JP2004509063A5 - - Google Patents
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- Publication number
- JP2004509063A5 JP2004509063A5 JP2001576759A JP2001576759A JP2004509063A5 JP 2004509063 A5 JP2004509063 A5 JP 2004509063A5 JP 2001576759 A JP2001576759 A JP 2001576759A JP 2001576759 A JP2001576759 A JP 2001576759A JP 2004509063 A5 JP2004509063 A5 JP 2004509063A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- prepared
- acid
- ethylsulfanyl
- desired product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 (butoxycarbonyl) amino Chemical group 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- JZBKYJZIWJSOPA-MRVPVSSYSA-N (2r)-4-ethylsulfanyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid Chemical compound CCSCC[C@H](C(O)=O)NC(=O)OC(C)(C)C JZBKYJZIWJSOPA-MRVPVSSYSA-N 0.000 description 1
- CPNCBQATOXCXPS-QNSVNVJESA-N (3r)-3-amino-3-cyclohexyl-2-hydroxy-n'-naphthalen-1-ylpropanehydrazide Chemical compound C1([C@H](C(O)C(=O)NNC=2C3=CC=CC=C3C=CC=2)N)CCCCC1 CPNCBQATOXCXPS-QNSVNVJESA-N 0.000 description 1
- XAMBIJWZVIZZOG-UHFFFAOYSA-N (4-methylphenyl)hydrazine Chemical compound CC1=CC=C(NN)C=C1 XAMBIJWZVIZZOG-UHFFFAOYSA-N 0.000 description 1
- BZFGKBQHQJVAHS-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-4-carboxylic acid Chemical compound OC(=O)C1=CC=NC(C(F)(F)F)=C1 BZFGKBQHQJVAHS-UHFFFAOYSA-N 0.000 description 1
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Natural products OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 description 1
- HKYAWWLCMWBLTG-NFJWQWPMSA-N n'-[(3r)-3-amino-5-ethylsulfanyl-2-hydroxypentanoyl]pyridine-4-carbohydrazide Chemical compound CCSCC[C@@H](N)C(O)C(=O)NNC(=O)C1=CC=NC=C1 HKYAWWLCMWBLTG-NFJWQWPMSA-N 0.000 description 1
- XBCIOBSQHJYVBQ-UHFFFAOYSA-N naphthalen-1-ylhydrazine Chemical group C1=CC=C2C(NN)=CC=CC2=C1 XBCIOBSQHJYVBQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54999500A | 2000-04-14 | 2000-04-14 | |
| US81300801A | 2001-03-21 | 2001-03-21 | |
| PCT/US2001/012274 WO2001079157A1 (en) | 2000-04-14 | 2001-04-13 | Hydrazide and alkoxyamide angiogenesis inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004509063A JP2004509063A (ja) | 2004-03-25 |
| JP2004509063A5 true JP2004509063A5 (https=) | 2008-03-06 |
Family
ID=27069307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001576759A Pending JP2004509063A (ja) | 2000-04-14 | 2001-04-13 | ヒドラジンおよびアルコキサミドの血管形成阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1272456B1 (https=) |
| JP (1) | JP2004509063A (https=) |
| AR (1) | AR028537A1 (https=) |
| AT (1) | ATE280753T1 (https=) |
| AU (1) | AU2001251631A1 (https=) |
| BR (1) | BR0107204A (https=) |
| CA (1) | CA2406442A1 (https=) |
| DE (1) | DE60106740T2 (https=) |
| DK (1) | DK1272456T3 (https=) |
| ES (1) | ES2231475T3 (https=) |
| HK (1) | HK1053825B (https=) |
| MX (1) | MXPA02010082A (https=) |
| PE (1) | PE20011222A1 (https=) |
| PT (1) | PT1272456E (https=) |
| UY (1) | UY26664A1 (https=) |
| WO (1) | WO2001079157A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005534702A (ja) * | 2002-08-06 | 2005-11-17 | アボット・ラボラトリーズ | ３−アミノ−２−ヒドロキシアルカン酸及びそのプロドラッグ |
| US8609881B2 (en) * | 2008-05-07 | 2013-12-17 | Henkel IP US LCC | Cure accelerators for anaerobic curable compositions |
| DE102008027574A1 (de) | 2008-06-10 | 2009-12-17 | Merck Patent Gmbh | Neue Pyrrolidinderivate als MetAP-2 Inhibitoren |
| DE102009005193A1 (de) | 2009-01-20 | 2010-07-22 | Merck Patent Gmbh | Neue heterocyclische Verbindungen als MetAP-2 Inhibitoren |
| DE102010048374A1 (de) | 2010-10-13 | 2012-04-19 | Merck Patent Gmbh | Pyrrolidinone als MetAP-2 Inhibitoren |
| DE102012006884A1 (de) | 2012-04-04 | 2013-10-10 | Merck Patent Gmbh | Cyclische Amide als MetAP-2 Inhibitoren |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5977408A (en) * | 1996-10-16 | 1999-11-02 | American Cyanamid Company | Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
| ID25639A (id) * | 1998-02-19 | 2000-10-19 | American Cyanamid Co | Alkil, aril atau heteroarilamida tersubstitusi n-hidroksi-2-(alkil, aril, atau heteroaril sulfanil, sulfinil atau sulfonil)-3 sebagai inhibitor matriks mataloproteinase |
| DE19831710A1 (de) * | 1998-07-15 | 2000-01-20 | Merck Patent Gmbh | Diacylhydrazinderivate |
-
2001
- 2001-04-11 AR ARP010101734A patent/AR028537A1/es unknown
- 2001-04-11 PE PE2001000340A patent/PE20011222A1/es not_active Application Discontinuation
- 2001-04-11 UY UY26664A patent/UY26664A1/es not_active Application Discontinuation
- 2001-04-13 DK DK01925029T patent/DK1272456T3/da active
- 2001-04-13 MX MXPA02010082A patent/MXPA02010082A/es active IP Right Grant
- 2001-04-13 EP EP01925029A patent/EP1272456B1/en not_active Expired - Lifetime
- 2001-04-13 JP JP2001576759A patent/JP2004509063A/ja active Pending
- 2001-04-13 AU AU2001251631A patent/AU2001251631A1/en not_active Abandoned
- 2001-04-13 ES ES01925029T patent/ES2231475T3/es not_active Expired - Lifetime
- 2001-04-13 WO PCT/US2001/012274 patent/WO2001079157A1/en not_active Ceased
- 2001-04-13 DE DE60106740T patent/DE60106740T2/de not_active Expired - Lifetime
- 2001-04-13 BR BR0107204-8A patent/BR0107204A/pt not_active Application Discontinuation
- 2001-04-13 AT AT01925029T patent/ATE280753T1/de active
- 2001-04-13 HK HK03104469.1A patent/HK1053825B/en not_active IP Right Cessation
- 2001-04-13 PT PT01925029T patent/PT1272456E/pt unknown
- 2001-04-13 CA CA002406442A patent/CA2406442A1/en not_active Abandoned
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