JP2003522522A5 - - Google Patents
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- Publication number
- JP2003522522A5 JP2003522522A5 JP2001511485A JP2001511485A JP2003522522A5 JP 2003522522 A5 JP2003522522 A5 JP 2003522522A5 JP 2001511485 A JP2001511485 A JP 2001511485A JP 2001511485 A JP2001511485 A JP 2001511485A JP 2003522522 A5 JP2003522522 A5 JP 2003522522A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- seq
- potassium channel
- sensitive potassium
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000623 proteins and genes Proteins 0.000 description 85
- 235000018102 proteins Nutrition 0.000 description 47
- 102000004169 proteins and genes Human genes 0.000 description 47
- 238000000034 method Methods 0.000 description 45
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 38
- 239000011575 calcium Substances 0.000 description 38
- 229910052791 calcium Inorganic materials 0.000 description 38
- 102000004257 Potassium Channel Human genes 0.000 description 37
- 108020001213 potassium channel Proteins 0.000 description 37
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 22
- 108020004414 DNA Proteins 0.000 description 21
- 239000012634 fragment Substances 0.000 description 21
- 102000053602 DNA Human genes 0.000 description 18
- 239000000126 substance Substances 0.000 description 18
- 239000002773 nucleotide Substances 0.000 description 14
- 125000003729 nucleotide group Chemical group 0.000 description 14
- 239000013598 vector Substances 0.000 description 12
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 10
- 229960001230 asparagine Drugs 0.000 description 10
- 235000009582 asparagine Nutrition 0.000 description 10
- 238000013518 transcription Methods 0.000 description 10
- 230000035897 transcription Effects 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 8
- 239000011159 matrix material Substances 0.000 description 8
- 102000039446 nucleic acids Human genes 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 239000002299 complementary DNA Substances 0.000 description 7
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 6
- 108091023040 Transcription factor Proteins 0.000 description 6
- 102000040945 Transcription factor Human genes 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 239000012190 activator Substances 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 3
- 238000012163 sequencing technique Methods 0.000 description 3
- 108700028146 Genetic Enhancer Elements Proteins 0.000 description 2
- 108700008625 Reporter Genes Proteins 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 108700026220 vif Genes Proteins 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000037425 regulation of transcription Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14476499P | 1999-07-20 | 1999-07-20 | |
| US60/144,764 | 1999-07-20 | ||
| PCT/US2000/019585 WO2001005828A1 (en) | 1999-07-20 | 2000-07-18 | Novel human calcium sensitive potassium channel subunits |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003522522A JP2003522522A (ja) | 2003-07-29 |
| JP2003522522A5 true JP2003522522A5 (enExample) | 2007-11-29 |
Family
ID=22510032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001511485A Withdrawn JP2003522522A (ja) | 1999-07-20 | 2000-07-18 | 新規ヒトカルシウム感受性カリウムチャンネルサブユニット |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20050255559A1 (enExample) |
| EP (1) | EP1200467A4 (enExample) |
| JP (1) | JP2003522522A (enExample) |
| CA (1) | CA2379580A1 (enExample) |
| WO (1) | WO2001005828A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6994968B1 (en) * | 1999-02-23 | 2006-02-07 | Icagen, Inc. | BK beta subunits of Slo family potassium channels |
| AU768352B2 (en) | 1999-02-23 | 2003-12-11 | Icagen, Inc. | BK beta subunits of SLO family potassium channels |
| US6902890B1 (en) | 1999-11-04 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing monitoring, staging, imaging and treating cancer |
| US8377691B2 (en) * | 2006-01-26 | 2013-02-19 | Integral Molecular, Inc. | Lipoparticles comprising ion channels, methods of making and using the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637470A (en) * | 1994-05-13 | 1997-06-10 | Merck & Co., Inc. | Screening array using cells expressing recombinant α and β subunits of the mammalian large-conductance (maxi-K) potassium channel |
| US5661035A (en) * | 1995-06-07 | 1997-08-26 | The Regents Of The University Of California | Voltage sensing by fluorescence resonance energy transfer |
| US6994968B1 (en) * | 1999-02-23 | 2006-02-07 | Icagen, Inc. | BK beta subunits of Slo family potassium channels |
-
2000
- 2000-07-18 JP JP2001511485A patent/JP2003522522A/ja not_active Withdrawn
- 2000-07-18 EP EP00950422A patent/EP1200467A4/en not_active Withdrawn
- 2000-07-18 WO PCT/US2000/019585 patent/WO2001005828A1/en not_active Ceased
- 2000-07-18 CA CA002379580A patent/CA2379580A1/en not_active Abandoned
-
2005
- 2005-06-23 US US11/159,597 patent/US20050255559A1/en not_active Abandoned
-
2007
- 2007-09-20 US US11/903,092 patent/US20090117590A1/en not_active Abandoned
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