JP2004509851A5 - - Google Patents
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- Publication number
- JP2004509851A5 JP2004509851A5 JP2002511731A JP2002511731A JP2004509851A5 JP 2004509851 A5 JP2004509851 A5 JP 2004509851A5 JP 2002511731 A JP2002511731 A JP 2002511731A JP 2002511731 A JP2002511731 A JP 2002511731A JP 2004509851 A5 JP2004509851 A5 JP 2004509851A5
- Authority
- JP
- Japan
- Prior art keywords
- tartaric acid
- substituted
- composition according
- toluoyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960001270 d- tartaric acid Drugs 0.000 description 28
- 150000001875 compounds Chemical class 0.000 description 24
- 239000008194 pharmaceutical composition Substances 0.000 description 24
- 239000001257 hydrogen Substances 0.000 description 20
- 229910052739 hydrogen Inorganic materials 0.000 description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 19
- 125000000623 heterocyclic group Chemical group 0.000 description 18
- 125000000217 alkyl group Chemical group 0.000 description 15
- 239000000203 mixture Substances 0.000 description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 11
- 229910052757 nitrogen Inorganic materials 0.000 description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 10
- 229910052799 carbon Chemical group 0.000 description 10
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 9
- 125000003118 aryl group Chemical group 0.000 description 9
- 125000000547 substituted alkyl group Chemical group 0.000 description 9
- 125000003107 substituted aryl group Chemical group 0.000 description 9
- YONLFQNRGZXBBF-ZIAGYGMSSA-N (2r,3r)-2,3-dibenzoyloxybutanedioic acid Chemical compound O([C@@H](C(=O)O)[C@@H](OC(=O)C=1C=CC=CC=1)C(O)=O)C(=O)C1=CC=CC=C1 YONLFQNRGZXBBF-ZIAGYGMSSA-N 0.000 description 8
- 125000001424 substituent group Chemical group 0.000 description 7
- 125000002877 alkyl aryl group Chemical group 0.000 description 6
- 125000003710 aryl alkyl group Chemical group 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 150000003839 salts Chemical group 0.000 description 5
- UFHJEZDFEHUYCR-HTQZYQBOSA-N (2r,3r)-2,3-bis(2,2-dimethylpropanoyloxy)butanedioic acid Chemical compound CC(C)(C)C(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(=O)C(C)(C)C UFHJEZDFEHUYCR-HTQZYQBOSA-N 0.000 description 4
- CMIBUZBMZCBCAT-HZPDHXFCSA-N (2r,3r)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid Chemical compound C1=CC(C)=CC=C1C(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(=O)C1=CC=C(C)C=C1 CMIBUZBMZCBCAT-HZPDHXFCSA-N 0.000 description 4
- CMIBUZBMZCBCAT-HOTGVXAUSA-N (2s,3s)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid Chemical compound C1=CC(C)=CC=C1C(=O)O[C@H](C(O)=O)[C@@H](C(O)=O)OC(=O)C1=CC=C(C)C=C1 CMIBUZBMZCBCAT-HOTGVXAUSA-N 0.000 description 4
- PEOCCFXRLGYKBM-UHFFFAOYSA-N 2-(1,3-benzodioxol-5-yl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1C1=CC=C(OCO2)C2=C1 PEOCCFXRLGYKBM-UHFFFAOYSA-N 0.000 description 4
- SNZMBGPVGUVXRP-UHFFFAOYSA-N 4,5-dichloroquinoline Chemical compound C1=CC(Cl)=C2C(Cl)=CC=CC2=N1 SNZMBGPVGUVXRP-UHFFFAOYSA-N 0.000 description 4
- DVMNOSBSAVUYEU-WOJBJXKFSA-N C1(=CC(=CC=C1)C(=O)[C@@]([C@@](C(=O)O)(O)C(=O)C=1C=C(C=CC1)C)(O)C(=O)O)C Chemical compound C1(=CC(=CC=C1)C(=O)[C@@]([C@@](C(=O)O)(O)C(=O)C=1C=C(C=CC1)C)(O)C(=O)O)C DVMNOSBSAVUYEU-WOJBJXKFSA-N 0.000 description 4
- OLBVUFHMDRJKTK-UHFFFAOYSA-N [N].[O] Chemical group [N].[O] OLBVUFHMDRJKTK-UHFFFAOYSA-N 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 125000000753 cycloalkyl group Chemical group 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 3
- BKLZIAYVINRQEJ-UHFFFAOYSA-K trifluoroalumane;trihydrate Chemical compound O.O.O.F[Al](F)F BKLZIAYVINRQEJ-UHFFFAOYSA-K 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 230000003957 neurotransmitter release Effects 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/616,743 US6432954B1 (en) | 2000-07-14 | 2000-07-14 | Pharmaceutical compositions and methods for use |
| PCT/US2001/021872 WO2002005798A2 (en) | 2000-07-14 | 2001-07-11 | Pharmaceutical compositions for treating neurological disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004509851A JP2004509851A (ja) | 2004-04-02 |
| JP2004509851A5 true JP2004509851A5 (https=) | 2008-08-28 |
Family
ID=24470778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002511731A Pending JP2004509851A (ja) | 2000-07-14 | 2001-07-11 | 神経疾患治療用医薬組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6432954B1 (https=) |
| EP (1) | EP1311265B1 (https=) |
| JP (1) | JP2004509851A (https=) |
| CN (2) | CN1680326A (https=) |
| AT (1) | ATE285773T1 (https=) |
| AU (2) | AU2002222909B2 (https=) |
| BR (1) | BR0112130A (https=) |
| CA (1) | CA2415901A1 (https=) |
| DE (1) | DE60108130T2 (https=) |
| HU (1) | HUP0301553A3 (https=) |
| IL (3) | IL153577A0 (https=) |
| NO (1) | NO20030155L (https=) |
| NZ (1) | NZ523606A (https=) |
| PL (1) | PL360532A1 (https=) |
| WO (1) | WO2002005798A2 (https=) |
| ZA (1) | ZA200300135B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979695B2 (en) * | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| NZ550175A (en) * | 2004-04-21 | 2009-05-31 | Basf Ag | Fungicidal mixtures |
| UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
| US7459469B2 (en) * | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
| TWI389889B (zh) * | 2006-05-09 | 2013-03-21 | Targacept Inc | （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型 |
| US8017785B2 (en) * | 2006-05-09 | 2011-09-13 | Astrazeneca Ab | Salt forms of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)y1]-4-penten 2-amine |
| US20080085888A1 (en) * | 2006-09-15 | 2008-04-10 | Breining Scott R | Therapeutic Combinations |
| WO2008091592A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| KR20100052490A (ko) * | 2007-07-31 | 2010-05-19 | 타가셉트 인코포레이티드 | (2ｓ)-(4ｅ)-ｎ-메틸-5-(3-(5-이소프로폭시피리딘)일)-4-펜텐-2-아민의 경피투여 |
| US8703802B2 (en) | 2010-05-20 | 2014-04-22 | Targacept, Inc. | Process for the preparation of aryl substituted olefinic amines |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1409551A (en) | 1972-04-14 | 1975-10-08 | Allen & Hanburys Ltd | Cyclopent a indene derivatives |
| US4528290A (en) | 1984-01-30 | 1985-07-09 | Eli Lilly And Company | Stimulating dopamine D-1 receptors |
| GB8606254D0 (en) | 1986-03-13 | 1986-04-16 | Wyeth John & Brother Ltd | Substituted pyrimidoindoles |
| FR2664600B1 (fr) | 1990-07-16 | 1994-09-02 | Rhone Poulenc Sante | Nouveau sel derive de la dialcoylaminoalcoyl-sulfonyl-26 pristinamycine iib. |
| US5278176A (en) * | 1992-08-21 | 1994-01-11 | Abbott Laboratories | Nicotine derivatives that enhance cognitive function |
| WO1996008468A1 (en) * | 1994-09-14 | 1996-03-21 | H. Lundbeck A/S | Carbamoyloxy amine compounds |
| US5597919A (en) * | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
| US5616716A (en) * | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
| US5663356A (en) * | 1996-04-23 | 1997-09-02 | Ruecroft; Graham | Method for preparation of aryl substituted alefinic secondary amino compounds |
| JP3603177B2 (ja) * | 1998-03-26 | 2004-12-22 | 参天製薬株式会社 | 新規ウレア誘導体 |
| ES2150353B1 (es) * | 1998-04-15 | 2001-07-01 | Esteve Labor Dr | Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos. |
| CA2677519A1 (en) * | 1998-06-16 | 1999-12-23 | Targacept, Inc. | Aryl substituted olefinic amines and their use as cholinergic receptors agonists |
| DE10032456A1 (de) * | 2000-07-04 | 2002-01-31 | Lohmann Therapie Syst Lts | Schnell zerfallende Darreichungsform zur Freisetzung von Wirkstoffen im Mundraum oder in Körperhöhlen |
| US6743812B1 (en) * | 2000-07-14 | 2004-06-01 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
-
2000
- 2000-07-14 US US09/616,743 patent/US6432954B1/en not_active Expired - Fee Related
-
2001
- 2001-07-11 CN CNA2005100541592A patent/CN1680326A/zh active Pending
- 2001-07-11 NZ NZ523606A patent/NZ523606A/xx unknown
- 2001-07-11 DE DE60108130T patent/DE60108130T2/de not_active Expired - Fee Related
- 2001-07-11 IL IL15357701A patent/IL153577A0/xx unknown
- 2001-07-11 AT AT01984212T patent/ATE285773T1/de not_active IP Right Cessation
- 2001-07-11 JP JP2002511731A patent/JP2004509851A/ja active Pending
- 2001-07-11 EP EP01984212A patent/EP1311265B1/en not_active Expired - Lifetime
- 2001-07-11 AU AU2002222909A patent/AU2002222909B2/en not_active Ceased
- 2001-07-11 BR BR0112130-8A patent/BR0112130A/pt not_active Application Discontinuation
- 2001-07-11 PL PL01360532A patent/PL360532A1/xx not_active Application Discontinuation
- 2001-07-11 CA CA002415901A patent/CA2415901A1/en not_active Abandoned
- 2001-07-11 HU HU0301553A patent/HUP0301553A3/hu unknown
- 2001-07-11 AU AU2290902A patent/AU2290902A/xx active Pending
- 2001-07-11 WO PCT/US2001/021872 patent/WO2002005798A2/en not_active Ceased
- 2001-07-11 CN CNA018127924A patent/CN1468100A/zh active Pending
-
2002
- 2002-12-22 IL IL153577A patent/IL153577A/en not_active IP Right Cessation
-
2003
- 2003-01-06 ZA ZA200300135A patent/ZA200300135B/en unknown
- 2003-01-13 NO NO20030155A patent/NO20030155L/no not_active Application Discontinuation
-
2008
- 2008-06-18 IL IL192287A patent/IL192287A0/en unknown
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