JP2004509853A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004509853A5 JP2004509853A5 JP2002511756A JP2002511756A JP2004509853A5 JP 2004509853 A5 JP2004509853 A5 JP 2004509853A5 JP 2002511756 A JP2002511756 A JP 2002511756A JP 2002511756 A JP2002511756 A JP 2002511756A JP 2004509853 A5 JP2004509853 A5 JP 2004509853A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- dihydroxyvitamin
- methyl
- composition according
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 16
- 239000011612 calcitriol Substances 0.000 description 12
- 208000001132 Osteoporosis Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000037118 bone strength Effects 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 description 1
- 208000029725 Metabolic bone disease Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010039984 Senile osteoporosis Diseases 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008416 bone turnover Effects 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- 208000001685 postmenopausal osteoporosis Diseases 0.000 description 1
- 201000006409 renal osteodystrophy Diseases 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/616,778 | 2000-07-14 | ||
| US09/616,778 US6306844B1 (en) | 1997-03-17 | 2000-07-14 | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| PCT/US2001/021660 WO2002005824A1 (en) | 2000-07-14 | 2001-07-10 | USE OF 2α-METHYL-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004509853A JP2004509853A (ja) | 2004-04-02 |
| JP2004509853A5 true JP2004509853A5 (OSRAM) | 2007-12-27 |
| JP4955895B2 JP4955895B2 (ja) | 2012-06-20 |
Family
ID=24470903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002511756A Expired - Fee Related JP4955895B2 (ja) | 2000-07-14 | 2001-07-10 | 骨強度を増加するための２α−メチル−１９−ノル−２０（Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US6306844B1 (OSRAM) |
| EP (1) | EP1305030B1 (OSRAM) |
| JP (1) | JP4955895B2 (OSRAM) |
| KR (1) | KR100572958B1 (OSRAM) |
| CN (1) | CN1250225C (OSRAM) |
| AT (1) | ATE359796T1 (OSRAM) |
| AU (2) | AU7330301A (OSRAM) |
| BR (1) | BR0112453A (OSRAM) |
| CA (1) | CA2416187A1 (OSRAM) |
| DE (1) | DE60127964T2 (OSRAM) |
| DK (1) | DK1305030T3 (OSRAM) |
| ES (1) | ES2286129T3 (OSRAM) |
| IL (2) | IL153908A0 (OSRAM) |
| MX (1) | MXPA03000405A (OSRAM) |
| NZ (1) | NZ524018A (OSRAM) |
| WO (1) | WO2002005824A1 (OSRAM) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| JP2004505022A (ja) * | 2000-07-14 | 2004-02-19 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | 骨強度を増加するための２−メチレン−１９−ノル−２０（Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用 |
| US7858602B2 (en) * | 2000-10-16 | 2010-12-28 | Rodriguez Victorio C | Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging disorders due to oxidative stress and as growth factors of stem cells |
| US20030195175A1 (en) * | 2002-03-25 | 2003-10-16 | Deluca Hector F. | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
| ATE346839T1 (de) | 2002-03-29 | 2006-12-15 | Wisconsin Alumni Res Found | Ein verfahren zur herstellung von 1-alpha-hydroxy-2-methylen-19-nor-homopregnacal iferol |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| RU2317992C2 (ru) | 2003-02-25 | 2008-02-27 | Кей Эн Си Лэборэтериз Ко., Лтд. | Новые промежуточные соединения для синтеза производных витамина d |
| CA2539361A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an estrogen agonist/antagonist |
| US7214671B2 (en) * | 2004-02-19 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
| EP1817279B1 (en) * | 2004-11-22 | 2010-05-26 | Wisconsin Alumni Research Foundation | 17,20(z)-dehydro vitamin d analogs and their uses |
| US20100144671A1 (en) * | 2005-03-04 | 2010-06-10 | Women And Infants Hospital Of Ri, Inc. | Compositions and Methods for Cancer Treatment |
| CA2605727A1 (en) * | 2005-05-03 | 2006-11-09 | Wisconsin Alumni Research Foundation | 19,26,27-trinor-1.alpha.,25-dihydroxyvitamin d3 compounds |
| US7803789B2 (en) * | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| EP2001860A2 (en) * | 2006-04-06 | 2008-12-17 | Wisconsin Alumni Research Foundation | 19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring |
| US7704981B2 (en) * | 2006-04-06 | 2010-04-27 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin D3 and uses thereof |
| ATE523487T1 (de) * | 2006-04-06 | 2011-09-15 | Wisconsin Alumni Res Found | 2-methylen-1-alpha-dihydroxy-19,21-dinor-vitami - d3-analoga und ihre anwendung |
| AU2007298673A1 (en) | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2- substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof |
| MX2008012673A (es) * | 2006-04-06 | 2008-10-15 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a-hidroxi-19, 21-dinorvitamina d3 y sus usos. |
| AU2007298651A1 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| CA2648521A1 (en) * | 2006-04-10 | 2008-02-28 | Wisconsin Alumni Research Foundation | 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-n0r-vitamin d compounds with a 1,1-dimethylpropyl side chain |
| AU2007249736A1 (en) * | 2006-05-15 | 2007-11-22 | Wisconsin Alumni Research Foundation | Pulmonary delivery of 1alpha,25-dihydroxyvitamin D3 and co-administration of parathyroid hormone or calcitonin |
| US7893043B2 (en) * | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
| US8222236B2 (en) * | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
| US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| JP5908402B2 (ja) * | 2009-08-03 | 2016-04-26 | ウィスコンシン・アルムニ・リサーチ・ファウンデーションＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 腎疾患の予防方法およびその症状を処置する方法 |
| EP2490695B1 (en) * | 2009-10-21 | 2013-11-20 | Wisconsin Alumni Research Foundation | Method of preventing type 1 diabetes |
| CA2794006C (en) * | 2010-03-23 | 2017-11-28 | Wisconsin Alumni Research Foundation | (20s)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-dihydroxyvitamin d3 and (20r)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-hydroxyvitamin d3 |
| JP5931845B2 (ja) * | 2010-03-23 | 2016-06-08 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| US20130295083A1 (en) * | 2012-05-02 | 2013-11-07 | Wisconsin Alumni Research Foundation | 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes |
| CA2877680C (en) | 2012-06-29 | 2017-08-29 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20s)-1.alpha., 25-dihydroxyvitamin d3 to treat secondary hyperparathyroidsm |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| WO2017184262A1 (en) * | 2016-04-18 | 2017-10-26 | Wisconsin Alumni Research Foundation | Use of 2amd and 2md to treat fibrosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3276167D1 (en) | 1981-11-02 | 1987-06-04 | Res Inst Medicine Chem | Intermediates in the synthesis of vitamin d derivatives |
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| US5246925A (en) | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
| EP0474517B1 (en) | 1990-09-07 | 1998-11-18 | Wisconsin Alumni Research Foundation | Novel use of 1alpha-hydroxylated-19-nor-vitamin D compounds to treat psoriasis |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP2898882B2 (ja) | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| WO1996001811A1 (en) | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US5962707A (en) * | 1998-08-18 | 1999-10-05 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D3 compounds with calcemic activity |
-
2000
- 2000-07-14 US US09/616,778 patent/US6306844B1/en not_active Expired - Lifetime
-
2001
- 2001-07-10 IL IL15390801A patent/IL153908A0/xx unknown
- 2001-07-10 MX MXPA03000405A patent/MXPA03000405A/es active IP Right Grant
- 2001-07-10 AT AT01952566T patent/ATE359796T1/de active
- 2001-07-10 CN CNB018155332A patent/CN1250225C/zh not_active Expired - Fee Related
- 2001-07-10 EP EP01952566A patent/EP1305030B1/en not_active Expired - Lifetime
- 2001-07-10 KR KR1020037000542A patent/KR100572958B1/ko not_active Expired - Fee Related
- 2001-07-10 JP JP2002511756A patent/JP4955895B2/ja not_active Expired - Fee Related
- 2001-07-10 WO PCT/US2001/021660 patent/WO2002005824A1/en not_active Ceased
- 2001-07-10 NZ NZ524018A patent/NZ524018A/en not_active IP Right Cessation
- 2001-07-10 DE DE60127964T patent/DE60127964T2/de not_active Expired - Lifetime
- 2001-07-10 AU AU7330301A patent/AU7330301A/xx active Pending
- 2001-07-10 AU AU2001273303A patent/AU2001273303B8/en not_active Ceased
- 2001-07-10 CA CA002416187A patent/CA2416187A1/en not_active Abandoned
- 2001-07-10 ES ES01952566T patent/ES2286129T3/es not_active Expired - Lifetime
- 2001-07-10 BR BR0112453-6A patent/BR0112453A/pt not_active Application Discontinuation
- 2001-07-10 DK DK01952566T patent/DK1305030T3/da active
- 2001-10-19 US US10/045,941 patent/US20020151528A1/en not_active Abandoned
-
2003
- 2003-01-13 IL IL153908A patent/IL153908A/en not_active IP Right Cessation
- 2003-09-29 US US10/673,618 patent/US6939868B2/en not_active Expired - Lifetime
-
2005
- 2005-08-31 US US11/216,951 patent/US20060003973A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004509853A5 (OSRAM) | ||
| CN1250225C (zh) | 2α－甲基－19－去甲－20(S)－1α,25－二羟维生素D3生产用于增加骨强度的药物的用途 | |
| JP2005529878A5 (OSRAM) | ||
| DE69807852T2 (de) | 2-alkyliden-19-nor-vitamin d-verbindungen | |
| Salzer-Kuntschik et al. | Morphological grades of regression in osteosarcoma after polychemotherapy—study COSS 80 | |
| JP2004508410A5 (OSRAM) | ||
| JP2004502638A5 (OSRAM) | ||
| EP1417975A4 (en) | AGENT FOR THE TREATMENT OF DISEASES COMING WITH BONE SCONES WITH EP SB 4 / SB AGONIST AS AN ACTIVE AGENT | |
| CN1217664C (zh) | 2－亚甲基－19－去甲－20(S)－1α，25－二羟维生素D3增加骨强度的用途 | |
| JP2007524627A5 (OSRAM) | ||
| JP2002510633A5 (OSRAM) | ||
| JP2007523162A5 (OSRAM) | ||
| JPH10147529A5 (OSRAM) | ||
| JP2001515881A5 (OSRAM) | ||
| JP2006523239A5 (OSRAM) | ||
| CA2516233A1 (en) | 2-propylidene-19-nor-vitamin d compounds | |
| JP3255926B2 (ja) | 腎機能障害患者における燐酸塩過剰血症予防のための１９−ノル−ビタミンｄ化合物の使用 | |
| EP0269311A3 (en) | Methods of treating bone diseases by administration of a cysteine proteinase inhibitor | |
| EP1722856B1 (en) | Use of 2-methylene-19-nor-20(s)-1alpha,25-dihydroxyvitamin d3 for the prophylaxis of bone diseases | |
| KR20040095346A (ko) | 신생 골의 형성을 유도하기 위한 탄소-2-개질된 19-노르-비타민 ｄ 유사체의 용도 | |
| SE8903529D0 (sv) | Medical use | |
| JP2008520709A5 (OSRAM) | ||
| JP2010504994A5 (OSRAM) | ||
| JP2002513733A5 (OSRAM) | ||
| JP2002537222A (ja) | カルセミック活性を持つ１９−ノル−ビタミンｄ３化合物 |