JP2003530814A5 - - Google Patents
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- JP2003530814A5 JP2003530814A5 JP2000562396A JP2000562396A JP2003530814A5 JP 2003530814 A5 JP2003530814 A5 JP 2003530814A5 JP 2000562396 A JP2000562396 A JP 2000562396A JP 2000562396 A JP2000562396 A JP 2000562396A JP 2003530814 A5 JP2003530814 A5 JP 2003530814A5
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- kcne1
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- 101000974726 Homo sapiens Potassium voltage-gated channel subfamily E member 1 Proteins 0.000 description 29
- 102100022755 Potassium voltage-gated channel subfamily E member 1 Human genes 0.000 description 25
- 238000000034 method Methods 0.000 description 25
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- 102000014021 KCNQ1 Potassium Channel Human genes 0.000 description 18
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- 230000006698 induction Effects 0.000 description 14
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- 208000004731 long QT syndrome Diseases 0.000 description 10
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- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 7
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- 102000046912 human KCNE1 Human genes 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 3
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- 239000000523 sample Substances 0.000 description 3
- 101001026226 Homo sapiens Potassium voltage-gated channel subfamily KQT member 1 Proteins 0.000 description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
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- 230000037430 deletion Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 102000053010 human KCNQ1 Human genes 0.000 description 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
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- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
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- 235000004279 alanine Nutrition 0.000 description 1
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- 235000009582 asparagine Nutrition 0.000 description 1
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- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9447798P | 1998-07-29 | 1998-07-29 | |
| US60/094,477 | 1998-07-29 | ||
| US09/135,020 | 1998-08-17 | ||
| US09/135,020 US6274332B1 (en) | 1995-12-22 | 1998-08-17 | Mutations in the KCNE1 gene encoding human minK which cause arrhythmia susceptibility thereby establishing KCNE1 as an LQT gene |
| PCT/US1998/017838 WO2000006600A1 (en) | 1998-07-29 | 1998-10-06 | Human mink gene mutations associated with arrhythmia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003530814A JP2003530814A (ja) | 2003-10-21 |
| JP2003530814A5 true JP2003530814A5 (enExample) | 2006-01-05 |
Family
ID=26788932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000562396A Pending JP2003530814A (ja) | 1998-07-29 | 1998-10-06 | 不整脈に関連するヒトｍｉｎｋ遺伝子突然変異 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US6274332B1 (enExample) |
| EP (1) | EP1100825B1 (enExample) |
| JP (1) | JP2003530814A (enExample) |
| KR (1) | KR20010085315A (enExample) |
| AT (1) | ATE359299T1 (enExample) |
| CA (1) | CA2337491C (enExample) |
| DE (1) | DE69837565T2 (enExample) |
| WO (1) | WO2000006600A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274332B1 (en) * | 1995-12-22 | 2001-08-14 | Univ. Of Utah Research Foundation | Mutations in the KCNE1 gene encoding human minK which cause arrhythmia susceptibility thereby establishing KCNE1 as an LQT gene |
| US6458542B1 (en) * | 1999-10-08 | 2002-10-01 | Vanderbilt University | Method of screening for susceptibility to drug-induced cardiac arrhythmia |
| US7115726B2 (en) * | 2001-03-30 | 2006-10-03 | Perlegen Sciences, Inc. | Haplotype structures of chromosome 21 |
| US7306911B2 (en) * | 2001-04-24 | 2007-12-11 | University Of Utah Research Foundation | Methods for assessing risk for cardiac dysrythmia in a human subject |
| US20030073085A1 (en) * | 2001-10-05 | 2003-04-17 | Fang Lai | Amplifying expressed sequences from genomic DNA of higher-order eukaryotic organisms for DNA arrays |
| US20040053232A1 (en) * | 2001-10-05 | 2004-03-18 | Perlegen Sciences, Inc. | Haplotype structures of chromosome 21 |
| US8013133B2 (en) | 2003-04-25 | 2011-09-06 | Medtronic, Inc. | Genetic modification of targeted regions of the cardiac conduction system |
| US7537928B2 (en) * | 2003-08-22 | 2009-05-26 | Masonic Medical Research Laboratory | Mutations in ion channel proteins associated with sudden cardiac death |
| US7608458B2 (en) * | 2004-02-05 | 2009-10-27 | Medtronic, Inc. | Identifying patients at risk for life threatening arrhythmias |
| WO2005078452A1 (en) * | 2004-02-05 | 2005-08-25 | Medtronic, Inc. | Methods and apparatus for identifying patients at risk for life threatening arrhythmias |
| US7127355B2 (en) | 2004-03-05 | 2006-10-24 | Perlegen Sciences, Inc. | Methods for genetic analysis |
| US20090087854A1 (en) * | 2007-09-27 | 2009-04-02 | Perlegen Sciences, Inc. | Methods for genetic analysis |
| US8335652B2 (en) * | 2004-06-23 | 2012-12-18 | Yougene Corp. | Self-improving identification method |
| US8027791B2 (en) * | 2004-06-23 | 2011-09-27 | Medtronic, Inc. | Self-improving classification system |
| US20050287574A1 (en) * | 2004-06-23 | 2005-12-29 | Medtronic, Inc. | Genetic diagnostic method for SCD risk stratification |
| US7833718B2 (en) * | 2006-11-06 | 2010-11-16 | Masonic Medical Research Laboratory | CACNA1C nucleic acid mutations as indicators of shorter than normal QT interval and ST segment elevation associated with sudden cardiac death |
| US20110143956A1 (en) * | 2007-11-14 | 2011-06-16 | Medtronic, Inc. | Diagnostic Kits and Methods for SCD or SCA Therapy Selection |
| EP2222877A4 (en) * | 2007-11-14 | 2011-10-12 | Medtronic Inc | GENETIC MARKERS FOR SCD OR SCA THERAPY SELECTION |
| EP2430184A2 (en) * | 2009-05-12 | 2012-03-21 | Medtronic, Inc. | Sca risk stratification by predicting patient response to anti-arrhythmics |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5397702A (en) * | 1989-03-06 | 1995-03-14 | The Regents Of The University Of California | Assay for and treatment of autoimmune diseases |
| US5387702A (en) * | 1993-09-29 | 1995-02-07 | Council Of Scientific And Industrial Research | Process for the preparation of cabofuran |
| US6274332B1 (en) * | 1995-12-22 | 2001-08-14 | Univ. Of Utah Research Foundation | Mutations in the KCNE1 gene encoding human minK which cause arrhythmia susceptibility thereby establishing KCNE1 as an LQT gene |
| EP2085478A1 (en) * | 1995-12-22 | 2009-08-05 | University Of Utah Research Foundation | A long QT syndrome gene which encodes KVLQT1 and its association with minK |
| US6150104A (en) * | 1997-06-13 | 2000-11-21 | University Of Utah Research Foundation | Homozygous mutation in KVLQT1 which causes Jervell and Lange Nielsen syndrome |
| US6207383B1 (en) * | 1998-07-27 | 2001-03-27 | University Of Utah Research Foundation | Mutations in and genomic structure of HERG—a long QT syndrome gene |
-
1998
- 1998-08-17 US US09/135,020 patent/US6274332B1/en not_active Expired - Lifetime
- 1998-10-06 CA CA2337491A patent/CA2337491C/en not_active Expired - Lifetime
- 1998-10-06 KR KR1020017001229A patent/KR20010085315A/ko not_active Ceased
- 1998-10-06 AT AT98943446T patent/ATE359299T1/de not_active IP Right Cessation
- 1998-10-06 WO PCT/US1998/017838 patent/WO2000006600A1/en not_active Ceased
- 1998-10-06 EP EP98943446A patent/EP1100825B1/en not_active Expired - Lifetime
- 1998-10-06 JP JP2000562396A patent/JP2003530814A/ja active Pending
- 1998-10-06 DE DE69837565T patent/DE69837565T2/de not_active Expired - Lifetime
-
1999
- 1999-11-22 US US09/444,295 patent/US6432644B1/en not_active Expired - Lifetime
- 1999-11-22 US US09/444,871 patent/US6323026B1/en not_active Expired - Lifetime
-
2002
- 2002-05-06 US US10/138,316 patent/US20030054380A1/en not_active Abandoned
-
2004
- 2004-06-07 US US10/861,520 patent/US20040235038A1/en not_active Abandoned
- 2004-08-05 US US10/911,678 patent/US7247436B2/en not_active Expired - Fee Related
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