JP2004507486A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004507486A5 JP2004507486A5 JP2002522855A JP2002522855A JP2004507486A5 JP 2004507486 A5 JP2004507486 A5 JP 2004507486A5 JP 2002522855 A JP2002522855 A JP 2002522855A JP 2002522855 A JP2002522855 A JP 2002522855A JP 2004507486 A5 JP2004507486 A5 JP 2004507486A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrite
- alkaline earth
- composition
- pharmacologically acceptable
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 alkali metal nitrite Chemical class 0.000 description 13
- 239000000203 mixture Substances 0.000 description 13
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 12
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 8
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 8
- 229960004194 lidocaine Drugs 0.000 description 8
- 239000002535 acidifier Substances 0.000 description 7
- 229910052783 alkali metal Inorganic materials 0.000 description 7
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 7
- 239000013543 active substance Substances 0.000 description 6
- 239000002243 precursor Substances 0.000 description 6
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 5
- 229960002372 tetracaine Drugs 0.000 description 5
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 5
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 description 4
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 4
- 230000003444 anaesthetic effect Effects 0.000 description 4
- 229960005274 benzocaine Drugs 0.000 description 4
- 229960003150 bupivacaine Drugs 0.000 description 4
- 229960003920 cocaine Drugs 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 229960002409 mepivacaine Drugs 0.000 description 4
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 4
- 229960001807 prilocaine Drugs 0.000 description 4
- 229960001549 ropivacaine Drugs 0.000 description 4
- 229940072358 xylocaine Drugs 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000007524 organic acids Chemical group 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000002691 topical anesthesia Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0021317.3A GB0021317D0 (en) | 2000-08-30 | 2000-08-30 | Transdermal pharmaceutical delivery composition |
| GB0021317.3 | 2000-08-30 | ||
| PCT/GB2001/003863 WO2002017881A2 (en) | 2000-08-30 | 2001-08-30 | Transdermal pharmaceutical delivery composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004507486A JP2004507486A (ja) | 2004-03-11 |
| JP2004507486A5 true JP2004507486A5 (enExample) | 2008-10-16 |
| JP4869540B2 JP4869540B2 (ja) | 2012-02-08 |
Family
ID=9898548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002522855A Expired - Fee Related JP4869540B2 (ja) | 2000-08-30 | 2001-08-30 | 経皮的製剤送達用組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8128964B2 (enExample) |
| EP (1) | EP1328252B1 (enExample) |
| JP (1) | JP4869540B2 (enExample) |
| AT (1) | ATE347879T1 (enExample) |
| AU (2) | AU2001284191B2 (enExample) |
| DE (1) | DE60125217T2 (enExample) |
| ES (1) | ES2275716T3 (enExample) |
| GB (1) | GB0021317D0 (enExample) |
| WO (1) | WO2002017881A2 (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0021317D0 (en) * | 2000-08-30 | 2000-10-18 | Queen Mary & Westfield College | Transdermal pharmaceutical delivery composition |
| WO2005004884A2 (en) | 2003-07-09 | 2005-01-20 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
| WO2006084911A2 (en) * | 2005-02-11 | 2006-08-17 | Nolabs Ab | Improved device for application of medicaments, manufacturing method therefor, and method of treatment |
| US8557300B2 (en) * | 2005-05-19 | 2013-10-15 | University Of Cincinnati | Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite |
| EP2669269B1 (en) | 2005-05-27 | 2019-05-22 | The University of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
| GB0607402D0 (en) | 2006-04-12 | 2006-05-24 | Barts & London Nhs Trust | Therapeutic composition and use |
| US8445018B2 (en) * | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| US7975699B2 (en) | 2007-10-30 | 2011-07-12 | The Invention Science Fund I, Llc | Condoms configured to facilitate release of nitric oxide |
| US8221690B2 (en) | 2007-10-30 | 2012-07-17 | The Invention Science Fund I, Llc | Systems and devices that utilize photolyzable nitric oxide donors |
| US8642093B2 (en) | 2007-10-30 | 2014-02-04 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
| US20090110933A1 (en) * | 2007-10-30 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems and devices related to nitric oxide releasing materials |
| US7862598B2 (en) * | 2007-10-30 | 2011-01-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
| US20110190604A1 (en) * | 2006-12-22 | 2011-08-04 | Hyde Roderick A | Nitric oxide sensors and systems |
| WO2009055008A1 (en) * | 2007-10-24 | 2009-04-30 | Wharton Innovative Products, Llc | Two part lotion for the delivery of nitrite ions to the skin |
| US10080823B2 (en) | 2007-10-30 | 2018-09-25 | Gearbox Llc | Substrates for nitric oxide releasing devices |
| US8349262B2 (en) | 2007-10-30 | 2013-01-08 | The Invention Science Fund I, Llc | Nitric oxide permeable housings |
| US8877508B2 (en) * | 2007-10-30 | 2014-11-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
| US7897399B2 (en) | 2007-10-30 | 2011-03-01 | The Invention Science Fund I, Llc | Nitric oxide sensors and systems |
| US8980332B2 (en) | 2007-10-30 | 2015-03-17 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
| US8303995B1 (en) * | 2008-06-13 | 2012-11-06 | Board Of Regents, The University Of Texas System | Nitrite formulations and their use as nitric oxide prodrugs |
| CA2738524C (en) | 2008-10-02 | 2013-11-26 | Mylan Inc. | Method for making a multilayer adhesive laminate |
| US20100098733A1 (en) * | 2008-10-16 | 2010-04-22 | Novan, Inc. | Nitric oxide releasing particles for oral care applications |
| GB0901456D0 (en) * | 2009-01-29 | 2009-03-11 | Insense Ltd | Treatment of psoriasis |
| EP2467173B8 (en) | 2009-08-21 | 2019-06-19 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| WO2011047013A1 (en) * | 2009-10-13 | 2011-04-21 | Novan, Inc. | Nitric oxide-releasing coatings |
| RU2445918C1 (ru) * | 2010-07-15 | 2012-03-27 | Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет | Способ неинвазивной дифференциальной диагностики патологии лимфатических и венозных сосудов нижних конечностей |
| PT2533773E (pt) | 2010-10-21 | 2015-12-01 | Kipax Ab | Dispositivo de administração de óxido nítrico por via cutânea tópica |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118819A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
| WO2012131412A2 (en) | 2011-03-31 | 2012-10-04 | Szabo Laszlo Gabor | Pharmaceutical composition containing no, process for the preparation and use thereof |
| BR112014003414B1 (pt) * | 2011-08-17 | 2021-09-21 | Board Of Regents, The University Of Texas System | Composição e sistema de entrega oral para aumento de níveis fisiológicos e terapêuticos de óxido nítrico |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| EP2782584B1 (en) | 2011-11-23 | 2021-06-09 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| GB201309092D0 (en) | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Transdermal delivery system |
| GB201309091D0 (en) | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Dressing system |
| EP3099358B1 (en) * | 2014-01-31 | 2018-12-12 | Galderma S.A. | Lubrication of an injection needle |
| AR100562A1 (es) | 2014-05-22 | 2016-10-12 | Therapeuticsmd Inc | Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal |
| US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
| ES2807200T3 (es) | 2014-07-11 | 2021-02-22 | Novan Inc | Composiciones antivirales tópicas y procedimientos de uso de las mismas |
| US10925689B2 (en) | 2014-07-14 | 2021-02-23 | Novan, Inc. | Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same |
| GB201420761D0 (en) | 2014-11-21 | 2015-01-07 | Edixomed Ltd And First Water Ltd | Dressing system |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10849864B2 (en) | 2015-07-28 | 2020-12-01 | Novan, Inc. | Combinations and methods for the treatment and/or prevention of fungal infections |
| GB201520990D0 (en) | 2015-11-27 | 2016-01-13 | Edixomed Ltd | Dressing system |
| WO2017132275A1 (en) | 2016-01-27 | 2017-08-03 | Syk Technologies, Llc | Nitric oxide topical application apparatus and methods |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| US10149843B1 (en) | 2017-02-07 | 2018-12-11 | Gneus Lifescineces Inc. | Pharmaceutical compositions and methods of using the same |
| US10231961B1 (en) | 2017-02-07 | 2019-03-19 | Genus Lifesciences Inc. | Pharmaceutical compositions and methods of using the same |
| US10413505B1 (en) | 2017-02-07 | 2019-09-17 | Genus Lifesciences Inc. | Pharmaceutical compositions and methods of using the same |
| US20220370493A1 (en) | 2019-06-04 | 2022-11-24 | Thirty Holdings Limited | Methods and compositions for generating nitric oxide and uses thereof |
| AU2020286987B2 (en) | 2019-06-04 | 2025-09-11 | Thirty Respiratory Limited | Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract |
| CA3313713A1 (en) * | 2019-06-12 | 2026-06-21 | Sanotize Research And Development Corp. | Medicament containment devices and associated compositions |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| US20230172973A1 (en) | 2020-04-23 | 2023-06-08 | Thirty Respiratory Limited | Methods and compositions for treating and combatting tuberculosis |
| WO2021214440A1 (en) | 2020-04-23 | 2021-10-28 | Thirty Respiratory Limited | Nitric oxide or nitric oxide releasing compositions for use in treating sars-cov and sars-cov-2 |
| US12459820B2 (en) | 2020-06-11 | 2025-11-04 | J. W. Randolph Miller | Stabilized and NO2-inhibited nitric oxide generating gels for inhaled nitric oxide therapy |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58913A (ja) * | 1981-06-26 | 1983-01-06 | Nitto Electric Ind Co Ltd | 局所系医薬製剤 |
| RO92445B1 (ro) * | 1985-08-12 | 1987-10-01 | Ludovic L. Elthes | Unguent medicamentos cu actiune antiinflamatoare, cicatrizanta si epitelizanta |
| US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| JPH07108849B2 (ja) | 1991-02-08 | 1995-11-22 | 奈良炭化工業株式会社 | 葉面散布用植物成育剤 |
| US5264219A (en) * | 1992-08-07 | 1993-11-23 | Minnesota Mining And Manufacturing Company | Transdermal drug delivery backing |
| US5891846A (en) * | 1994-02-17 | 1999-04-06 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| GB9804469D0 (en) * | 1998-03-02 | 1998-04-29 | Univ Aberdeen | Antiviral composition |
| CN1145491C (zh) * | 1994-02-21 | 2004-04-14 | 阿伯丁大学 | 用作抗微生物剂的酸化亚硝酸盐 |
| US5648101A (en) | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| SE9700617D0 (sv) * | 1997-02-21 | 1997-02-21 | Kjell Alving | New composition |
| US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US5900249A (en) * | 1998-02-09 | 1999-05-04 | Smith; David J. | Multicomponent pain relief topical medication |
| US6103275A (en) * | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
| GB0021317D0 (en) * | 2000-08-30 | 2000-10-18 | Queen Mary & Westfield College | Transdermal pharmaceutical delivery composition |
-
2000
- 2000-08-30 GB GBGB0021317.3A patent/GB0021317D0/en not_active Ceased
-
2001
- 2001-08-30 DE DE60125217T patent/DE60125217T2/de not_active Expired - Lifetime
- 2001-08-30 US US10/363,439 patent/US8128964B2/en not_active Expired - Fee Related
- 2001-08-30 AT AT01963158T patent/ATE347879T1/de not_active IP Right Cessation
- 2001-08-30 EP EP01963158A patent/EP1328252B1/en not_active Expired - Lifetime
- 2001-08-30 AU AU2001284191A patent/AU2001284191B2/en not_active Ceased
- 2001-08-30 ES ES01963158T patent/ES2275716T3/es not_active Expired - Lifetime
- 2001-08-30 AU AU8419101A patent/AU8419101A/xx active Pending
- 2001-08-30 JP JP2002522855A patent/JP4869540B2/ja not_active Expired - Fee Related
- 2001-08-30 WO PCT/GB2001/003863 patent/WO2002017881A2/en not_active Ceased
-
2008
- 2008-09-03 US US12/231,555 patent/US8114442B2/en not_active Expired - Fee Related
-
2012
- 2012-01-27 US US13/360,601 patent/US20120183595A1/en not_active Abandoned
-
2013
- 2013-07-03 US US13/935,070 patent/US20140187481A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2203676T3 (es) | Preparaciones en aerosol de prilocaina e hidrofluorocarbono. | |
| ZA200806671B (en) | Therapeutic compositions for intranasal administration of ketorolac | |
| US6586478B2 (en) | Methods and compositions for improving sleep | |
| Adriani et al. | Clinical effectiveness of drugs used for topical anesthesia | |
| US4782047A (en) | Aqueous steroid formulations for nasal administration | |
| CN100370986C (zh) | 包含高效长效β2－激动剂和其它活性成分的药物组合物 | |
| JP2007506766A5 (enExample) | ||
| RU2000106597A (ru) | Новое применение будезонида и формотерола | |
| EP1285667B1 (en) | Pharmaceutical injectable solution of paracetamol and combinations of paracetamol with other active substances | |
| KR20010072931A (ko) | 폐 질환 치료 요법 | |
| EA200600497A1 (ru) | Композиция для аэрозольной ингаляции, содержащая антихолинергическое средство | |
| CA2302700A1 (en) | New use for budesonide and formoterol | |
| WO2002009707A1 (en) | Fentanyl composition for nasal administration | |
| US12611431B2 (en) | Approach to sustained production and delivery of nitric oxide and S-nitrosothiols | |
| ATE347879T1 (de) | Transdermale pharmazeutische zusammensetzung zur wirkstoffverabreichung | |
| JPH01268633A (ja) | Ｌ−ドーパの直腸被吸収性形態 | |
| JP2023526583A (ja) | 結核を治療及び抑制するための方法及び組成物 | |
| Sinclair et al. | Postoperative pain relief by topical lidocaine in the surgical wound of hysterectomized patients | |
| US20240342156A1 (en) | Methods for treating pain | |
| WO2002000166A3 (en) | New compounds useful as antibacterial agents | |
| ES2309357T3 (es) | Nueva combinacion sinergica que comprende roflumilast y formoterol. | |
| CN101357116B (zh) | 透皮透粘膜局部麻醉止痛剂及其凝胶性制剂的制备方法 | |
| JP2005513105A5 (enExample) | ||
| US20050020569A1 (en) | Composition and method for treating erectile dysfunction and reducing fibrosis in erectile tissue of the human penis | |
| KR20130140672A (ko) | 기침 치료용 카보네이트 유도체 |