JP2003530100A5 - - Google Patents
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- Publication number
- JP2003530100A5 JP2003530100A5 JP2001575152A JP2001575152A JP2003530100A5 JP 2003530100 A5 JP2003530100 A5 JP 2003530100A5 JP 2001575152 A JP2001575152 A JP 2001575152A JP 2001575152 A JP2001575152 A JP 2001575152A JP 2003530100 A5 JP2003530100 A5 JP 2003530100A5
- Authority
- JP
- Japan
- Prior art keywords
- derived epithelial
- tube
- derived
- cytokeratin
- epithelial cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002919 epithelial cell Anatomy 0.000 description 33
- 210000004027 cell Anatomy 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 6
- 102000011782 Keratins Human genes 0.000 description 4
- 108010076876 Keratins Proteins 0.000 description 4
- 239000012679 serum free medium Substances 0.000 description 4
- 239000002458 cell surface marker Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 210000000318 mullerian duct Anatomy 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 108091005461 Nucleic proteins Proteins 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 210000003101 oviduct Anatomy 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- 108010039627 Aprotinin Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102100040487 Keratin, type I cytoskeletal 13 Human genes 0.000 description 1
- 102100040443 Keratin, type I cytoskeletal 15 Human genes 0.000 description 1
- 102100040441 Keratin, type I cytoskeletal 16 Human genes 0.000 description 1
- 102100033421 Keratin, type I cytoskeletal 18 Human genes 0.000 description 1
- 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 description 1
- 101710194922 Keratin, type II cytoskeletal 1 Proteins 0.000 description 1
- 102100022905 Keratin, type II cytoskeletal 1 Human genes 0.000 description 1
- 102100025756 Keratin, type II cytoskeletal 5 Human genes 0.000 description 1
- 102100023974 Keratin, type II cytoskeletal 7 Human genes 0.000 description 1
- 102100023972 Keratin, type II cytoskeletal 8 Human genes 0.000 description 1
- 108010065070 Keratin-13 Proteins 0.000 description 1
- 108010066330 Keratin-15 Proteins 0.000 description 1
- 108010066364 Keratin-16 Proteins 0.000 description 1
- 108010066327 Keratin-18 Proteins 0.000 description 1
- 108010066302 Keratin-19 Proteins 0.000 description 1
- 108010070553 Keratin-5 Proteins 0.000 description 1
- 102000005706 Keratin-6 Human genes 0.000 description 1
- 108010070557 Keratin-6 Proteins 0.000 description 1
- 108010070507 Keratin-7 Proteins 0.000 description 1
- 108010070511 Keratin-8 Proteins 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- 102100035071 Vimentin Human genes 0.000 description 1
- 108010065472 Vimentin Proteins 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 229960004405 aprotinin Drugs 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000011170 pharmaceutical development Methods 0.000 description 1
- 238000013334 tissue model Methods 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 210000005048 vimentin Anatomy 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/545,435 US6416999B1 (en) | 2000-04-07 | 2000-04-07 | Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof |
| US09/545,435 | 2000-04-07 | ||
| PCT/US2001/010998 WO2001077298A2 (en) | 2000-04-07 | 2001-04-04 | Human müllerian duct-derived epithelial cells and methods of isolation and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003530100A JP2003530100A (ja) | 2003-10-14 |
| JP2003530100A5 true JP2003530100A5 (https=) | 2006-10-12 |
| JP4748700B2 JP4748700B2 (ja) | 2011-08-17 |
Family
ID=24176236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001575152A Expired - Fee Related JP4748700B2 (ja) | 2000-04-07 | 2001-04-04 | ヒトミュラー管由来上皮細胞ならびにその単離方法および使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6416999B1 (https=) |
| EP (1) | EP1276850B1 (https=) |
| JP (1) | JP4748700B2 (https=) |
| KR (1) | KR100748039B1 (https=) |
| CN (1) | CN1423692A (https=) |
| AT (1) | ATE398671T1 (https=) |
| AU (2) | AU2001251311B2 (https=) |
| CA (1) | CA2404634A1 (https=) |
| DE (1) | DE60134469D1 (https=) |
| DK (1) | DK1276850T3 (https=) |
| WO (1) | WO2001077298A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6416999B1 (en) * | 2000-04-07 | 2002-07-09 | Raven Biotechnologies, Inc. | Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof |
| CA2475356A1 (en) * | 2002-02-12 | 2003-08-21 | Raven Biotechnologies, Inc. | Human fetal bladder-derived epithelial cells |
| US20040045045A1 (en) * | 2002-05-30 | 2004-03-04 | Mather Jennie P. | Animal model for toxicology and dose prediction |
| MXPA04012664A (es) * | 2002-06-19 | 2005-08-15 | Raven Biotechnologies Inc | Objetivo de superficie celular raag10 novedoso y una familia de anticuerpos que reconocen ese objetivo. |
| WO2004043239A2 (en) * | 2002-11-13 | 2004-05-27 | Raven Biotechnologies, Inc. | Antigen pipa and antibodies that bind thereto |
| EP2422802A3 (en) | 2006-03-07 | 2013-03-06 | Geeta Shroff | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation |
| KR101523698B1 (ko) * | 2007-01-22 | 2015-05-29 | 마크로제닉스 웨스트 인코퍼레이티드 | 사람 암 줄기세포 |
| ES2666152T3 (es) | 2009-08-13 | 2018-05-03 | The Johns Hopkins University | Métodos de modulación de la función inmunitaria con anticuerpos anti-B7-H7CR |
| CN102732479B (zh) * | 2011-03-31 | 2014-08-27 | 北京大学 | 胸腺上皮前体细胞的制备方法及其专用培养基 |
| AU2013248265B2 (en) * | 2012-11-08 | 2018-11-01 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| CN108061804B (zh) * | 2016-11-09 | 2020-05-12 | 北京大学人民医院 | 用于诊断子宫内膜异位症的生物标志物 |
| CN107475369B (zh) * | 2017-07-07 | 2021-05-04 | 南方医科大学 | Hoxa9基因在制备治疗皮肤鳞状细胞癌药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT802257E (pt) * | 1996-04-19 | 2003-01-31 | Nestle Sa | Linhagem imortalizada de celulas epiteliais do colon humano |
| US6004528A (en) | 1997-09-18 | 1999-12-21 | Bergstein; Ivan | Methods of cancer diagnosis and therapy targeted against the cancer stemline |
| US6416999B1 (en) | 2000-04-07 | 2002-07-09 | Raven Biotechnologies, Inc. | Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof |
-
2000
- 2000-04-07 US US09/545,435 patent/US6416999B1/en not_active Expired - Fee Related
-
2001
- 2001-04-04 JP JP2001575152A patent/JP4748700B2/ja not_active Expired - Fee Related
- 2001-04-04 DK DK01924679T patent/DK1276850T3/da active
- 2001-04-04 DE DE60134469T patent/DE60134469D1/de not_active Expired - Lifetime
- 2001-04-04 CA CA002404634A patent/CA2404634A1/en not_active Abandoned
- 2001-04-04 EP EP01924679A patent/EP1276850B1/en not_active Expired - Lifetime
- 2001-04-04 WO PCT/US2001/010998 patent/WO2001077298A2/en not_active Ceased
- 2001-04-04 AT AT01924679T patent/ATE398671T1/de not_active IP Right Cessation
- 2001-04-04 KR KR1020027013431A patent/KR100748039B1/ko not_active Expired - Fee Related
- 2001-04-04 AU AU2001251311A patent/AU2001251311B2/en not_active Ceased
- 2001-04-04 CN CN01808098A patent/CN1423692A/zh active Pending
- 2001-04-04 AU AU5131101A patent/AU5131101A/xx active Pending
-
2002
- 2002-04-05 US US10/117,895 patent/US7125713B2/en not_active Expired - Fee Related
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