JP2004002446A5 - - Google Patents
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- Publication number
- JP2004002446A5 JP2004002446A5 JP2003193159A JP2003193159A JP2004002446A5 JP 2004002446 A5 JP2004002446 A5 JP 2004002446A5 JP 2003193159 A JP2003193159 A JP 2003193159A JP 2003193159 A JP2003193159 A JP 2003193159A JP 2004002446 A5 JP2004002446 A5 JP 2004002446A5
- Authority
- JP
- Japan
- Prior art keywords
- nadh
- nadph
- inhibit
- oxidation
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 4
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 claims 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37314795A | 1995-01-17 | 1995-01-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8005513A Division JPH08231404A (ja) | 1995-01-17 | 1996-01-17 | 経鼻、経舌下、経直腸及び経皮投与のためのｎａｄｈ及びｎａｄｐｈ治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004002446A JP2004002446A (ja) | 2004-01-08 |
| JP2004002446A5 true JP2004002446A5 (https=) | 2005-04-07 |
Family
ID=23471176
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8005513A Pending JPH08231404A (ja) | 1995-01-17 | 1996-01-17 | 経鼻、経舌下、経直腸及び経皮投与のためのｎａｄｈ及びｎａｄｐｈ治療剤 |
| JP2003193159A Pending JP2004002446A (ja) | 1995-01-17 | 2003-07-07 | 経鼻、経舌下、経直腸及び経皮投与のためのｎａｄｈ及びｎａｄｐｈ治療剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8005513A Pending JPH08231404A (ja) | 1995-01-17 | 1996-01-17 | 経鼻、経舌下、経直腸及び経皮投与のためのｎａｄｈ及びｎａｄｐｈ治療剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US5654288A (https=) |
| EP (1) | EP0722734A1 (https=) |
| JP (2) | JPH08231404A (https=) |
| CA (2) | CA2167104A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001515916A (ja) * | 1997-09-11 | 2001-09-25 | オクシジェン，インコーポレイテッド | 悪性および伝染性疾患の治療用にニコチンアミド・アデニン・ジヌクレオチドならびにその類似物を用いる治療法 |
| AU2173400A (en) * | 1998-12-09 | 2000-06-26 | Chiron Corporation | Method for administering agents to the central nervous system |
| US6340474B1 (en) | 1999-08-03 | 2002-01-22 | Charles A. Mesko | Composition for potentiating a growth hormone and a method for preparation of said composition |
| DE10004547A1 (de) * | 2000-02-02 | 2001-08-09 | Liedtke Pharmed Gmbh | Verfahren zur selektiven Verabreichung zentralnervös aktiver Stoffe |
| US20020177614A1 (en) * | 2001-03-23 | 2002-11-28 | Merril Carl R. | Methods for treating nuerodegenerative diseases including alzheimer's |
| KR20080070782A (ko) * | 2001-04-13 | 2008-07-30 | 오츠카 세이야쿠 가부시키가이샤 | 당 흡수 촉진제 |
| ITBO20020140A1 (it) * | 2002-03-21 | 2003-09-22 | Valpharma Sa | Formulazioni a base di nadh in forma di multiparticolato con rivestimento gastroresistente o a rilascio modificato |
| AT502435B1 (de) * | 2002-11-19 | 2008-01-15 | Oekopharm Forschungs Und Entwi | Pharmazeutische zusammensetzung umfassend ein wasserstoffübertragendes coenzym und chlorophyll |
| US20040126751A1 (en) * | 2002-12-27 | 2004-07-01 | Birkmayer Jorg G.D. | Method of prolonging the life-span of living cells using NADH, NADPH and ADP-ribose |
| JP4709739B2 (ja) * | 2003-02-28 | 2011-06-22 | イーエルシー マネージメント エルエルシー | 毛髪成長の増進方法 |
| US7666442B2 (en) * | 2004-08-31 | 2010-02-23 | Tracie Martyn International, Llc | Topical compositions comprising benfotiamine and pyridoxamine |
| US7776915B2 (en) * | 2005-03-24 | 2010-08-17 | Tracie Martyn International, Llc | Topical formulations and methods of use |
| US20090246234A1 (en) * | 2008-04-01 | 2009-10-01 | Benjamin Johnson | Therapeutic Treatment Using Niacin for Skin Disorders |
| US8642655B2 (en) | 2011-03-09 | 2014-02-04 | Benjamin Johnson | Systems and methods for preventing cancer and treating skin lesions |
| US20220202844A1 (en) * | 2020-12-31 | 2022-06-30 | Richard Clark Kaufman | Drug delivery composition and a method of administering the drug |
| JP2024517463A (ja) * | 2021-05-04 | 2024-04-22 | ソヴィダ ソリューションズ リミテッド | ニコチンアミドアデニンジヌクレオチド（ｎａｄ）組成物、それらの製造方法、及びそれらの使用方法 |
| WO2022234336A1 (en) * | 2021-05-04 | 2022-11-10 | Sovida Solutions Ltd. | Nicotinamide adenine dinucleotide (nad) compositions, methods of manufacturing thereof, and methods of use thereof |
| CN116217895B (zh) * | 2021-12-02 | 2025-08-19 | 中国科学院化学研究所 | 定向光催化合成的方法以及共轭聚合物的应用 |
| DE202022000567U1 (de) | 2022-03-06 | 2022-03-16 | Penta Phi Eg | Liposomale Formulierung |
| CN119157897A (zh) * | 2023-10-12 | 2024-12-20 | 苏州人本药业有限公司 | Nadph在制备治疗重性抑郁症、双向抑郁症、脑卒中后抑郁症或神经炎症药物的用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0256472A3 (en) * | 1986-08-11 | 1988-09-07 | Lion Corporation | Cosmetic agent for application to skin |
| JPS63301810A (ja) * | 1987-06-01 | 1988-12-08 | Keikichi Sugiyama | 毛髪用組成物 |
| EP0331620B1 (de) * | 1988-03-01 | 1993-08-11 | Birkmayer, Walther, Prof. Dr. | Mittel zur Behandlung des Parkinson-Syndroms |
| AT397201B (de) * | 1988-06-03 | 1994-02-25 | Birkmayer Joerg Ddr | Verwendung des enzym-cofaktors nadph zur herstellung eines arzneimittels |
| WO1991007947A1 (en) * | 1989-12-05 | 1991-06-13 | Ramsey Foundation | Neurologic agents for nasal administration to the brain |
| US5312819A (en) * | 1990-08-20 | 1994-05-17 | Sandoz Ltd. | Pharmaceutical compositions comprising clozapine and a radical scavenger |
| DE4100361C1 (https=) * | 1991-01-04 | 1992-04-23 | Birkmayer, Joerg, Univ.-Prof. Ddr., Wien, At | |
| DE4102240C1 (https=) * | 1991-01-24 | 1992-04-09 | Birkmayer, Joerg, Univ.-Prof. Ddr., Wien, At | |
| DE4218291A1 (de) * | 1992-06-03 | 1993-12-09 | Mattern Et Partner Pharmazeuti | Dosierspray für pernasale Applikation |
| EP0615747B1 (en) * | 1993-03-18 | 1999-09-29 | Terumo Kabushiki Kaisha | Hemoglobin-encapsulating liposome and method for making the same |
| US5332727A (en) * | 1993-04-29 | 1994-07-26 | Birkmayer U.S.A. | Stable, ingestable and absorbable NADH and NADPH therapeutic compositions |
-
1996
- 1996-01-12 CA CA002167104A patent/CA2167104A1/en not_active Abandoned
- 1996-01-12 CA CA2735293A patent/CA2735293A1/en not_active Abandoned
- 1996-01-17 EP EP96100612A patent/EP0722734A1/en not_active Ceased
- 1996-01-17 JP JP8005513A patent/JPH08231404A/ja active Pending
- 1996-04-10 US US08/632,373 patent/US5654288A/en not_active Expired - Lifetime
- 1996-07-11 US US08/673,407 patent/US5750512A/en not_active Expired - Lifetime
-
1998
- 1998-02-17 US US09/024,361 patent/US5952312A/en not_active Expired - Fee Related
-
2003
- 2003-07-07 JP JP2003193159A patent/JP2004002446A/ja active Pending