JP2004248675A5 - - Google Patents

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Publication number
JP2004248675A5
JP2004248675A5 JP2004087151A JP2004087151A JP2004248675A5 JP 2004248675 A5 JP2004248675 A5 JP 2004248675A5 JP 2004087151 A JP2004087151 A JP 2004087151A JP 2004087151 A JP2004087151 A JP 2004087151A JP 2004248675 A5 JP2004248675 A5 JP 2004248675A5
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JP
Japan
Prior art keywords
substrate
enzyme
mutant
orthogonal
accepts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2004087151A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004248675A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2004248675A publication Critical patent/JP2004248675A/ja
Publication of JP2004248675A5 publication Critical patent/JP2004248675A5/ja
Withdrawn legal-status Critical Current

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JP2004087151A 1997-02-07 2004-03-24 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ Withdrawn JP2004248675A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79752297A 1997-02-07 1997-02-07
US4672797P 1997-05-16 1997-05-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP53499998A Division JP3784076B2 (ja) 1997-02-07 1998-02-09 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ

Publications (2)

Publication Number Publication Date
JP2004248675A JP2004248675A (ja) 2004-09-09
JP2004248675A5 true JP2004248675A5 (enExample) 2005-07-28

Family

ID=26724237

Family Applications (2)

Application Number Title Priority Date Filing Date
JP53499998A Expired - Fee Related JP3784076B2 (ja) 1997-02-07 1998-02-09 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ
JP2004087151A Withdrawn JP2004248675A (ja) 1997-02-07 2004-03-24 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP53499998A Expired - Fee Related JP3784076B2 (ja) 1997-02-07 1998-02-09 変性ヌクレオチド三燐酸基質を利用できる組み換えタンパクキナーゼ

Country Status (8)

Country Link
US (5) US6390821B1 (enExample)
EP (1) EP1017823B1 (enExample)
JP (2) JP3784076B2 (enExample)
AT (1) ATE271130T1 (enExample)
AU (1) AU755062B2 (enExample)
CA (1) CA2279846C (enExample)
DE (1) DE69825066T2 (enExample)
WO (1) WO1998035048A2 (enExample)

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AU2002245133A1 (en) * 2000-12-15 2002-07-30 The Salk Institute For Biological Studies Methods of producing polyketide synthase mutants and compositions and uses thereof
ATE433751T1 (de) 2001-04-30 2009-07-15 Vertex Pharma Inhibitoren von gsk-3 und kristallstrukturen von gsk-3beta-protein und -proteinkomplexen
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AU2003267145A1 (en) * 2002-09-13 2004-04-30 Irm, Llc Highly specific modulators of gtpases for target validation
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US7429596B2 (en) * 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
AU2004266227A1 (en) 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine NMDA/NR2B antagonists
PT1811957E (pt) * 2004-10-19 2009-01-27 Krka Tovarna Zdravil D D Novo Composição farmacêutica sólida contendo cloridrato de donepezil
WO2006068760A2 (en) * 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
US20090215080A1 (en) * 2005-10-13 2009-08-27 Activesite Pharmaceuticals Methods for identification of inhibitors of enzyme activity
KR20120051760A (ko) * 2006-04-04 2012-05-22 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 키나제 길항물질
WO2008095140A1 (en) * 2007-01-31 2008-08-07 Bids Trading, L.P. Electronic block trading system and method of operation
US20110160232A1 (en) * 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
SG187426A1 (en) 2008-01-04 2013-02-28 Intellikine Llc Certain chemical entities, compositions and methods
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8065217B2 (en) * 2008-02-12 2011-11-22 Bids Trading, L.P. Real-time portfolio balancing and/or optimization system and method
WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
WO2010006072A2 (en) * 2008-07-08 2010-01-14 The Regents Of The University Of California Mtor modulators and uses thereof
CA2730106A1 (en) 2008-07-08 2010-01-14 Intellikine, Inc. Kinase inhibitors and methods of use
EP2346508B1 (en) 2008-09-26 2016-08-24 Intellikine, LLC Heterocyclic kinase inhibitors
ES2570429T3 (es) 2008-10-16 2016-05-18 Univ California Inhibidores de heteroaril quinasa de anillo condensado
US8476282B2 (en) 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
CA2760791C (en) 2009-05-07 2017-06-20 Intellikine, Inc. Heterocyclic compounds and uses thereof
JP5819831B2 (ja) 2009-08-17 2015-11-24 インテリカイン, エルエルシー 複素環式化合物およびそれらの使用
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
CA2799579A1 (en) 2010-05-21 2011-11-24 Intellikine, Inc. Chemical compounds, compositions and methods for kinase modulation
EP2637669A4 (en) 2010-11-10 2014-04-02 Infinity Pharmaceuticals Inc Heterocyclic compounds and their use
EP3238722B1 (en) 2011-01-10 2019-03-13 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones
AR085397A1 (es) 2011-02-23 2013-09-25 Intellikine Inc Combinacion de inhibidores de quinasa y sus usos
JP6027610B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ, インコーポレイテッド 複素環式化合物及びその使用
CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CN103998442B (zh) 2011-08-29 2016-09-14 无限药品股份有限公司 杂环化合物及其用途
AU2012341028C1 (en) 2011-09-02 2017-10-19 Mount Sinai School Of Medicine Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
SG11201502331RA (en) 2012-09-26 2015-04-29 Univ California Modulation of ire1
EP2914296B2 (en) 2012-11-01 2021-09-29 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
CA2907726A1 (en) 2013-03-22 2014-09-25 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc1/2 inhibitors and selective inhibitors of aurora a kinase
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UA121104C2 (uk) 2013-10-04 2020-04-10 Інфініті Фармасьютикалз, Інк. Гетероциклічні сполуки і їх застосування
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CN114230571B (zh) 2015-09-14 2025-07-08 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US11147818B2 (en) 2016-06-24 2021-10-19 Infinity Pharmaceuticals, Inc. Combination therapies
CN113194752A (zh) 2018-06-01 2021-07-30 康奈尔大学 Pi3k相关疾病或病症的组合疗法
AU2020412779A1 (en) * 2019-12-23 2022-06-23 Sanford Burnham Prebys Medical Discovery Institute Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) modulators and uses thereof
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US5593997A (en) 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
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AU720135B2 (en) 1996-10-02 2000-05-25 Novartis Ag Pyrimidine derivatives and processes for the preparation thereof
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US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
US6162613A (en) 1998-02-18 2000-12-19 Vertex Pharmaceuticals, Inc. Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
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US6610483B1 (en) 1999-07-23 2003-08-26 Princeton University Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof

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