JP2004269372A - Composition for coating and applying to human body - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition, a cosmetic and a quasi-drug protecting skin or mucous membrane from drying, ultraviolet rays, oxidation, etc., noxious to the skin or mucous membrane independent of age, sex or physical conditions of users, maintaining and recovering the constancy essentially possessed by the skin or mucous membrane, ameliorating dyschromia, retarding an aging phenomenon, ameliorating symptoms such as dry skin, atopic skin, skin roughening or mucitis, further exhibiting remarkable effects on prophylaxis of skin cancer, mucosal cancer, etc. <P>SOLUTION: A base for the composition or cosmetic or quasi-drug coated or applied to the human body and at least one kind of zinc carbonate, zinc carbonate hydroxide and zinc carbonate hydroxide hydrate in an amount of 0.00000001-98 wt.% based on the total weight are contained. The feature is to absorb the ingredient of the zinc carbonate, zinc carbonate hydroxide and zinc carbonate hydroxide hydrate by the skin and mucous membranes and simultaneously remarkably inhibit the excessive formation and accumulation of active oxygen or activated lipids. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

【００１２５】
＋−１５ｍＶ の範囲で以上の結果を得た。また、水に溶解すると約２重量％で飽和になり還元電位に無関係になる。また、例えば、乳酸、アスコルビン酸、塩酸、硫酸等の酸を１モル以上用いると酸の性状により異なるが、約２０重量％〜４０重量％溶解する。
なお、実験の方法として、炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１ｇを１，０００ｃｃに溶解させ、その中から１ｃｃを取り９９９ｃｃの溶媒（水）に入れ合計１，０００ｃｃを攪拌し、その中から１ｃｃを取り９９９ｃｃ溶媒（水）に入れ合計１，０００ｃｃを攪拌し、その中から１ｃｃを取り９９９ｃｃの溶媒（水）に入れ合計１，０００ｃｃを攪拌したものの重量％は０． ００００００００１重量％になる。この方法に順じ重量％を得た。
【００１２６】
以上の酸化還元電位の実験結果により、水道水に炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物が総重量に対し０．００００００００１重量％で溶解したｐＨ７．６４の水の還元電位には誤差範囲の変化しかなく、総重量に対し０．０００００００１重量％の炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物を溶解させた水は還元力の強い事が証明された。
【００１２７】
また、電気分解したｐＨ２．７１の酸性水の酸化還元電位は１．０９０ｍＶであったが、総重量に対し０．０００００００１重量％の炭酸亜鉛と炭酸水酸化亜鉛１水和物を溶解させた水は酸化還元電位が７３０ｍＶに下がり還元力の強い事が証明された。よって、炭酸亜鉛、炭酸水酸化亜鉛１水和物が総重量に対し０．０００００００１重量％以上で溶解させた水溶液は人体に塗布、付着させる組成物、化粧品、医薬部外品に応用することが出来る。
【００１２８】
以下、クリームの実施例及びクリームの比較対照例を挙げ、前実施形態を更に具体的に説明する。
【００１２９】
〔実施例２５〕
（Ａ）：実施例２４の沈殿物を乾燥させた粉末１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに実施例９の上澄み液９８ｇを添加して１，０００ｇの化粧クリームＡを取り出した。炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物は約０．６６重量％である。
【００１３０】
〔実施例２６〕
（Ｂ）：炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物粉末１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに精製水に炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物を０．００００１％重量比で混合した酸性水９８ｇを添加して１，０００ｇの化粧クリームＢを取り出した。炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物は約０．０９１重量％である。
【００１３１】
〔比較対照例１１〕：
（Ｃ）：トルマリン粉末１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇにトルマリンを０．０１％重量比で混合した酸性水９８ｇを添加して１，０００ｇの化粧クリームＣを取り出した。
【００１３２】
〔比較対照例１２〕：
（Ｄ）：麦飯石粉末１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに麦飯石を０．０１％重量比で混合した酸性水９８ｇを添加して１，０００ｇの化粧クリームＤを取り出した。
【００１３３】
〔比較対照例１３〕：
（Ｅ）：カーボン粉末１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇにカーボンを０．０１％重量比で混合した酸性水９８ｇを添加して１，０００ｇの化粧クリームＥを取り出した。
【００１３４】
〔比較対照例１４〕：
（Ｆ）：海藻灰粉末１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに海藻灰を０．０１％重量比で混合した酸性水９８ｇを添加して１，０００ｇの化粧クリームＦを取り出した。
【００１３５】
〔比較対照例１５〕：
（Ｇ）：酸化鉄粉末１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに酸化鉄を０．０１％重量比で混合した酸性水９８ｇを添加して１，０００ｇの化粧クリームＧを取り出した。
【００１３６】
〔比較対照例１６〕：
（Ｈ）：酸化チタン粉末１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに酸化チタンを０．１％重量比で混合した酸性水９８ｇを添加して１，０００ｇの化粧クリームＨを取り出した。
【００１３７】
〔比較対照例１７〕：
（Ｉ）：酸化亜鉛粉末１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに酸化亜鉛を０．０１％重量比で混合した酸性水９８ｇを添加して１，０００ｇの化粧クリームＩを取り出した。
【００１３８】
〔比較対照例１８〕：
（Ｊ）：蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに蒸留水を９８ｇ添加して１，０００ｇの化粧クリームＪを取り出した。
【００１３９】
試験１：保湿性試験、前記実施例２５、２６の化粧クリームＡとＢ、及び前記比較対照例１１〜１８の化粧クリームＣ、化粧クリームＤ、化粧クリームＥ、化粧クリームＦ、化粧クリームＧ、化粧クリームＨ、化粧クリームＩ、化粧クリームＪについて、試験前後における皮膚や粘膜の保湿性の比較試験を行った。各試料につき、３０名のパネラー（２５〜６５歳の男女）により評価した。
【００１４０】
各パネラーに、化粧クリームＡ、化粧クリームＢ、化粧クリームＣ、化粧クリームＤ、化粧クリームＥを左前腕内側に、化粧クリームＦ、化粧クリームＧ、化粧クリームＨ、化粧クリームＩ、化粧クリームＪを右前腕内側に塗布して、６０分経過後、その塗布部を水洗いし、２時間経過後に３．５ＭＨｚ 高周波電気伝導度測定装置（ＳＫＩＣＯＮ２００，ＩＢＳ社製）により測定し、皮膚表面の水分量を測定した。なお、保湿性効果は相対比（試験後の皮膚水分量／試験前の皮膚水分量）を算出した。この値が高いほど、皮膚における保湿性が高い事を示す。
【００１４１】
その結果、保湿性相対比は、化粧クリームＡは１．９８、化粧クリームＢは１．８８、化粧クリームＣは１２５、化粧クリームＤは１．５１、化粧クリームＥは１．０７、化粧クリームＦは１．５３、化粧クリームＧは１．０９、化粧クリームＨは１．１３、化粧クリームＩは１．３２、化粧クリームＪは１．０５、となった。従って、本発明の実施例２５、２６の化粧クリームＡ、Ｂは高い保湿作用を示す事が確認できた。
【００１４２】
試験２：抗酸化試験（皮脂過酸化脂質生成抑制）前記実施例２５、２６の化粧クリームＡ、Ｂ及び前記比較対照例１１〜１８の化粧クリームＣ、化粧クリームＤ、化粧クリームＥ、化粧クリームＦ、化粧クリームＧ、化粧クリームＨ、化粧クリームＩ、化粧クリームＪについて、過酸化脂質生成抑制作用試験ＴＢＡ法（アナリティカル、バイオケミストリーカル Ｖｏｌ．９５、ｐ．３５１〜３５８、１９７９）をもとに、リノレン酸の過酸化物生成抑制作用を検討し、以下の試験方法で測定した。
【００１４３】
０．８％ラウリル硫酸ナトリウム水溶液にリノレン酸０．１％を加え溶解し、この溶液３．９ｍｌを１０ｍｌの透明なガラススクリュー瓶にとる。前記ガラススクリュー瓶に、検体として化粧クリームＡ０．１ｍｌを加え、紫外線ランプ（ＳＡＮＧＡＢＲＩＥＬ社製、ＭｏｄｅｌＵＶＧＬ−２５）を用いて紫外線を距離１５ｃｍにて３時間照射した後、この液１ｍｌを取り、０．６７％チオバルビツール酸水溶液と１５％酢酸水溶液（ｐＨ３．５）の混合液を１ｍｌ、４．５％ジブチルヒドロキシトルエン２０μｌを加え、９５℃で１時間加熱する。
【００１４４】
冷却後、メタノール：ｎ−ブタノール（１５：８５）４ｍｌを加え良く振った後、遠心分離する。次に、このｎ−ブタノール層の５３４ｎｍにおける吸光度を測定し、過酸化脂質量とした。なお、検体を加えて紫外線を照射した場合の過酸化脂質量をａ、検体を加えて紫外線を照射していない場合の過酸化脂質量をｂ、検体の代わりに精製水を加えて紫外線を照射した場合の過酸化脂質量をａ’ 、検体の代わりに精製水を加えて紫外線を照射しない場合の過酸化脂質量をｂ’ として、過酸化脂質生成抑制率を以下の算出式により求めた。
【００１４５】
過酸化脂質生成抑制率（％）＝［ １−（ａ−ｂ）／（ａ’ −ｂ’ ）］ ×１００ また、化粧クリームＢ、化粧クリームＣ、化粧クリームＤ、化粧クリームＥ、化粧クリームＦ、化粧クリームＧ、化粧クリームＨ、化粧クリームＩ、化粧クリームＪについても同様の操作を行い過酸化脂質生成抑制率を算出した。その結果、過酸化脂質生成抑制率は化粧クリームＡは９８．２％、化粧クリームＢは９６．３％、化粧クリームＣは６０．３％、化粧クリームＤは６４．６％、化粧クリームＥは５２．４％、化粧クリームＦは７３．９％、化粧クリームＧは５２．８％、化粧クリームＨは５１．３％、化粧クリームＩは６１．８％、化粧クリームＪは５０．８％、となった。従って、本発明の実施例２５、２６の化粧クリームＡ、Ｂは高い過酸化脂質生成抑制作用を示す事が確認できた。
【００１４６】
試験３：肌荒れ改善試験、前記実施例２５、２６の化粧クリームＡ、Ｂ、及び前記比較対照例１１〜１８の化粧クリームＢ、化粧クリームＣ、化粧クリームＤ、化粧クリームＥ、化粧クリームＦ、化粧クリームＧ、化粧クリームＨ、化粧クリームＩ、化粧クリームＪについて、試験前後における皮膚や粘膜状態の改善効果の比較試験を行った。
【００１４７】
各試料につき、３０名のパネラー（２５〜６５歳の男女）により評価した。各パネラーにつき２週間にわたり被験試料を、顔面皮膚や口唇粘膜に適量１日２回塗布した。肌荒れ改善効果は、試験前後において各パネラーの顔面皮膚や口唇粘膜を顕微鏡で観察した。また、表皮面積１ｃｍ２ に対する剥離角質部分（肌荒れ部）の面積を測定し、初期値と２週間後の測定値から改善度［ （初期値―２週間後の測定値）／初期値×１００］を計算し、その平均値を算出した。
【００１４８】
この値が高いほど、皮膚や粘膜における肌荒れの改善度合いが高い事になる。その結果、肌荒れ改善度は化粧クリームＡは８８．５％、化粧クリームＢは８７．３％、化粧クリームＣは２３．４％、化粧クリームＤは６０．５％、化粧クリームＥは２３．１％、化粧クリームＦは６０．７％、化粧クリームＧは２３．５％、化粧クリームＨは２２．８％、化粧クリームＩは２５．４％、化粧クリームＪは２０．５％、となった。また、口唇粘膜を顕微鏡で観察した結果、比較対照例１１〜１８の化粧クリームを塗布したパネラー２４０名は、変化が見られず、実施例２５、２６の化粧クリームを塗布したパネラー６０名は、明らかに頬部皮膚や口唇粘膜の荒れが改善されていた。
【００１４９】
従って、本願請求項の発明の実施例２５、２６であるクリームＡ、Ｂは高い肌荒れ抑制作用を示す事が確認できた。上記に示した保湿性試験、抗酸化試験、肌荒れ改善試験、によると、炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物を溶解させて使用したものと、粉末を配合した化粧クリームＡと炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物の粉末を配合した化粧クリームＢは、トルマリン粉末、麦飯石粉末、カーボン粉末、海藻灰粉末、酸化鉄粉末、酸化チタン粉末を配合した各化粧クリーム（Ｃ〜Ｉ）および、何も配合しない化粧クリーム（Ｊ）に比べ、明らかに高い抗酸化性（皮脂過酸化脂質の生成抑制）及び肌の保湿性が確認された。
【００１５０】
また、比較試験３においても化粧クリームＡ、Ｂは、各化粧クリーム（Ｃ〜Ｊ）に比べ、明らかに高い皮膚の剥離角質部分、口唇粘膜の改善が確認され、高い肌荒れ抑制効果が確認された。
【００１５１】
〔実施例２７〕
炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１ｇ、蜂蜜０．５ｇ、基剤としてヒアルロン酸ナトリウム０．５ｇ、１，３−ブチレングリコール４．００ｇ、モノオレイン酸ポリオキシエチレンソルビタン１．０ｇ、ｄ１−ピロリドンカルボン酸０．１０ｇ、ｄ１−ピロリドンカルボン酸ナトリウム１，０００ｇに精製水９４ｇを添加して１，０００ｇの化粧水を取り出した。炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物は約０．０９１重量％である。
【００１５２】
この化粧水に対して試験１、２、３と同じ、保湿性試験、抗酸化試験、肌荒れ改善試験を３０名のパネラー（２５〜６５歳の男女）により評価した。その結果、高い保湿性、高い抗酸化性が確認された。また、高い皮膚の剥離角質部分、口唇粘膜の改善が確認され、高い肌荒れ抑制効果が確認された。
【００１５３】
〔実施例２８〕
炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１ｇ、蜂蜜０．１ｇ、基剤として１，３−ブチレングリコール５．００ｇ、キサンタンガム０．３ｇ、大豆リゾリン脂質液１，０００ｇ、ステアリン酸１，０００ｇ、ラベンダー油０．５ｇ、ｄ１−ピロリドンカルボン酸０．１０ｇ、ｄ１−ピロリドンカルボン酸ナトリウム１，０００ｇに精製水９２ｇを添加して１，０００ｇの乳液を取り出した。炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物は約０．０３２重量％である。
【００１５４】
この乳液に対して試験１、２、３と同じ、保湿性試験、抗酸化試験、肌荒れ改善試験を３０名のパネラー（２５〜６５歳の男女）により評価した。その結果、高い保湿性、高い抗酸化性が確認された。また、高い皮膚の剥離角質部分、口唇粘膜の改善が確認され、高い肌荒れ抑制効果が確認された。
【００１５５】
〔実施例２９〕
炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１ｇ、蜂蜜０．１ｇ、基剤としてヒアルロン酸ナトリウム０．３０ｇ、ポリオキシエチレン硬化ヒマシ油０．５０ｇ、１，３−ブチレングリコール１，０００ｇ、ラベンダー油０．５ｇ、ｄ１−ピロリドンカルボン酸０．１０ｇ、ｄ１−ピロリドンカルボン酸ナトリウム１，０００ｇに精製水８８ｇを添加して１，０００ｇの化粧エッセンスを取り出した。炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物は約０．０４８重量％である。
【００１５６】
この化粧エッセンスに対して試験１、２、３と同じ、保湿性試験、抗酸化試験、肌荒れ改善試験を３０名のパネラー（２５〜６５歳の男女）により評価した。その結果、高い保湿性、高い抗酸化性が確認された。また、高い皮膚の剥離角質部分、口唇粘膜の改善が確認され、高い肌荒れ抑制効果が確認された。
【００１５７】
〔実施例３０〕
炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１００ｇ、蜂蜜０．１ｇ、基剤としてステアリン酸４．０ｇ、モノステアリン酸グリセリン３．０ｇ、ミリスチン酸イソプロピル９８ｇ、流動パラフィン１，０００ｇ、サラシミツロウ３．０ｇ、カオリン３．０ｇ、タルク１．０ｇ、着色顔料１．０ｇ、トリエタノールアミン３．０ｇ、グリセリン３．０ｇ、ベントナイト１．０ｇ、防腐剤適量、香料適量及び精製水を添加して１，０００ｇのファンデーションを取り出した。炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物は約８．９重量％である。
【００１５８】
このファンデーョンに対して試験１、２、３と同じ、保湿性試験、抗酸化試験、肌荒れ改善試験を３０名のパネラー（２５〜６５歳の男女）により評価した。その結果、高い保湿性、高い抗酸化性が確認された。また、高い皮膚の剥離角質部分、口唇粘膜の改善が確認され、高い肌荒れ抑制効果が確認された。
【００１５９】
〔実施例３１〕
炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１ｇ、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに精製水９８ｇを添加し、１，０００ｇの化粧クリームを取り出した。炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物は約０．０９１重量％である。
【００１６０】
この化粧クリームを試験１、２、３と同じ、保湿性試験、抗酸化試験、肌荒れ改善試験を３０名のパネラー（２５〜６５歳の男女）により評価した。その結果、高い保湿性、高い抗酸化性が確認された。また、高い皮膚の剥離角質部分、口唇粘膜の改善が確認され、高い肌荒れ抑制効果が確認された。
【００１６１】
〔実施例３２〕
炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１ｇ、炭酸水素ナトリウム６０．０ｇ、無水硫酸ナトリウム３２．０ｇ及びホウ砂３．０ｇに精製水を添加して１，０００ｇとし浴用剤を得た。炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物は約０．０９１重量％である。
【００１６２】
この浴用剤を使用し、肌荒れがある人を対象に試験例３に記載の肌荒れ改善試験を行った。すなわち、原則として他の浴用剤を使用させず、毎日１回１週間、入浴時に浴用剤２０ｇを溶かし込み試験前後における剥離角質部分の改善度を３０名のパネラー（２５〜６５歳の男女）により評価した。その結果、高い皮膚の剥離角質部分、口唇粘膜の改善が確認され、高い肌荒れ抑制効果が確認された。
【００１６３】
〔実施例３３〕
炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１ｇ、蜂蜜０．５ｇ、マカデミアナッツ油５．０ｇ、水酸化ナトリウム０．２８ｇ、キシリット０．５ｇ、塩化ナトリウム１ｇ、塩化カリウム０．５ｇ、尿素３０ｇ、パーム核油１，０００ｇに精製水９８ｇを添加して１，０００ｇの美容オイルを取り出した。炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物は約０．０８８重量％である。
【００１６４】
〔比較対照例１９〕：炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１ｇの代わりにトルマリンと酸化亜鉛と酸化チタンの混合物１ｇに変えた以外は実施例３３と同じにし、比較対照例１９の美容オイルを製造した。それをコントロールとし、下記の効能試験による比較試験４を行った。この結果を表２に示す。
【００１６５】
本願請求項の発明の化粧品の効能試験は乾燥肌、手の荒れ、アトピー性皮膚や粘膜炎、フケ症に悩む成人男女１２５名から、各５０名、合計１００名をランダムに選出し１２ケ月間実施した。残りの２５名をコントロールとした。効能試験結果を表２に示し、表３にコントロールを示した。
【００１６６】
表２（試験者：１００人）表中の数字は、治癒した患者数
【表２】

【００１６７】
表３（コントロール：２５人）表中の数字は、治癒した患者数
【表３】

【００１６８】
なお、前記実施例に限定されるものではなく、変更して構成する事もできる。例えば、次に示す実施例３４のように使用することもできる。
【００１６９】
〔実施例３４〕
実施例３１の炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物１ｇ、精製水９８ｇを使用せず、亜鉛２０ｇを２０重量％の塩酸水溶液１，０００ｇに溶解し、そこに５重量％の炭酸水１００ｇを加え攪拌する。そこに２０重量％の水酸化ナトリウムでｐＨ７．２前後に中和し、溶液中に亜鉛イオン、炭酸イオン、水酸基、ナトリウムイオン、塩素イオンを含む水溶液中を作成し、蜂蜜０．５ｇ、基剤としてモノステアリン酸ポリエチレングリコール０．５ｇ、モノステアリン酸エチレングリコール２．４ｇ、マカデミアナッツ油５．０ｇ、カルボキシビニルポリマー０．７ｇ、水酸化ナトリウム０．２８ｇ、１，３−ブチレングリコール１，０００ｇに精製水９８ｇの代わりに９８ｇの上記水溶液を添加し、実施例３１と同様に１，０００ｇの化粧クリームを取り出した。
【００１７０】
この化粧クリームを試験１、２、３と同じ、保湿性試験、抗酸化試験、肌荒れ改善試験を３０名のパネラー（２５〜６５歳の男女）により評価した。その結果、実施例３１で使用した炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物ほどではないが、保湿性、抗酸化性が確認された。また、皮膚の剥離角質部分、口唇粘膜の改善が確認され、肌荒れ抑制効果が確認された。
しかし、実施例３１で用いた炭酸亜鉛と炭酸水酸化亜鉛と炭酸水酸化亜鉛１水和物の混合物より皮膚刺激性は強かった。
【００１７１】
次に、前記実施形態から把握できる技術的思想について以下に記載する。
炭酸亜鉛、炭酸水酸化亜鉛、炭酸水酸化亜鉛水和物の少なくとも一種を含有する事を特徴とする人体に塗布、付着させる組成物、化粧品、医薬部外品として、清浄用化粧品、頭髪化粧品、基礎化粧品、メークアップ化粧品、芳香化粧品、日焼け化粧品、日焼け止め化粧品、爪化粧品、アイライナー化粧品、口唇化粧品、口腔化粧品、入浴用化粧品が挙げられる。
【００１７２】
具体的には、クレンジング、石鹸、液体ボディー洗浄、洗髪用化粧品類、シャンプー、リンス、ヘアーローション、ヘアーエッセンス、ヘアークリーム、ヘアートリートメント、ヘアーカラーリング剤、毛髪仕上げ用化粧品、育毛剤、化粧水、美容液類、化粧クリーム、乳液、パック、ジェル、マスク、エッセンス、ボディーローション、ボディークリーム、ひげ剃り用化粧料、ハンドケア剤、ファンデーション、チークメイクアップ、香水、コロン、日焼け止めクリーム、サンケア製品、ネイルトリートメント、マニキュア、美爪剤、アイメイクアップベース、アイメイクアップ、リップメイクアップ、口紅、歯磨き剤、洗口剤、浴用剤などにおいて保湿性及び抗酸化性により肌荒れ抑制効果を発揮できた。
【００１７３】
【発明の効果】
以上、説明したように、本発明に係る化粧品は、生命活動に必要不可欠な亜鉛元素を皮膚吸収、粘膜吸収により効率よく摂取する事ができる結果、皮膚や粘膜本来の持つ恒常性の維持、回復を補助し、しみ、ソバカス等の色素異常症の改善、くすみ、しわ、たるみ、脱毛等の老化現象の遅延や、肌荒れ、乾燥肌、ニキビ、しもやけ、カブレ、アレルギー、アトピー性皮膚炎や粘膜炎等の症状改善、虫歯、辺縁性歯周炎等の予防、汗疹、肩こり、神経痛、冷え性等の緩和に著しい効果を発揮できた。
【００１７４】
即ち、炭酸亜鉛、炭酸水酸化亜鉛、炭酸水酸化亜鉛水和物の少なくとも一種を含む本発明の化粧品は、亜鉛イオンを取り巻く水の外廓の水分子のクラスターサイズが非常に小さく、このため、本願請求項の発明の人体に塗布、付着させる組成物、化粧品、医薬部外品は、皮膚吸収、粘膜吸収に優れる、という効果を得ることができた。
【００１７５】
特に、上記した如く、本願請求項の発明の人体に塗布、付着させる組成物、化粧品、医薬部外品には、炭酸亜鉛、炭酸水酸化亜鉛、炭酸水酸化亜鉛水和物を亜鉛成分として配合しているものであるが、この炭酸亜鉛、炭酸水酸化亜鉛、炭酸水酸化亜鉛水和物の少なくとも一種から用いられる亜鉛は炭酸化、炭酸水酸化されており、酸化を嫌い酸化性の物質に対して還元作用を示すといった特別顕著な効果も有す。
【００１７６】
加えて、本願請求項の発明の人体に塗布、付着させる組成物、化粧品、医薬部外品により殺菌、防腐作用を付与し、炭酸亜鉛、炭酸水酸化亜鉛、炭酸水酸化亜鉛水和物の発現する還元力は、人体に塗布、付着させる組成物、化粧品、医薬部外品に配合される他の有効成分、例えば、アスコルビン酸等が酸化される事を防止する作用（抗酸化作用）を与える事ができるため、本願請求項の発明の人体に塗布、付着させる組成物、化粧品、医薬部外品においては、抗菌剤や防腐剤、或いは酸化防止剤等の添加量を減らす事ができる結果、本願請求項の発明の人体に塗布、付着させる組成物、化粧品、医薬部外品は、皮膚や粘膜刺激の極めて少ない人体に塗布、付着させる組成物、化粧品、医薬部外品となり得た。
【００１７７】
本願請求項の発明によると、皮膚や粘膜の表面及び内面において異物（アレルゲン）とならない理想的な環境（メディア）を提供し、表皮を含む皮膚や粘膜の障害細胞に対してバランスを整え、それら障害細胞を正常活性化できた。
【００１７８】
本願請求項の発明の人体に塗布、付着させる組成物、化粧品、医薬部外品は、皮膚や粘膜細胞内外の酸−塩基のアンバランスを緩和させ、細胞のバランスを改善し、神経伝達物質の分泌を促進しつつ、真皮の血流を調節、制御しながら健常皮膚や粘膜細胞の生成、増殖を図り得る理想的な人体に塗布、付着させる組成物、化粧品、医薬部外品であり、乾燥肌、アトピー性皮膚炎や粘膜炎、フケ症、色素沈着（シミ）、掻痒感（カユミ）、発赤（赤顔）等を緩和し、使用者の年齢、性別、人種、体調に関わらず、美白効果、しみそばかすの解消、肌荒れ抑制の効果を発揮する事ができる。また使用量により確実に人体に塗布、付着させる組成物、化粧品、医薬部外品の使用感と効果を両立する事ができた。[0001]
TECHNICAL FIELD OF THE INVENTION
The invention of the present application relates to a composition to be applied to and adhered to the human body, cosmetics, and quasi-drugs. More specifically, a composition to be applied and adhered to a human body containing zinc carbonate, zinc carbonate hydroxide, zinc carbonate hydroxide hydrate, etc. Pertaining to goods, cosmetics, and quasi-drugs.
[0002]
[Prior art]
One of the worst cosmetic problems for women is pigmentation disorders such as spots and freckles.In general, these pigmentation disorders cause melanocytes to abnormally express melanin in the spinous cell layer in the epidermis. It is said to be caused by release to
[0003]
In addition, aging phenomena such as rough skin, dullness, wrinkles, sagging, and hair loss do not suddenly worsen one day.In addition to excessive intake of energy such as protein and fat and insufficient intake of minerals due to uneven eating, ultraviolet rays As a result of the accumulation of lifestyle habits such as excessive drinking of alcohol and cigarettes, the so-called skin age increases, and a base on which the aging phenomenon appears is completed.
[0004]
Experientially, excessive intake of energy, protein, fat, etc., insufficient intake of minerals due to unbalanced eating, ingestion such as excessive drinking of alcohol and tobacco, and external factors such as ultraviolet rays are bad for physical health. It has been known to promote pigmentation disorders and aging phenomena, but it is still unknown recently how to increase melanin pigment and increase skin age.
[0005]
Recent studies have revealed that active oxygen and activated lipids are closely related to some of these pigmentation disorders and aging phenomena. It has been recognized that melanin pigments proliferate and greatly affect the increase of skin age.
[0006]
The skin and mucous membranes, especially the skin of women, develop problems such as blackening, spots, and wrinkles with aging. In order to solve these problems, cosmetics and quasi-drugs have been developed with the aim of improving moisturizing properties, antioxidant properties, antibacterial properties, and the like, which are effective in whitening and suppressing skin roughness. At present, natural extracts such as koji extract, peach leaf extract, and other extracts that are said to have a whitening effect, such as the composition, amount, and depth of water, have been devised. Zinc carbonate, zinc hydroxide hydroxide, carbonated water Zinc oxide hydrate has not been utilized in the cosmetics and quasi-drug fields. And the literature related to these could not be found.
[0007]
[Problems to be solved by the invention]
As compositions for cosmetics and quasi-drugs, artificially produced substances and natural products are used. However, conventionally used compositions that are applied to and adhered to the human body have a limited effect of individual components, and are used by mixing a plurality of compositions and adding the sole effect of each component. I have.
[0008]
Therefore, conventional cosmetics and quasi-drugs protect the skin and mucous membranes from drying, ultraviolet rays, oxidation, etc., which are harmful to the skin and mucous membranes, maintain and restore the original homeostasis of the skin and mucous membranes, stains, Aging phenomenon such as dullness, wrinkles, sagging, hair loss, etc., and improvement of symptoms such as rough skin, dry skin, acne, bruising, rash, allergy, atopic skin and mucositis, and hair damage Sufficiently effective in improving skin, improving nail damage, preventing tooth decay, marginal periodontitis (alveolar pyorrhea), alleviating sweat rash, stiff shoulders, neuralgia, chilliness, and preventing skin and mucous membrane cancer It was not something that could be demonstrated.
[0009]
Recently, cosmetics and medicines containing mineral water such as hot springs and groundwater, seawater, etc., in order to easily obtain the effects of thalassotherapy, which normalizes metabolism and blood circulation, by absorbing skin components and mucous membranes of mineral components. Quasi-products have been proposed.
[0010]
However, mineral water such as hot springs and groundwater, seawater, etc. are mixed with domestic wastewater and industrial wastewater, and microorganisms such as bacteria are generated. Therefore, it is necessary to add a bactericide, heat treatment, or irradiate ultraviolet rays, because of the possibility of causing deterioration in quality such as yellowing or deterioration, irritation of skin and mucous membranes, and the like.
[0011]
However, the addition of a disinfectant has a problem that, depending on the user, the skin and mucous membranes are more irritated and the feeling of use is impaired. At the same time, necessary mineral components are removed, and a sufficient effect cannot be obtained.
[0012]
Therefore, a method of artificially adding mineral components to mineral water or seawater such as distilled water, hot water after treatment such as heat treatment or ultraviolet irradiation, groundwater, etc., is considered. The cluster size of the water molecules in the outer periphery of the water surrounding the ions is relatively large, which causes a problem that it is difficult to absorb the skin and the mucous membrane.
[0013]
Also, recently, cosmetics and quasi-drugs containing so-called deep sea water as a mineral component have been proposed.
[0014]
However, due to the action of the ocean circulation, surface water and deep water in the ocean are constantly circulating. As a result, the mineral balance of the withdrawn deep water is different each time, and there is a problem that it is difficult to obtain a stable one.
[0015]
Also, due to the action of ocean circulation, when deep water springs up to the surface and receives oxygen, sunlight, or the food chain of living organisms, the mineral components contained therein are oxidized and sent back to the depths. However, since it takes a long time to recover the reducing power, the mineral component contained in the deep water contains many inactive substances.
[0016]
The present inventors have conducted intensive studies to solve the above technical problem, and as a result, applied or adhered to a human body containing at least one of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate. The composition, especially cosmetics and quasi-drugs, has high penetration into skin and mucous membranes, can efficiently take in zinc element into the human body, and sufficiently suppress the strong oxidizing effect of active oxygen. I got the knowledge that I can do it.
[0017]
Zinc is said to have an antioxidant action similar to ascorbic acid, which prevents oxidation in vivo. Further, when zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate are dissolved in an aqueous solution, the cluster size of water molecules around the water surrounding zinc ions becomes very small. Therefore, compositions, cosmetics, and quasi-drugs that are applied or adhered to the human body exhibit an effect of being excellent in skin and mucous membrane penetration. From this, it was found that the zinc component was re-absorbed and taken up by the leachate from the body even when zinc carbonate, zinc carbonate hydroxide, and 100% by weight of zinc carbonate hydroxide hydrate were used.
[0018]
In addition, zinc carbonate, zinc hydroxide hydroxide, and zinc carbonate hydroxide hydrate have been carbonated and carbonated and hydrated. Focusing on the fact that zinc has a reducing effect on oxidizing substances, zinc is added to the skin or mucous membrane by blending it as a component for applying or attaching it to the human body, especially for cosmetics or quasi-drugs. The present invention has been completed based on the knowledge that cosmetics and quasi-drugs can be obtained, which can simultaneously suppress the excessive generation and accumulation of active oxygen and activated lipids.
[0019]
Therefore, the invention claimed in the present application has been developed to solve the problems existing in the prior art as described above. Its purpose is to protect skin and mucous membranes from drying, ultraviolet rays, oxidation, etc. harmful to skin and mucous membranes, normalize metabolism and blood circulation, regardless of the age, gender, race, physical condition of the user, Maintains and restores the original homeostasis of the skin and mucous membranes.For oral mucosa, peripheral periodontitis, mucosal cancer, conjunctivitis for the eyes, rectum for the rectum, pigmentation for the skin, spots, freckles, etc. Improvement, delay of aging phenomena such as dullness, wrinkles, sagging, hair loss, etc., improvement of symptoms such as rough skin, dry skin, acne, rash, rash, allergy, atopic dermatitis and mucositis, improvement of hair damage, nail A composition to be applied or adhered to a human body, which has a sufficient effect for improving pain, preventing tooth decay, marginal periodontitis, etc., alleviating sweat rash, stiff shoulder, neuralgia, chilliness, etc., and further preventing skin cancer, etc. In providing cosmetics and quasi-drugs .
[0020]
[Means for Solving the Problems]
In order to achieve this object, the invention of claim 1 of the present application relates to a composition, cosmetic or quasi-drug which is applied to and adhered to a human body, wherein at least one of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate is used. It is characterized by combining one type.
Any one of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate is contained in an amount of 0.0000001 to 98% by weight based on the total weight.
Further, two or three kinds of the above-mentioned zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate are contained in a total amount of 0.00000001 to 98% by weight based on the total weight.
The composition applied and adhered to the human body is a cosmetic.
The composition applied to and adhered to the human body is a quasi-drug.
[0021]
In the invention claimed in the present application, by using such zinc carbonate, zinc carbonate hydroxide, zinc carbonate hydroxide hydrate, a large amount of zinc element indispensable for life activity can be absorbed into skin and mucous membrane. it can.
[0022]
Also, when zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate are dissolved in water, the cluster size of water molecules in the outer periphery of water surrounding zinc ions is very small, and as a result, skin, mucous membrane, The penetrating power can be very high.
[0023]
In particular, zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate exhibit a reducing action on oxidizing substances.
[0024]
In addition, zinc carbonate, zinc carbonate hydroxide, as a secondary advantage of zinc carbonate hydroxide hydrate, applied to the human body, the composition to be adhered, cosmetics, impart bactericidal, preservative action to quasi-drugs, Moreover, zinc carbonate, zinc carbonate hydroxide, the reducing power expressed by zinc carbonate hydroxide hydrate is applied to the human body, the composition to be adhered, cosmetics, other active ingredients blended in quasi-drugs, for example, It can provide an antioxidant effect for preventing ascorbic acid or the like from being oxidized. Since the zinc component functions to remove active oxygen in the body in the same manner as ascorbic acid, the composition, cosmetics, and quasi-drugs to be applied and adhered to the human body according to the claimed invention are antibacterial agents and preservatives Alternatively, the amount of the antioxidant or the like added can be reduced, and as a result, a composition, cosmetic or quasi-drug that can be applied and adhered to a human body with little skin irritation or mucous membrane irritation can be obtained.
[0025]
BEST MODE FOR CARRYING OUT THE INVENTION
The composition, cosmetics, and quasi-drugs to be applied and adhered to the human body according to the invention of the present application are characterized in that at least one of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate is blended as a zinc component. In the process of applying and adhering to the human body, in the process of producing a composition, cosmetics, and quasi-drugs, adding, admixing, moistening, etc. It is formulated by the method, but it is applied as a composition to be applied to and adhered to the human body, as a form of a mixture of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate when added to cosmetics and quasi-drugs. Is not particularly limited, for example, may be used by dissolving zinc carbonate, zinc hydroxide hydroxide, zinc carbonate hydroxide hydrate in water or alcohol, etc., further dried and used as powder , Increase Agent were added gel, and processed into a paste may be improved handling properties.
[0026]
In order to further improve the utility of the composition, cosmetics, and quasi-drugs to be applied and adhered to the human body of the claimed invention, it is preferable to use not only a powder but also a dissolved one, but the powder remains as it is. Even if mixed with a base, an effect can be obtained.
[0027]
Compositions to be applied and adhered to the human body according to the claimed invention, cosmetics, and quasi-drug product forms include at least one of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate. It is not particularly limited as long as it is present, and may be processed into the same form as a known composition, cosmetic or quasi-drug to be applied and adhered to a human body. Specifically, as cosmetics and quasi-drugs, cleaning cosmetics, hair cosmetics, basic cosmetics, make-up cosmetics, aromatic cosmetics, tanning cosmetics, sunscreen cosmetics, nail cosmetics, eyeliner cosmetics, lip cosmetics, oral cosmetics, Can be used as bath cosmetics.
[0028]
More specifically, cleansing, soap, liquid body washing, cosmetics for shampoo, shampoo, rinse, hair lotion, hair essence, hair cream, hair treatment, hair coloring agent, hair finishing cosmetics, hair restorer, makeup Water, serums, cosmetic creams, emulsions, packs, gels, masks, essences, body lotions, body creams, shaving cosmetics, hand care agents, foundations, cheek makeup, perfumes, colons, sunscreens, sun care products , Nail treatment, nail polish, nail polish, eye makeup base, eye makeup, lip makeup, lipstick, dentifrice, mouthwash, bath, eye drops, suppository and the like.
[0029]
By the way, the composition, cosmetics, and quasi-drugs to be applied and adhered to the human body according to the claimed invention are characterized in that at least one of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate is blended. However, the other components are not particularly limited, and those currently used as additives for cosmetics and quasi-drugs can be appropriately compounded.
[0030]
Compositions, cosmetics, and quasi-drug bases to be applied and adhered to the human body include, for example, hydrocarbons such as α-olefin oligomers, paraffin wax, ceresin, and microcrystalline wax, persic oil, olive oil, and tallow. And animal and vegetable oils such as mink oil, synthetic esters such as cetyl octoate, isopropyl myristate, and cetyl palmitate; natural animal and plant waxes such as jojoba oil, carnauba wax, candelilla wax, mocro, and beeswax; sorbitan stearate; tristearin And silicone oils such as polyoxyethylene glycerate, polyoxyethylene lauryl ether, decaglyceryl trioleate, sucrose monolaurate, dimethylpolysiloxane and methylphenylpolysiloxane, and derivatives thereof.
[0031]
Fluorinated resins such as perfluoropolyether, alcohols such as ethanol, 1,3-butylene glycol, propylene glycol and diglycerin, carrageenan, xanthan gum, sodium carboxymethylcellulose, proteins such as collagen, elastin, silk, lactoferrin and the like Powders of decomposition products, silicic anhydride, nylon powder, polyalkyl acrylate, alumina, iron oxide, etc.
[0032]
In addition, ultraviolet absorbers, vitamins, urea, dried seawater, anti-inflammatory agents, amino acids and their derivatives, lecithin, coloring agents, fragrances, preservatives, etc., such as egg yolk oil, macadamia nut oil, cottonseed oil, avocado oil, Palm oil, palm oil, palm kernel oil, corn oil, peanut oil, tallow, carnauba wax.
[0033]
Other examples include beeswax, liquid paraffin, lanolin, squalane, stearic acid, lauric esters, myristic esters, isostearyl alcohol, purified water, electrolyzed water, ethyl alcohol, methyl alcohol and the like. That is, it is generally blended in common with cosmetics and quasi-drugs.
[0034]
For example, as other components, they are selected according to those actually added to cosmetics and quasi-drugs. Although not strictly distinguishable, humectants include glycerin, sorbitol, polyethylene glycol, pyrrolidone carboxylic acid and its salts, collagen, 1,3-butylene glycol, hyaluronic acid and its salts, chondroitin sulfate and its salts, xanthan gum And the like.
[0035]
Examples of the antioxidant include ascorbic acid, α-tocopherol, dibutylhydroxytoluene, parahydroxyanisole and the like. Examples of the surfactant include sodium stearyl sulfate, diethanolamine cetyl sulfate, polyethylene glycol monostearate, ethylene glycol monostearate, polyoxyethylene hydrogenated castor oil, soybean lysophospholipid liquid, polyoxyethylene sorbitan monooleate, and the like.
[0036]
Preservatives include phenoxyethanol, ethyl paraben, butyl paraben and the like.
Examples of anti-inflammatory agents include glycyrrhizic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin and the like.
Examples of whitening agents include placenta extract, glutathione, saxifraga extract, ascorbic acid derivative, arbutin and the like.
[0037]
Examples of the blood circulation promoter include γ-oryzanol, dextran sodium sulfate and the like.
Antiseborrheic agents include sulfur, thiantol and the like.
Examples of the thickener include a carboxyvinyl polymer.
Examples of the pH adjuster include lactic acid, citric acid, malic acid, glycolic acid, sodium hydroxide and the like.
Examples of the coloring agent include titanium yellow, carsamine, safflower red and the like.
Examples of sequestering agents include tetrasodium hydroxyethanedisulfonate.
[0038]
As the fragrance, lavender oil and the like can be mentioned.
Examples of the extender include talc, kaolin, mica, calcium carbonate and the like.
Examples of the white pigment include titanium oxide and zinc oxide.
Examples of the coloring pigment include chromium oxide, chromium hydroxide, carbon black, tar pigment, chlorophyll and the like.
Further, purified water and alcohol are exemplified.
[0039]
In general, cosmetics, quasi-drug cosmetic creams, milky lotions, beauty essences and lotions contain oils, purified water and alcohol as main components, surfactants, humectants, antioxidants, At least one selected from a viscosity agent, an antiseborrheic agent, a blood circulation promoter, a whitening agent, a pH adjuster, a pigment, a preservative, and a fragrance is appropriately blended.
[0040]
Cosmetic foundations are mainly composed of oils, extenders and white pigments, surfactants, moisturizers, antioxidants, thickeners, antiseborrheic agents, blood circulation promoters, pH adjusters, preservatives, antioxidants At least one selected from agents, whitening agents, preservatives, fragrances, coloring pigments and purified water is appropriately blended.
Further, lipsticks are mainly composed of oils and white pigments, surfactants, humectants, antioxidants, thickeners, antiseborrheic agents, blood circulation promoters, pH adjusters, preservatives, antioxidants, At least one selected from a whitening agent, a preservative, a fragrance, a coloring pigment, and purified water is appropriately blended.
[0041]
Other components include herbs such as peonies, saxifraga, agetsu, gougon, panax ginseng and melissa, and plant extracts such as orange extract, reishi extract, bacterial extract such as koji extract and the like. Any of those described in the Pharmaceutical Safety Bureau Review Study Group of the Ministry of Health and Welfare "Yakuji Nipposha" may be included. The above items are selected depending on what is actually added to cosmetics and quasi-drugs.
[0042]
By the way, the range of cosmetics and quasi-drugs is expanding due to recent diversification of cosmetics, and it is necessary to strictly limit the definition of cosmetics and quasi-drugs also in the cosmetics of the present invention. But not general cosmetics or quasi-drugs.
[0043]
In addition, the solvent refers to a liquid for dissolving zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate, and the base is the composition other than the other compositions, cosmetics, and quasi-drugs. Base, cosmetic base and quasi-drug base.
[0044]
The contents of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate in the compositions, cosmetics, and quasi-drugs applied and adhered to the human body are described below.
[0045]
The criteria for determining the effective weight% of zinc carbonate, zinc carbonate hydroxide, zinc carbonate hydroxide hydrate in compositions, cosmetics and quasi-drugs to be applied to and adhered to the human body are based on oral bacteria and HeLa cells (HeLa cells are HeLa cells). The experiment of Example 1 was conducted using cultivated cervical cancer cells of a person referred to as HeLa cells, which are mainly used as controls in toxicity tests.
[0046]
[Example 1]
1 cm of oral bacteria in 3% Eagle's MEM medium ² The colonies were unified into about 1 to 2 colonies and cultured at 37 ° C. for 48 hours, and 0.000000001% by weight, 0.0000001% by weight of zinc carbonate, zinc carbonate hydroxide, zinc carbonate hydroxide monohydrate, 0.0000001% by weight, 0.000001% by weight, 0.00001% by weight, 0.0001% by weight, 0.001% by weight, 0.01% by weight, 0.1% by weight, 1% by weight, 5% by weight, At concentrations of 10%, 15%, 20%, 25%, 30%, 35%, 40%, 41%, 42%, 43%, 44%, 45% by weight The determination was made based on the number of bacterial colonies in the oral cavity.
[0047]
On the other hand, a toxicity test was performed by placing HeLa cells in a 3% Eagle's MEM medium for 1 cm in a petri dish. ² And cultivated at 37 ° C for 48 hours, and 0.000000001%, 0.00000001%, 0.00000001% by weight of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate monohydrate. %, 0.000001% by weight, 0.00001% by weight, 0.0001% by weight, 0.001% by weight, 0.01% by weight, 0.1% by weight, 1% by weight, 5% by weight, 10% by weight, Proliferation of HeLa cells at concentrations of 15%, 20%, 25%, 30%, 35%, 40%, 41%, 42%, 43%, 44%, and 45% by weight It was judged by the state.
[0048]
As a result, in the experiment using zinc carbonate in terms of weight%, zinc carbonate with respect to the total weight (the same applies hereinafter) and 0.000000001% by weight allowed HeLa cells to grow, but did not inhibit bacterial growth. When it exceeds 0.00000001% by weight, HeLa cells proliferate, and conversely, it is recognized that the growth of oral bacteria is suppressed.
[0049]
Further, in the experiment using the weight percentage of zinc hydroxide, zinc hydroxide with respect to the total weight, and HeLa cells grew at 0.000000001 weight%, but did not suppress the growth of bacteria. When it exceeds 0.00000001% by weight, HeLa cells proliferate, and conversely, it is recognized that the growth of oral bacteria is suppressed.
[0050]
In addition, in the experiment using zinc hydroxide monohydrate by weight%, zinc hydroxide monohydrate based on the total weight, and HeLa cells grew at 0.000000001 wt% with respect to the total weight, but did not inhibit bacterial growth. Was. When it exceeds 0.00000001% by weight, HeLa cells proliferate, and conversely, it is recognized that the growth of oral bacteria is suppressed.
[0051]
In the experiment using the weight% of the mixture of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate, the mixture of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate was 0.00000000001 relative to the total weight. HeLa cells grew by weight percent, but did not inhibit bacterial growth. When it exceeds 0.00000001% by weight, HeLa cells proliferate, and conversely, it is recognized that the growth of oral bacteria is suppressed.
[0052]
The results obtained in Example 1 showed that zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate each act at almost the same weight percent. Also, the correlation between the weight percent of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate was 0.001% by weight between HeLa cells and oral bacteria, and the proliferation of HeLa cells became vigorous. Bacterial growth was further suppressed. Further, up to 40% by weight, remarkable proliferation of HeLa cells was shown, and above 40% by weight, the result was that the proliferation of cells was slightly reduced. This effect is similar to that of antibiotics. Therefore, when the amount is 0.00000001% by weight or more, the amount of an antibacterial agent, a preservative, an antioxidant, or the like can be reduced. In other words, it was found that the more preferable weight percentage of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate is 0.001 to 40% by weight.
[0053]
[Example 2]
Zinc carbonate monohydrate is easy to form a crystal structure and can be used as a powder, and a mixture of zinc carbonate and zinc carbonate monohydrate exhibits a pink color, It is also possible to use 100% as it is as a foundation.
As a method, zinc carbonate and zinc carbonate monohydrate were mixed in 50 cc of distilled water, stirred, molded under a pressure of 10 atm, and water was removed by freeze-drying to obtain a foundation.
[0054]
[Example 3]
To 50 cc of distilled water, 0.5 g of glyceryl monostearate, 0.5 g of isopropyl myristate, 0.5 g of liquid paraffin, and 0.5 g of beeswax are added as a base material, and a total of 2 g is added thereto. After 98 g of zinc hydroxide monohydrate was mixed and stirred, the mixture was molded by applying a pressure of 10 atm, and water was removed by freeze-drying to obtain a foundation.
[0055]
The foundation obtained in Example 2 had a problem that makeup was easily disintegrated.
The foundation obtained in Example 3 was hard to lose its shape. In other words, if the content exceeds 98% by weight, the feeling of use when used as a foundation tends to be impaired, but the foundation obtained as in Example 3 can be used.
[0056]
On the other hand, it is desirable that the amount of the base cosmetics such as foundation cream, lotion, serum, etc. and those directly contacting the skin be less than 40% by weight.
[0057]
Here, the zinc carbonate hydroxide hydrate becomes ions when dissolved in water, and all the hydrates become water, so that their functions are almost the same. Therefore, the hydrated zinc carbonate hydroxide of the present application does not specify the hydration number.
[0058]
As described above, HeLa cells slightly decrease at 40% by weight or more. However, when it is actually used as a foundation, it is not applied directly to the skin, but rather is placed on a base cream, and the direct contact with the skin is about 20 to 30% of that. Even if zinc carbonate, zinc carbonate hydroxide, zinc carbonate monohydrate, and a foundation of 100% by weight are used, there is no problem except that the composition easily collapses and the feeling of use is impaired.
[0059]
In other words, the content of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate is preferably 0.0000001 to 98% by weight of the total weight of the composition, cosmetics, and quasi-drugs applied to and adhered to the human body. %, More preferably 0.001 to 40% by weight. If the content is less than 0.00000001% by weight, a sufficient effect cannot be obtained. On the other hand, if the content is 98% by weight or more, makeup tends to be disintegrated and the feeling of use tends to be impaired.
[0060]
Embodiments 4 to 24 described below are lotions, but may be used on any part of the body such as the body, scalp, face, neck, limbs, and the like.
[0061]
[Example 4]
0.5 g of zinc carbonate and 0.5 g of zinc carbonate monohydrate are added to 1,000 cc of electrolyzed acidic water having a pH of 2.7 and mixed with stirring for 12 hours, and the mixture is centrifuged to give a clear supernatant. Got. 30 g of dried seawater (30 g of urea and 30 cc of glycerin) was added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.092% by weight.
[0062]
[Comparative Example 1]: Same as Example 4 except that zinc oxide 0.5 g and titanium oxide 0.5 g were used instead of zinc carbonate 0.5 g and zinc carbonate monohydrate 0.5 g, The lotion of Comparative Example 1 was produced. A comparative experiment was performed using the lotion of Example 4 and the lotion of Comparative Example 1.
[0063]
Using the lotion obtained in Example 4 and Comparative Example 1, a test for normalization of skin keratin water content (a test for osmotic power and a restoration of homeostasis function of skin) and a test for a whitening effect (melanin pigment) Test for the reduction of).
[0064]
The whitening effect after using the lotion of Example 4 and the lotion of Comparative Example 1 was determined by 60 panelists (female 25 to 65 years old) suffering from spots and freckles.
[0065]
Before the test, as an index of the horny water content of the panelists, high frequency electrical conductivity of the skin surface of the left and right cheek skins of all 60 persons divided into two groups (30 persons as one group, 30 persons as two groups) was obtained. The skin surface conductance) was measured with a 3.5 MHz high-frequency electric conductivity measuring device (SKICON200, manufactured by IBS), and the water content on the skin surface was measured. As a result, the average value of the conductance of the skin surface of the 60 panelists was 4.2 (1 / μ ohm), and it was confirmed that the skin surface was in a so-called rough skin state where partial exfoliation of keratin was observed. Was done.
[0066]
Thereafter, 30 panelists applied the lotion of Example 4 to the left and right cheeks, and the remaining 30 panelists applied the lotion of Comparative Example 1 to the left and right cheeks. Was washed with water, and after 2 hours, the water content on the skin surface was measured by a 3.5 MHz high-frequency electric conductivity measuring device (SKICON200, manufactured by IBS). As a result, the average value of the skin surface conductance of 30 panelists in the lotion of Comparative Control Example 1 was 4.2 (1 / μOhm), which was not changed. The average value of the skin surface conductance of 30 panelists in the lotion of Example 4 was improved to 7.4 (1 / μOhm), confirming the improvement of the properties of the skin surface.
[0067]
Also, the lotion of Example 4 was applied to the lips of 30 panelists, and the remaining 30 panelists applied the lotion of Comparative Example 1 to the lips. After 60 minutes had elapsed, the applied portion was washed with water. After 2 hours, cheek skin and lip mucosa of each panel before and after the test were observed with a microscope.
As a result of observation with a microscope, 30 panelists who applied the lotion of Comparative Control Example 1 showed no change, and 30 panelists who applied the lotion of Example 4 clearly showed the cheek skin and lip mucous membrane. Roughness had been improved.
[0068]
Using the lotion obtained in Example 4 and Comparative Example 1, 30 people were instructed to use twice a day after washing their face every morning and after bathing, respectively. The whitening effect such as spots and freckles on the face was determined. The whitening effect of this Example 4 and Comparative Control Example 1 by repeated use of the lotion is as follows.
[0069]
By repeated use of the lotion in Example 4, forehead on the face, the outer corner of the eye and the periphery of the outer corner of the eye and cheeks, there were 20 people who recognized that the whitening effect on the face was inconspicuous and the whitening effect was remarkable, There were 6 people who recognized that the stains and freckles became thin and hardly noticeable, and there was a whitening effect, and the other four claimed that the stains and freckles became somewhat thinner and some whitening effect was recognized. did.
[0070]
By repeated use of the lotion of Comparative Example 1, two persons claimed that the spots and freckles were somewhat thinned and that some whitening effect was observed, and the remaining 28 persons showed no change and no whitening effect. Argued not.
[0071]
From the above results, the lotion containing zinc carbonate and zinc carbonate monohydrate of the present invention has an effect of reducing the melanin pigment on the skin and mucous membranes and making the facial spots and freckles less noticeable. In addition, it was found that the skin had a high osmotic power to normalize the keratin water content and restore the homeostatic function of the skin and mucous membranes.
[0072]
A cotton nonwoven fabric was laminated on a support made of a polyethylene film for two groups of the above-mentioned panelists, each of 30 persons, and a total of 60 persons, and this was applied to the lotion of Example 4 and the lotion of Comparative Example 1, respectively. Were impregnated with a saturated amount, and these were respectively attached to the inner surface of the upper arm, and a loosening test of the stratum corneum of the skin was performed 1 hour later. The lotion of Example 4 has a higher penetrating power than the lotion of Comparative Example 1, promotes the loosening of the stratum corneum, and promotes the skin absorption of active ingredients of cosmetics and quasi-drugs. The thing was admitted.
[0073]
[Example 5]
1 g of zinc carbonate was added to 1,000 cc of distilled water having a pH of 7.3, mixed with stirring for 12 hours, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. Zinc carbonate is about 0.092% by weight.
[0074]
[Example 6]
1 g of zinc carbonate was added to 1,000 cc of distilled water having a pH of 7.3, and the mixture was stirred and mixed for 12 hours. A clear supernatant was obtained by centrifugation of the mixture. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. Zinc carbonate hydroxide is about 0.092% by weight.
[0075]
[Example 7]
1 g of zinc carbonate hydroxide monohydrate was added to 1,000 cc of distilled water having a pH of 7.3 and mixed with stirring for 12 hours, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. Zinc carbonate monohydrate is about 0.092% by weight.
[0076]
[Comparative Example 2]: Titanium oxide 1 was added to 1,000 cc of distilled water having a pH of 7.3, and the mixture was stirred and mixed for 12 hours, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion of Comparative Control Example 2.
[0077]
Using the lotions obtained in Examples 5, 6, 7 and Comparative Example 2, 40 panelists (25 to 65 years old females) were divided into four groups as ten indices of keratin water content, and ten persons were divided into four groups. The high-frequency electric conductivity (skin surface conductance) of the cheek skin surface of all 40 subjects divided into four groups was measured by a 3.5 MHz high-frequency electric conductivity measuring device (SKICON200, manufactured by IBS), and the skin surface was measured. Was measured for water content. After that, 30 panelists applied 10 lotions to one group, and applied the lotion of Examples 5, 6, and 7 to the cheek, and the remaining 10 panelists applied the lotion of Comparative Example 2 to the cheek. After a lapse of 60 minutes, the applied portion was washed with water, and after a lapse of 2 hours, the water content of the skin surface was measured by a 3.5 MHz high-frequency electric conductivity measuring device (SKICON200, manufactured by IBS).
[0078]
In addition, 40 panelists applied 10 lotions to the lips for each of 10 persons, and the remaining 10 panelists applied the lotion of Comparative Example 2 to the lips. After a lapse of 60 minutes, the applied area was washed with water. After a lapse of 2 hours, the buccal skin and the lip mucosa of each paneler were observed with a microscope before and after the test.
[0079]
Before the test, as an index of the horny water content of the panelists, high-frequency electric conductivity of 40 skins was divided into 4 groups, 10 were divided into 1 group, and all 40 skins divided into 4 groups were measured. The average value of the skin surface conductance of 40 panelists was 3.9 (1 / μOhm).
[0080]
Further, the skin surface conductance of 10 panelists in the lotion of Comparative Control Example 2 after the test and 30 panelists in the lotions of Examples 5, 6, and 7 was measured. The average skin surface conductance of 10 panelists in the lotion of Comparative Control Example 2 was 4.0 (1 / μOhm), and the average skin surface conductance of 10 panelists in the lotion of Example 5 was 6. The average value of the skin surface conductance of 10 panelists in the lotion of Example 6 was 6 (1 / μ ohm), and the skin surface conductance of 10 panelists in the lotion of Example 7 was 6. Has improved to 6.7 (1 / μOhm), confirming improvement in the properties of the skin surface.
In addition, as a result of observing the cheek skin and the lip mucous membrane with a microscope, the panelists who applied the lotion of Comparative Example 2 showed no change, and the panelists who applied the lotion of Examples 5, 6, and 7 showed no change. Thirty patients had apparently improved roughness of the buccal skin and mucous membrane of the lips.
[0081]
Example 8
1 g of zinc carbonate was added to 1,000 cc of electrolyzed acidic water having a pH of 2.7 and mixed with stirring for 12 hours, and the mixture was centrifuged to obtain a clear supernatant. 3 g of dried seawater, 3 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. Zinc carbonate is about 0.092% by weight.
[0082]
[Example 9]
1 g of zinc carbonate hydroxide monohydrate was added to 1,000 cc of electrolyzed acidic water having a pH of 2.7 and mixed with stirring for 12 hours, and the mixture was centrifuged to obtain a clear supernatant. 3 g of dried seawater, 3 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. Zinc carbonate monohydrate is about 0.092% by weight.
[0083]
[Example 10]
1 g of zinc carbonate hydroxide monohydrate was added to 1,000 cc of electrolyzed acidic water having a pH of 2.7 and mixed with stirring for 12 hours, and the mixture was centrifuged to obtain a clear supernatant. 3 g of dried seawater, 3 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. Zinc carbonate monohydrate is about 0.092% by weight.
[0084]
[Comparative Example 3] 1 g of iron oxide was added to 1,000 cc of electrolyzed acidic water (pH 2.7), mixed with stirring for 12 hours, and the mixture was centrifuged to obtain a clear supernatant. 3 g of dried seawater, 3 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion of Comparative Control Example 3.
[0085]
Using the lotions obtained in Examples 8, 9, and 10 and Comparative Example 3, the measurement of the amount of keratin water and microscopic observation were performed in the same manner as Comparative Example 2.
The average value of the skin surface conductance of 40 panelists was 4.0 (1 / μOhm).
[0086]
As a result, the average value of the skin surface conductance of 10 panelists in the lotion of Comparative Control Example 3 was 4.1 (1 / μOhm), and the average value of the skin surface conductance of 10 panelists in the lotion of Example 8 was 6.7 (1 / μ ohm), average skin surface conductance of 10 panelists in the lotion of Example 9 was 6.8 (1 / μ ohm), and 10 panelists of skin in the lotion of Example 10 The average value of the surface conductance was improved to 6.7 (1 / μOhm), confirming improvement in the properties of the skin surface. Further, as a result of observing the cheek skin and the lip mucous membrane with a microscope, no change was observed in the ten panelists who applied the lotion of Comparative Example 3, and the panelists who applied the lotion of Examples 8, 9, and 10 were applied. Thirty patients had apparently improved roughness of the buccal skin and mucous membrane of the lips.
[0087]
[Example 11]
A mixture of 1 g of zinc carbonate and 1 g of zinc hydroxide was added to 1,000 cc of distilled water having a pH of 7.30, and mixed by stirring for 12 hours. The mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.183% by weight.
[0088]
[Example 12]
A mixture of 1 g of zinc carbonate and 1 g of zinc carbonate monohydrate was added to 1,000 cc of distilled water having a pH of 7.30, and the mixture was stirred and mixed for 12 hours, and a clear supernatant was obtained by centrifugation. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.183% by weight.
[0089]
[Example 13]
A mixture of 1 g of zinc carbonate and 1 g of zinc carbonate monohydrate was added to 1,000 cc of distilled water having a pH of 7.30 and stirred and mixed for 12 hours, and the mixture was centrifuged to obtain a clear supernatant. . 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.183% by weight.
[0090]
[Comparative Example 4]: A mixture of 1 g of zinc oxide and 1 g of titanium oxide was added to 1,000 cc of distilled water having a pH of 7.30 and mixed with stirring for 12 hours, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion of Comparative Example 4.
[0091]
Using the lotions obtained in Examples 11, 12, and 13 and Comparative Example 4, measurement of the amount of keratin water and microscopic observation were performed in the same manner as Comparative Example 2.
The average value of the skin surface conductance of 40 panelists was 3.9 (1 / μOhm).
[0092]
As a result, the average value of the skin surface conductance of 10 panelists in the lotion of Comparative Control Example 4 was 4.0 (1 / μ ohm), and the average value of the skin surface conductance of 10 panelists in the lotion of Example 11 was 6.5 (1 / μOhm), average skin surface conductance of 10 panelists in the lotion of Example 12 was 6.7 (1 / μOhm), and skin of 10 panelists in the lotion of Example 13 The average value of the surface conductance was improved to 6.6 (1 / μΩ), confirming the improvement of the properties of the skin surface. In addition, as a result of observing the cheek skin and the lip mucous membrane with a microscope, the panelists who applied the lotion of Comparative Example 4 showed no change, and the panelists who applied the lotion of Examples 11, 12, and 13 showed no change. Thirty patients had apparently improved roughness of the buccal skin and mucous membrane of the lips.
[0093]
[Example 14]
3 g of ascorbic acid is dissolved in 1,000 cc of distilled water having a pH of 7.3 to prepare a solvent having a pH of 2.0, and a mixture of 1 g of zinc carbonate and 1 g of zinc hydroxide is added thereto, and the mixture is stirred for 12 hours to dissolve and centrifuged. A clear supernatant was obtained. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.183% by weight.
[0094]
[Example 15]
3 g of ascorbic acid is dissolved in 1,000 cc of distilled water having a pH of 7.3 to prepare a solvent having a pH of 2.0. A mixture of 1 g of zinc carbonate and 1 g of zinc hydroxide monohydrate is added thereto, and the mixture is stirred for 12 hours to be dissolved. A clear supernatant was obtained by centrifugation. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.183% by weight.
[0095]
[Example 16]
3 g of ascorbic acid is dissolved in 1,000 cc of distilled water having a pH of 7.3 to prepare a solvent having a pH of 2.0, and a mixture of zinc carbonate 1 g and zinc carbonate monohydrate 1 g is added thereto and stirred for 12 hours. After dissolution, a clear supernatant was obtained by centrifugation. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.183% by weight.
[0096]
[Comparative Example 5]: 3 g of ascorbic acid was dissolved in 1,000 cc of distilled water having a pH of 7.3 to prepare a solvent having a pH of 2.0, and a mixture of 1 g of zinc oxide and 1 g of iron oxide was added thereto, followed by stirring for 12 hours to dissolve. The mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea and 30 cc of glycerin were added to the supernatant to prepare a lotion of Comparative Control Example 5.
[0097]
Using the lotions obtained in Examples 14, 15, 16 and Comparative Example 5, the measurement of the amount of keratin water and microscopic observation were performed in the same manner as Comparative Example 2.
The average value of the skin surface conductance of 40 panelists was 4.1 (1 / μOhm).
[0098]
As a result, the average value of the skin surface conductance of 10 panelists in the lotion of Comparative Control Example 5 was 4.1 (1 / μ ohm), and the average value of the skin surface conductance of 10 panelists in the lotion of Example 14 was 6.6 (1 / μOhm), the average value of the skin surface conductance of 10 panelists in the lotion of Example 15 was 6.7 (1 / μOhm), and the skin of 10 panelists in the lotion of Example 16 The average value of the surface conductance was improved to 6.8 (1 / μOhm), and it was confirmed that the properties of the skin surface were improved. As a result of observing the cheek skin and the lip mucous membrane with a microscope, no change was observed in the ten panelists who applied the lotion of Comparative Example 5, and the panelists who applied the lotion of Examples 14, 15, and 16 were applied. Thirty patients had apparently improved roughness of the buccal skin and mucous membrane of the lips.
[0099]
[Example 17]
1 g of zinc carbonate was added to 1,000 cc of distilled water having a pH of 7.3, stirred for 12 hours to dissolve, and a clear supernatant was obtained by a centrifugation method. 6 g of glutamic acid was allowed to react with the supernatant for 1 hour, and then 4 g of L-arginine was stirred and mixed for 1 hour, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. Zinc carbonate is about 0.091% by weight.
[00100]
[Example 18]
1 g of zinc carbonate was added to 1,000 cc of distilled water having a pH of 7.3, stirred for 12 hours to dissolve, and a clear supernatant was obtained by centrifugation. 6 g of glutamic acid was allowed to react with the supernatant for 1 hour, and then 4 g of L-arginine was stirred and mixed for 1 hour, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. Zinc carbonate is about 0.091% by weight.
[00101]
[Example 19]
1 g of zinc carbonate monohydrate was added to 1,000 cc of distilled water having a pH of 7.3, stirred for 12 hours, dissolved and centrifuged to obtain a clear supernatant. 6 g of glutamic acid was allowed to react with the supernatant for 1 hour, and then 4 g of L-arginine was stirred and mixed for 1 hour, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. Zinc carbonate is about 0.091% by weight.
[00102]
[Comparative Example 6] 1 g of zinc oxide was added to 1,000 cc of distilled water having a pH of 7.3, stirred for 12 hours and dissolved, and a clear supernatant was obtained by centrifugation. 6 g of glutamic acid was allowed to react with the supernatant for 1 hour, and then 4 g of L-arginine was stirred and mixed for 1 hour, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion.
[00103]
Using the lotion obtained in Examples 17, 18, and 19 and Comparative Example 6, the measurement of the amount of keratin water and microscopic observation were performed in the same manner as Comparative Example 2.
The average value of the skin surface conductance of 40 panelists was 4.0 (1 / μOhm).
[00104]
As a result, the average value of the skin surface conductance of 10 panelists in the lotion of Comparative Control Example 6 was 4.1 (1 / μOhm), and the average value of the skin surface conductance of 10 panelists in the lotion of Example 17 was 6.8 (1 / μOhm), the average value of the skin surface conductance of 10 panelists in the lotion of Example 18 was 6.7 (1 / μOhm), and the skin of 10 panelists in the lotion of Example 19 The average value of the surface conductance was improved to 6.8 (1 / μOhm), and it was confirmed that the properties of the skin surface were improved. In addition, as a result of observing the cheek skin and the lip mucous membrane with a microscope, the panelists who applied the lotion of Comparative Example 6 showed no change, and the panelists who applied the lotion of Examples 17, 18, and 19 showed no change. Thirty patients had apparently improved roughness of the buccal skin and mucous membrane of the lips.
[00105]
[Example 20]
Dissolve 3 cc of lactic acid and 3 g of ascorbic acid in 1,000 cc of distilled water having a pH of 7.3 to prepare a solvent of pH 2.2, and add a mixture of 3 g of zinc carbonate and 3 g of zinc hydroxide carbonate thereto, and stir and mix for 12 hours. The liquid was centrifuged to obtain a clear supernatant. The supernatant was reacted with 6 g of glutamic acid for 1 hour, and then 4 g of L-arginine was stirred and mixed for 1 hour, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.540% by weight.
[00106]
[Example 21]
3 cc of lactic acid and 3 g of ascorbic acid are dissolved in 1,000 cc of distilled water of pH 7.3 to prepare a solvent of pH 2.2, and a mixture of 3 g of zinc carbonate and 3 g of zinc carbonate monohydrate is added thereto and stirred for 12 hours. After mixing, the mixture was centrifuged to obtain a clear supernatant. The supernatant was reacted with 6 g of glutamic acid for 1 hour, and then 4 g of L-arginine was stirred and mixed for 1 hour, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.540% by weight.
[00107]
[Example 22]
3 cc of lactic acid and 3 g of ascorbic acid are dissolved in 1,000 cc of distilled water having a pH of 7.3 to prepare a solvent having a pH of 2.2, and a mixture of 3 g of zinc hydroxide and 3 g of zinc hydroxide monohydrate is added thereto. The mixture was stirred and mixed for an hour, and a clear supernatant was obtained from the mixture by centrifugation. The supernatant was reacted with 6 g of glutamic acid for 1 hour, and then 4 g of L-arginine was stirred and mixed for 1 hour, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 0.540% by weight.
[00108]
[Comparative Example 7]: 3 cc of lactic acid and 3 g of ascorbic acid were dissolved in 1,000 cc of distilled water having a pH of 7.3 to prepare a solvent having a pH of 2.2, and a mixture of 3 g of zinc oxide and 3 g of titanium oxide was added thereto, followed by 12 hours. The mixture was stirred and mixed, and a clear supernatant was obtained by centrifugation. The supernatant was reacted with 6 g of glutamic acid for 1 hour, and then 4 g of L-arginine was stirred and mixed for 1 hour, and the mixture was centrifuged to obtain a clear supernatant. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion.
[00109]
Using the lotion obtained in Examples 20, 21, and 22 and Comparative Example 7, the measurement of the amount of keratin water and microscopic observation were performed in the same manner as Comparative Example 2.
The average value of the skin surface conductance of 40 panelists was 3.9 (1 / μOhm).
[00110]
As a result, the average value of the skin surface conductance of 10 panelists in the lotion of Comparative Example 7 was 4.0 (1 / μ ohm), and the average value of the skin surface conductance of 10 panelists in the lotion of Example 20 was 6.8 (1 / μOhm), average skin surface conductance of 10 panelists in the lotion of Example 21 was 6.7 (1 / μOhm), and skin of 10 panelists in the lotion of Example 22 The average value of the surface conductance was improved to 6.9 (1 / μOhm), confirming the improvement of the skin surface properties. In addition, as a result of observing the cheek skin and the lip mucous membrane with a microscope, 10 panelists who applied the lotion of Comparative Example 7 showed no change, and the panelists who applied the lotion of Examples 20, 21, and 22 Thirty patients had apparently improved roughness of the buccal skin and mucous membrane of the lips.
[00111]
[Example 23]
After dissolving 75 cc of lactic acid in 1,000 cc of electrolyzed acidic water of pH 2.7, 25 g of zinc carbonate and 25 g of zinc carbonate are stirred and mixed for 12 hours, and the mixture is centrifuged to obtain a clear supernatant. Was. Thereafter, 75 g of ascorbic acid was added, and 50 g of zinc carbonate hydroxide monohydrate was stirred and mixed for 12 hours, and the mixture was again centrifuged to obtain a clear supernatant.
[00112]
Glycine, alanine, valine, leucine, isoleucine, oxyamino acid serine, threonine, sulfur-containing amino acid cysteine, cystine, methionine, aromatic amino acid phenylalanine, tyrosine, tryptophan, neutral amino acids in this supernatant liquid 1 g of each of 16 types of proline of imino acid and asparagine and glutamine of acidic amino acid amide were mixed simultaneously at a total of 16 g and reacted for 10 hours, and a clear supernatant was again obtained by centrifugation.
[00113]
The supernatant was mixed with 20 g of aspartic acid and 20 g of glutamic acid and stirred for 3 hours to obtain a clear supernatant by centrifugation again. Thereafter, the pH was adjusted to 6.0 to 6.5 with arginine, histidine, and lysine. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The mixture of zinc carbonate and zinc carbonate monohydrate is about 4.0% by weight.
[00114]
[Comparative Example 8]: Except that 25 g of zinc oxide and 25 g of zinc carbonate were replaced with 25 g of zinc oxide and 25 g of titanium oxide, and 50 g of zinc carbonate hydroxide monohydrate was replaced with 50 g of iron oxide. In the same manner as in Example 23, a lotion of Comparative Control Example 8 was produced.
[00115]
Using the lotion obtained in Example 23 and Comparative Example 8, the measurement of keratin water content and microscopic observation were performed in the same manner as Comparative Example 2.
The average value of the skin surface conductance of 20 panelists was 4.1 (1 / μOhm).
[00116]
As a result, the average value of the skin surface conductance of 10 panelists in the lotion of Comparative Control Example 8 was 4.1 (1 / μΩ), and the average value of the skin surface conductance of 10 panelists in the lotion of Example 23 was It was improved to 7.3 (1 / μOhm), confirming improvement in the properties of the skin surface. Further, as a result of observing the cheek skin and the lip mucous membrane with a microscope, 10 panelists who applied the lotion of Comparative Example 8 showed no change, and 10 panelists who applied the lotion of Example 23 showed that Apparently, the roughness of the buccal skin and mucous membrane of the lips had been improved.
[00117]
[Example 24]
After dissolving 75 g of ascorbic acid and 75 cc of lactic acid in 1,000 cc of electrolyzed acidic water of pH 2.7, 100 g of a mixture of zinc carbonate, zinc carbonate hydroxide and zinc carbonate monohydrate was stirred and mixed for 12 hours. The mixture was centrifuged to obtain a clear supernatant. In this supernatant, neutral amino acids such as glycine, alanine, valine, leucine, isoleucine, oxyamino acids serine, threonine, and sulfur-containing amino acids cysteine, cystine, methionine, and aromatic amino acids phenylalanine, tyrosine, and tryptophan are used. , Imino acid proline, acidic amino acid amide asparagine, and glutamine were mixed in 1 g each, and a total of 16 g were simultaneously mixed and reacted for 10 hours.
[00118]
After 50 g of L-arginine and 50 g of glutamic acid were mixed therein, the pH was adjusted to 5.5 to 6.5 with histidine and lysine, and a clear brown supernatant liquid and a precipitate were obtained by centrifugation again. 30 g of dried seawater, 30 g of urea, and 30 cc of glycerin were added to the supernatant to prepare a lotion. The remaining precipitate was separately used as a cream material. The mixture of zinc carbonate, zinc carbonate hydroxide and zinc carbonate hydroxide monohydrate is about 7.4% by weight.
[00119]
[Comparative Example 9]: The same as Example 24 except that the mixture of zinc carbonate, zinc carbonate and zinc hydroxide monohydrate was replaced with 100 g of a mixture of zinc oxide, titanium oxide and iron oxide instead of 100 g of the mixture of zinc carbonate and zinc hydroxide. Then, a lotion of Comparative Control Example 9 was produced.
[00120]
Using the lotion obtained in Example 24 and Comparative Example 9, the measurement of the amount of keratin water and microscopic observation were performed in the same manner as in Comparative Example 2.
The average value of the skin surface conductance of 20 panelists was 4.1 (1 / μOhm).
[00121]
As a result, the average value of the skin surface conductance of 10 panelists in the lotion of Comparative Control Example 9 was 4.3 (1 / μOhm), and the average value of the skin surface conductance of 10 panelists in the lotion of Example 24 was It was improved to 7.8 (1 / μ ohm), confirming improvement in the properties of the skin surface. Further, as a result of observing the cheek skin and the lip mucous membrane with a microscope, 10 panelists who applied the lotion of Comparative Example 9 did not show any change, and 10 panelists who applied the lotion of Example 24 showed that Apparently, the roughness of the buccal skin and mucous membrane of the lips had been improved.
[00122]
[Comparative Example 10]: The oxidation-reduction potential of the aqueous solution produced by the following experimental method was measured at 14.4 ° C. For the measurement, an ORP water temperature system KP-2Z manufactured by Kasasa Rika Kogyo Co., Ltd. was used. The results in Table 1 below were obtained. As for the oxidation-reduction potential, the larger the negative value of the potential, the stronger the reducing power, and the larger the positive value, the stronger the oxidizing power.
[00123]
As a method of increasing the antibacterial action without using a drug, there is electrolysis of water. This is performed because the effect of suppressing bacteria is enhanced whether the electrolyzed water is acidic or alkaline. The reason is in the process of debate.Electrolyzed acidic water and alkaline water are added once again to return to water with almost the same pH and the same reduction potential as the original, but once electrolyzed water becomes acidic water, alkaline water It is known that it has a bacteriostatic effect as well as water. Therefore, when this water is used as a solvent for cosmetics, the amount of preservative can be reduced.
[00124]
[Table 1]

[00125]
The above results were obtained in the range of + -15 mV. When dissolved in water, it is saturated at about 2% by weight and becomes independent of the reduction potential. For example, when an acid such as lactic acid, ascorbic acid, hydrochloric acid or sulfuric acid is used in an amount of 1 mol or more, it dissolves in about 20% by weight to 40% by weight, depending on the nature of the acid.
As a method of the experiment, 1 g of a mixture of zinc carbonate, zinc carbonate hydroxide and zinc carbonate hydroxide monohydrate was dissolved in 1,000 cc, and 1 cc was taken out of the mixture and put into 999 cc solvent (water) for a total of 1 cc. 2,000 cc was stirred, 1 cc was taken therefrom, put into a 999 cc solvent (water), stirred for a total of 1,000 cc, 1 cc was taken therefrom, put into a 999 cc solvent (water), and a total of 1,000 cc were stirred. % Is 0. 000000001% by weight. According to this method, weight% was obtained.
[00126]
According to the above-described experimental results of the oxidation-reduction potential, the reduction potential of pH 7.64 water in which zinc carbonate, zinc carbonate hydroxide and zinc carbonate monohydrate were dissolved in tap water at 0.000000001% by weight based on the total weight. Has only a change in the error range, and it has been proved that water in which 0.00000001% by weight of zinc carbonate, zinc carbonate hydroxide and zinc carbonate monohydrate are dissolved with respect to the total weight has a strong reducing power. .
[00127]
The oxidation-reduction potential of the electrolyzed acidic water having a pH of 2.71 was 1.090 mV, but water in which 0.00000001% by weight of zinc carbonate and zinc carbonate monohydrate was dissolved based on the total weight. It was proved that the oxidation-reduction potential dropped to 730 mV and the reducing power was strong. Therefore, an aqueous solution in which zinc carbonate and zinc carbonate monohydrate are dissolved in an amount of 0.0000001% by weight or more based on the total weight can be applied to compositions, cosmetics, and quasi-drugs to be applied and adhered to the human body. I can do it.
[00128]
Hereinafter, the embodiment of the present invention will be described more specifically with reference to examples of cream and comparative examples of cream.
[00129]
[Example 25]
(A): 1 g of powder obtained by drying the precipitate of Example 24, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate as a base, 2.4 g of ethylene glycol monostearate, 5.0 g of macadamia nut oil, carboxy 98 g of the supernatant of Example 9 was added to 0.7 g of a vinyl polymer, 0.28 g of sodium hydroxide, and 1,000 g of 1,3-butylene glycol, and 1,000 g of cosmetic cream A was taken out. The mixture of zinc carbonate, zinc hydroxide hydroxide and zinc carbonate hydroxide monohydrate is about 0.66% by weight.
[00130]
[Example 26]
(B): 1 g of a powder mixture of zinc carbonate, zinc carbonate hydroxide and zinc carbonate hydroxide monohydrate, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate and 2.4 g of ethylene glycol monostearate as bases 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, 0.28 g of sodium hydroxide, 1,000 g of 1,3-butylene glycol in purified water Zinc carbonate, zinc carbonate hydroxide and zinc carbonate monohydrate The mixture was mixed at a weight ratio of 0.00001%, and 98 g of acidic water was added to take out 1,000 g of cosmetic cream B. The mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate is about 0.091% by weight.
[00131]
[Comparative Example 11]:
(C): 1 g of tourmaline powder, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate as a base, 2.4 g of ethylene glycol monostearate, 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, sodium hydroxide 98 g of acidic water in which tourmaline was mixed at a weight ratio of 0.01% to 0.28 g and 1,000 g of 1,3-butylene glycol was added, and 1,000 g of cosmetic cream C was taken out.
[00132]
[Comparative Example 12]:
(D): 1 g of barley rice powder, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate, 2.4 g of ethylene glycol monostearate as a base, 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, hydroxylation 98 g of acidic water in which barley rice was mixed at a weight ratio of 0.01% to 0.28 g of sodium and 1,000 g of 1,3-butylene glycol was added, and 1,000 g of cosmetic cream D was taken out.
[00133]
[Comparative Example 13]:
(E): 1 g of carbon powder, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate as a base, 2.4 g of ethylene glycol monostearate, 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, sodium hydroxide 98 g of acidic water obtained by mixing carbon at a weight ratio of 0.01% to 0.28 g and 1,000 g of 1,3-butylene glycol was added, and 1,000 g of cosmetic cream E was taken out.
[00134]
[Comparative Example 14]:
(F): 1 g of seaweed ash powder, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate as a base, 2.4 g of ethylene glycol monostearate, 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, hydroxylation 98 g of acidic water obtained by mixing seaweed ash at a weight ratio of 0.01% to 0.28 g of sodium and 1,000 g of 1,3-butylene glycol was added, and 1,000 g of cosmetic cream F was taken out.
[00135]
[Comparative Example 15]:
(G): 1 g of iron oxide powder, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate as a base, 2.4 g of ethylene glycol monostearate, 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, hydroxylation 98 g of acidic water in which iron oxide was mixed at a weight ratio of 0.01% to 0.28 g of sodium and 1,000 g of 1,3-butylene glycol was added, and 1,000 g of cosmetic cream G was taken out.
[00136]
[Comparative Example 16]:
(H): 1 g of titanium oxide powder, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate as a base, 2.4 g of ethylene glycol monostearate, 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, hydroxylation 98 g of acidic water obtained by mixing 0.28 g of sodium and 1,000 g of 1,3-butylene glycol with 0.1% by weight of titanium oxide was added, and 1,000 g of cosmetic cream H was taken out.
[00137]
[Comparative Example 17]:
(I): 1 g of zinc oxide powder, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate as a base, 2.4 g of ethylene glycol monostearate, 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, hydroxylation 98 g of acidic water obtained by mixing 0.01% by weight of zinc oxide with 0.28 g of sodium and 1,000 g of 1,3-butylene glycol was added, and 1,000 g of cosmetic cream I was taken out.
[00138]
[Comparative Example 18]:
(J): 0.5 g of honey, 0.5 g of polyethylene glycol monostearate as a base, 2.4 g of ethylene glycol monostearate, 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, 0.28 g of sodium hydroxide, 98 g of distilled water was added to 1,000 g of 1,3-butylene glycol, and 1,000 g of cosmetic cream J was taken out.
[00139]
Test 1: Moisturizing test, cosmetic creams A and B of Examples 25 and 26, and cosmetic cream C, cosmetic cream D, cosmetic cream E, cosmetic cream F, cosmetic cream G, cosmetic of Comparative Examples 11 to 18 For Cream H, Makeup Cream I, and Makeup Cream J, a comparative test of the moisturizing properties of the skin and mucous membrane before and after the test was performed. Each sample was evaluated by 30 panelists (male and female 25-65 years old).
[00140]
Makeup cream A, Makeup cream B, Makeup cream C, Makeup cream D, Makeup cream E are on the inside of the left forearm, Makeup cream F, Makeup cream G, Makeup cream H, Makeup cream I, Makeup cream J are right on each paneler After 60 minutes have passed, the applied area was washed with water, and after 2 hours, measured with a 3.5 MHz high-frequency electric conductivity measuring device (SKICON200, manufactured by IBS) to measure the water content on the skin surface did. The moisturizing effect was calculated as a relative ratio (skin moisture content after test / skin moisture content before test). The higher this value, the higher the moisturizing property on the skin.
[00141]
As a result, the relative moisturizing ratio was 1.98 for makeup cream A, 1.88 for makeup cream B, 125 for makeup cream C, 1.51 for makeup cream D, 1.51 for makeup cream E, 1.07 for makeup cream F 1.53, cosmetic cream G was 1.09, cosmetic cream H was 1.13, cosmetic cream I was 1.32, and cosmetic cream J was 1.05. Therefore, it was confirmed that the cosmetic creams A and B of Examples 25 and 26 of the present invention exhibited a high moisturizing effect.
[00142]
Test 2: Antioxidant test (suppression of sebum lipid peroxide production) Cosmetic creams A and B of Examples 25 and 26 and Cosmetic cream C, Cosmetic cream D, Cosmetic cream E and Cosmetic cream F of Comparative Examples 11 to 18 , Makeup Cream G, Makeup Cream H, Makeup Cream I, and Makeup Cream J, based on the lipid peroxide production inhibitory test TBA method (Analytical, Biochemistry Vol. 95, pp. 351-358, 1979) The effect of linolenic acid on the production of peroxide was examined and measured by the following test method.
[00143]
0.1% linolenic acid is added to and dissolved in a 0.8% aqueous sodium lauryl sulfate solution, and 3.9 ml of this solution is placed in a 10 ml transparent glass screw bottle. To the glass screw bottle, 0.1 ml of cosmetic cream A was added as a specimen, and the mixture was irradiated with ultraviolet rays at a distance of 15 cm for 3 hours using an ultraviolet lamp (Model UVGL-25, manufactured by SANGABRIEL). 1 ml of a mixture of a 67% thiobarbituric acid aqueous solution and a 15% acetic acid aqueous solution (pH 3.5) is added thereto, and the mixture is heated at 95 ° C. for 1 hour.
[00144]
After cooling, add 4 ml of methanol: n-butanol (15:85), shake well, and centrifuge. Next, the absorbance at 534 nm of this n-butanol layer was measured and defined as the amount of lipid peroxide. The amount of lipid peroxide when a sample is added and irradiated with ultraviolet light is a, the amount of lipid peroxide when the sample is not irradiated with ultraviolet light is b, and purified water is added instead of the sample and irradiated with ultraviolet light. The amount of lipid peroxide in this case was defined as a ', and the amount of lipid peroxide in the case where purified water was added instead of the sample and ultraviolet light was not irradiated was defined as b'.
[00145]
Lipid peroxide production inhibition rate (%) = [1- (ab) / (a'-b ')] × 100 Further, cosmetic cream B, cosmetic cream C, cosmetic cream D, cosmetic cream E, cosmetic cream F The same operation was performed for the cosmetic cream G, the cosmetic cream H, the cosmetic cream I, and the cosmetic cream J, and the lipid peroxide production inhibition rate was calculated. As a result, the lipid peroxide production inhibition rate was 98.2% for cosmetic cream A, 96.3% for cosmetic cream B, 60.3% for cosmetic cream C, 64.6% for cosmetic cream D, and 64.6% for cosmetic cream E. 52.4%, makeup cream F is 73.9%, makeup cream G is 52.8%, makeup cream H is 51.3%, makeup cream I is 61.8%, makeup cream J is 50.8%, It became. Therefore, it was confirmed that the cosmetic creams A and B of Examples 25 and 26 of the present invention exhibited a high lipid peroxide production inhibitory action.
[00146]
Test 3: Skin roughness improvement test, cosmetic creams A and B of Examples 25 and 26, and cosmetic cream B, cosmetic cream C, cosmetic cream D, cosmetic cream E, cosmetic cream F and cosmetic of Comparative Examples 11 to 18 For the cream G, the cosmetic cream H, the cosmetic cream I, and the cosmetic cream J, a comparative test of the effect of improving the skin and mucous membrane condition before and after the test was performed.
[00147]
Each sample was evaluated by 30 panelists (male and female 25-65 years old). An appropriate amount of the test sample was applied to the facial skin and lip mucosa twice a day for two weeks for each panelist. The effect of improving skin roughness was observed with a microscope on the facial skin and lip mucosa of each paneler before and after the test. In addition, the area of the exfoliated keratin part (skin rough part) with respect to the skin area of 1 cm 2 was measured, and the degree of improvement [(initial value−measured value after two weeks) / initial value × 100] was determined from the initial value and the measured value after two weeks. Calculated and the average was calculated.
[00148]
The higher this value, the higher the degree of improvement in skin roughness on the skin and mucous membranes. As a result, the degree of improvement in skin roughness was 88.5% for makeup cream A, 87.3% for makeup cream B, 23.4% for makeup cream C, 60.5% for makeup cream D, and 23.1% for makeup cream E. %, Makeup cream F was 60.7%, makeup cream G was 23.5%, makeup cream H was 22.8%, makeup cream I was 25.4%, and makeup cream J was 20.5%. . In addition, as a result of observing the lip mucosa with a microscope, 240 panelists who applied the cosmetic creams of Comparative Control Examples 11 to 18 showed no change, and 60 panelists who applied the cosmetic creams of Examples 25 and 26 had Apparently, the roughness of the buccal skin and mucous membrane of the lips had been improved.
[00149]
Therefore, it was confirmed that the creams A and B, which are Examples 25 and 26 of the invention claimed in the present application, show a high skin roughness suppressing action. According to the above-mentioned moisturizing test, antioxidant test and skin roughness improvement test, a mixture of zinc carbonate, zinc carbonate hydroxide and zinc carbonate monohydrate dissolved and used was mixed with powder. Cosmetic cream B containing a powder of a mixture of makeup cream A, zinc carbonate, zinc carbonate hydroxide and zinc carbonate hydroxide monohydrate is made up of tourmaline powder, malt stone powder, carbon powder, seaweed ash powder, iron oxide powder, Clearly higher antioxidant properties (suppression of generation of sebum lipid peroxide) and moisturizing properties of the skin compared to each of the cosmetic creams (CI) containing titanium oxide powder and the cosmetic creams (J) not containing any. Was done.
[00150]
Also in Comparative Test 3, the cosmetic creams A and B clearly showed higher exfoliation of the skin and improved lip mucosa than the cosmetic creams (C to J), and a high effect of suppressing rough skin was confirmed. .
[00151]
[Example 27]
1 g of a mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate, 0.5 g of honey, 0.5 g of sodium hyaluronate as a base, 4.00 g of 1,3-butylene glycol, polyoxymonooleate 94 g of purified water was added to 1.0 g of ethylene sorbitan, 0.10 g of d1-pyrrolidone carboxylic acid, and 1,000 g of sodium d1-pyrrolidone carboxylate, and 1,000 g of lotion was taken out. The mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate is about 0.091% by weight.
[00152]
The same moisturizing test, antioxidant test, and rough skin improvement test as in Tests 1, 2 and 3 were evaluated by 30 panelists (male and female, 25 to 65 years old). As a result, high moisture retention and high antioxidant properties were confirmed. In addition, high exfoliation of the skin and improvement of the mucous membrane of the lips were confirmed, and a high effect of suppressing rough skin was confirmed.
[00153]
(Example 28)
1 g of a mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate, 0.1 g of honey, 5.00 g of 1,3-butylene glycol as a base, 0.3 g of xanthan gum, 1,000 g of soybean lysophospholipid liquid , 1,000 g of stearic acid, 0.5 g of lavender oil, 0.10 g of d1-pyrrolidone carboxylic acid, and 1,000 g of sodium d1-pyrrolidone carboxylate were added with 92 g of purified water to take out 1,000 g of an emulsion. The mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate is about 0.032% by weight.
[00154]
The emulsion was evaluated in the same manner as in Tests 1, 2, and 3 by the moisture retention test, the antioxidant test, and the skin roughness improvement test by 30 panelists (males 25 to 65 years old). As a result, high moisture retention and high antioxidant properties were confirmed. In addition, high exfoliation of the skin and improvement of the mucous membrane of the lips were confirmed, and a high effect of suppressing rough skin was confirmed.
[00155]
[Example 29]
1 g of a mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate, 0.1 g of honey, 0.30 g of sodium hyaluronate as a base, 0.50 g of polyoxyethylene hydrogenated castor oil, 1,3-butylene 88 g of purified water was added to 1,000 g of glycol, 0.5 g of lavender oil, 0.10 g of d1-pyrrolidone carboxylic acid, and 1,000 g of sodium d1-pyrrolidone carboxylate to take out 1,000 g of cosmetic essence. The mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate is about 0.048% by weight.
[00156]
For this cosmetic essence, 30 panelists (male and female aged 25 to 65) evaluated the same moisturizing test, antioxidant test, and rough skin improvement test as in Tests 1, 2, and 3. As a result, high moisture retention and high antioxidant properties were confirmed. In addition, high exfoliation of the skin and improvement of the mucous membrane of the lips were confirmed, and a high effect of suppressing rough skin was confirmed.
[00157]
[Example 30]
100 g of a mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate, 0.1 g of honey, 4.0 g of stearic acid as a base, 3.0 g of glyceryl monostearate, 98 g of isopropyl myristate, and liquid paraffin 1 2,000 g, salami beeswax 3.0 g, kaolin 3.0 g, talc 1.0 g, coloring pigment 1.0 g, triethanolamine 3.0 g, glycerin 3.0 g, bentonite 1.0 g, preservative appropriate amount, perfume appropriate amount and purification Water was added to take out 1,000 g of the foundation. The mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate is about 8.9% by weight.
[00158]
The same moisturizing test, antioxidant test, and skin roughness improvement test as in Tests 1, 2, and 3 were evaluated by 30 panelists (male and female, 25 to 65 years old). As a result, high moisture retention and high antioxidant properties were confirmed. In addition, high exfoliation of the skin and improvement of the mucous membrane of the lips were confirmed, and a high effect of suppressing rough skin was confirmed.
[00159]
[Example 31]
4. 1 g of a mixture of zinc carbonate, zinc carbonate and zinc carbonate monohydrate, 0.5 g of honey, 0.5 g of polyethylene glycol monostearate, 2.4 g of ethylene glycol monostearate as a base, and macadamia nut oil 98 g of purified water was added to 0 g, 0.7 g of carboxyvinyl polymer, 0.28 g of sodium hydroxide, and 1,000 g of 1,3-butylene glycol, and 1,000 g of a cosmetic cream was taken out. The mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate is about 0.091% by weight.
[00160]
This cosmetic cream was evaluated in the same manner as in Tests 1, 2, and 3 by the moisture retention test, the antioxidant test, and the skin roughness improvement test by 30 panelists (male and female, 25 to 65 years old). As a result, high moisture retention and high antioxidant properties were confirmed. In addition, high exfoliation of the skin and improvement of the mucous membrane of the lips were confirmed, and a high effect of suppressing rough skin was confirmed.
[00161]
[Example 32]
Purified water was added to 1 g of a mixture of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide monohydrate, 60.0 g of sodium hydrogen carbonate, 32.0 g of anhydrous sodium sulfate, and 3.0 g of borax to make 1,000 g. A bath agent was obtained. The mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate is about 0.091% by weight.
[00162]
Using this bath agent, a skin roughness improvement test described in Test Example 3 was conducted for a person with rough skin. That is, as a rule, 20 g of the bath agent was dissolved at the time of bathing once a week for one week without using other bath agents, and the degree of improvement of the exfoliated keratin portion before and after the test was evaluated by 30 panelists (male and female, 25 to 65 years old). evaluated. As a result, high exfoliation of the skin and improvement of the lip mucosa were confirmed, and a high skin roughness suppressing effect was confirmed.
[00163]
(Example 33)
1 g of a mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate, 0.5 g of honey, 5.0 g of macadamia nut oil, 0.28 g of sodium hydroxide, 0.5 g of xylit, 1 g of sodium chloride, 0 g of potassium chloride Purified water (98 g) was added to 0.5 g, 30 g of urea, and 1,000 g of palm kernel oil, and 1,000 g of cosmetic oil was taken out. The mixture of zinc carbonate, zinc carbonate hydroxide and zinc carbonate hydroxide monohydrate is about 0.088% by weight.
[00164]
[Comparative Example 19]: Same as Example 33 except that 1 g of a mixture of tourmaline, zinc oxide and titanium oxide was used instead of 1 g of a mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate. A cosmetic oil of Comparative Example 19 was produced. Using this as a control, a comparative test 4 by the following efficacy test was performed. Table 2 shows the results.
[00165]
The efficacy test of the cosmetic of the invention claimed in the present application was carried out for 12 months for a total of 100 persons, each of which was randomly selected from 125 adult men and women suffering from dry skin, rough hands, atopic skin and mucositis, and dandruff for a total of 12 persons. Carried out. The remaining 25 people served as controls. The results of the efficacy test are shown in Table 2, and the control is shown in Table 3.
[00166]
Table 2 (testers: 100) The numbers in the table indicate the number of cured patients
[Table 2]

[00167]
Table 3 (control: 25) The numbers in the table indicate the number of cured patients
[Table 3]

[00168]
It should be noted that the present invention is not limited to the above embodiment, but may be modified. For example, it can be used as in Example 34 shown below.
[00169]
(Example 34)
Without using 1 g of a mixture of zinc carbonate and zinc carbonate monohydrate of Example 31 and 98 g of purified water, 20 g of zinc was dissolved in 1,000 g of a 20% by weight aqueous hydrochloric acid solution, and 5% by weight was dissolved therein. And stirred. The solution is neutralized with 20% by weight of sodium hydroxide to a pH of about 7.2, and an aqueous solution containing zinc ions, carbonate ions, hydroxyl groups, sodium ions, and chloride ions is formed in the solution, and 0.5 g of honey and base are prepared. Purified to 0.5 g of polyethylene glycol monostearate, 2.4 g of ethylene glycol monostearate, 5.0 g of macadamia nut oil, 0.7 g of carboxyvinyl polymer, 0.28 g of sodium hydroxide, and 1,000 g of 1,3-butylene glycol 98 g of the above aqueous solution was added instead of water 98 g, and 1,000 g of a cosmetic cream was taken out in the same manner as in Example 31.
[00170]
This cosmetic cream was evaluated in the same manner as in Tests 1, 2, and 3 by the moisture retention test, the antioxidant test, and the skin roughness improvement test by 30 panelists (male and female, 25 to 65 years old). As a result, although not as great as the mixture of zinc carbonate, zinc hydroxide and zinc carbonate monohydrate used in Example 31, the moisture retention and antioxidant properties were confirmed. In addition, the exfoliation of the skin and the improvement of the mucous membrane of the lips were confirmed, and the effect of suppressing skin roughness was confirmed.
However, the skin irritation was stronger than the mixture of zinc carbonate, zinc carbonate hydroxide and zinc carbonate monohydrate used in Example 31.
[00171]
Next, technical ideas that can be grasped from the embodiment will be described below.
Compositions, cosmetics, quasi-drugs, such as cleaning cosmetics, hair cosmetics, which are applied and adhered to the human body, characterized by containing at least one of zinc carbonate, zinc carbonated hydroxide, and zinc carbonated hydroxide hydrate. Basic cosmetics, make-up cosmetics, aromatic cosmetics, tanning cosmetics, sunscreen cosmetics, nail cosmetics, eyeliner cosmetics, lip cosmetics, oral cosmetics, and bath cosmetics.
[00172]
Specifically, cleansing, soap, liquid body washing, cosmetics for shampoo, shampoo, rinse, hair lotion, hair essence, hair cream, hair treatment, hair coloring agent, hair finishing cosmetics, hair restorer, lotion, Essences, cosmetic creams, emulsions, packs, gels, masks, essences, body lotions, body creams, shaving cosmetics, hand care agents, foundations, cheek makeup, perfumes, colons, sunscreens, sun care products, nails In treatments, manicures, nail polish, eye makeup bases, eye makeup, lip makeup, lipsticks, dentifrices, mouthwashes, bath preparations, etc., the effect of suppressing skin roughness was exhibited by moisturizing properties and antioxidant properties.
[00173]
【The invention's effect】
As described above, the cosmetic according to the present invention can efficiently ingest the zinc element indispensable for life activity by skin absorption and mucous membrane absorption, thereby maintaining and restoring the original homeostasis of skin and mucous membranes. For improving pigmentation disorders such as spots and freckles, delaying aging phenomena such as dullness, wrinkles, sagging, and hair loss, as well as rough skin, dry skin, acne, mushrooms, rash, allergies, atopic dermatitis and mucositis It was able to exert a remarkable effect in improving symptoms such as inflammation, preventing tooth decay, marginal periodontitis, etc., and alleviating sweat rash, stiff shoulder, neuralgia, coldness and the like.
[00174]
That is, the cosmetic of the present invention containing at least one of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate has a very small cluster size of water molecules in the outer periphery of water surrounding zinc ions. The composition, cosmetics, and quasi-drugs to be applied to and adhered to the human body according to the invention claimed in the present application were able to obtain the effect of excellent skin absorption and mucosal absorption.
[00175]
In particular, as described above, the composition, cosmetics, and quasi-drug to be applied and adhered to the human body according to the claimed invention contains zinc carbonate, zinc carbonate hydroxide, zinc carbonate hydroxide hydrate as a zinc component. However, zinc used from at least one of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate has been carbonated and carbonated and oxidized. On the other hand, it has a particularly remarkable effect such as exhibiting a reducing action.
[00176]
In addition, the composition of the invention claimed in the present application, applied to and adhered to the human body, cosmetics, imparts a bactericidal and antiseptic action by quasi-drugs, and exhibits zinc carbonate, zinc hydroxide hydroxide, and zinc carbonate hydroxide hydrate. The reducing power exerts an action (antioxidant action) of preventing other active ingredients, for example, ascorbic acid and the like, which are blended in the composition, cosmetics and quasi-drugs to be applied and adhered to the human body, from being oxidized. Because it can be applied to the human body of the claimed invention, the composition to be adhered, cosmetics, in quasi-drugs, as a result of being able to reduce the amount of antibacterial agents and preservatives, or antioxidants and the like, The compositions, cosmetics, and quasi-drugs to be applied and adhered to the human body according to the invention of the claimed invention could be the compositions, cosmetics, and quasi-drugs to be applied and adhered to the human body with very little skin or mucous membrane irritation.
[00177]
According to the invention claimed in the present application, an ideal environment (media) that does not become a foreign substance (allergen) on the surface and the inner surface of the skin and mucous membrane is provided, and the skin and mucous membranes including the epidermis are balanced and damaged. Injured cells could be activated normally.
[00178]
Compositions, cosmetics and quasi-drugs to be applied to and adhered to the human body according to the claimed invention of the present invention reduce acid-base imbalance in and out of skin and mucous membrane cells, improve cell balance, and improve neurotransmitters. A composition, cosmetic, and quasi-drug that is applied and adhered to an ideal human body that promotes secretion, regulates and controls blood flow in the dermis, and produces and proliferates healthy skin and mucous membrane cells while controlling secretion. Relieves skin, atopic dermatitis and mucositis, dandruff, pigmentation (stain), pruritus (kayumi), redness (red face), etc., regardless of the user's age, gender, race, physical condition, It can be effective in whitening, eliminating freckles, and suppressing skin roughness. Also, depending on the amount used, it was possible to achieve both the feeling of use and the effect of the composition, cosmetics, and quasi-drugs to be surely applied and adhered to the human body.

Claims (5)

A composition to be applied to and adhered to a human body, characterized in that the composition base and solvent to be applied and adhered to the human body contain at least one of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate. 2. The composition according to claim 1, wherein the composition comprises 0.00000001 to 98% by weight of zinc carbonate, zinc carbonate hydroxide, and zinc carbonate hydroxide hydrate based on the total weight. 2. The human body according to claim 1, wherein said zinc carbonate, zinc carbonate hydroxide, or zinc carbonate hydroxide hydrate contains 0.0000001 to 98% by weight of the total weight of the total, The composition to be deposited. The composition applied to and adhered to a human body according to any one of claims 1 to 3, wherein the composition applied to and adhered to the human body is a cosmetic. The composition applied to and adhered to a human body according to any one of claims 1 to 3, wherein the composition applied to and adhered to the human body is a quasi-drug.