JP2004503519A - サルメテロールの新規な調製方法 - Google Patents
サルメテロールの新規な調製方法 Download PDFInfo
- Publication number
- JP2004503519A JP2004503519A JP2002510422A JP2002510422A JP2004503519A JP 2004503519 A JP2004503519 A JP 2004503519A JP 2002510422 A JP2002510422 A JP 2002510422A JP 2002510422 A JP2002510422 A JP 2002510422A JP 2004503519 A JP2004503519 A JP 2004503519A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- salt
- solvate
- compound
- single enantiomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NUOIPTOXJSHBDW-UHFFFAOYSA-N CC(C)(OC1)Oc(cc2)c1cc2C(CNC(CO)c1ccccc1)=O Chemical compound CC(C)(OC1)Oc(cc2)c1cc2C(CNC(CO)c1ccccc1)=O NUOIPTOXJSHBDW-UHFFFAOYSA-N 0.000 description 1
- 0 CN(CCCCCCOCCCCc1ccccc1)C[C@](c(cc1)cc(C*)c1O)O Chemical compound CN(CCCCCCOCCCCc1ccccc1)C[C@](c(cc1)cc(C*)c1O)O 0.000 description 1
- UGVJMOHJYRICSS-UHFFFAOYSA-N OCC(c1ccccc1)NCC(c(cc1)cc(CO)c1O)O Chemical compound OCC(c1ccccc1)NCC(c(cc1)cc(CO)c1O)O UGVJMOHJYRICSS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0014546.6A GB0014546D0 (en) | 2000-06-14 | 2000-06-14 | A novel process |
| PCT/GB2001/002624 WO2001096278A2 (en) | 2000-06-14 | 2001-06-13 | A novel process for preparing salmeterol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004503519A true JP2004503519A (ja) | 2004-02-05 |
| JP2004503519A5 JP2004503519A5 (https=) | 2008-03-27 |
Family
ID=9893647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002510422A Pending JP2004503519A (ja) | 2000-06-14 | 2001-06-13 | サルメテロールの新規な調製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6911560B2 (https=) |
| EP (1) | EP1289926A2 (https=) |
| JP (1) | JP2004503519A (https=) |
| AU (1) | AU2001264119A1 (https=) |
| GB (1) | GB0014546D0 (https=) |
| WO (1) | WO2001096278A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE390407T1 (de) | 2002-10-28 | 2008-04-15 | Glaxo Group Ltd | Phenethanolamin-derivate zur behandlung von atemwegserkrankungen |
| CA2838520C (en) | 2005-10-17 | 2017-02-21 | Vinayak G. Gore | Processes for the preparation of salmeterol and its salts |
| CN102584608B (zh) * | 2011-01-06 | 2014-11-19 | 上海医药工业研究院 | α-(氨甲基)-4-羟基-1,3-苯二甲醇的制备方法及其中间体 |
| US9447067B2 (en) * | 2014-10-03 | 2016-09-20 | Amphastar Pahmaceuticals, Inc. | Method of preparing intermediate of salmeterol |
| CN105884625B (zh) * | 2016-05-10 | 2018-11-13 | 浙江工业大学 | 一种r-沙美特罗的合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63264443A (ja) * | 1983-04-18 | 1988-11-01 | グラクソ、グループ、リミテッド | フェネタノールアミン誘導体 |
| JPH03133946A (ja) * | 1989-10-10 | 1991-06-07 | Glaxo Group Ltd | フェンエタノールアミン化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA09501A (en) | 1990-06-05 | 1992-11-15 | Glaxo Group Limited Angleterre | Dichloroaniline compound. |
-
2000
- 2000-06-14 GB GBGB0014546.6A patent/GB0014546D0/en not_active Ceased
-
2001
- 2001-06-13 US US10/297,130 patent/US6911560B2/en not_active Expired - Fee Related
- 2001-06-13 EP EP01938442A patent/EP1289926A2/en not_active Withdrawn
- 2001-06-13 WO PCT/GB2001/002624 patent/WO2001096278A2/en not_active Ceased
- 2001-06-13 AU AU2001264119A patent/AU2001264119A1/en not_active Abandoned
- 2001-06-13 JP JP2002510422A patent/JP2004503519A/ja active Pending
-
2005
- 2005-05-13 US US11/128,639 patent/US7294725B1/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63264443A (ja) * | 1983-04-18 | 1988-11-01 | グラクソ、グループ、リミテッド | フェネタノールアミン誘導体 |
| JPH03133946A (ja) * | 1989-10-10 | 1991-06-07 | Glaxo Group Ltd | フェンエタノールアミン化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1289926A2 (en) | 2003-03-12 |
| WO2001096278A2 (en) | 2001-12-20 |
| US6911560B2 (en) | 2005-06-28 |
| GB0014546D0 (en) | 2000-08-09 |
| AU2001264119A1 (en) | 2001-12-24 |
| US20030162840A1 (en) | 2003-08-28 |
| US7294725B1 (en) | 2007-11-13 |
| WO2001096278A3 (en) | 2002-03-21 |
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| A521 | Request for written amendment filed |
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| A621 | Written request for application examination |
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| A131 | Notification of reasons for refusal |
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