JP2004510162A5 - - Google Patents

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Publication number
JP2004510162A5
JP2004510162A5 JP2002530645A JP2002530645A JP2004510162A5 JP 2004510162 A5 JP2004510162 A5 JP 2004510162A5 JP 2002530645 A JP2002530645 A JP 2002530645A JP 2002530645 A JP2002530645 A JP 2002530645A JP 2004510162 A5 JP2004510162 A5 JP 2004510162A5
Authority
JP
Japan
Prior art keywords
linker
conjugate
biomolecule
reagent composition
uniform stoichiometry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002530645A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004510162A (ja
JP3836429B2 (ja
Filing date
Publication date
Priority claimed from DE10048417A external-priority patent/DE10048417A1/de
Priority claimed from EP01107491A external-priority patent/EP1245956A1/en
Application filed filed Critical
Priority claimed from PCT/EP2001/011101 external-priority patent/WO2002027317A2/en
Publication of JP2004510162A publication Critical patent/JP2004510162A/ja
Publication of JP2004510162A5 publication Critical patent/JP2004510162A5/ja
Application granted granted Critical
Publication of JP3836429B2 publication Critical patent/JP3836429B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002530645A 2000-09-29 2001-09-26 規定した化学量論の結合体 Expired - Fee Related JP3836429B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10048417A DE10048417A1 (de) 2000-09-29 2000-09-29 Verbindungen mit verzweigtem Linker
EP01107491A EP1245956A1 (en) 2001-03-29 2001-03-29 Conjugates of defined stoichiometry
PCT/EP2001/011101 WO2002027317A2 (en) 2000-09-29 2001-09-26 Conjugates of defined stoichiometry

Publications (3)

Publication Number Publication Date
JP2004510162A JP2004510162A (ja) 2004-04-02
JP2004510162A5 true JP2004510162A5 (enExample) 2005-03-03
JP3836429B2 JP3836429B2 (ja) 2006-10-25

Family

ID=26007222

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002530645A Expired - Fee Related JP3836429B2 (ja) 2000-09-29 2001-09-26 規定した化学量論の結合体

Country Status (9)

Country Link
US (1) US7897404B2 (enExample)
EP (2) EP1625857A3 (enExample)
JP (1) JP3836429B2 (enExample)
AT (1) ATE313796T1 (enExample)
AU (1) AU2001289923A1 (enExample)
CA (1) CA2420768C (enExample)
DE (1) DE60116146T2 (enExample)
ES (1) ES2254489T3 (enExample)
WO (1) WO2002027317A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100361933B1 (ko) 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
WO2001093914A2 (en) 2000-06-08 2001-12-13 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
BR112013007614B1 (pt) 2010-10-25 2020-12-29 F. Hoffmann-La Roche Ag método para medir um analito, composição reagente, mistura reagente, uso de uma composição reagente, uso de uma amida de ácido carbônico e kit
CA2891280C (en) 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
WO2019175845A2 (en) * 2018-03-15 2019-09-19 Levim Biotech Llp Antibody-biomolecule conjugates linked through multifunctional macromolecule and uses thereof
WO2021055880A1 (en) * 2019-09-20 2021-03-25 University Of Florida Researchfoundation, Incorporated Detection of antibodies against ran proteins from serum and tissue lysates

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2493382A (en) * 1948-10-29 1950-01-03 American Cyanamid Co Automatic sample collector
GB2095818B (en) 1981-03-27 1985-10-02 Exxon Research Engineering Co Staged adsorption/resorption heat pump
US5047324A (en) * 1986-12-09 1991-09-10 Miles Inc. Substantially pure enzyme-antibody conjugate preparations
US5554748A (en) * 1989-04-07 1996-09-10 Nycomed Salutar, Inc. Adducts of macrocyclic chelants
AU657483B2 (en) * 1990-07-20 1995-03-16 Pharmacia Ab Heterobifunctional reagents and conjugates with oxaalkylene units for amphiphilic bridge structures
US6120768A (en) * 1993-05-17 2000-09-19 Immunomedics, Inc. Dota-biotin derivatives
CN1114106C (zh) 1994-07-25 2003-07-09 罗切诊断学有限公司 金属螯合物标记的肽及其制备方法
DE59511054D1 (de) 1994-07-25 2006-08-10 Roche Diagnostics Gmbh Bestimmung von spezifischem immunglobulin unter verwendung multipler antigene
DE59507438D1 (de) * 1994-07-25 2000-01-20 Roche Diagnostics Gmbh Hydrophile metallkomplexe
ATE214073T1 (de) 1994-07-25 2002-03-15 Roche Diagnostics Gmbh Hapten-markierte peptide
DE4430972A1 (de) * 1994-07-25 1996-02-01 Boehringer Mannheim Gmbh Bestimmung von spezifischem Immunglobulin unter Verwendung multipler Antigene
US5958783A (en) 1994-07-25 1999-09-28 Roche Diagnostics Gmbh Metal complexes with a charged linker
GB9415143D0 (en) 1994-07-27 1994-09-14 Edwards Raymond Glycated haemoglobin assay
CA2258744A1 (en) * 1996-06-27 1997-12-31 G.D. Searle And Co. Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications

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