JP2004168749A - 血液流動性改善剤 - Google Patents
血液流動性改善剤 Download PDFInfo
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- JP2004168749A JP2004168749A JP2003309524A JP2003309524A JP2004168749A JP 2004168749 A JP2004168749 A JP 2004168749A JP 2003309524 A JP2003309524 A JP 2003309524A JP 2003309524 A JP2003309524 A JP 2003309524A JP 2004168749 A JP2004168749 A JP 2004168749A
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- acid
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- chlorogenic acids
- blood flow
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Abstract
【解決手段】 クロロゲン酸類、カフェ酸、フェルラ酸及びそれらの薬学的に許容される塩から選ばれる1種以上を有効成分とする血液流動性改善剤及び/又は血行促進剤。
【選択図】 なし
Description
すなわち、本発明は、クロロゲン酸類、カフェ酸、フェルラ酸及びそれらの薬学的に許容される塩から選ばれる1種以上を有効成分とする血液流動改善剤、血行促進剤、冷え改善剤及び体温低下改善剤を提供するものである。
例えば、クロロゲン酸類は、コーヒー生豆、南天の葉、リンゴ未熟果等の植物体から抽出したものが好ましい。更にアカネ科コーヒー(Coffee arabica LINNE)の種子より、温時アスコルビン酸、クエン酸酸性水溶液又は熱水で抽出して得たものがより好ましい。
血液流動性改善効果の測定方法としては、マイクロチャネル法(Kikuchi, Y., Sato, K., Ohki H and Kaneko T.:“Optically accessible microchannels formed in a sngle-crystal silicon substrate for studies of blood rheology."Microvasc. Res. 44, 226-240 (1992))、レーザー回折法(Manno S.,Takakuwa Y.,Nagao K.,Mohandas N.,:"Modulation of erythrocyte membrane mechanical function by beta-spectrin phosphorylation and dephosphorylation." J.Biol.Chem.270(10),5659-5665(1995))、フィルター法(Oonishi T.,Sakashita K., Uyesaka N.,:"Regulation of red bloood cell filterability by Ca2+ influx and cAMP-mediated signaling pathways."Am.J.Physiol.273(6),C1828-1834(1997))、マイクロピペット法(Discher D.E.,Mohandas N.,:"Kinematics of red cell aspiration by fluorescence-imaged microdeformation."Biophys J.71 (4)1680-1694(1996))が挙げられる。
このなかで、特に、マイクロチャネル法は最も汎用されている方法である。
経口用組成物としては、錠剤、顆粒剤、細粒剤、丸剤、散剤、カプセル剤(硬カプセル剤及び軟カプセル剤を含む)、トローチ剤、チュアブル剤、サプリメント等の固形状製剤あるいは粉末状製剤等などが挙げられる。またこれらの製剤は、サプリメント等の食品として用いてもよい。
これらの製剤中の本発明の成分の含有量は、1日あたりの有効摂取量を考慮すると0.1〜80重量%、特に10〜60重量%が好ましい。
液状、乳状又はペースト状の食品又は半固形状食品中の本発明の成分の含有量は、1日あたりの有効摂取量を考慮すると0.01〜50重量%、特に0.05〜10重量%が好ましい。
i)実験材料及び方法
(a)使用動物
6週齢の脳卒中易発性高血圧ラット(SHRSP/Izm、オス)を1週間以上馴化したのちに試験を開始した。ラットはすべて温度20〜26℃、湿度40〜70%、照明時間12時間(午前6時〜午後6時)の条件下で飼育した。
(b)投与方法及び投与量
実施例、比較例の検体を8週齢から1日1回、28日間反復投与した。投与方法は経口投与とし、金属製経口ゾンデを取り付けたポリプロピレン製ディスポーザブル注射筒を用いて強制投与した。実施例はクロロゲン酸(シグマケミカル社)を50mg/kg/日、比較例は注射用水(大塚製薬)を使用した。実験例の媒体は、注射用水とした。
飼料は、入荷から群分けまでは、固形飼料(CRF-1、オリエンタル酵母工業(株))を、群分け後は固形飼料(SP(0.4%食塩含有飼料)、オリエンタル酵母工業(株))を自由摂取させた。飲料水は、入荷から群分けまでは、水道水を、群分け後は1%食塩水を自由摂取させた。
(c)試験方法
検体を28日間反復投与終了後、予め抗凝固剤であるヘパリン350μL(全血に対し5%添加)を注入したベノジェクトII 真空採血管7mL(テルモ社)に採血した。採血後に、すばやく混合して血液測定サンプルとした。測定装置は、細胞マイクロレオロジー測定装置(MC-FAN:日立原町電子工業社)を使用した。装置は、毛細血管のモデルとなる微小流路のアレイを組み込み、一定の圧力差の下で、血液細胞の流れ特性を測定するものである。毛細血管モデルは、シリコン単結晶基板に7μmの微小流路を加工したものを用いた。
測定は、まず生理食塩水100μLが20cm水柱の圧力差下で毛細血管モデルを通過する時間を測定した(測定値は補正に使用)。次に血液測定サンプル100μLの通過時間(秒)を計測した。計測は、10μLごとに行った。顕微鏡により、血液測定サンプルの毛細血管モデルの通過を観察した。通過時間を血液流動性の指標とし、通過時間が短いほど流動性が改善されたと判定した。
表1から明らかなように、実験例(クロロゲン酸投与群)は比較例(注射用水投与群)に比べ通過時間が短くなっていることから血液流動性の改善が認められた。
i)実験材料及び方法
末梢循環機能が低下している健常女性5名に実施例として生コーヒー豆抽出物配合野菜果汁飲料125mL(クロロゲン酸類として140mg配合(0.1重量%))を、1日1本ずつ6週間飲用させた。6週間飲用後3週間おいて、同じ被験者に比較例として生コーヒー豆抽出物を含有していない野菜果汁飲料125mL(クロロゲン酸類として6mg配合(0.005重量%))を、1日1本ずつ6週間飲用させた。この被験者の末梢循環機能を冷水浸漬試験により評価した。試験は被験者を20℃(50RH%)で30分馴化後、左手手首まで15℃の冷水に5分間浸漬し、除去後の左手第3指末節指腹皮膚温の回復温度を測定した(アンリツ HPD-2236 DIGITAL THERMOMETER)。
得られた結果を表2に示す。尚、表2には飲用前及び6週間飲用後の45分後の回復温度を示した。表2から明らかなように、実施例の方が有意な体温上昇が認められクロロゲン酸類の服用により末梢循環機能、すなわち血行が改善されたことがわかる。また、血行改善により冷えの改善及び体温低下改善の効果も認められた。
i)実験材料及び方法
男4名を対象に実施例としてフェルラ酸19mg配合錠剤(2重量%)、比較例としてフェルラ酸無配合錠剤(0重量%)を作り、冷え、体温低下の症状の変化を評価した。
試験は午前中の症状の程度を評価した後に錠剤を摂取し、午後の症状の程度を評価した。症状の程度は次ぎの5段階で評価し改善スコアで評価した。
1 症状を感じる
2 症状をやや感じる
3 どちらとも言えない
4 症状をあまり感じない
5 症状を感じない
改善スコア=摂取後の評点−摂取前の評点
表3に冷え、表4に体温低下の結果を示した。本発明は、いずれの症状とも改善スコアが高くこれらの症状の軽減を認めた。
ゼラチン 70.0(重量%)
グリセリン 22.9
パラオキシ安息香酸メチル 0.15
パラオキシ安息香酸プロピル 0.51
水 6.44
上記組成からなる軟カプセル剤皮(オバール型、重さ150mg)の中に大豆油400mgとカフェ酸50mgとフェルラ酸50mgを定法により充填し、軟カプセル剤を製造した。
次に飲料としての利用例を示す。
脱脂粉乳 3.5(重量%)
ミルクカゼイン酵素分解物 3.5
フラクトース 9.0
クロロゲン酸 0.3
フェルラ酸ナトリウム 1.0
クエン酸 0.1
アスコルビン酸 0.1
香料 0.1
水 82.4
上記組成の飲料の保存安定性は高く、また、風味も良好であった。
Claims (6)
- クロロゲン酸類、カフェ酸、フェルラ酸及びそれらの薬学的に許容される塩から選ばれる1種以上を有効成分とする血液流動性改善剤。
- クロロゲン酸類、カフェ酸、フェルラ酸及びそれらの薬学的に許容される塩から選ばれる1種以上の含有量が0.01〜80重量%である請求項1記載の血液流動性改善剤。
- クロロゲン酸類、カフェ酸及びそれらの薬学的に許容される塩から選ばれる1種以上を有効成分とする血行促進剤。
- クロロゲン酸類、カフェ酸及びそれらの薬学的に許容される塩から選ばれる1種以上の含有量が0.01〜80重量%である請求項2記載の血行促進剤。
- クロロゲン酸類、カフェ酸、フェルラ酸及びそれらの薬学的に許容される塩から選ばれる1種以上を有効成分とする冷え改善剤。
- クロロゲン酸類、カフェ酸、フェルラ酸及びそれらの薬学的に許容される塩から選ばれる1種以上を有効成分とする体温低下改善剤。
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JP2006306747A (ja) * | 2005-04-27 | 2006-11-09 | Nippon Menaade Keshohin Kk | フキタンポポ抽出物を含有した生活習慣病予防または改善剤 |
WO2007049628A1 (ja) * | 2005-10-25 | 2007-05-03 | Kyowa Hakko Kogyo Co., Ltd. | 血液流動性改善剤 |
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JP2006306747A (ja) * | 2005-04-27 | 2006-11-09 | Nippon Menaade Keshohin Kk | フキタンポポ抽出物を含有した生活習慣病予防または改善剤 |
WO2007049628A1 (ja) * | 2005-10-25 | 2007-05-03 | Kyowa Hakko Kogyo Co., Ltd. | 血液流動性改善剤 |
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