AU779495B2 - Tuberculosis vaccine and diagnostics based on the mycobacterium tuberculosis esat-6 gene family - Google Patents

Tuberculosis vaccine and diagnostics based on the mycobacterium tuberculosis esat-6 gene family Download PDF

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Publication number
AU779495B2
AU779495B2 AU59664/00A AU5966400A AU779495B2 AU 779495 B2 AU779495 B2 AU 779495B2 AU 59664/00 A AU59664/00 A AU 59664/00A AU 5966400 A AU5966400 A AU 5966400A AU 779495 B2 AU779495 B2 AU 779495B2
Authority
AU
Australia
Prior art keywords
polypeptide
ala
tuberculosis
amino acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU59664/00A
Other languages
English (en)
Other versions
AU5966400A (en
Inventor
Peter Andersen
Rikke Skjot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Statens Serum Institut SSI
Original Assignee
Statens Serum Institut SSI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Statens Serum Institut SSI filed Critical Statens Serum Institut SSI
Publication of AU5966400A publication Critical patent/AU5966400A/en
Application granted granted Critical
Publication of AU779495B2 publication Critical patent/AU779495B2/en
Priority to AU2005201767A priority Critical patent/AU2005201767B2/en
Priority to AU2008224343A priority patent/AU2008224343B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU59664/00A 1999-07-13 2000-07-13 Tuberculosis vaccine and diagnostics based on the mycobacterium tuberculosis esat-6 gene family Ceased AU779495B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2005201767A AU2005201767B2 (en) 1999-07-13 2005-04-27 Tuberculosis vaccine and diagnostics based on the Mycobacterium tuberculosis esat-6 gene family
AU2008224343A AU2008224343B2 (en) 1999-07-13 2008-09-24 Tuberculosis vaccine and diagnostics based on the Mycobacterium tuberculosis esat-6 gene family

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK199901020 1999-07-13
DKPA199901020 1999-07-13
US14401199P 1999-07-15 1999-07-15
US60/144011 1999-07-15
PCT/DK2000/000398 WO2001004151A2 (en) 1999-07-13 2000-07-13 TUBERCULOSIS VACCINE AND DIAGNOSTICS BASED ON THE MYCOBACTERIUM TUBERCULOSIS esat-6 GENE FAMILY

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2005201767A Division AU2005201767B2 (en) 1999-07-13 2005-04-27 Tuberculosis vaccine and diagnostics based on the Mycobacterium tuberculosis esat-6 gene family

Publications (2)

Publication Number Publication Date
AU5966400A AU5966400A (en) 2001-01-30
AU779495B2 true AU779495B2 (en) 2005-01-27

Family

ID=26065081

Family Applications (3)

Application Number Title Priority Date Filing Date
AU59664/00A Ceased AU779495B2 (en) 1999-07-13 2000-07-13 Tuberculosis vaccine and diagnostics based on the mycobacterium tuberculosis esat-6 gene family
AU2005201767A Expired AU2005201767B2 (en) 1999-07-13 2005-04-27 Tuberculosis vaccine and diagnostics based on the Mycobacterium tuberculosis esat-6 gene family
AU2008224343A Ceased AU2008224343B2 (en) 1999-07-13 2008-09-24 Tuberculosis vaccine and diagnostics based on the Mycobacterium tuberculosis esat-6 gene family

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2005201767A Expired AU2005201767B2 (en) 1999-07-13 2005-04-27 Tuberculosis vaccine and diagnostics based on the Mycobacterium tuberculosis esat-6 gene family
AU2008224343A Ceased AU2008224343B2 (en) 1999-07-13 2008-09-24 Tuberculosis vaccine and diagnostics based on the Mycobacterium tuberculosis esat-6 gene family

Country Status (6)

Country Link
US (1) US7867502B1 (enExample)
EP (1) EP1200466A2 (enExample)
JP (1) JP5010079B2 (enExample)
AU (3) AU779495B2 (enExample)
CA (1) CA2378763A1 (enExample)
WO (1) WO2001004151A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100401066C (zh) * 2005-09-23 2008-07-09 中国人民解放军第三○九医院 基于组合蛋白的结核分枝杆菌金标诊断试剂

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291190B1 (en) * 1998-08-25 2001-09-18 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the M. tuberculosis complex
CN1350546A (zh) * 1998-11-04 2002-05-22 Isis创新有限公司 结核诊断测验
CA2433236C (en) 2001-01-08 2016-10-04 Isis Innovation Limited Assay to determine efficacy of treatment for m. tuberculosis infection
GB0215710D0 (en) 2002-07-05 2002-08-14 Isis Innovation Diagnostic method
WO2004099771A1 (en) * 2003-05-08 2004-11-18 Statens Serum Institut A new specific epitope based immunological diagnosis of tuberculosis
WO2005070959A2 (en) * 2004-01-23 2005-08-04 Vievax Corp. Compositions comprising immune response altering agents and methods of use
ITRM20040091A1 (it) 2004-02-19 2004-05-19 Istituto Naz Per Le Malattie Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare.
FR2872579B1 (fr) * 2004-06-30 2006-11-24 Pasteur Institut Detection de la tuberculose et de l'infection par mycobacterium tuberculosis a l'aide de hbha
NZ555907A (en) 2004-11-16 2009-12-24 Aeras Global Tb Vaccine Found Multivalent vaccines comprising recombinant viral vectors
IN2015DN03125A (enExample) * 2006-09-05 2015-10-02 Hvidovre Hospital
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker
US20100015171A1 (en) * 2008-07-15 2010-01-21 Statens Serum Institute Vaccines comprising tb 10.4
CN102413837B (zh) 2009-04-24 2015-11-25 国立血清研究所 预防再激活的结核病tb疫苗
CN102713629B (zh) 2009-11-20 2016-02-24 俄勒冈健康科学大学 用于检测结核分枝杆菌感染的方法
GB201012072D0 (en) * 2010-07-19 2010-09-01 Sec Dep For Environment Food A Diagnostic reagents
ITRM20100411A1 (it) * 2010-07-23 2012-01-24 Massimo Amicosante Uso di sequenze amminoacidiche da mycobacterium tuberculosis o dei loro corrispondenti acidi nucleici per la diagnosi e la prevenzione di infezione tubercolare, relativo kit diagnostico e vaccino.
CN102183649A (zh) * 2011-01-31 2011-09-14 中国农业大学 牛结核病抗原特异性γ-干扰素ELISA试剂盒
US10641770B2 (en) * 2013-12-16 2020-05-05 Statens Serum Institut Diagnostic reagents for improved in vivo or in vitro cell-mediated immunological diagnosis of tuberculosis
CN103974483B (zh) * 2014-05-25 2016-03-16 上海洞舟实业有限公司 一种电感电致发光线
KR101696514B1 (ko) * 2014-08-18 2017-01-24 서울대학교산학협력단 신규한 온도 민감성 마이코박테리아 균주 및 이를 포함하는 마이코박테리아 감염증에 대한 백신 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053075A2 (en) * 1997-05-20 1998-11-26 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
WO1998053076A2 (en) * 1997-05-20 1998-11-26 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024577A1 (en) 1997-11-10 1999-05-20 Statens Serum Institut NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053075A2 (en) * 1997-05-20 1998-11-26 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
WO1998053076A2 (en) * 1997-05-20 1998-11-26 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NATURE 1998 VOL. 393 PP 537-544 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100401066C (zh) * 2005-09-23 2008-07-09 中国人民解放军第三○九医院 基于组合蛋白的结核分枝杆菌金标诊断试剂

Also Published As

Publication number Publication date
JP2003510018A (ja) 2003-03-18
US7867502B1 (en) 2011-01-11
CA2378763A1 (en) 2001-01-18
AU5966400A (en) 2001-01-30
WO2001004151A2 (en) 2001-01-18
WO2001004151A3 (en) 2001-07-12
JP5010079B2 (ja) 2012-08-29
EP1200466A2 (en) 2002-05-02
AU2005201767B2 (en) 2008-06-26
AU2008224343A1 (en) 2008-10-16
AU2005201767A1 (en) 2005-05-19
AU2008224343B2 (en) 2012-05-10

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