JP2004248675A5 - - Google Patents

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Publication number
JP2004248675A5
JP2004248675A5 JP2004087151A JP2004087151A JP2004248675A5 JP 2004248675 A5 JP2004248675 A5 JP 2004248675A5 JP 2004087151 A JP2004087151 A JP 2004087151A JP 2004087151 A JP2004087151 A JP 2004087151A JP 2004248675 A5 JP2004248675 A5 JP 2004248675A5
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JP
Japan
Prior art keywords
substrate
enzyme
mutant
orthogonal
accepts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2004087151A
Other languages
English (en)
Japanese (ja)
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JP2004248675A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2004248675A publication Critical patent/JP2004248675A/ja
Publication of JP2004248675A5 publication Critical patent/JP2004248675A5/ja
Withdrawn legal-status Critical Current

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JP2004087151A 1997-02-07 2004-03-24 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ Withdrawn JP2004248675A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79752297A 1997-02-07 1997-02-07
US4672797P 1997-05-16 1997-05-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP53499998A Division JP3784076B2 (ja) 1997-02-07 1998-02-09 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ

Publications (2)

Publication Number Publication Date
JP2004248675A JP2004248675A (ja) 2004-09-09
JP2004248675A5 true JP2004248675A5 (enExample) 2005-07-28

Family

ID=26724237

Family Applications (2)

Application Number Title Priority Date Filing Date
JP53499998A Expired - Fee Related JP3784076B2 (ja) 1997-02-07 1998-02-09 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ
JP2004087151A Withdrawn JP2004248675A (ja) 1997-02-07 2004-03-24 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP53499998A Expired - Fee Related JP3784076B2 (ja) 1997-02-07 1998-02-09 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ

Country Status (8)

Country Link
US (5) US6390821B1 (enExample)
EP (1) EP1017823B1 (enExample)
JP (2) JP3784076B2 (enExample)
AT (1) ATE271130T1 (enExample)
AU (1) AU755062B2 (enExample)
CA (1) CA2279846C (enExample)
DE (1) DE69825066T2 (enExample)
WO (1) WO1998035048A2 (enExample)

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JP3784076B2 (ja) 1997-02-07 2006-06-07 プリンストン ユニヴァーシティ 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ
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EP1435957B1 (en) 2001-04-30 2009-06-17 Vertex Pharmaceuticals Incorporated Inhibitors of gsk-3 and crystal structures of gsk-3beta protein and protein complexes
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WO2003105723A2 (en) * 2002-06-14 2003-12-24 The Salk Institute For Biological Studies Mutant plant caffeic acid/5-hydroxyferulic acid 3/5-0-methyltransferases (comt), methods for preparation and use thereof
WO2004024082A2 (en) * 2002-09-13 2004-03-25 Irm, Llc Highly specific modulators of gtpases for target validation
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US7429596B2 (en) * 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
JP2007502772A (ja) 2003-08-15 2007-02-15 メルク エンド カムパニー インコーポレーテッド 4−シクロアルキルアミノピラゾロピリミジンnmda/nr2b拮抗薬
EP2283811A1 (en) * 2004-10-19 2011-02-16 Krka Tovarna Zdravil, D.D., Novo Mesto Solid pharmaceutical composition comprising donepezil hydrochloride
JP2008520744A (ja) * 2004-11-19 2008-06-19 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 抗炎症性ピラゾロピリミジン
WO2007044932A2 (en) * 2005-10-13 2007-04-19 Activesite Pharmaceuticals Methods for indentification of inhibitors of enzyme activity
KR20130087054A (ko) * 2006-04-04 2013-08-05 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 키나제 길항물질
US7890417B2 (en) * 2007-01-31 2011-02-15 Bids Trading, L.P. Electronic block trading system and method of operation
WO2009046448A1 (en) * 2007-10-04 2009-04-09 Intellikine, Inc. Chemical entities and therapeutic uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
MX358640B (es) 2008-01-04 2018-08-29 Intellikine Llc Isoquinolin-1 (2h) -onas y tieno [2,3-d]pirimidin-4(3h) -onas substituidas, y metodos de uso de las mismas.
WO2009102867A1 (en) * 2008-02-12 2009-08-20 Bids Trading, L.P. Real-time portfolio balancing and/or optimization system and method
JP5547099B2 (ja) 2008-03-14 2014-07-09 インテリカイン, エルエルシー キナーゼ阻害剤および使用方法
WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
WO2010006072A2 (en) 2008-07-08 2010-01-14 The Regents Of The University Of California Mtor modulators and uses thereof
US9096611B2 (en) 2008-07-08 2015-08-04 Intellikine Llc Kinase inhibitors and methods of use
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
JP5819195B2 (ja) 2008-10-16 2015-11-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 融合環ヘテロアリールキナーゼ阻害剤
US8476431B2 (en) * 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン, エルエルシー 複素環式化合物およびその使用
HRP20190016T1 (hr) 2009-08-17 2019-03-08 Intellikine, Llc Heterociklički spojevi i njihova upotreba
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
EP2571357B1 (en) 2010-05-21 2016-07-06 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
TWI546305B (zh) 2011-01-10 2016-08-21 英菲尼提製藥股份有限公司 製備異喹啉酮之方法及異喹啉酮之固體形式
EP2678018A4 (en) 2011-02-23 2015-09-30 Intellikine Llc COMBINATION OF CHINESE HEMMER AND USES THEREOF
WO2013012918A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
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MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
RU2015115631A (ru) 2012-09-26 2016-11-20 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Модулирование ire1
CN105102000B (zh) 2012-11-01 2021-10-22 无限药品公司 使用pi3激酶亚型调节剂的癌症疗法
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US9724354B2 (en) 2013-03-22 2017-08-08 Millennium Pharmaceuticals, Inc. Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase
US10769725B1 (en) 2013-06-05 2020-09-08 Bids Trading, L.P. System and methods for optimizing the effectiveness of interaction between participants in an electronic trading environment
MX389256B (es) 2013-10-04 2025-03-20 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EA201691872A1 (ru) 2014-03-19 2017-04-28 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств
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WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN108349985A (zh) 2015-09-14 2018-07-31 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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EP3801069A4 (en) 2018-06-01 2022-03-16 Cornell University MULTIPLE THERAPY FOR DISEASE OR DISORDER ASSOCIATED WITH PI3K
US20230121698A1 (en) * 2019-12-23 2023-04-20 Sanford Burnham Prebys Medical Discovery Institute Ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1) modulators and uses thereof
US12215108B2 (en) 2022-01-10 2025-02-04 Southern Research Institute Development of potential antidotes for arsenicals

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US5620676A (en) * 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs
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US5593997A (en) 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
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JP3784076B2 (ja) * 1997-02-07 2006-06-07 プリンストン ユニヴァーシティ 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ
US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
US6162613A (en) 1998-02-18 2000-12-19 Vertex Pharmaceuticals, Inc. Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
US5965352A (en) 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
DE1140938T1 (de) 1999-01-11 2003-01-09 Princeton University, Princeton Kinase-inhibitoren mit hoher affinität zur ziel detektion und ihre verwendung
US6610483B1 (en) 1999-07-23 2003-08-26 Princeton University Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof

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