HK1049486A1 - 作為mcp-1受體拮抗劑的吲類衍生物 - Google Patents

作為mcp-1受體拮抗劑的吲類衍生物 Download PDF

Info

Publication number
HK1049486A1
HK1049486A1 HK03101662.2A HK03101662A HK1049486A1 HK 1049486 A1 HK1049486 A1 HK 1049486A1 HK 03101662 A HK03101662 A HK 03101662A HK 1049486 A1 HK1049486 A1 HK 1049486A1
Authority
HK
Hong Kong
Prior art keywords
halo
hydrogen
mcp
receptor antagonists
indole derivatives
Prior art date
Application number
HK03101662.2A
Other languages
English (en)
Chinese (zh)
Inventor
Wellington Faull Alan
Grant Kettle Jason
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1049486A1 publication Critical patent/HK1049486A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
HK03101662.2A 2000-01-13 2001-01-11 作為mcp-1受體拮抗劑的吲類衍生物 HK1049486A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0000626.2A GB0000626D0 (en) 2000-01-13 2000-01-13 Chemical compounds
GB0000626 2000-01-13
PCT/GB2001/000069 WO2001051466A1 (en) 2000-01-13 2001-01-11 Indole derivatives as mcp-1 receptor antagonists

Publications (1)

Publication Number Publication Date
HK1049486A1 true HK1049486A1 (zh) 2003-05-16

Family

ID=9883551

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101662.2A HK1049486A1 (zh) 2000-01-13 2001-01-11 作為mcp-1受體拮抗劑的吲類衍生物

Country Status (25)

Country Link
US (1) US20030144339A1 (enExample)
EP (1) EP1252142A1 (enExample)
JP (1) JP2003519683A (enExample)
KR (1) KR20020064375A (enExample)
CN (1) CN1395565A (enExample)
AR (1) AR026839A1 (enExample)
AU (1) AU780992B2 (enExample)
BG (1) BG106894A (enExample)
BR (1) BR0107404A (enExample)
CA (1) CA2393592A1 (enExample)
CO (1) CO5271703A1 (enExample)
EE (1) EE200200394A (enExample)
GB (1) GB0000626D0 (enExample)
HK (1) HK1049486A1 (enExample)
HU (1) HUP0300694A3 (enExample)
IL (1) IL150272A0 (enExample)
IS (1) IS6429A (enExample)
MX (1) MXPA02006611A (enExample)
NO (1) NO20023380L (enExample)
NZ (1) NZ519312A (enExample)
PL (1) PL356031A1 (enExample)
RU (1) RU2002121636A (enExample)
SK (1) SK10072002A3 (enExample)
WO (1) WO2001051466A1 (enExample)
ZA (1) ZA200204354B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
WO2004069809A1 (en) * 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
EP1811007B1 (en) * 2004-09-13 2010-03-31 Kureha Corporation Thermally foaming microsphere, method for production thereof, use thereof, composition containing the same, and article
CN101321761A (zh) 2005-12-09 2008-12-10 霍夫曼-拉罗奇有限公司 用于治疗肥胖病的三环酰胺衍生物
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7507736B2 (en) 2007-02-07 2009-03-24 Hoffmann-La Roche Inc. Indol-2-yl-piperazin-1-yl-methanone derivatives
CA2951295C (en) * 2007-04-16 2020-04-28 Abbvie Inc. 7-nonsubstituted indole mcl-1 inhibitors
US20250320186A1 (en) * 2022-05-17 2025-10-16 Inipharm, Inc. Hsd17b13 inhibitors and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529724A (en) * 1983-10-11 1985-07-16 Mcneilab, Inc. 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives
DE3907388A1 (de) * 1989-03-08 1990-09-13 Kali Chemie Pharma Gmbh Verfahren zur herstellung von indolcarbonsaeurederivaten
US5272145A (en) * 1989-08-22 1993-12-21 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5081145A (en) * 1990-02-01 1992-01-14 Merck Frosst Canada, Inc. Indole-2-alkanoic acids compositions of and anti allergic use thereof
US5273980A (en) * 1991-09-30 1993-12-28 Merck Frosst Canada Inc. Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) * 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) * 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) * 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5288743A (en) * 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
US5852046A (en) * 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
US5686481A (en) * 1993-12-21 1997-11-11 Smithkline Beecham Corporation Endothelin receptor antagonists
US5482960A (en) * 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
US5684032A (en) * 1994-12-13 1997-11-04 Smithkline Beecham Corporation Compounds
JP2000507556A (ja) * 1996-03-28 2000-06-20 スミスクライン・ビーチャム・コーポレイション ケモカインのカルボン酸インドール阻害剤
EP0927167A1 (en) * 1996-08-14 1999-07-07 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
GB9716657D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9716656D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9803228D0 (en) * 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9803226D0 (en) * 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9902461D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
ZA200204354B (en) 2003-09-01
BG106894A (bg) 2003-04-30
KR20020064375A (ko) 2002-08-07
CO5271703A1 (es) 2003-04-30
RU2002121636A (ru) 2004-01-10
PL356031A1 (en) 2004-06-14
AU780992B2 (en) 2005-04-28
MXPA02006611A (es) 2002-09-30
US20030144339A1 (en) 2003-07-31
CA2393592A1 (en) 2001-07-19
NO20023380D0 (no) 2002-07-12
SK10072002A3 (sk) 2003-06-03
IS6429A (is) 2002-06-19
CN1395565A (zh) 2003-02-05
AU2532401A (en) 2001-07-24
NO20023380L (no) 2002-09-03
AR026839A1 (es) 2003-02-26
IL150272A0 (en) 2002-12-01
NZ519312A (en) 2004-04-30
JP2003519683A (ja) 2003-06-24
EP1252142A1 (en) 2002-10-30
EE200200394A (et) 2003-12-15
HUP0300694A3 (en) 2005-08-29
HUP0300694A2 (hu) 2003-07-28
WO2001051466A1 (en) 2001-07-19
BR0107404A (pt) 2002-10-08
GB0000626D0 (en) 2000-03-01

Similar Documents

Publication Publication Date Title
MXPA06000716A (es) Derivados de quinolina y quinazolina que tienen afinidad hacia receptores del tipo 5ht1.
WO2006098918A3 (en) Substituted gamma lactams as therapeutic agents
JO2282B1 (en) Oxazole derivatives
MY137156A (en) Dual nk1/nk3 derivatives
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
MX2008016423A (es) Arilamidas sustituidas con tetrazol.
WO2002057252A3 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
MY130803A (en) New quinuclidine amide derivatives
AU2002246728A1 (en) Carboline derivatives
TR200102489T2 (tr) 3-Fenilpiridin Türevleri ve bunların NK-1 alıcı antagonistler olarak kullanılması
ATE349432T1 (de) 2-anilino-pyrimidin-derivate als cyclin-abhängige kinase hemmer
MXPA04002338A (es) Derivados de carbazol y su uso como antagonistas receptores del npy5.
WO2001064645A3 (en) Derivatives of quinoline as alpha-2 antagonists
HK1046405A1 (zh) 作为nmda受体拮抗剂用於治疗疼痛的取代的1，5-二氢吡咯-2-酮衍生物
AU2002249890A1 (en) Carboline derivatives
AU6518998A (en) Morphinane derivatives and medicinal use thereof
AU2003239389A1 (en) Opioid receptor antagonists
HK1049486A1 (zh) 作為mcp-1受體拮抗劑的吲類衍生物
WO2006038006A3 (en) 5-sulfonyl-1-piperidinyl substituted indole derivatives as 5-ht6 receptor antagonists for the treatment of cns disorders
WO2005075450A3 (en) Spiro-benzodioxoles and their use as cb1 antagonists
WO2004067703A3 (en) 5ht7 antagonists and inverse agonists
DK1204658T3 (da) Benzofurylpiperazin-serotoninagonister
AU2001261707A1 (en) Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives
CA2427573A1 (en) Indole derivatives as pde5-inhibitors
MXPA04003278A (es) Derivados de 5-metoxi-8-aril-?1,2,4?triazolo?1,5-a?piridina como antagonistas del receptor de adenosina.