CA2426120A1 (en) 2002-04-25
KR20030046509A (ko) 2003-06-12
US20050009861A1 (en) 2005-01-13
US20020151591A1 (en) 2002-10-17
WO2002032412A2 (en) 2002-04-25
AU9411701A (en) 2002-04-29
ZA200302918B (en) 2004-04-13
WO2002032412A3 (en) 2003-03-20
HUP0302476A3 (en) 2005-05-30

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