JP2004248675A5 - - Google Patents

Download PDF

Info

Publication number
JP2004248675A5
JP2004248675A5 JP2004087151A JP2004087151A JP2004248675A5 JP 2004248675 A5 JP2004248675 A5 JP 2004248675A5 JP 2004087151 A JP2004087151 A JP 2004087151A JP 2004087151 A JP2004087151 A JP 2004087151A JP 2004248675 A5 JP2004248675 A5 JP 2004248675A5
Authority
JP
Japan
Prior art keywords
substrate
enzyme
mutant
orthogonal
accepts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2004087151A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004248675A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2004248675A publication Critical patent/JP2004248675A/ja
Publication of JP2004248675A5 publication Critical patent/JP2004248675A5/ja
Withdrawn legal-status Critical Current

Links

JP2004087151A 1997-02-07 2004-03-24 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ Withdrawn JP2004248675A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79752297A 1997-02-07 1997-02-07
US4672797P 1997-05-16 1997-05-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP53499998A Division JP3784076B2 (ja) 1997-02-07 1998-02-09 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ

Publications (2)

Publication Number Publication Date
JP2004248675A JP2004248675A (ja) 2004-09-09
JP2004248675A5 true JP2004248675A5 (enExample) 2005-07-28

Family

ID=26724237

Family Applications (2)

Application Number Title Priority Date Filing Date
JP53499998A Expired - Fee Related JP3784076B2 (ja) 1997-02-07 1998-02-09 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ
JP2004087151A Withdrawn JP2004248675A (ja) 1997-02-07 2004-03-24 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP53499998A Expired - Fee Related JP3784076B2 (ja) 1997-02-07 1998-02-09 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ

Country Status (8)

Country Link
US (5) US6390821B1 (enExample)
EP (1) EP1017823B1 (enExample)
JP (2) JP3784076B2 (enExample)
AT (1) ATE271130T1 (enExample)
AU (1) AU755062B2 (enExample)
CA (1) CA2279846C (enExample)
DE (1) DE69825066T2 (enExample)
WO (1) WO1998035048A2 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035048A2 (en) * 1997-02-07 1998-08-13 Princeton University Engineered protein kinases which can utilize modified nucleotide triphosphate substrates
US6162613A (en) 1998-02-18 2000-12-19 Vertex Pharmaceuticals, Inc. Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
US7383135B1 (en) 1998-05-04 2008-06-03 Vertex Pharmaceuticals Incorporated Methods of designing inhibitors for JNK kinases
US6610483B1 (en) * 1999-07-23 2003-08-26 Princeton University Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof
DE10024174A1 (de) * 2000-05-17 2001-11-29 Gsf Forschungszentrum Umwelt Verfahren zum Selektieren von Inhibitoren für Enzyme
WO2002018604A2 (en) * 2000-08-30 2002-03-07 The Salk Institute For Biological Studies Methods and compositions for determining isomerase enzymatic activity
AU2002245133A1 (en) * 2000-12-15 2002-07-30 The Salk Institute For Biological Studies Methods of producing polyketide synthase mutants and compositions and uses thereof
CA2444882A1 (en) 2001-04-30 2002-11-07 Vertex Pharmaceuticals Incorporated Inhibitors of gsk-3 and crystal structures of gsk-3.beta. protein and protein complexes
US20060263800A1 (en) * 2001-11-01 2006-11-23 Princeton University Engineered protein kinases which can utilize modified nucleotide triphosphate substrates
WO2003105723A2 (en) * 2002-06-14 2003-12-24 The Salk Institute For Biological Studies Mutant plant caffeic acid/5-hydroxyferulic acid 3/5-0-methyltransferases (comt), methods for preparation and use thereof
AU2003267145A1 (en) * 2002-09-13 2004-04-30 Irm, Llc Highly specific modulators of gtpases for target validation
US7425547B2 (en) * 2002-09-30 2008-09-16 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
US7429596B2 (en) * 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
EP1656379B1 (en) 2003-08-15 2007-01-10 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
EA012220B1 (ru) * 2004-10-19 2009-08-28 Крка, Товарна Здравил, Д. Д., Ново Место Твёрдая фармацевтическая композиция, содержащая донепезила гидрохлорид
EP1831225A2 (en) * 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
US20090215080A1 (en) * 2005-10-13 2009-08-27 Activesite Pharmaceuticals Methods for identification of inhibitors of enzyme activity
EA200870409A1 (ru) * 2006-04-04 2009-04-28 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Антагонисты киназы pi3
WO2008095140A1 (en) * 2007-01-31 2008-08-07 Bids Trading, L.P. Electronic block trading system and method of operation
GB2467670B (en) * 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
CA2711558C (en) 2008-01-04 2016-12-13 Intellikine, Inc. Phosphatidyl inositol-3 kinase inhibiting compounds
WO2009102867A1 (en) * 2008-02-12 2009-08-20 Bids Trading, L.P. Real-time portfolio balancing and/or optimization system and method
JP5547099B2 (ja) 2008-03-14 2014-07-09 インテリカイン， エルエルシー キナーゼ阻害剤および使用方法
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
WO2010006072A2 (en) 2008-07-08 2010-01-14 The Regents Of The University Of California Mtor modulators and uses thereof
AU2009268611B2 (en) 2008-07-08 2015-04-09 Intellikine, Llc Kinase inhibitors and methods of use
JP5731978B2 (ja) 2008-09-26 2015-06-10 インテリカイン， エルエルシー 複素環キナーゼ阻害剤
CA2740885C (en) 2008-10-16 2018-04-03 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476282B2 (en) * 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
EP2427195B1 (en) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclic compounds and uses thereof
MY162604A (en) 2009-08-17 2017-06-30 Intellikine Llc Heterocyclic compounds and uses thereof
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
AU2011255218B2 (en) 2010-05-21 2015-03-12 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
AU2012205669B2 (en) 2011-01-10 2015-08-20 Infinity Pharmaceuticals Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
US9056877B2 (en) 2011-07-19 2015-06-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP6027610B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
EP2751093A1 (en) 2011-08-29 2014-07-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
MX2015003874A (es) 2012-09-26 2015-12-16 Univ California Modulacion de ire1.
KR102229478B1 (ko) 2012-11-01 2021-03-18 인피니티 파마슈티칼스, 인코포레이티드 Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2014153509A1 (en) 2013-03-22 2014-09-25 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
US10769725B1 (en) 2013-06-05 2020-09-08 Bids Trading, L.P. System and methods for optimizing the effectiveness of interaction between participants in an electronic trading environment
PE20160685A1 (es) 2013-10-04 2016-07-23 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
SG10201808053XA (en) 2014-03-19 2018-10-30 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10160761B2 (en) 2015-09-14 2018-12-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX391135B (es) 2016-06-24 2025-03-21 Infinity Pharmaceuticals Inc Terapias de combinacion.
CN113194752A (zh) 2018-06-01 2021-07-30 康奈尔大学 Pi3k相关疾病或病症的组合疗法
CN115151550B (zh) * 2019-12-23 2024-11-22 桑福德·伯纳姆·普雷比医学发现研究所 外核苷酸焦磷酸酶/磷酸二酯酶1(enpp1)调节剂及其用途
US20230417751A1 (en) * 2021-05-13 2023-12-28 Texas Tech University System Analysis of protein kinases in live cells
US12215108B2 (en) 2022-01-10 2025-02-04 Southern Research Institute Development of potential antidotes for arsenicals

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5352660A (en) 1991-10-31 1994-10-04 Mount Sinai Hospital Corporation Method for assaying for a substance that affects a SH2-phosphorylated ligand regulatory system
US5443962A (en) 1993-06-04 1995-08-22 Mitotix, Inc. Methods of identifying inhibitors of cdc25 phosphatase
US5620676A (en) * 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs
US5731343A (en) 1995-02-24 1998-03-24 The Scripps Research Institute Method of use of radicicol for treatment of immunopathological disorders
US5593997A (en) 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
US5914393A (en) * 1995-12-05 1999-06-22 Incyte Pharmaceuticals, Inc. Human Jak2 kinase
ES2239779T3 (es) 1996-10-02 2005-10-01 Novartis Ag Derivados de pirimidina y procedimientos para la preparacion de los mismos.
WO1998035048A2 (en) 1997-02-07 1998-08-13 Princeton University Engineered protein kinases which can utilize modified nucleotide triphosphate substrates
US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
US6162613A (en) 1998-02-18 2000-12-19 Vertex Pharmaceuticals, Inc. Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
US5965352A (en) 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
DK1140938T3 (da) 1999-01-11 2003-12-22 Univ Princeton Højaffinitetsinhibitorer for målvalidering og anvendelser heraf
US6610483B1 (en) 1999-07-23 2003-08-26 Princeton University Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof

Similar Documents

Publication Publication Date Title
USD961778S1 (en) Analyte sensor device
USD782697S1 (en) Rail
USD623041S1 (en) Hinge
USD542236S1 (en) Hand held device key set
USD555657S1 (en) Monitor support arm
USD580044S1 (en) Ceiling fan blade
USD545422S1 (en) Ceiling fan
USD779313S1 (en) Cushion clip
USD627193S1 (en) Cooking container with ornamentation
USD613356S1 (en) Ball
USD569976S1 (en) Stent
USD590617S1 (en) Perch for sitting
JP2006524283A5 (enExample)
USD541601S1 (en) Utility portion of culinary whisk
USD646319S1 (en) Bottle trumpet
USD600442S1 (en) Sling
JP2007522873A5 (enExample)
USD539676S1 (en) LCD wall-mounted touchscreen with rotary encoder wheel
USD569757S1 (en) Gemstone
USD557949S1 (en) Armrest
USD591007S1 (en) Panel member for a feeder assembly
USD532296S1 (en) Full round non-hollow point shaped overcap
AU301460S (en) Clip-operator and upper shaft portion of a writing instrument
USD522390S1 (en) Stud tape
USD585501S1 (en) Puzzle