JP2003510018A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003510018A5 JP2003510018A5 JP2001509760A JP2001509760A JP2003510018A5 JP 2003510018 A5 JP2003510018 A5 JP 2003510018A5 JP 2001509760 A JP2001509760 A JP 2001509760A JP 2001509760 A JP2001509760 A JP 2001509760A JP 2003510018 A5 JP2003510018 A5 JP 2003510018A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- tuberculosis
- fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 77
- 102000004196 processed proteins & peptides Human genes 0.000 description 76
- 229920001184 polypeptide Polymers 0.000 description 75
- 239000012634 fragment Substances 0.000 description 33
- 241001465754 Metazoa Species 0.000 description 27
- 229960005486 vaccine Drugs 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 20
- 238000000034 method Methods 0.000 description 20
- 150000007523 nucleic acids Chemical group 0.000 description 19
- 150000001413 amino acids Chemical group 0.000 description 18
- 230000004927 fusion Effects 0.000 description 17
- 201000008827 tuberculosis Diseases 0.000 description 16
- 210000001744 T-lymphocyte Anatomy 0.000 description 15
- 239000000203 mixture Substances 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 14
- 241000282412 Homo Species 0.000 description 13
- 239000000523 sample Substances 0.000 description 12
- 239000013598 vector Substances 0.000 description 11
- 239000000427 antigen Substances 0.000 description 9
- 244000005700 microbiome Species 0.000 description 9
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 8
- 108091007433 antigens Proteins 0.000 description 8
- -1 Amino Chemical group 0.000 description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 241001467553 Mycobacterium africanum Species 0.000 description 6
- 241000186366 Mycobacterium bovis Species 0.000 description 6
- 230000003053 immunization Effects 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 239000003981 vehicle Substances 0.000 description 6
- 108090000695 Cytokines Proteins 0.000 description 5
- 102000004127 Cytokines Human genes 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 5
- 241001467552 Mycobacterium bovis BCG Species 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 231100000430 skin reaction Toxicity 0.000 description 5
- 108010074328 Interferon-gamma Proteins 0.000 description 4
- 241001302239 Mycobacterium tuberculosis complex Species 0.000 description 4
- 125000000539 amino acid group Chemical group 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 230000005847 immunogenicity Effects 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 244000000010 microbial pathogen Species 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 101710166488 6 kDa early secretory antigenic target Proteins 0.000 description 3
- 102100037850 Interferon gamma Human genes 0.000 description 3
- 241000186359 Mycobacterium Species 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 238000009396 hybridization Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000005087 mononuclear cell Anatomy 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 238000010647 peptide synthesis reaction Methods 0.000 description 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 230000002194 synthesizing effect Effects 0.000 description 3
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 2
- 108010000916 Fimbriae Proteins Proteins 0.000 description 2
- 102000013462 Interleukin-12 Human genes 0.000 description 2
- 108010065805 Interleukin-12 Proteins 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 102000000588 Interleukin-2 Human genes 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 206010062207 Mycobacterial infection Diseases 0.000 description 2
- 101100291912 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) mpb64 gene Proteins 0.000 description 2
- 241000589516 Pseudomonas Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical group [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 description 2
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 229940035032 monophosphoryl lipid a Drugs 0.000 description 2
- 101150014428 mpt64 gene Proteins 0.000 description 2
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 2
- 208000027531 mycobacterial infectious disease Diseases 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000003362 replicative effect Effects 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 102100024341 10 kDa heat shock protein, mitochondrial Human genes 0.000 description 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 description 1
- 108010031025 Alanine Dehydrogenase Proteins 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 108010059013 Chaperonin 10 Proteins 0.000 description 1
- 108010058432 Chaperonin 60 Proteins 0.000 description 1
- 108010041986 DNA Vaccines Proteins 0.000 description 1
- 229940021995 DNA vaccine Drugs 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241001522878 Escherichia coli B Species 0.000 description 1
- 241001646716 Escherichia coli K-12 Species 0.000 description 1
- 241001302584 Escherichia coli str. K-12 substr. W3110 Species 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 108091092566 Extrachromosomal DNA Proteins 0.000 description 1
- 102000005720 Glutathione transferase Human genes 0.000 description 1
- 108010070675 Glutathione transferase Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- 241000194036 Lactococcus Species 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 description 1
- 241000187480 Mycobacterium smegmatis Species 0.000 description 1
- 101001043272 Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) Lipoprotein LpqH Proteins 0.000 description 1
- 101000856404 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Carboxylesterase Culp1 Proteins 0.000 description 1
- 101000941208 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Probable carboxylesterase Culp2 Proteins 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 241001442654 Percnon planissimum Species 0.000 description 1
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 description 1
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 description 1
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 108700008625 Reporter Genes Proteins 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- 230000006052 T cell proliferation Effects 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 1
- 102000007362 alpha-Crystallins Human genes 0.000 description 1
- 108010007908 alpha-Crystallins Proteins 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 101150079015 esxB gene Proteins 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 1
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 1
- 102000005396 glutamine synthetase Human genes 0.000 description 1
- 108020002326 glutamine synthetase Proteins 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- 230000029226 lipidation Effects 0.000 description 1
- 101150047914 mpt51 gene Proteins 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199901020 | 1999-07-13 | ||
| DKPA199901020 | 1999-07-13 | ||
| DKPA199901020 | 1999-07-13 | ||
| US14401199P | 1999-07-15 | 1999-07-15 | |
| US60/144,011 | 1999-07-15 | ||
| PCT/DK2000/000398 WO2001004151A2 (en) | 1999-07-13 | 2000-07-13 | TUBERCULOSIS VACCINE AND DIAGNOSTICS BASED ON THE MYCOBACTERIUM TUBERCULOSIS esat-6 GENE FAMILY |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010262852A Division JP5075969B2 (ja) | 1999-07-13 | 2010-11-25 | マイコバクテリウム・ツベルクローシスｅｓａｔ−６遺伝子ファミリーベースの結核ワクチン及び診断法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003510018A JP2003510018A (ja) | 2003-03-18 |
| JP2003510018A5 true JP2003510018A5 (enExample) | 2007-08-30 |
| JP5010079B2 JP5010079B2 (ja) | 2012-08-29 |
Family
ID=26065081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001509760A Expired - Lifetime JP5010079B2 (ja) | 1999-07-13 | 2000-07-13 | マイコバクテリウム・ツベルクローシスｅｓａｔ−６遺伝子ファミリーベースの結核ワクチン及び診断法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7867502B1 (enExample) |
| EP (1) | EP1200466A2 (enExample) |
| JP (1) | JP5010079B2 (enExample) |
| AU (3) | AU779495B2 (enExample) |
| CA (1) | CA2378763A1 (enExample) |
| WO (1) | WO2001004151A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291190B1 (en) * | 1998-08-25 | 2001-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Molecular differences between species of the M. tuberculosis complex |
| CN1350546A (zh) * | 1998-11-04 | 2002-05-22 | Isis创新有限公司 | 结核诊断测验 |
| CA2433236C (en) | 2001-01-08 | 2016-10-04 | Isis Innovation Limited | Assay to determine efficacy of treatment for m. tuberculosis infection |
| GB0215710D0 (en) | 2002-07-05 | 2002-08-14 | Isis Innovation | Diagnostic method |
| WO2004099771A1 (en) * | 2003-05-08 | 2004-11-18 | Statens Serum Institut | A new specific epitope based immunological diagnosis of tuberculosis |
| WO2005070959A2 (en) * | 2004-01-23 | 2005-08-04 | Vievax Corp. | Compositions comprising immune response altering agents and methods of use |
| ITRM20040091A1 (it) | 2004-02-19 | 2004-05-19 | Istituto Naz Per Le Malattie | Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare. |
| FR2872579B1 (fr) * | 2004-06-30 | 2006-11-24 | Pasteur Institut | Detection de la tuberculose et de l'infection par mycobacterium tuberculosis a l'aide de hbha |
| NZ555907A (en) | 2004-11-16 | 2009-12-24 | Aeras Global Tb Vaccine Found | Multivalent vaccines comprising recombinant viral vectors |
| CN100401066C (zh) * | 2005-09-23 | 2008-07-09 | 中国人民解放军第三○九医院 | 基于组合蛋白的结核分枝杆菌金标诊断试剂 |
| IN2015DN03125A (enExample) * | 2006-09-05 | 2015-10-02 | Hvidovre Hospital | |
| GB0618127D0 (en) * | 2006-09-14 | 2006-10-25 | Isis Innovation | Biomarker |
| US20100015171A1 (en) * | 2008-07-15 | 2010-01-21 | Statens Serum Institute | Vaccines comprising tb 10.4 |
| CN102413837B (zh) | 2009-04-24 | 2015-11-25 | 国立血清研究所 | 预防再激活的结核病tb疫苗 |
| CN102713629B (zh) | 2009-11-20 | 2016-02-24 | 俄勒冈健康科学大学 | 用于检测结核分枝杆菌感染的方法 |
| GB201012072D0 (en) * | 2010-07-19 | 2010-09-01 | Sec Dep For Environment Food A | Diagnostic reagents |
| ITRM20100411A1 (it) * | 2010-07-23 | 2012-01-24 | Massimo Amicosante | Uso di sequenze amminoacidiche da mycobacterium tuberculosis o dei loro corrispondenti acidi nucleici per la diagnosi e la prevenzione di infezione tubercolare, relativo kit diagnostico e vaccino. |
| CN102183649A (zh) * | 2011-01-31 | 2011-09-14 | 中国农业大学 | 牛结核病抗原特异性γ-干扰素ELISA试剂盒 |
| US10641770B2 (en) * | 2013-12-16 | 2020-05-05 | Statens Serum Institut | Diagnostic reagents for improved in vivo or in vitro cell-mediated immunological diagnosis of tuberculosis |
| CN103974483B (zh) * | 2014-05-25 | 2016-03-16 | 上海洞舟实业有限公司 | 一种电感电致发光线 |
| KR101696514B1 (ko) * | 2014-08-18 | 2017-01-24 | 서울대학교산학협력단 | 신규한 온도 민감성 마이코박테리아 균주 및 이를 포함하는 마이코박테리아 감염증에 대한 백신 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6555653B2 (en) * | 1997-05-20 | 2003-04-29 | Corixa Corporation | Compounds for diagnosis of tuberculosis and methods for their use |
| US6613881B1 (en) * | 1997-05-20 | 2003-09-02 | Corixa Corporation | Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use |
| WO1999024577A1 (en) | 1997-11-10 | 1999-05-20 | Statens Serum Institut | NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS) |
-
2000
- 2000-07-13 EP EP00945660A patent/EP1200466A2/en not_active Withdrawn
- 2000-07-13 AU AU59664/00A patent/AU779495B2/en not_active Ceased
- 2000-07-13 CA CA002378763A patent/CA2378763A1/en not_active Expired - Lifetime
- 2000-07-13 JP JP2001509760A patent/JP5010079B2/ja not_active Expired - Lifetime
- 2000-07-13 WO PCT/DK2000/000398 patent/WO2001004151A2/en not_active Ceased
-
2003
- 2003-11-26 US US10/723,908 patent/US7867502B1/en not_active Expired - Lifetime
-
2005
- 2005-04-27 AU AU2005201767A patent/AU2005201767B2/en not_active Expired
-
2008
- 2008-09-24 AU AU2008224343A patent/AU2008224343B2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2008224343B2 (en) | Tuberculosis vaccine and diagnostics based on the Mycobacterium tuberculosis esat-6 gene family | |
| JP2003510018A5 (enExample) | ||
| US8142797B2 (en) | Therapeutic TB vaccine | |
| AU2010238943B9 (en) | A tuberculosis TB vaccine to prevent reactivation | |
| US7579141B2 (en) | Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines | |
| WO2001079274A2 (en) | Tuberculosis antigens and methods of use thereof | |
| WO2005061534A2 (en) | Improved tuberculosis vaccines | |
| AU766093B2 (en) | Tuberculosis vaccine and diagnostic reagents based on antigens from the mycobacterium tuberculosis cell | |
| US20040013685A1 (en) | Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis | |
| JP5075969B2 (ja) | マイコバクテリウム・ツベルクローシスｅｓａｔ−６遺伝子ファミリーベースの結核ワクチン及び診断法 | |
| AU2012202486B2 (en) | Tuberculosis vaccine and diagnostics based on the Mycobacterium tuberculosis esat-6 gene family | |
| EP1146889A2 (en) | Identification of specific differentially expressed mycobacterial antigens | |
| JP2011102299A5 (enExample) | ||
| EP1787994A1 (en) | TB vaccine and diagnostic based on antigens from M. tuberculosis cell |