JP2004508043A - Ｔｎｆレセプター様分子およびその使用 - Google Patents

Ｔｎｆレセプター様分子およびその使用 Download PDF

Info

Publication number
JP2004508043A
JP2004508043A JP2002525769A JP2002525769A JP2004508043A JP 2004508043 A JP2004508043 A JP 2004508043A JP 2002525769 A JP2002525769 A JP 2002525769A JP 2002525769 A JP2002525769 A JP 2002525769A JP 2004508043 A JP2004508043 A JP 2004508043A
Authority
JP
Japan
Prior art keywords
seq
polypeptide
amino acid
activity
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002525769A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004508043A5 (OSRAM
Inventor
セイル，　ラース　アイド
イェー，　リチャード
シルビガー，　スコット　マイケル
ユー，　ガン
セナルディ，　ジョージオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of JP2004508043A publication Critical patent/JP2004508043A/ja
Publication of JP2004508043A5 publication Critical patent/JP2004508043A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2002525769A 2000-09-05 2001-09-05 Ｔｎｆレセプター様分子およびその使用 Pending JP2004508043A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23019100P 2000-09-05 2000-09-05
PCT/US2001/027631 WO2002020762A2 (en) 2000-09-05 2001-09-05 Tnf receptor-like molecules and uses thereof

Publications (2)

Publication Number Publication Date
JP2004508043A true JP2004508043A (ja) 2004-03-18
JP2004508043A5 JP2004508043A5 (OSRAM) 2008-09-11

Family

ID=22864263

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002525769A Pending JP2004508043A (ja) 2000-09-05 2001-09-05 Ｔｎｆレセプター様分子およびその使用

Country Status (10)

Country Link
US (3) US7153669B2 (OSRAM)
EP (1) EP1317536B1 (OSRAM)
JP (1) JP2004508043A (OSRAM)
AT (1) ATE431405T1 (OSRAM)
AU (2) AU2001288812B2 (OSRAM)
CA (1) CA2421588C (OSRAM)
DE (1) DE60138715D1 (OSRAM)
ES (1) ES2327102T3 (OSRAM)
MX (1) MXPA03001930A (OSRAM)
WO (1) WO2002020762A2 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531428A (ja) * 2009-06-25 2012-12-10 アムジエン・インコーポレーテツド 哺乳類以外の系で発現されるタンパク質の捕獲精製プロセス

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1424392B1 (en) * 2001-09-03 2012-10-24 Takeda Pharmaceutical Company Limited RF-peptide ligands of G-protein coupled receptor
EP1338609A1 (de) * 2002-02-21 2003-08-27 MEMOREC Stoffel GmbH-Medizinisch-Molekulare Entwicklung, Köln Ein weiterer KDR Rezeptor und seine Anwendung
WO2006042132A2 (en) * 2004-10-08 2006-04-20 Georgia Tech Research Corporation Microencapsulation of cells in hydrogels using electrostatic potentials
US8952138B2 (en) 2009-06-22 2015-02-10 Amgen Inc. Refolding proteins using a chemically controlled redox state
KR20140015152A (ko) 2009-12-02 2014-02-06 악셀레론 파마 인코포레이티드 Ｆｃ 융합 단백질의 혈청 반감기를 증가시키는 조성물들 및 방법들
WO2012075238A1 (en) 2010-12-02 2012-06-07 Genentech, Inc. Novel receptor-ligand interaction and uses thereof
EP2718328A4 (en) 2011-06-08 2014-12-24 Acceleron Pharma Inc COMPOSITIONS AND METHODS FOR INCREASING THE HALF TIME OF SERUM
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
US9708375B2 (en) 2013-03-15 2017-07-18 Amgen Inc. Inhibitory polypeptides specific to WNT inhibitors
CA2923145C (en) 2013-09-05 2025-09-16 Amgen Inc. MOLECULES CONTAINING FCS AND EXHIBITING PREDICTABLE, UNIFORM AND REPRODUCIBLE GLYCOFORM PROFILES
JP6671298B2 (ja) 2014-05-16 2020-03-25 アムジェン インコーポレイテッド Ｔｈ１及びｔｈ２細胞集団を検出するためのアッセイ
US12503700B2 (en) 2017-03-14 2025-12-23 Amgen Inc. Control of total afucosylated glycoforms of antibodies produced in cell culture
SG11202009216YA (en) 2018-03-26 2020-10-29 Amgen Inc Total afucosylated glycoforms of antibodies produced in cell culture
EP4034556A1 (en) 2019-09-26 2022-08-03 Amgen Inc. Methods of producing antibody compositions
CA3164129A1 (en) * 2019-12-20 2021-06-24 Amgen Inc. Mesothelin-targeted cd40 agonistic multispecific antibody constructs for the treatment of solid tumors
US20230273126A1 (en) 2020-06-04 2023-08-31 Amgen Inc. Assessment of cleaning procedures of a biotherapeutic manufacturing process
CA3197930A1 (en) 2020-10-15 2022-04-21 Amgen Inc. Relative unpaired glycans in antibody production methods
WO2022261021A1 (en) 2021-06-07 2022-12-15 Amgen Inc. Using fucosidase to control afucosylation level of glycosylated proteins
WO2023059607A1 (en) 2021-10-05 2023-04-13 Amgen Inc. Fc-gamma receptor ii binding and glycan content
WO2023215725A1 (en) 2022-05-02 2023-11-09 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
AU2024256160A1 (en) 2023-04-20 2025-10-02 Amgen Inc. Methods of determining relative unpaired glycan content
CN116459344B (zh) * 2023-04-28 2025-03-18 上海市生物医药技术研究院 一种MNSFβ/RC3H1 PPI干扰多肽的抗炎治疗应用
WO2025038600A1 (en) 2023-08-14 2025-02-20 Amgen Inc. Methods for reducing yellow color
WO2025101820A1 (en) 2023-11-08 2025-05-15 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2238070T3 (es) 1989-04-21 2005-08-16 Amgen Inc. Receptor del tnf, proteina ligante del tnf y adn codante para estos.
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc Method for the production of a human recombinant tumor necrosis factor inhibitor
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
DE4004317A1 (de) 1990-02-13 1991-08-14 Basf Ag Neue 3-substituierte pyridinmethanole und diese enthaltende fungizide
US5521288A (en) * 1990-03-26 1996-05-28 Bristol-Myers Squibb Company CD28IG fusion protein
US5843789A (en) 1995-05-16 1998-12-01 Neomecs Incorporated Method of analysis of genomic biopolymer and porous materials for genomic analyses
CA2323830A1 (en) * 1998-03-16 1999-09-23 Millennium Pharmaceuticals, Inc. Methods and compositions for diagnosing and treating chromosome-18p related disorders
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
WO2001055309A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US6783969B1 (en) * 2001-03-05 2004-08-31 Nuvelo, Inc. Cathepsin V-like polypeptides

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6011004054, ""ｗｊ４５ｅ０７．ｘ１ ＮＣＩ＿ＣＧＡＰ＿Ｌｕ１９ Ｈｏｍｏ ｓａｐｉｅｎｓ ｃＤＮＡ ｃｌｏｎｅ ＩＭＡＧＥ：２４０５７９６ ３−， ｍＲＮＡ ｓｅｑｕｅｎｃｅ"", ＮＣＢＩ ＥＳＴ *
JPN6011004056, ""ｗｆ２４ｄ０１．ｘ１ Ｓｏａｒｅｓ＿ＮＦＬ＿Ｔ＿ＧＢＣ＿Ｓ１ Ｈｏｍｏ ｓａｐｉｅｎｓ ｃＤＮＡ ｃｌｏｎｅ ＩＭＡＧＥ：２３５６５１３ ３− ｓｉｍｉｌａｒ ｔｏ ｃｏｎｔａｉｎｓ ＭＥＲ２２．ｔ", ＮＣＢＩ ＥＳＴ *
JPN6011004058, ""６０１１０９１５８Ｆ１ ＮＩＨ＿ＭＧＣ＿１６ Ｈｏｍｏ ｓａｐｉｅｎｓ ｃＤＮＡ ｃｌｏｎｅ ＩＭＡＧＥ：３３４９９５８ ５−， ｍＲＮＡ ｓｅｑｕｅｎｃｅ"", ＮＣＢＩ ＥＳＴ *
JPN6011004059, ""ｔｎ４５ｇ１０．ｘ１ ＮＣＩ＿ＣＧＡＰ＿Ｂｒｎ２５ Ｈｏｍｏ ｓａｐｉｅｎｓ ｃＤＮＡ ｃｌｏｎｅ ＩＭＡＧＥ：２１７０６２６ ３−， ｍＲＮＡ ｓｅｑｕｅｎｃｅ"", ＮＣＢＩ ＥＳＴ *
JPN6011004060, ""ｑａ７１ｂ０３．ｘ１ Ｓｏａｒｅｓ＿ｆｅｔａｌ＿ｈｅａｒｔ＿ＮｂＨＨ１９Ｗ Ｈｏｍｏ ｓａｐｉｅｎｓ ｃＤＮＡ ｃｌｏｎｅ ＩＭＡＧＥ：１６９２１７３ ３− ｓｉｍｉｌａｒ ｔｏ ｃｏｎｔａｉｎｓ", ＮＣＢＩ ＥＳＴ *
JPN6011004062, ""ｘｖ３０ｄ０６．ｘ１ Ｓｏａｒｅｓ＿ＮＦＬ＿Ｔ＿ＧＢＣ＿Ｓ１ Ｈｏｍｏ ｓａｐｉｅｎｓ ｃＤＮＡ ｃｌｏｎｅ ＩＭＡＧＥ：２８１４６３５ ３−， ｍＲＮＡ ｓｅｑｕｅｎｃｅ"", ＮＣＢＩ ＥＳＴ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531428A (ja) * 2009-06-25 2012-12-10 アムジエン・インコーポレーテツド 哺乳類以外の系で発現されるタンパク質の捕獲精製プロセス

Also Published As

Publication number Publication date
AU8881201A (en) 2002-03-22
MXPA03001930A (es) 2003-06-19
ATE431405T1 (de) 2009-05-15
US7569387B2 (en) 2009-08-04
EP1317536B1 (en) 2009-05-13
WO2002020762A8 (en) 2004-03-04
WO2002020762A3 (en) 2002-08-08
WO2002020762A2 (en) 2002-03-14
CA2421588C (en) 2010-01-26
DE60138715D1 (de) 2009-06-25
US7153669B2 (en) 2006-12-26
CA2421588A1 (en) 2002-03-14
ES2327102T3 (es) 2009-10-26
EP1317536A2 (en) 2003-06-11
US20090325880A1 (en) 2009-12-31
US20020150977A1 (en) 2002-10-17
AU2001288812B2 (en) 2007-05-10
US20070015219A1 (en) 2007-01-18

Similar Documents

Publication Publication Date Title
US20090325880A1 (en) Tnf receptor-like molecules and uses thereof
US20060024267A1 (en) TNFr/OPG-like molecules and uses thereof
AU2001288812A1 (en) TNF receptor-like molecules and uses thereof
JP2004500063A5 (OSRAM)
JP2004504064A (ja) Ｉｌ−１７分子およびその用途
AU2001259029B2 (en) Il-17 receptor like molecules and uses thereof
US20020045213A1 (en) IL-17 receptor like molecules and uses thereof
JP2007014331A (ja) インターフェロン様分子およびその使用
AU784727B2 (en) IL-17 like molecules and uses thereof
MXPA04005956A (es) Moleculas tipo il-17 y usos de las mismas.
AU1805101A (en) Interleukin-1 receptor antagonist-like molecules and uses thereof
JP3842647B2 (ja) インターロイキン−１レセプターアンタゴニスト関連分子およびその使用
HUP0203689A2 (hu) Interleukin-1 receptor antagonistaszerű molekulák és ezek használata
JP2003516132A (ja) インターロイキン−１レセプターアンタゴニスト様分子およびその使用
US20030099980A1 (en) IL-17 receptor like molecules and uses thereof
AU2007200885A1 (en) IL-17 Receptor Like Molecules and Uses Thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080723

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080723

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110126

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110909