JP2004331174A - Volatile chemical package film and package using the film - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a volatile chemical package film and a package which prevents the adsorption of a volatile chemical during distribution or storage, enables the use of the chemical without wasting it, and prevents a degradation in the effects of the chemical. <P>SOLUTION: The volatile chemical package film is used for a package in which a volatile chemical or a holder containing the volatile chemical is put. The film is formed from a material containing a mixture of a chemical non-adsorbent material and a heat-sealable material. The volatile chemical package film constitutes at least part of the package in which the volatile chemical or the holder containing the chemicals. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

【００４２】
【表２】

【００４３】
上記表２から明らかなように、本発明品の揮散性薬剤包装用フィルムを包装に使用した場合には、比較品のフィルムを使用した場合に比べ残存薬剤量が多く、薬剤を無駄なく使用でき薬剤効力の低下がなかった。
【００４４】
実 施 例 ２
ポリペットハードタイプ（大倉工業（株）製 ＰＥＴ：ＰＰ＝７：３）（厚さ３０ミクロン）を用いて、２軸式三方製袋機にて縦５ｃｍ×横５ｃｍの袋を製袋した。一方、３ｃｍ×４ｃｍ×０．１ｃｍの濾紙にエンペントリン１００ｍｇを含浸させたものを、図１に示した引き出し用防虫剤容器に収納し、防虫器を作成した。次いで、この防虫器を上記袋に入れ、４０℃で１ヶ月間保存した。
【００４５】
上記期間の後開封したところ、防虫剤容器にも袋の内面にもエンペントリンの吸着、付着は見られなかった。次いで、開封した防虫剤容器をタンスの引き出しに設置したが、このものは約６ヶ月の間、充分な防虫効果を有した。
【００４６】
実 施 例 ３
ポリペットハードタイプ（大倉工業（株）製ＰＥＴ：ＰＰ＝７：３）に二軸延伸ポリプロピレンフィルムをドライラミネートしたフィルムを用いて、二軸延伸ポリプロピレンが外側になるようにして、二軸式三方製袋機にて縦５ｃｍ×横５ｃｍの袋を製袋した。一方、３ｃｍ×４ｃｍ×０．１ｃｍの濾紙にエンペントリン１００ｍｇを含浸させたものを、図１に示した引き出し用防虫剤容器に収納し、防虫器を作成した。次いで、この防虫器を上記袋に入れ、４０℃で１ヶ月間保存した。
【００４７】
上記期間の後開封したところ、防虫剤容器にも袋の内面にもエンペントリンの吸着、付着は見られなかった。次いで、開封した防虫剤容器をタンスの引き出しに設置したが、このものは約６ヶ月の間、充分な防虫効果を有した。
【００４８】
【発明の効果】
本発明の揮散性薬剤包装用フィルムを用いると、流通段階や保存時において、揮散性薬剤のフィルム内面への吸着がなく、その結果、薬剤を無駄なく使用でき、十分な薬剤効力を得ることができる。
【図面の簡単な説明】
【図１】本発明の揮散性薬剤包装用フィルムで包装される引き出し用防虫器の一例である。
【符号の説明】
１ ・・・・防虫器
２ ・・・・防虫剤容器
２ｃ・・・・上容器体
２ｄ・・・・下容器体
３ ・・・・揮散孔
４ ・・・・揮散性薬剤含浸体[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a volatile drug packaging film and a volatile drug package using the film, and more particularly, to a volatile drug packaging film in which a drug is effectively vaporized without waste and no reduction in efficacy occurs, and a film for the volatile drug packaging. The present invention relates to a volatile drug package used.
[0002]
[Prior art]
BACKGROUND ART Conventionally, paper, a carrier such as pulp, a fragrance, an insecticide or an insecticide such as an insecticide is carried, and an aromatic device, an insecticide device or an insecticide device and the like stored in a molded container having a volatilization opening have been proposed. I have. For example, as an insect repellent used to protect clothes and the like from pest damage, a normal temperature volatile pyrethroid is carried on a carrier, and this is stored in a thermoplastic resin molded container, and clothes dance, a closet, It has been proposed that an insect repellent be volatilized in a drawer, a clothes case, or the like so that the insect repellent is volatilized inside the clothes dance or the like to exhibit an insect repellent effect.
[0003]
Further, for example, as an aroma device for imparting fragrance to a space such as a toilet, a room or a car, a fragrance is mixed with a lipophilic surfactant, glycol, glycol ether, glycerin ester or a wax component, and a carrier such as pulp is used. There has been proposed a structure in which a material carried on a resin is housed in a resin-made molding container, and a solution in which a liquid or gel-like fragrance is housed in a molding container having a volatilization port.
[0004]
In general, resins such as polypropylene and polyethylene are used as materials for the molded containers used for these insect repellents and fragrances, but molded containers using these resins are volatilized at room temperature during the distribution stage. Pyrethroids and fragrances are adsorbed on the container, and these components once adsorbed hardly volatilize, so that the amount of the active ingredient is substantially reduced, and as a result, sufficient insect repellency is maintained during the original use period. There has been a problem that the effect and the fragrance effect cannot be exhibited.
[0005]
In order to solve this problem, an insect repellent mat or insect repellent sheet carrying a normal-temperature volatile pyrethroid was housed in a breathable plastic molded container made of a resin such as polyester, polyamide, and polycarbonate that does not absorb a normal-temperature volatile pyrethroid. An insect repellent device (see Patent Document 1) has been proposed.
[0006]
The use of the insect repellent as described above can prevent adsorption of the volatile drug in the container at the distribution stage, but in general, the insect repellent and the aroma are used before the commencement of the distribution stage or use by the consumer, such as insect repellents and fragrances. Since the volatile drug is stored in a package through which the drug does not permeate so as not to be volatilized, the adsorption of the drug to the package becomes the next problem.
[0007]
In general, packages for packaging containers of volatile chemicals are made of non-adsorbent films such as stretched polyester films and stretched nylon films. Therefore, a heat-sealing layer such as polyethylene or polypropylene is usually provided on the inner surface of the film (see Patent Document 2). However, when such a film is used to package a volatile drug, there is a problem that the drug is adsorbed to the heat-sealable layer in a long-term distribution stage.
[0008]
Furthermore, the volatile chemicals adsorbed on the heat-sealable layer hardly volatilize once they are adsorbed, and after being opened, they are discarded together with the package as garbage. The effective amount of the active ingredient is reduced, and as a result, there has been a problem that a sufficient insect repellent effect and an aroma effect cannot be exhibited during the use period.
[0009]
In order to solve these problems, a method has been proposed in which a drug non-adsorbing layer such as a stretched polyester film is packaged with the inner surface facing the inside (see Patent Document 3). Since such a non-drug-adsorbing layer does not have a heat-sealing property, the heat-sealing layer on the outer surface must be folded inside at the end to be packed, so that the packing form has to be complicated.
[0010]
[Patent Document 1]
JP-A-2-275805 [Patent Document 2]
JP-A-2002-97104 [Patent Document 3]
JP-A-2003-72859
[Problems to be solved by the invention]
Therefore, in the distribution stage and storage by the user, there is no adsorption of the volatile drug, and as a result, the drug can be used without waste, and the provision of a volatile drug packaging film and a volatile drug package without a decrease in drug efficacy. And the provision of these is an object of the present invention.
[0012]
[Means for Solving the Problems]
The present inventors have conducted intensive studies on a packaging film used for a volatile drug package that does not cause the above-described problem, and as a result, used a material obtained by mixing a drug non-adsorbing material and a heat sealing material as a raw material resin. The present inventors have found that the packaging film can achieve both heat sealing properties and low drug absorption, and can solve the above-mentioned problems, and have reached the present invention.
[0013]
That is, the present invention is a volatile drug packaging film used for a package for packaging a volatile drug or a holder containing the same, wherein the film is a mixture of a drug non-adsorbing material and a heat sealing material. An object of the present invention is to provide a volatile chemical packaging film characterized by being formed of a material.
[0014]
Further, a volatile agent packaging film used for a package for packaging a volatile agent or a holder containing the same, wherein the film has a structure in which at least two or more layers are laminated, and the innermost layer thereof Is composed of a material obtained by mixing a drug non-adsorbing material and a heat sealing material.
[0015]
Further, the present invention provides a volatile medicine package characterized in that at least a part of a package for packaging a volatile medicine or a holder containing the same is composed of the volatile medicine packaging film.
[0016]
BEST MODE FOR CARRYING OUT THE INVENTION
The volatile drug packaging film of the present invention is produced by mixing a drug non-adsorbing material and a heat-sealing material, and forming this mixture into a film.
[0017]
In the present invention, the drug non-adsorbing material refers to a material having a property of adsorbing a volatile drug at 40 ° C. of 5% by mass or less according to the test method of JIS K-7114.
[0018]
The drug non-adsorbing material in the present invention is determined by the type of volatile agent used. For example, preferred examples of using the insect repellent empentrin as the volatile agent include polyethylene terephthalate and polybutylene terephthalate. , Polyamide, polyacetal, polycarbonate, and methylpentene polymer. Of these, polyethylene terephthalate is more preferred in terms of cost, film formability, versatility, and the like.
[0019]
In addition, the heat-sealing material in the present invention refers to a material that exhibits heat-sealing property at about 60 ° C. or more, and specifically, polyethylene, polypropylene, copolymerized polyester, ethylene-vinyl acetate copolymer, ethylene- One or more selected from the group consisting of alkyl (meth) acrylate copolymers, ethylene- (meth) acrylic acid copolymers, urethane-based elastomers, polystyrene-based elastomers, polyolefin-based elastomers, and ionomers. Particularly, polyethylene and / or polypropylene are preferable from the viewpoint of cost, adhesiveness, film forming property, and the like.
[0020]
The method for producing the volatile drug packaging film of the present invention is not particularly limited, and any method may be used as long as it is a method for forming a film in a state where the drug non-adsorbing material and the heat sealing material are sufficiently mixed. The method may be a specific method. Examples of the method include mixing a non-adsorbent material pellet, a heat-sealing material pellet and, if necessary, other additives such as a compatibilizer under heating. Into a film by a conventionally known method such as a melt extrusion method such as an inflation method or a T-die method, a casting method or a calender method.
[0021]
The mixing ratio of the drug non-adsorbing material and the heat-sealable material in the production of the volatile drug packaging film is appropriately determined depending on the materials to be mixed and the drug used, but generally, the drug non-adsorptive material: heat seal Active material = 99: 1 to 1:99, preferably 9: 1 to 1: 9, and more preferably 9: 1 to 6: 4. If the amount of the drug non-adsorbing material is larger than this ratio, the volatile drug volatilized in the packaging film adheres to the packaging film in the form of droplets, and contaminates the user's hands and clothes when opened. If the amount of heat-sealable material exceeds this ratio, the packaging film will adsorb the volatile chemicals when the volatile chemicals are packaged, and not only will the chemicals be wasted, but the necessary medicinal effect will be obtained for the required period. May not be possible.
[0022]
The most preferable combination of the drug non-adsorbing material and the heat sealing material is a combination of the drug non-adsorbing material of polyethylene terephthalate and the heat sealing material of polyethylene and / or polypropylene. Polypet (trade name; manufactured by Okura Industry Co., Ltd.) is commercially available as a film prepared by combining a drug non-adsorbing material and a heat-sealing material, and is used as a volatile chemical packaging film. You can also.
[0023]
The volatile drug packaging film of the present invention described above may be used as a single layer, but for the purpose of supplementing the performance as a packaging film such as securing strength, a film made of another material is laminated on the outer layer. May be. The film laminated on the outer layer may be a conventionally known film.Specific examples of the material of the film include polyethylene, polypropylene, nylon, polyvinyl chloride, cellophane, polyimide, polyester, aramid, and polystyrene. Can be.
[0024]
On the other hand, the volatile medicine package of the present invention is a package for packaging a volatile medicine or a holder containing the same, at least a part of which is formed of the volatile medicine packaging film.
[0025]
The form of the package can be selected from various known forms. One of the preferable forms is a bag for ease of storage. Examples of a method for producing such a bag include three-side seal packaging, horizontal pillow packaging, and vertical pillow packaging using a conventionally known bag making machine.
[0026]
As another form, there can be mentioned a container body formed by sealing the opening of the container with another thermoplastic material with the packaging film of the present invention.
[0027]
In the volatile drug package of the present invention, the volatile drug packaging film only needs to be used for at least a part thereof.
[0028]
The volatile chemical used in the volatile chemical package of the present invention is a chemical which is volatilized at normal temperature or by heating, and includes fragrance, deodorant, insect repellent, insecticide, fungicide and the like.
[0029]
Among them, as the fragrance, any of a natural fragrance and an artificial fragrance can be used, and a blended fragrance obtained by mixing two or more of them may be used. In addition, the natural flavor may be animal flavor or vegetable flavor.
[0030]
Specific examples of animal flavors include musk, spirit cats, and Tatsunobu. In addition, as the vegetable flavor, avies oil, almond oil, angelica root oil, pagel oil, bergamot oil, perch oil, pore parose oil, kayabuchi oil, cananga oil, capsicum oil, caraway oil, cardamom oil, cassia oil, celery oil Oil, cinnamon oil, citronella oil, cognac oil, coriander oil, cumin oil, camphor oil, jill oil, estgolan oil, eucalyptus oil, fennel oil, garlic oil, ginger oil, grapefruit oil, hop oil, lemon oil, lemongrass oil , Nutmeg oil, mandarin oil, peppermint oil, orange oil, sage oil, star anise oil, turpentine oil and the like.
[0031]
Further, artificial flavors are synthetic flavors or extractable flavors, for example, hydrocarbon-based flavors such as pinene and limonene, linalool, geraniol, citronellol, menthol, borneol, benzyl alcohol, anis alcohol, and alcohols such as β-phenethyl alcohol. Fragrances, phenolic fragrances such as anethole, eugenol, etc., aldehydes such as n-butyraldehyde, isobutyraldehyde, hexylaldehyde, citral, citronellal, benzaldehyde, cinamic aldehyde, ketones such as carboxyl, menthone, camphor, acetophenone, ionone, etc. Fragrances, such as lactone-based fragrances such as γ-butyrolactone, coumarin, and cineol, octyl acetate, benzyl acetate, cinnamyl acetate, butyl propionate, and methyl benzoate And the like.
[0032]
On the other hand, among the volatile agents, as the deodorant, one or more of lauryl methacrylate, geranyl chloride, citronellyl senesionate, terpene aldehydes and the like can be used in combination.
[0033]
Insect repellents include, but are not limited to, arethrin, prarethrin, phthalthrine, resmethrin, permethrin, phenothrin, fenvalerate, cypermethrin, cyphenothrin, empentrin, terarethrin, imiprosulin, transfluthrin, fenpropatrin, fenfluthrin, 2,3, Pyrethroid insect repellents such as 5,6-tetrafluoro-4-methylbenzyl (1R) -trans-3- (2-chloro-2-fluorovinyl) -2,2-dimethylcyclopropanecarboxylate, paradichlorobenzene, and naphthalene , Camphor and the like can be used alone or in combination of two or more. Among them, the packaging film of the present invention can be particularly suitably used for empentrin.
[0034]
Further, as a fungicide, thymol, α-bromocinnamic aldehyde, parachloromethaxylenol, orthophenylphenol, 3-iodo-2-propylbutylcarbamate, N- (fluorodichloromethylthio) -phthalimide, N-dichlorofluoro One or more of methylthio-N ', N'-dimethyl-N-phenylsulfamide and the like can be used in combination.
[0035]
In the volatile drug package of the present invention, an antioxidant, an ultraviolet absorber, a fungicide, a bactericide, a pigment, a metal deactivator, an efficacy enhancer, and the like can be further added to these volatile agents. .
[0036]
The form of the volatile drug package of the present invention thus obtained is a form in which the solid, gel or liquid volatile drug itself is packaged, and the volatile drug is impregnated in a suitable support and the support is packaged. Or a form in which a volatile agent or a holder containing the same is stored in a container having a volatilization opening, and the volatilization opening is sealed.
[0037]
In addition, the holding | maintenance body used in a volatile chemical | medical agent package is not specifically limited if a volatile chemical | medical agent, such as a pyrethroid, can be impregnated at normal temperature. Specifically, pulp, paper, wood chips, silica gel, woven or non-woven fabric, and the like can be used in the form of granules, spheres, plates, mats, or films.
[0038]
【Example】
Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited by these Examples.
[0039]
Example 1
Using the films described in Table 1, bags of 5 cm long and 5 cm wide were formed with a two-axis paper container three-way bag making machine. A 3 cm × 4 cm × 0.1 cm pulp filter paper impregnated with 100 mg of empentrin was stored in the bag to prepare volatile drug packages of Inventions 1 to 3, and the storage stability was examined. In addition, about the comparative article 1, the thing which accommodated the said empentrin impregnated filter paper was used so that PET might be outside.
[0040]
The storage stability is as follows: After leaving Invention Products 1 to 3 and Comparative Product 1 at 40 ° C. for 30 days, open the packaging film, extract the remaining empentrin on the filter paper with acetone, and determine the amount of remaining empentrin. Was evaluated by measuring using gas chromatography. Table 2 shows the results.
[0041]
[Table 1]

[0042]
[Table 2]

[0043]
As is clear from Table 2 above, when the volatile drug packaging film of the present invention is used for packaging, the amount of residual drug is larger than when the film of the comparative product is used, and the drug can be used without waste. There was no reduction in drug efficacy.
[0044]
Example 2
Using a polypet hard type (PET: PP = 7: 3, manufactured by Okura Industry Co., Ltd.) (thickness: 30 μm), a bag of 5 cm long × 5 cm wide was formed by a biaxial three-way bag making machine. On the other hand, a filter paper of 3 cm × 4 cm × 0.1 cm impregnated with 100 mg of empentrin was stored in the drawer insect repellent container shown in FIG. 1 to prepare an insect repellent. Then, the insect repellent was put in the above bag and stored at 40 ° C. for one month.
[0045]
Upon opening the container after the above period, no adsorption or adhesion of empentrin was found on the insect repellent container or on the inner surface of the bag. Next, the opened insect repellent container was placed in the drawer of the closet, and this had a sufficient insect repellent effect for about 6 months.
[0046]
Example 3
Using a film obtained by dry laminating a biaxially oriented polypropylene film on a polypet hard type (PET: PP = 7: 3 manufactured by Okura Industries Co., Ltd.), with the biaxially oriented polypropylene on the outside, a biaxial three-way A bag having a length of 5 cm and a width of 5 cm was formed by a bag making machine. On the other hand, a filter paper of 3 cm × 4 cm × 0.1 cm impregnated with 100 mg of empentrin was stored in the drawer insect repellent container shown in FIG. 1 to prepare an insect repellent. Then, the insect repellent was put in the above bag and stored at 40 ° C. for one month.
[0047]
Upon opening the container after the above period, no adsorption or adhesion of empentrin was found on the insect repellent container or on the inner surface of the bag. Next, the opened insect repellent container was placed in the drawer of the closet, and this had a sufficient insect repellent effect for about 6 months.
[0048]
【The invention's effect】
When the volatile drug packaging film of the present invention is used, at the distribution stage or during storage, there is no adsorption of the volatile drug to the inner surface of the film, and as a result, the drug can be used without waste and sufficient drug efficacy can be obtained. it can.
[Brief description of the drawings]
FIG. 1 is an example of a drawer insect repellent device packaged with the volatile chemical packaging film of the present invention.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 ... Insect repellent device 2 ... Insect repellent container 2c ... Upper container 2d ... Lower container 3 ... Volatilization hole 4 ... Volatile drug impregnated body

Claims (12)

A volatile agent packaging film used for packaging a volatile drug or a holder containing the same, wherein the film is formed from a material obtained by mixing a drug non-adsorbing material and a heat sealing material. A volatile chemical packaging film characterized by the following. The volatile chemical packaging film according to claim 1, wherein the volatile chemical packaging film has heat sealing properties. A film for a volatile drug package used for a package for packaging a volatile drug or a holder containing the same, wherein the film has a structure in which at least two layers are laminated, and the innermost layer is a drug. A volatile drug packaging film comprising a material obtained by mixing a non-adsorbing material and a heat-sealing material. The volatile chemical packaging film according to claim 3, wherein the innermost layer has a heat sealing property. 5. The non-adsorbent material is one or more selected from the group consisting of polyethylene terephthalate, polybutylene terephthalate, polyamide, polyacetal, polycarbonate and methylpentene polymer. The volatile chemical packaging film according to claim 1. The heat sealing material is polyethylene, polypropylene, copolymerized polyester, ethylene-vinyl acetate copolymer, ethylene-alkyl acrylate copolymer, ethylene-alkyl methacrylate copolymer, urethane-based elastomer, polystyrene-based elastomer, polyolefin-based elastomer and The volatile chemical packaging film according to any one of claims 1 to 4, wherein the film is one or more selected from the group consisting of ionomers. The volatile drug packaging film according to any one of claims 1 to 6, wherein the drug non-adsorbing material is polyethylene terephthalate, and the heat sealing material is polyethylene and / or polypropylene. The volatile drug packaging according to any one of claims 1 to 7, wherein a mixing ratio of the drug non-adsorbing material and the heat sealing material is in the range of 9: 1 to 6: 4. the film. The volatile chemical packaging film according to any one of claims 1 to 8, wherein the volatile chemical is empentrin. At least a part of a package for packaging a volatile agent or a holder containing the same is the packaging film according to any one of claims 1 to 9. Volatile drug packaging. The volatile drug package according to claim 10, wherein the package is a bag. The volatile substance is a container in which an opening of a container having an opening in a part thereof is sealed with a packaging film according to any one of claims 1 to 8. Packaging.

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