JP2004504842A5 - - Google Patents
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- Publication number
- JP2004504842A5 JP2004504842A5 JP2002516309A JP2002516309A JP2004504842A5 JP 2004504842 A5 JP2004504842 A5 JP 2004504842A5 JP 2002516309 A JP2002516309 A JP 2002516309A JP 2002516309 A JP2002516309 A JP 2002516309A JP 2004504842 A5 JP2004504842 A5 JP 2004504842A5
- Authority
- JP
- Japan
- Prior art keywords
- tif
- molecule
- modulator
- cell
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000694 effects Effects 0.000 claims description 4
- 230000014616 translation Effects 0.000 claims description 3
- 102100022524 Alpha-1-antichymotrypsin Human genes 0.000 claims description 2
- 102000014702 Haptoglobin Human genes 0.000 claims description 2
- 108050005077 Haptoglobin Proteins 0.000 claims description 2
- 108010091628 alpha 1-Antichymotrypsin Proteins 0.000 claims description 2
- 102100030703 Interleukin-22 Human genes 0.000 claims 36
- 238000000034 method Methods 0.000 claims 24
- 108010054016 IL-TIF IL-10-related T cell-derived inducible factor Proteins 0.000 claims 17
- 108010074108 interleukin-21 Proteins 0.000 claims 17
- 108010074109 interleukin-22 Proteins 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 9
- 239000000126 substance Substances 0.000 claims 7
- 102000011767 Acute-Phase Proteins Human genes 0.000 claims 5
- 108010062271 Acute-Phase Proteins Proteins 0.000 claims 5
- 108040006870 interleukin-10 receptor activity proteins Proteins 0.000 claims 5
- 101001010626 Homo sapiens Interleukin-22 Proteins 0.000 claims 4
- 101001010621 Homo sapiens Interleukin-21 Proteins 0.000 claims 3
- 102000040945 Transcription factor Human genes 0.000 claims 3
- 108091023040 Transcription factor Proteins 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 2
- 102000004495 STAT3 Transcription Factor Human genes 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 102100030704 Interleukin-21 Human genes 0.000 claims 1
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims 1
- 102000006381 STAT1 Transcription Factor Human genes 0.000 claims 1
- 108700028909 Serum Amyloid A Proteins 0.000 claims 1
- 102000054727 Serum Amyloid A Human genes 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62661700A | 2000-07-27 | 2000-07-27 | |
| PCT/US2001/020485 WO2002010393A2 (en) | 2000-07-27 | 2001-06-27 | Isolated nucleic acid molecules which encode t cell inducible factors, or interleukin-21, the proteins encoded, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004504842A JP2004504842A (ja) | 2004-02-19 |
| JP2004504842A5 true JP2004504842A5 (enExample) | 2005-04-14 |
| JP4113773B2 JP4113773B2 (ja) | 2008-07-09 |
Family
ID=24511131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002516309A Expired - Fee Related JP4113773B2 (ja) | 2000-07-27 | 2001-06-27 | Ｔ細胞誘導性因子またはインターロイキン２１をコードする単離された核酸分子、それらがコードするタンパク質およびその用途 |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP1806404B1 (enExample) |
| JP (1) | JP4113773B2 (enExample) |
| CN (3) | CN100497628C (enExample) |
| AT (2) | ATE478148T1 (enExample) |
| AU (1) | AU7303301A (enExample) |
| CA (1) | CA2416820A1 (enExample) |
| DE (2) | DE60142861D1 (enExample) |
| ES (1) | ES2349312T3 (enExample) |
| WO (1) | WO2002010393A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7307161B1 (en) | 1999-04-28 | 2007-12-11 | Genetics Institute, Llc | Human Gil-19/AE289 polynucleotides |
| US6939545B2 (en) | 1999-04-28 | 2005-09-06 | Genetics Institute, Llc | Composition and method for treating inflammatory disorders |
| US20030170823A1 (en) | 1999-12-23 | 2003-09-11 | Presnell Scott R. | Novel cytokine ZCYTO18 |
| US20030012788A1 (en) | 2000-07-27 | 2003-01-16 | Jean-Christophe Renauld | Method for influencing kinase pathways with IL-22 |
| US20030023033A1 (en) * | 2001-07-26 | 2003-01-30 | Laure Dumoutier | Novel class II cytokine receptors and uses thereof |
| ES2277947T3 (es) * | 2000-10-13 | 2007-08-01 | Eli Lilly And Company | Procedimientos de uso de un polipeptido afin a il-17 humana para tratar enfermedades. |
| US7638604B2 (en) | 2001-02-23 | 2009-12-29 | Genetics Institute, Llc | Monoclonal antibodies against interleukin-22 |
| WO2003083062A2 (en) | 2002-03-22 | 2003-10-09 | Zymogenetics, Inc. | Anti-il-tif antibodies and methods of using in inflammation |
| AU2003251633A1 (en) | 2002-07-01 | 2004-01-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Il-21 as a regulator of immunoglobin production |
| CA2497661A1 (en) * | 2002-09-11 | 2004-03-25 | Genentech, Inc. | Compositions and methods for the diagnosis of immune related diseases using pro71061 |
| US20060177421A1 (en) * | 2002-10-11 | 2006-08-10 | Novo Nordisk A/S | Treatment of allergic conditions by use of il 21 |
| EP1553970A1 (en) * | 2002-10-11 | 2005-07-20 | Novo Nordisk A/S | Treatment of allergic conditions by use of il 21 |
| ATE490275T1 (de) * | 2003-06-23 | 2010-12-15 | Genetics Inst Llc | Antikörper gegen interleukin-22 und verwendungen dafür |
| EP3006466B1 (en) | 2005-12-02 | 2018-08-01 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r |
| TWI417301B (zh) | 2006-02-21 | 2013-12-01 | Wyeth Corp | 對抗人類介白素-２２（ｉｌ-２２）之抗體及其用途 |
| TW200744634A (en) | 2006-02-21 | 2007-12-16 | Wyeth Corp | Methods of using antibodies against human IL-22 |
| IT1404858B1 (it) | 2011-02-21 | 2013-12-09 | Milano Politecnico | Supporto anti-sismico. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843697A (en) | 1996-07-17 | 1998-12-01 | University Of Medicine And Dentistry Of New Jersey | Cells expressing IL-10 receptor and the CRFB4 gene product, an IL-10 receptor accessory protein |
| DE19848683B4 (de) | 1998-10-22 | 2004-05-06 | Basf Ag | Verbundschichtplatte |
| JP3769189B2 (ja) * | 1998-10-26 | 2006-04-19 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Ｔ細胞誘導性因子（ｔｉｆ）をコードする単離された核酸分子、コードされたタンパク質およびその使用 |
| EP1177312B1 (en) * | 1999-04-28 | 2007-10-31 | Genetics Institute, LLC | Human gil-19/ae289 proteins and polynucleotides encoding same |
| WO2000073457A1 (en) * | 1999-05-27 | 2000-12-07 | Schering-Corporation | Mammalian interleukin-10 homologs: il-d110 and il-d210 |
| CA2393369A1 (en) * | 1999-12-03 | 2001-06-07 | Zymogenetics, Inc. | Human cytokine receptor |
-
2001
- 2001-06-27 AT AT07002409T patent/ATE478148T1/de not_active IP Right Cessation
- 2001-06-27 CN CNB2005101169978A patent/CN100497628C/zh not_active Expired - Fee Related
- 2001-06-27 CN CNB018131255A patent/CN100448994C/zh not_active Expired - Fee Related
- 2001-06-27 EP EP07002409A patent/EP1806404B1/en not_active Expired - Lifetime
- 2001-06-27 AU AU7303301A patent/AU7303301A/xx not_active Withdrawn
- 2001-06-27 AT AT01952260T patent/ATE365801T1/de not_active IP Right Cessation
- 2001-06-27 JP JP2002516309A patent/JP4113773B2/ja not_active Expired - Fee Related
- 2001-06-27 EP EP01952260A patent/EP1305419B1/en not_active Expired - Lifetime
- 2001-06-27 DE DE60142861T patent/DE60142861D1/de not_active Expired - Lifetime
- 2001-06-27 ES ES07002409T patent/ES2349312T3/es not_active Expired - Lifetime
- 2001-06-27 CA CA002416820A patent/CA2416820A1/en not_active Abandoned
- 2001-06-27 DE DE60129137T patent/DE60129137D1/de not_active Expired - Lifetime
- 2001-06-27 CN CNA2008101764854A patent/CN101423551A/zh active Pending
- 2001-06-27 WO PCT/US2001/020485 patent/WO2002010393A2/en not_active Ceased
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