JP2003535025A5 - - Google Patents
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- Publication number
- JP2003535025A5 JP2003535025A5 JP2001506851A JP2001506851A JP2003535025A5 JP 2003535025 A5 JP2003535025 A5 JP 2003535025A5 JP 2001506851 A JP2001506851 A JP 2001506851A JP 2001506851 A JP2001506851 A JP 2001506851A JP 2003535025 A5 JP2003535025 A5 JP 2003535025A5
- Authority
- JP
- Japan
- Prior art keywords
- organ
- micro
- mammal
- tissue
- polynucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 31
- 241000124008 Mammalia Species 0.000 description 15
- 210000001519 tissue Anatomy 0.000 description 13
- 210000000056 organ Anatomy 0.000 description 11
- 102000040430 polynucleotide Human genes 0.000 description 11
- 108091033319 polynucleotide Proteins 0.000 description 11
- 239000002157 polynucleotide Substances 0.000 description 11
- 230000033115 angiogenesis Effects 0.000 description 9
- 239000002870 angiogenesis inducing agent Substances 0.000 description 5
- 230000001023 pro-angiogenic effect Effects 0.000 description 5
- 239000003636 conditioned culture medium Substances 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000007758 minimum essential medium Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14074899P | 1999-06-25 | 1999-06-25 | |
| US60/140,748 | 1999-06-25 | ||
| PCT/IL2000/000365 WO2001000859A1 (en) | 1999-06-25 | 2000-06-22 | Method of inducing angiogenesis by micro-organs |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003305960A Division JP2004073206A (ja) | 1999-06-25 | 2003-08-29 | 遺伝的に改変された微小器官外植片、その生産方法およびその使用 |
| JP2010271065A Division JP2011087592A (ja) | 1999-06-25 | 2010-12-06 | 微小器官外植片、及びその生産方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003535025A JP2003535025A (ja) | 2003-11-25 |
| JP2003535025A5 true JP2003535025A5 (enExample) | 2007-08-02 |
Family
ID=22492636
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001506851A Pending JP2003535025A (ja) | 1999-06-25 | 2000-06-22 | 微小器官で血管新生を誘発する方法 |
| JP2003305960A Pending JP2004073206A (ja) | 1999-06-25 | 2003-08-29 | 遺伝的に改変された微小器官外植片、その生産方法およびその使用 |
| JP2010271065A Pending JP2011087592A (ja) | 1999-06-25 | 2010-12-06 | 微小器官外植片、及びその生産方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003305960A Pending JP2004073206A (ja) | 1999-06-25 | 2003-08-29 | 遺伝的に改変された微小器官外植片、その生産方法およびその使用 |
| JP2010271065A Pending JP2011087592A (ja) | 1999-06-25 | 2010-12-06 | 微小器官外植片、及びその生産方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20030086914A1 (enExample) |
| EP (2) | EP1190082A4 (enExample) |
| JP (3) | JP2003535025A (enExample) |
| CN (1) | CN1420933A (enExample) |
| AU (1) | AU5423300A (enExample) |
| CA (2) | CA2435411A1 (enExample) |
| WO (1) | WO2001000859A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003035851A1 (en) * | 2001-10-23 | 2003-05-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs, and uses related thereto |
| US20030157074A1 (en) * | 1994-11-16 | 2003-08-21 | Mitrani Eduardo N. | Vitro micro-organs, and uses related thereto |
| US7687057B2 (en) * | 1998-01-09 | 2010-03-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs, and uses related thereto |
| US20030152562A1 (en) * | 2001-10-23 | 2003-08-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Vitro micro-organs, and uses related thereto |
| US20060127366A1 (en) * | 1999-06-25 | 2006-06-15 | Mitrani Eduardo N | Method and device for inducing biological processes by micro-organs |
| US8088568B2 (en) | 2001-11-05 | 2012-01-03 | Medgentics, Inc. | Dermal micro-organs, methods and apparatuses for producing and using the same |
| US7468242B2 (en) | 2001-11-05 | 2008-12-23 | Medgenics, Inc. | Dermal micro organs, methods and apparatuses for producing and using the same |
| CN101352365B (zh) * | 2001-11-05 | 2010-09-08 | 迈德詹尼克斯公司 | 用于固定微器官的定位器 |
| US8501396B2 (en) | 2001-11-05 | 2013-08-06 | Medgenics Medical Israel Ltd. | Dermal micro-organs, methods and apparatuses for producing and using the same |
| US7297540B2 (en) | 2002-01-15 | 2007-11-20 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs |
| EP2377404A1 (en) | 2003-05-01 | 2011-10-19 | Medgenics, Inc. | A dermal micro-organ which is an explant of living tissue |
| IL155783A (en) | 2003-05-05 | 2010-11-30 | Technion Res & Dev Foundation | Multicellular systems of multi-potential embryonic human stem cells and cancer cells and their use |
| US20050244967A1 (en) * | 2004-05-03 | 2005-11-03 | Pearlman Andrew L | Closed automated system for tissue based therapy |
| WO2007047718A2 (en) * | 2005-10-18 | 2007-04-26 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Generation and use of vasculogenic tumors |
| US8038595B2 (en) | 2006-01-25 | 2011-10-18 | Beth Israel Deaconess Medical Center | Devices and methods for tissue transplant and regeneration |
| US9127084B2 (en) | 2006-09-14 | 2015-09-08 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
| KR101470472B1 (ko) | 2006-09-14 | 2014-12-09 | 메드제닉스 메디칼 이스라엘 리미티드 | 장기 지속형 약물 제형 |
| US8454948B2 (en) | 2006-09-14 | 2013-06-04 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
| IL196820A0 (en) | 2009-02-01 | 2009-11-18 | Yissum Res Dev Co | Devitalized, acellular scaffold matrices derived from micro-organs seeded with various cells |
| JP2017195778A (ja) * | 2014-09-01 | 2017-11-02 | 株式会社オーガンテクノロジーズ | 三次元血管網を有する器官をinvivoで形成させる方法、及び、三次元血管網を有する器官の形成用組成物 |
| CN111500447B (zh) * | 2020-04-26 | 2023-06-06 | 广东康盾创新产业集团股份公司 | 一种用于免疫细胞扩增的细胞培养装置 |
| CN111588423A (zh) * | 2020-06-08 | 2020-08-28 | 刘绍才 | 一种可微调切割面积的病变细胞组织切除装置 |
| CN114812463B (zh) * | 2022-06-27 | 2022-09-30 | 山西嘉世达机器人技术有限公司 | 检测清洁机到达边缘的方法、检测装置、清洁机和介质 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) * | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) * | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) * | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) * | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) * | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| US3850578A (en) * | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) * | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) * | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) * | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) * | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) * | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
| US4879219A (en) * | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US4353888A (en) * | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
| JPS59134728A (ja) * | 1983-01-21 | 1984-08-02 | Seiji Takayama | 免疫抗癌剤及びその製法 |
| US5011771A (en) * | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4736866B1 (en) * | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US4666828A (en) * | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| JPS61233694A (ja) * | 1985-04-08 | 1986-10-17 | Morinaga & Co Ltd | ウシ脾臓中に含まれる成長因子及びその単離方法 |
| US4801531A (en) * | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
| ATE132266T1 (de) * | 1987-05-01 | 1996-01-15 | Stratagene Inc | Mutagenesetest durch verwendung von nicht menschlichen lebewesen, die test-dns-sequenzen enthalten |
| US5175385A (en) * | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
| US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| US5055296A (en) * | 1988-08-04 | 1991-10-08 | Wagle Sudhakar S | Method of treating chronic fatigue syndrome |
| US5221778A (en) * | 1988-08-24 | 1993-06-22 | Yale University | Multiplex gene regulation |
| US5272057A (en) * | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5175384A (en) * | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5175383A (en) * | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5387742A (en) * | 1990-06-15 | 1995-02-07 | Scios Nova Inc. | Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease |
| US5288846A (en) * | 1990-10-19 | 1994-02-22 | The General Hospital Corporation | Cell specific gene regulators |
| US5298422A (en) * | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
| US5281521A (en) * | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US5888720A (en) * | 1992-10-27 | 1999-03-30 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs |
| US6372482B1 (en) * | 1997-01-16 | 2002-04-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Device and method for performing a biological modification of a fluid |
| US6472200B1 (en) * | 1999-07-23 | 2002-10-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Device and method for performing a biological modification of a fluid |
| US20030157074A1 (en) * | 1994-11-16 | 2003-08-21 | Mitrani Eduardo N. | Vitro micro-organs, and uses related thereto |
| US20030152909A1 (en) * | 1994-11-16 | 2003-08-14 | Mitrani Eduardo N. | In vitro micro-organs, and uses related thereto |
| US6090618A (en) * | 1996-10-07 | 2000-07-18 | Arch Development Corporation | DNA constructs and viral vectors comprising a smooth muscle promoter |
| US6375989B1 (en) * | 1996-12-10 | 2002-04-23 | Purdue Research Foundation | Submucosa extracts |
| ATE296117T1 (de) * | 1997-03-07 | 2005-06-15 | Wistar Inst | Verwendung von adenoviralen vektoren, die pdgf oder vegf exprimieren, zur heilung von gewebsdefekten und zur induzierung der hypervaskulität in säugergeweben |
| US6110459A (en) * | 1997-05-28 | 2000-08-29 | Mickle; Donald A. G. | Transplants for myocardial scars and methods and cellular preparations |
| JP2001511462A (ja) * | 1997-07-31 | 2001-08-14 | セント エリザベス メディカル センター オブ ボストン インク. | 移植片処置法 |
| WO1999008522A1 (en) * | 1997-08-15 | 1999-02-25 | Ludwig Institute For Cancer Research | Stimulation, modulation and/or inhibition of endothelial proteolytic activity and/or angiogenic activity |
| US7687057B2 (en) * | 1998-01-09 | 2010-03-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs, and uses related thereto |
| US20030152562A1 (en) * | 2001-10-23 | 2003-08-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Vitro micro-organs, and uses related thereto |
-
2000
- 2000-06-22 CN CN00811874A patent/CN1420933A/zh active Pending
- 2000-06-22 JP JP2001506851A patent/JP2003535025A/ja active Pending
- 2000-06-22 AU AU54233/00A patent/AU5423300A/en not_active Abandoned
- 2000-06-22 CA CA002435411A patent/CA2435411A1/en not_active Abandoned
- 2000-06-22 EP EP00939024A patent/EP1190082A4/en not_active Withdrawn
- 2000-06-22 CA CA002377541A patent/CA2377541A1/en not_active Abandoned
- 2000-06-22 EP EP03016266A patent/EP1374889A1/en not_active Ceased
- 2000-06-22 WO PCT/IL2000/000365 patent/WO2001000859A1/en not_active Ceased
-
2002
- 2002-07-12 US US10/193,136 patent/US20030086914A1/en not_active Abandoned
-
2003
- 2003-08-29 JP JP2003305960A patent/JP2004073206A/ja active Pending
-
2010
- 2010-12-06 JP JP2010271065A patent/JP2011087592A/ja active Pending
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