JP2003510054A - 単一ヌクレオチド多形性の平行遺伝子型決定のための三次元ミクロアレイシステム - Google Patents
単一ヌクレオチド多形性の平行遺伝子型決定のための三次元ミクロアレイシステムInfo
- Publication number
- JP2003510054A JP2003510054A JP2001525396A JP2001525396A JP2003510054A JP 2003510054 A JP2003510054 A JP 2003510054A JP 2001525396 A JP2001525396 A JP 2001525396A JP 2001525396 A JP2001525396 A JP 2001525396A JP 2003510054 A JP2003510054 A JP 2003510054A
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- Prior art keywords
- oligonucleotide
- nucleic acid
- chain terminating
- species
- terminating nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00664—Three-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
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- Immunology (AREA)
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- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15543199P | 1999-09-22 | 1999-09-22 | |
| US60/155,431 | 1999-09-22 | ||
| PCT/US2000/025988 WO2001021838A2 (fr) | 1999-09-22 | 2000-09-22 | Systeme tridimensionnel de micro-reseau servant au genotypage en parallele du polymorphisme de nucleotides isoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003510054A true JP2003510054A (ja) | 2003-03-18 |
| JP2003510054A5 JP2003510054A5 (fr) | 2007-11-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001525396A Pending JP2003510054A (ja) | 1999-09-22 | 2000-09-22 | 単一ヌクレオチド多形性の平行遺伝子型決定のための三次元ミクロアレイシステム |
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| EP (1) | EP1222310A2 (fr) |
| JP (1) | JP2003510054A (fr) |
| AU (1) | AU7708500A (fr) |
| CA (1) | CA2385851A1 (fr) |
| WO (1) | WO2001021838A2 (fr) |
Families Citing this family (14)
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| US7427497B2 (en) * | 2001-11-01 | 2008-09-23 | Rensselaer Polytechnic Institute | In vitro metabolic engineering on microscale devices |
| US11001881B2 (en) | 2006-08-24 | 2021-05-11 | California Institute Of Technology | Methods for detecting analytes |
| US8048626B2 (en) | 2006-07-28 | 2011-11-01 | California Institute Of Technology | Multiplex Q-PCR arrays |
| US11525156B2 (en) | 2006-07-28 | 2022-12-13 | California Institute Of Technology | Multiplex Q-PCR arrays |
| US11560588B2 (en) | 2006-08-24 | 2023-01-24 | California Institute Of Technology | Multiplex Q-PCR arrays |
| US20120141986A1 (en) * | 2007-03-27 | 2012-06-07 | Kenneth Kuhn | Multivalent substrate elements for detection of nucleic acid sequences |
| EP2558859B1 (fr) * | 2010-04-15 | 2017-09-27 | Digital Sensing Limited | Micro-reseaux tri-dimensionnel |
| US9708647B2 (en) | 2015-03-23 | 2017-07-18 | Insilixa, Inc. | Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays |
| US9499861B1 (en) | 2015-09-10 | 2016-11-22 | Insilixa, Inc. | Methods and systems for multiplex quantitative nucleic acid amplification |
| WO2017155858A1 (fr) | 2016-03-07 | 2017-09-14 | Insilixa, Inc. | Identification de séquence d'acide nucléique à l'aide d'une extension de base unique cyclique en phase solide |
| CN110678557A (zh) | 2017-03-31 | 2020-01-10 | 玛赛拉·基亚里 | 通过管内杂交与通用标签-微阵列的组合的突变的基因分型 |
| JP2022525322A (ja) | 2019-03-14 | 2022-05-12 | インシリクサ， インコーポレイテッド | 時間ゲート蛍光ベースの検出のための方法およびシステム |
| CN116023412A (zh) * | 2021-10-25 | 2023-04-28 | 中元汇吉生物技术股份有限公司 | 一种修饰的核苷酸、组合物及试剂 |
| CN113943324B (zh) * | 2021-10-25 | 2023-07-28 | 中元汇吉生物技术股份有限公司 | 一种修饰的核苷酸，组合物及试剂 |
Family Cites Families (8)
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| IE66572B1 (en) * | 1989-02-13 | 1996-01-24 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
| RU1794088C (ru) * | 1991-03-18 | 1993-02-07 | Институт Молекулярной Биологии Ан@ Ссср | Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени |
| WO1993025563A1 (fr) * | 1992-06-17 | 1993-12-23 | City Of Hope | Procede de detection de sequences d'acide nucleique et de discrimination entre ces sequences |
| RU2041261C1 (ru) * | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ изготовления матрицы для детектирования мисматчей |
| AUPO427996A0 (en) * | 1996-12-20 | 1997-01-23 | Co-Operative Research Centre For Diagnostic Technologies | Method for detecting a nucleotide at a specific location within a polynucleotide sequence and apparatus therefor |
| AU6846798A (en) * | 1997-04-01 | 1998-10-22 | Glaxo Group Limited | Method of nucleic acid sequencing |
| US6048692A (en) * | 1997-10-07 | 2000-04-11 | Motorola, Inc. | Sensors for electrically sensing binding events for supported molecular receptors |
| US6391937B1 (en) * | 1998-11-25 | 2002-05-21 | Motorola, Inc. | Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers |
-
2000
- 2000-09-22 EP EP00966797A patent/EP1222310A2/fr not_active Withdrawn
- 2000-09-22 CA CA002385851A patent/CA2385851A1/fr not_active Abandoned
- 2000-09-22 JP JP2001525396A patent/JP2003510054A/ja active Pending
- 2000-09-22 WO PCT/US2000/025988 patent/WO2001021838A2/fr active Application Filing
- 2000-09-22 AU AU77085/00A patent/AU7708500A/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| JPN6010035042, Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓ．， ２７［１８］（Ａｕｇ １９９９） ｐ．ｅ１９（ｉ−ｖｉ） * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001021838A3 (fr) | 2001-10-25 |
| EP1222310A2 (fr) | 2002-07-17 |
| CA2385851A1 (fr) | 2001-03-29 |
| AU7708500A (en) | 2001-04-24 |
| WO2001021838A2 (fr) | 2001-03-29 |
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