JP2003519683A5 - - Google Patents
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- Publication number
- JP2003519683A5 JP2003519683A5 JP2001551848A JP2001551848A JP2003519683A5 JP 2003519683 A5 JP2003519683 A5 JP 2003519683A5 JP 2001551848 A JP2001551848 A JP 2001551848A JP 2001551848 A JP2001551848 A JP 2001551848A JP 2003519683 A5 JP2003519683 A5 JP 2003519683A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxylic acid
- trifluoromethyl
- hydroxyindole
- chlorobenzyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 229910052801 chlorine Inorganic materials 0.000 claims 12
- 239000000460 chlorine Substances 0.000 claims 12
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 11
- 239000000651 prodrug Substances 0.000 claims 11
- 229940002612 prodrug Drugs 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 9
- 229910052731 fluorine Inorganic materials 0.000 claims 9
- 239000011737 fluorine Substances 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 8
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 6
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 6
- 229910052794 bromium Inorganic materials 0.000 claims 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 5
- 229910052740 iodine Inorganic materials 0.000 claims 5
- 239000011630 iodine Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 5
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 4
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 230000003042 antagnostic effect Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- FFJIOGAAFGBMMO-UHFFFAOYSA-N 1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=CC=C2N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 FFJIOGAAFGBMMO-UHFFFAOYSA-N 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- VHPDLTZTLBFZJT-UHFFFAOYSA-N 1-[(3,4-dichlorophenyl)methyl]-6-fluoro-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=C(F)C=C2N1CC1=CC=C(Cl)C(Cl)=C1 VHPDLTZTLBFZJT-UHFFFAOYSA-N 0.000 claims 1
- CVJXQVZPWKDJFD-UHFFFAOYSA-N 1-[(3-bromo-4-chlorophenyl)methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=CC=C2N1CC1=CC=C(Cl)C(Br)=C1 CVJXQVZPWKDJFD-UHFFFAOYSA-N 0.000 claims 1
- AZZMKZQUHOQKOF-UHFFFAOYSA-N 1-[(3-bromo-4-fluorophenyl)methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=CC=C2N1CC1=CC=C(F)C(Br)=C1 AZZMKZQUHOQKOF-UHFFFAOYSA-N 0.000 claims 1
- YWENOMRUEZAFGD-UHFFFAOYSA-N 1-[(4-bromo-3-fluorophenyl)methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=CC=C2N1CC1=CC=C(Br)C(F)=C1 YWENOMRUEZAFGD-UHFFFAOYSA-N 0.000 claims 1
- DYOWZWIWUWQILS-UHFFFAOYSA-N 1-[[3-chloro-4-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=CC=C2N1CC1=CC=C(C(F)(F)F)C(Cl)=C1 DYOWZWIWUWQILS-UHFFFAOYSA-N 0.000 claims 1
- ASUIQMIBTSRRHL-UHFFFAOYSA-N 1-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-5-hydroxy-3-iodoindole-2-carboxylic acid Chemical compound OC(=O)C1=C(I)C2=CC(O)=CC=C2N1CC1=CC=C(C(F)(F)F)C(F)=C1 ASUIQMIBTSRRHL-UHFFFAOYSA-N 0.000 claims 1
- VZHNQRSOIOXODL-UHFFFAOYSA-N 1-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=CC=C2N1CC1=CC=C(C(F)(F)F)C(F)=C1 VZHNQRSOIOXODL-UHFFFAOYSA-N 0.000 claims 1
- IPNKCDSWDXVBCS-UHFFFAOYSA-N 1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxy-3-methoxyindole-2-carboxylic acid Chemical compound C12=CC=C(O)C=C2C(OC)=C(C(O)=O)N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 IPNKCDSWDXVBCS-UHFFFAOYSA-N 0.000 claims 1
- JERXCFGEKCNECK-UHFFFAOYSA-N 1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-6-fluoro-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=C(F)C=C2N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 JERXCFGEKCNECK-UHFFFAOYSA-N 0.000 claims 1
- NPZKVFPFDJWZFD-UHFFFAOYSA-N 1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-7-fluoro-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=CC(F)=C2N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 NPZKVFPFDJWZFD-UHFFFAOYSA-N 0.000 claims 1
- TZLPFOAQHIZWMN-UHFFFAOYSA-N 3-bromo-1-[[3-chloro-4-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=C(Br)C2=CC(O)=CC=C2N1CC1=CC=C(C(F)(F)F)C(Cl)=C1 TZLPFOAQHIZWMN-UHFFFAOYSA-N 0.000 claims 1
- PKHPHZXPWYGMCA-UHFFFAOYSA-N 3-bromo-1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=C(Br)C2=CC(O)=CC=C2N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 PKHPHZXPWYGMCA-UHFFFAOYSA-N 0.000 claims 1
- BMDQSNQWUHNZRT-UHFFFAOYSA-N 3-bromo-1-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=C(Br)C2=CC(O)=CC=C2N1CC1=CC=C(F)C(C(F)(F)F)=C1 BMDQSNQWUHNZRT-UHFFFAOYSA-N 0.000 claims 1
- FMTJTNFXYHDRRD-UHFFFAOYSA-N 3-chloro-1-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=C(Cl)C2=CC(O)=CC=C2N1CC1=CC=C(C(F)(F)F)C(F)=C1 FMTJTNFXYHDRRD-UHFFFAOYSA-N 0.000 claims 1
- VKSKGPMWYOCWFW-UHFFFAOYSA-N 4,6-dichloro-1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=C(Cl)C(O)=C(Cl)C=C2N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 VKSKGPMWYOCWFW-UHFFFAOYSA-N 0.000 claims 1
- JGFMABXCOAPPOS-UHFFFAOYSA-N 4,6-difluoro-1-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=C(F)C(O)=C(F)C=C2N1CC1=CC=C(F)C(C(F)(F)F)=C1 JGFMABXCOAPPOS-UHFFFAOYSA-N 0.000 claims 1
- IPUPNCFHSUXZQC-UHFFFAOYSA-N 4-chloro-1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=C(Cl)C(O)=CC=C2N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 IPUPNCFHSUXZQC-UHFFFAOYSA-N 0.000 claims 1
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims 1
- XLSXVVWAGZFQMY-UHFFFAOYSA-N 5-acetyloxy-1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]indole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(OC(=O)C)=CC=C2N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 XLSXVVWAGZFQMY-UHFFFAOYSA-N 0.000 claims 1
- JOYQPINQNBHROU-UHFFFAOYSA-N 6-bromo-1-[(3,4-dichlorophenyl)methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=C(Br)C=C2N1CC1=CC=C(Cl)C(Cl)=C1 JOYQPINQNBHROU-UHFFFAOYSA-N 0.000 claims 1
- BEOZLFMCZQOJOJ-UHFFFAOYSA-N 6-bromo-1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=C(Br)C=C2N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 BEOZLFMCZQOJOJ-UHFFFAOYSA-N 0.000 claims 1
- GLHOHBQJNKZQSN-UHFFFAOYSA-N 6-chloro-1-[(3,4-dichlorophenyl)methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=C(Cl)C=C2N1CC1=CC=C(Cl)C(Cl)=C1 GLHOHBQJNKZQSN-UHFFFAOYSA-N 0.000 claims 1
- MZBARAFRMKJZRC-UHFFFAOYSA-N 6-chloro-1-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=C(Cl)C=C2N1CC1=CC=C(Cl)C(C(F)(F)F)=C1 MZBARAFRMKJZRC-UHFFFAOYSA-N 0.000 claims 1
- YUESWVLVTXPMEW-UHFFFAOYSA-N 6-chloro-1-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl]-5-hydroxyindole-2-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(O)=C(Cl)C=C2N1CC1=CC=C(F)C(C(F)(F)F)=C1 YUESWVLVTXPMEW-UHFFFAOYSA-N 0.000 claims 1
- PQODGLRZNILPBB-UHFFFAOYSA-N FC(C=1C=C(CN2C(=CC3=C(C(=CC=C23)O)F)C(=O)O)C=CC1Cl)(F)F.FC(C=1C=C(CN2C(=CC3=C(C(=CC=C23)O)F)C(=O)O)C=CC1F)(F)F Chemical compound FC(C=1C=C(CN2C(=CC3=C(C(=CC=C23)O)F)C(=O)O)C=CC1Cl)(F)F.FC(C=1C=C(CN2C(=CC3=C(C(=CC=C23)O)F)C(=O)O)C=CC1F)(F)F PQODGLRZNILPBB-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0000626.2A GB0000626D0 (en) | 2000-01-13 | 2000-01-13 | Chemical compounds |
| GB0000626.2 | 2000-01-13 | ||
| PCT/GB2001/000069 WO2001051466A1 (en) | 2000-01-13 | 2001-01-11 | Indole derivatives as mcp-1 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519683A JP2003519683A (ja) | 2003-06-24 |
| JP2003519683A5 true JP2003519683A5 (enExample) | 2005-06-30 |
Family
ID=9883551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551848A Pending JP2003519683A (ja) | 2000-01-13 | 2001-01-11 | Ｍｃｐ−１受容体アンタゴニストとしてのインドール誘導体 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20030144339A1 (enExample) |
| EP (1) | EP1252142A1 (enExample) |
| JP (1) | JP2003519683A (enExample) |
| KR (1) | KR20020064375A (enExample) |
| CN (1) | CN1395565A (enExample) |
| AR (1) | AR026839A1 (enExample) |
| AU (1) | AU780992B2 (enExample) |
| BG (1) | BG106894A (enExample) |
| BR (1) | BR0107404A (enExample) |
| CA (1) | CA2393592A1 (enExample) |
| CO (1) | CO5271703A1 (enExample) |
| EE (1) | EE200200394A (enExample) |
| GB (1) | GB0000626D0 (enExample) |
| HK (1) | HK1049486A1 (enExample) |
| HU (1) | HUP0300694A3 (enExample) |
| IL (1) | IL150272A0 (enExample) |
| IS (1) | IS6429A (enExample) |
| MX (1) | MXPA02006611A (enExample) |
| NO (1) | NO20023380L (enExample) |
| NZ (1) | NZ519312A (enExample) |
| PL (1) | PL356031A1 (enExample) |
| RU (1) | RU2002121636A (enExample) |
| SK (1) | SK10072002A3 (enExample) |
| WO (1) | WO2001051466A1 (enExample) |
| ZA (1) | ZA200204354B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| WO2004069809A1 (en) * | 2003-02-03 | 2004-08-19 | Janssen Pharmaceutica N.V. | Mercaptoimidazoles as ccr2 receptor antagonists |
| CN100566811C (zh) * | 2004-09-13 | 2009-12-09 | 株式会社吴羽 | 热发泡性微球及其制造方法、其用途、含有其的组合物、和物品 |
| US7579351B2 (en) | 2005-12-09 | 2009-08-25 | Hoffmann-La Roche Inc. | Tricyclic amide derivatives |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| US7507736B2 (en) | 2007-02-07 | 2009-03-24 | Hoffmann-La Roche Inc. | Indol-2-yl-piperazin-1-yl-methanone derivatives |
| PL2134685T3 (pl) | 2007-04-16 | 2016-02-29 | Abbvie Inc | Pochodne indolu niepodstawione w pozycji 7 jako inhibitory Mcl-1 |
| US20250320186A1 (en) * | 2022-05-17 | 2025-10-16 | Inipharm, Inc. | Hsd17b13 inhibitors and uses thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529724A (en) * | 1983-10-11 | 1985-07-16 | Mcneilab, Inc. | 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives |
| DE3907388A1 (de) * | 1989-03-08 | 1990-09-13 | Kali Chemie Pharma Gmbh | Verfahren zur herstellung von indolcarbonsaeurederivaten |
| US5272145A (en) * | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5081145A (en) * | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
| US5389650A (en) * | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5273980A (en) * | 1991-09-30 | 1993-12-28 | Merck Frosst Canada Inc. | Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5288743A (en) * | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
| US5852046A (en) * | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
| US5686481A (en) * | 1993-12-21 | 1997-11-11 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| US5482960A (en) * | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
| US5684032A (en) * | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| JP2000507556A (ja) * | 1996-03-28 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | ケモカインのカルボン酸インドール阻害剤 |
| JP2000516611A (ja) * | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Ｍｃｐ―１アンタゴニストとしての２―フェニルベンズイミダゾール誘導体 |
| GB9716656D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9803228D0 (en) * | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| GB9803226D0 (en) * | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
-
2000
- 2000-01-13 GB GBGB0000626.2A patent/GB0000626D0/en not_active Ceased
-
2001
- 2001-01-11 AU AU25324/01A patent/AU780992B2/en not_active Ceased
- 2001-01-11 EP EP01900494A patent/EP1252142A1/en not_active Withdrawn
- 2001-01-11 SK SK1007-2002A patent/SK10072002A3/sk unknown
- 2001-01-11 KR KR1020027009021A patent/KR20020064375A/ko not_active Withdrawn
- 2001-01-11 CA CA002393592A patent/CA2393592A1/en not_active Abandoned
- 2001-01-11 CN CN01803645A patent/CN1395565A/zh active Pending
- 2001-01-11 EE EEP200200394A patent/EE200200394A/xx unknown
- 2001-01-11 WO PCT/GB2001/000069 patent/WO2001051466A1/en not_active Ceased
- 2001-01-11 JP JP2001551848A patent/JP2003519683A/ja active Pending
- 2001-01-11 BR BR0107404-0A patent/BR0107404A/pt not_active IP Right Cessation
- 2001-01-11 IL IL15027201A patent/IL150272A0/xx unknown
- 2001-01-11 PL PL01356031A patent/PL356031A1/xx not_active Application Discontinuation
- 2001-01-11 MX MXPA02006611A patent/MXPA02006611A/es unknown
- 2001-01-11 RU RU2002121636/04A patent/RU2002121636A/ru not_active Application Discontinuation
- 2001-01-11 NZ NZ519312A patent/NZ519312A/en unknown
- 2001-01-11 HK HK03101662.2A patent/HK1049486A1/zh unknown
- 2001-01-11 US US10/169,717 patent/US20030144339A1/en not_active Abandoned
- 2001-01-11 HU HU0300694A patent/HUP0300694A3/hu unknown
- 2001-01-12 AR ARP010100144A patent/AR026839A1/es not_active Application Discontinuation
- 2001-01-15 CO CO01002379A patent/CO5271703A1/es not_active Application Discontinuation
-
2002
- 2002-05-30 ZA ZA200204354A patent/ZA200204354B/en unknown
- 2002-06-19 IS IS6429A patent/IS6429A/is unknown
- 2002-07-02 BG BG106894A patent/BG106894A/bg unknown
- 2002-07-12 NO NO20023380A patent/NO20023380L/no not_active Application Discontinuation