JP2004141152A - リソグラフィ・マスクの設計および基板上での多様なプローブの合成 - Google Patents
リソグラフィ・マスクの設計および基板上での多様なプローブの合成 Download PDFInfo
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Abstract
【解決手段】基板上にプローブを合成するシステムおよび方法を用意する。1つまたは複数のシフト・レチクルを利用して、基板の指定の場所に単量体を一様に付加する。シフト・レチクルは、単量体付加の段階と段階の間に、基板に対してシフトされる。さらに、所望のプローブの特性を合成時に指定することができる。
【選択図】 図6
Description
本発明はプローブのアレイをより経済的に基板上に合成する手法を提供する。1つまたは複数の「シフト」レチクルを利用して、多くの異なるプローブ・セットを基板上に合成する。シフト・レチクルは、単量体付加段階後に(位置1つ分またはそれ以上)シフトされ、その後、再使用されるレチクルであり、これは、必要なレチクル(またはマスク)の数を低減させる。さらにこのシフト・マスクは合成時に、基板の、あるプローブ場所に単量体を一様に追加する。本発明の実施態様によって、プローブの長さおよび照会位置を合成時に指定することができるようになり、そのため、チップ合成における柔軟性が向上する。
n×(i−1)+1
によって指定された単量体付加領域を有するレチクルを設計する段階を含み、上式で、n=種類の異なる単量体の数、i=標的配列中の第1の単量体の位置である方法が提供される。
以下の用語は、本明細書で使用するとき、以下の意味を有するものとする。
「マスク」は、光を選択的に通過させるいくつかの開口を有する、通常はガラス製のプレートであるリソグラフィ部材について言う。マスクは、1つまたは複数のレチクルを含むことができる。
「レチクル」は、露光中に基板に光を導くのに使用するマスク全体またはマスクの特定の部分について言う。
本明細書では、光誘導合成手法を使用し、高密度で小型の分子プローブ・アレイを製作する。該アレイを、オリゴヌクレオチド、ペプチド、小分子(ベンゾジアザピン、プロスタグランジン、βターン・ミメティックなど)、非天然配位子、または酵素のアレイ、あるいは、オリゴ糖など「ビルディング・ブロック」形式で合成されるその他の広範な分子のアレイとすることができる。オリゴヌクレオチド・プローブ・アレイは、本明細書の発明の特定の例に従って使用することができるアレイの代表的なものである。
一実施形態で、本発明は、所望のプローブを基板上に合成するのにシフト・レチクルのセットを利用する。シフト・レチクル・セットは、基板に追加するそれぞれの単量体に対して1つのレチクルを含む。これらのレチクルを利用して、プローブの長さおよび照会位置を、合成時に、例えばレチクルを生成した後に指定することができる。
別の実施形態において、本発明は、標的配列に相補的なプローブを合成するために用いることができる単一シフト・レチクルを提供する。本発明の本実施形態に従って生成させるための方法の高水準流れ図を、図16に示す。段階602で、標的配列の完全相補ヌクレオチドの番号付けを行う。図3Aに示すように標的配列がTGACATのとき、完全相補はACTGTAとなる。したがって、完全相補中のヌクレオチドは、始めのAが1、Cが2、始めのTが3のように、1〜6の番号が振られる。
別の実施形態において、本発明は、突然変異、削除などを検出するためのプローブを合成するために用いることができるシフト・レチクルを提供する。これらのシフト・レチクルは標的配列構造特異的ではないので、標的配列は合成時に指定することができる。言い換えれば、1セットの「一般」シフト・レチクルを用いて、任意の標的配列を解析するためのプローブを合成することができる。さらに、これらのプローブは極めて少ないレチクルで生成させることができる。
本発明のいくつかの実施形態ではスペックル・マスクを利用する。「スペックル・マスク」は、結論から言うと、各位置に開口を有し、それによって実際にフル・オープン・マスクを生成できると言われている1セットのレチクルである。スペックル・マスクの簡単な例を図22に示す。示すように、3つのレチクルは、異なる位置に単一単量体付加開口を有している。開口を加え合わせると、フル・オープン・マスクが生成する。これがスペックル・マスクの性質である。
前述の実施形態においては、矩形グリッドとしてレチクルをデザインした。矩形グリッドは、マトリックス表示を切り換えるのに適しているために用いられる。スイッチ・マトリックスは、組合せマスクの優れた生成を提供するが、通常、すべてのセルが同一サイズである矩形セルのアレイを含むチップを要求する。ブランク・レーン(プローブを含まないレーン)がプローブを含むレーンと同一のサイズであるため、これらのチップには無駄な空間を含む。
基板の活性領域を最大限利用するため、A、C、G、およびTレーン群をブランク・レーンなしに詰めることは有益であることがある。複数グループのA、C、G、およびTレーン1002を含む基板活性領域1000を図27Aに示す。示すように、レーン1002の各グループを隔てるブランク・レーンはない。活性領域の物的財産の最も優れた利用に見えるが、あるグループのTレーンにおけるプローブの合成は、別のグループの隣接するAレーンにおけるプローブの合成に悪影響を与えることがある。
いくつかの例において、標的中の特定の塩基位置を照会する種々のプローブを合成することは有益かもしれない。例えば、遺伝子中の特定の点突然変異にのみ興味を持つこともある。特定の塩基を十分に照会するため、位置を照会する多数の異なるプローブ(例えば、長さおよび/またはプローブ中の照会位置)を手にすることは有益であろう。
Claims (14)
- 基板上にプローブを合成する方法において、
基板の指定の場所に単量体を一様に付加するための少なくとも1つのレチクルを用意する段階と、
前記少なくとも1つのレチクルを利用して合成しようとするプローブの特性に関する入力を受け取る段階と、
前記少なくとも1つのレチクルを利用して、基板上に前記所望のプローブを合成する段階と
を含むことを特徴とする方法。 - 前記所望のプローブの前記特性が合成時に入力されることを特徴とする請求項1に記載の方法。
- 前記特性が、前記所望のプローブの長さであることを特徴とする請求項1に記載の方法。
- 前記特性が、前記所望のプローブの照会位置であることを特徴とする請求項1に記載の方法。
- 前記特性が、前記所望のプローブを合成するための単量体付加順序であることを特徴とする請求項1に記載の方法。
- コンピュータ・システムにおいて、基板上にプローブを合成するためのレチクルのレイアウトを決定するための方法であって、
標的単量体配列の入力を受け取る段階と、
前記標的配列中の単量体の種類を選択する段階と、
前記標的配列中の前記選択した種類のそれぞれの単量体の位置に対応する単量体付加領域を有するレチクルを設計する段階と
を含むことを特徴とする方法。 - 前記標的配列中のそれぞれの種類の単量体について、前記選択段階および前記設計段階を繰り返す段階をさらに含むことを特徴とする請求項6に記載の方法。
- コンピュータ・システムにおいて、基板上にプローブを合成するためのレチクルのレイアウトを決定するための方法であって、
標的単量体配列の入力を受け取る段階と、
前記標的配列中の単量体の種類を選択する段階と、
n×(i−1)+1
によって指定される単量体付加領域を有するレチクルを設計する段階と
を含み、
上式で、n=種類の異なる単量体の数、i=標的配列中の第1の単量体の位置である
ことを特徴とする方法。 - 前記レチクルを設計する前記段階が、
n×(i−1)+2
によって指定される単量体付加領域を有するレチクルを形成する段階をさらに含み、上式で、n=種類の異なる単量体の数、i=標的配列中の第2の単量体の位置であることを特徴とする請求項8に記載の方法。 - コンピュータ・システムにおいて、基板上に合成されたプローブを含む基板のレイアウトを指定するための方法であって、
基板上に合成するプローブを、それぞれがプローブを含む分析領域の配列リストとして定義する段階と、
分析領域の前記配列リストの特性に関する入力を受け取る段階と、
前記入力された特性を用いて、それぞれの分析領域のプローブを基板上に合成するために、少なくとも1つのレチクルを設計する段階と
を含むことを特徴とする方法。 - 前記特性が、前記分析領域のスケールであることを特徴とする請求項10に記載の方法。
- 前記特性が、前記分析領域の向きであることを特徴とする請求項10に記載の方法。
- 前記分析領域が、基板上で円形パターンに配置されることを特徴とする請求項10に記載の方法。
- 前記分析領域が、基板上でらせん形パターンに配置されることを特徴とする請求項10に記載の方法。
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JP2003333828A Expired - Lifetime JP3711352B2 (ja) | 1996-12-17 | 2003-09-25 | リソグラフィ・マスクの設計および基板上での多様なプローブの合成 |
JP2005152683A Pending JP2005338089A (ja) | 1996-12-17 | 2005-05-25 | リソグラフィ・マスクの設計および基板上での多様なプローブの合成 |
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US (2) | US6153743A (ja) |
EP (1) | EP1007969A4 (ja) |
JP (3) | JP2001517300A (ja) |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007064927A (ja) * | 2005-09-02 | 2007-03-15 | Nipro Corp | 定性反応用試験片 |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19706570C1 (de) | 1997-02-19 | 1998-02-26 | Inst Physikalische Hochtech Ev | Verfahren zur Herstellung von strukturierten, selbstorganisierten molekularen Monolagen einzelner molekularer Spezies, insbesondere von Substanzbibliotheken |
US6771376B2 (en) | 1999-07-05 | 2004-08-03 | Novartis Ag | Sensor platform, apparatus incorporating the platform, and process using the platform |
AU5824300A (en) | 1999-07-05 | 2001-01-22 | Novartis Ag | Sensor platform, apparatus incorporating the platform, and process using the platform |
US7117095B2 (en) * | 2000-11-21 | 2006-10-03 | Affymetrix, Inc. | Methods for selecting nucleic acid probes |
US6949638B2 (en) * | 2001-01-29 | 2005-09-27 | Affymetrix, Inc. | Photolithographic method and system for efficient mask usage in manufacturing DNA arrays |
US7297553B2 (en) | 2002-05-28 | 2007-11-20 | Nanosphere, Inc. | Method for attachment of silylated molecules to glass surfaces |
WO2003006676A2 (en) | 2001-07-13 | 2003-01-23 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
WO2003033128A2 (en) * | 2001-10-12 | 2003-04-24 | Duke University | Methods for image analysis of high-density synthetic dna microarrays |
US20030087289A1 (en) * | 2001-10-12 | 2003-05-08 | Harry Zuzan | Image analysis of high-density synthetic DNA microarrays |
US8271202B1 (en) | 2002-02-11 | 2012-09-18 | Fernandez Dennis S | Modified host bio-data management |
US7504364B2 (en) * | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
US20050136483A1 (en) * | 2003-09-03 | 2005-06-23 | Receptors Llc | Nanodevices employing combinatorial artificial receptors |
US20050037428A1 (en) * | 2002-09-16 | 2005-02-17 | Receptors Llc | Artificial receptors including reversibly immobilized building blocks, the building blocks, and methods |
US20050037429A1 (en) * | 2003-03-28 | 2005-02-17 | Receptors Llc | Artificial receptors including reversibly immobilized building blocks and methods |
US20040137481A1 (en) * | 2002-09-16 | 2004-07-15 | Receptors Llc | Artificial receptor building blocks, components, and kits |
US7469076B2 (en) * | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
US20050170385A1 (en) * | 2002-09-16 | 2005-08-04 | Receptors Llc | Artificial receptors including gradients |
US20060057625A1 (en) * | 2002-09-16 | 2006-03-16 | Carlson Robert E | Scaffold-based artificial receptors and methods |
US20050037381A1 (en) * | 2002-09-16 | 2005-02-17 | Receptors Llc | Artificial receptors, building blocks, and methods |
DE10393431T5 (de) * | 2002-10-01 | 2005-11-17 | Nimblegen Systems, Inc., Madison | Mikroarrays mit mehreren Oligonukleotiden in einzelnen Array Features |
US20040115654A1 (en) * | 2002-12-16 | 2004-06-17 | Intel Corporation | Laser exposure of photosensitive masks for DNA microarray fabrication |
EP1613737A4 (en) * | 2003-03-28 | 2008-12-03 | Receptors Llc | ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS |
US7537939B2 (en) * | 2003-04-29 | 2009-05-26 | Nxp B.V. | System and method for characterizing lithography effects on a wafer |
DE102004041812A1 (de) * | 2004-08-26 | 2006-03-09 | Siemens Ag | Reaktor zum Erzeugen von Oberflächenreaktionen und dessen Verwendung |
WO2006029234A1 (en) * | 2004-09-03 | 2006-03-16 | Receptors Llc | Combinatorial artificial receptors including tether building blocks |
WO2006029383A2 (en) * | 2004-09-11 | 2006-03-16 | Receptors Llc | Combinatorial artificial receptors including peptide building blocks |
US7349080B2 (en) | 2004-12-30 | 2008-03-25 | Corning Incorporated | Label-independent detection of unpurified analytes |
US8009889B2 (en) | 2006-06-27 | 2011-08-30 | Affymetrix, Inc. | Feature intensity reconstruction of biological probe array |
KR100819006B1 (ko) | 2007-02-13 | 2008-04-03 | 삼성전자주식회사 | 마이크로 어레이용 마스크 세트, 이의 제조 방법, 및마스크 세트를 이용한 마이크로 어레이의 제조 방법 |
JP2009092440A (ja) * | 2007-10-04 | 2009-04-30 | Shimadzu Corp | 卵巣癌の診断システム及び卵巣癌の診断方法 |
US7812318B1 (en) | 2008-03-14 | 2010-10-12 | Advanced Technology Applications, Llc | Electromagnetic biosensor |
US8735846B1 (en) | 2008-03-14 | 2014-05-27 | Advanced Technology Applications, Llc | Electromagnetic biosensor |
GB2511600B (en) | 2011-05-09 | 2019-12-04 | Woodbury Neal | Methods for performing patterned chemistry |
US10046293B2 (en) | 2012-10-17 | 2018-08-14 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona | In situ chemical patterning |
US10758886B2 (en) | 2015-09-14 | 2020-09-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Conditioned surfaces for in situ molecular array synthesis |
US11420941B2 (en) | 2017-06-29 | 2022-08-23 | Cowper Sciences Inc. | Methods and systems for mask alignment in manufacturing process of arrays |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700637A (en) * | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US5424186A (en) * | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5527681A (en) * | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5460908A (en) * | 1991-08-02 | 1995-10-24 | Micron Technology, Inc. | Phase shifting retical fabrication method |
US5235626A (en) * | 1991-10-22 | 1993-08-10 | International Business Machines Corporation | Segmented mask and exposure system for x-ray lithography |
US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5440016A (en) * | 1993-06-18 | 1995-08-08 | Torrey Pines Institute For Molecular Studies | Peptides of the formula (KFmoc) ZZZ and their uses |
JPH09507121A (ja) * | 1993-10-26 | 1997-07-22 | アフィマックス テクノロジーズ ナームロゼ ベノートスハップ | 生物学的チップ上の核酸プローブアレー |
-
1997
- 1997-12-17 EP EP97953287A patent/EP1007969A4/en not_active Withdrawn
- 1997-12-17 WO PCT/US1997/023360 patent/WO1998027430A1/en not_active Application Discontinuation
- 1997-12-17 JP JP52797098A patent/JP2001517300A/ja active Pending
-
1998
- 1998-04-13 US US09/059,779 patent/US6153743A/en not_active Expired - Lifetime
-
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- 2003-09-25 JP JP2003333828A patent/JP3711352B2/ja not_active Expired - Lifetime
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- 2005-05-25 JP JP2005152683A patent/JP2005338089A/ja active Pending
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US6153743A (en) | 2000-11-28 |
EP1007969A1 (en) | 2000-06-14 |
US20060094040A1 (en) | 2006-05-04 |
JP3711352B2 (ja) | 2005-11-02 |
WO1998027430A1 (en) | 1998-06-25 |
JP2005338089A (ja) | 2005-12-08 |
EP1007969A4 (en) | 2006-12-13 |
JP2001517300A (ja) | 2001-10-02 |
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