JP2003506407A5 - - Google Patents
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- Publication number
- JP2003506407A5 JP2003506407A5 JP2001514950A JP2001514950A JP2003506407A5 JP 2003506407 A5 JP2003506407 A5 JP 2003506407A5 JP 2001514950 A JP2001514950 A JP 2001514950A JP 2001514950 A JP2001514950 A JP 2001514950A JP 2003506407 A5 JP2003506407 A5 JP 2003506407A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- administering
- delivery
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 description 26
- 150000001875 compounds Chemical class 0.000 description 25
- 150000001408 amides Chemical class 0.000 description 8
- 238000007913 intrathecal administration Methods 0.000 description 5
- 230000001148 spastic effect Effects 0.000 description 5
- WCVPFJVXEXJFLB-UHFFFAOYSA-N 4-aminobutanamide Chemical compound NCCCC(N)=O WCVPFJVXEXJFLB-UHFFFAOYSA-N 0.000 description 4
- RGTXVXDNHPWPHH-UHFFFAOYSA-N butane-1,3-diamine Chemical compound CC(N)CCN RGTXVXDNHPWPHH-UHFFFAOYSA-N 0.000 description 4
- 239000006227 byproduct Substances 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000000543 intermediate Substances 0.000 description 4
- 238000007914 intraventricular administration Methods 0.000 description 4
- 239000002207 metabolite Substances 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- -1 γ-aminobutyl Chemical group 0.000 description 4
- 208000010118 dystonia Diseases 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- IBALRBWGSVJPAP-UHFFFAOYSA-N progabide Chemical compound C=1C(F)=CC=C(O)C=1C(=NCCCC(=O)N)C1=CC=C(Cl)C=C1 IBALRBWGSVJPAP-UHFFFAOYSA-N 0.000 description 3
- 208000005819 Dystonia Musculorum Deformans Diseases 0.000 description 2
- 208000016570 early-onset generalized limb-onset dystonia Diseases 0.000 description 2
- 208000011110 idiopathic torsion dystonia Diseases 0.000 description 2
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000014094 Dystonic disease Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 229960000794 baclofen Drugs 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14815999P | 1999-08-10 | 1999-08-10 | |
| US60/148,159 | 1999-08-10 | ||
| PCT/US2000/021886 WO2001010432A1 (en) | 1999-08-10 | 2000-08-10 | Use of gaba agonists for treatment of spastic disorders, convulsions, and epilepsy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003506407A JP2003506407A (ja) | 2003-02-18 |
| JP2003506407A5 true JP2003506407A5 (enExample) | 2007-08-02 |
Family
ID=22524556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001514950A Pending JP2003506407A (ja) | 1999-08-10 | 2000-08-10 | 痙性障害、痙攣、及び癲癇の治療のためのγ−アミノ酪酸アゴニストの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060142396A1 (enExample) |
| EP (1) | EP1202720A4 (enExample) |
| JP (1) | JP2003506407A (enExample) |
| AU (1) | AU771115B2 (enExample) |
| CA (1) | CA2378955A1 (enExample) |
| IL (1) | IL148052A0 (enExample) |
| NZ (1) | NZ517407A (enExample) |
| WO (1) | WO2001010432A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6892098B2 (en) | 2001-04-26 | 2005-05-10 | Biocontrol Medical Ltd. | Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders |
| US6907295B2 (en) | 2001-08-31 | 2005-06-14 | Biocontrol Medical Ltd. | Electrode assembly for nerve control |
| US7778711B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Reduction of heart rate variability by parasympathetic stimulation |
| US7778703B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Selective nerve fiber stimulation for treating heart conditions |
| US7561922B2 (en) | 2004-12-22 | 2009-07-14 | Biocontrol Medical Ltd. | Construction of electrode assembly for nerve control |
| US7321793B2 (en) | 2003-06-13 | 2008-01-22 | Biocontrol Medical Ltd. | Vagal stimulation for atrial fibrillation therapy |
| US8880192B2 (en) | 2012-04-02 | 2014-11-04 | Bio Control Medical (B.C.M.) Ltd. | Electrode cuffs |
| US7627384B2 (en) | 2004-11-15 | 2009-12-01 | Bio Control Medical (B.C.M.) Ltd. | Techniques for nerve stimulation |
| US20050090549A1 (en) * | 2003-10-23 | 2005-04-28 | Medtronic, Inc. | Intrathecal gabapentin for treatment of pain |
| US7824697B2 (en) | 2004-07-12 | 2010-11-02 | Board Of Regents, The University Of Texas System | High concentration baclofen preparations |
| RS55585B1 (sr) * | 2006-11-22 | 2017-06-30 | Clinical Research Associates LLC | Postupci za lečenje daunovog sindroma, krhkog x sindroma i autizma |
| US20150258279A1 (en) | 2008-03-18 | 2015-09-17 | Mallinckrodt Llc | Intrathecal baclofen pharmaceutical dosage forms and related delivery system |
| US8969414B2 (en) | 2009-02-06 | 2015-03-03 | Mallinckrodt Llc | Intrathecal baclofen pharmaceutical dosage forms with fewer degradation products |
| US8475823B2 (en) * | 2008-04-18 | 2013-07-02 | Medtronic, Inc. | Baclofen formulation in a polyorthoester carrier |
| WO2010027266A1 (en) * | 2008-09-05 | 2010-03-11 | Van De Langenberg, Hendrikus Theodorus Ardina Hubertus | Means and methods for counteracting neurological disorders |
| WO2011113904A1 (en) | 2010-03-17 | 2011-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration |
| US9186504B2 (en) | 2010-11-15 | 2015-11-17 | Rainbow Medical Ltd | Sleep apnea treatment |
| US9457186B2 (en) | 2010-11-15 | 2016-10-04 | Bluewind Medical Ltd. | Bilateral feedback |
| US20150018728A1 (en) | 2012-01-26 | 2015-01-15 | Bluewind Medical Ltd. | Wireless neurostimulators |
| WO2014087337A1 (en) | 2012-12-06 | 2014-06-12 | Bluewind Medical Ltd. | Delivery of implantable neurostimulators |
| US9370660B2 (en) | 2013-03-29 | 2016-06-21 | Rainbow Medical Ltd. | Independently-controlled bidirectional nerve stimulation |
| US10004896B2 (en) | 2015-01-21 | 2018-06-26 | Bluewind Medical Ltd. | Anchors and implant devices |
| US9764146B2 (en) | 2015-01-21 | 2017-09-19 | Bluewind Medical Ltd. | Extracorporeal implant controllers |
| US9597521B2 (en) | 2015-01-21 | 2017-03-21 | Bluewind Medical Ltd. | Transmitting coils for neurostimulation |
| US9782589B2 (en) | 2015-06-10 | 2017-10-10 | Bluewind Medical Ltd. | Implantable electrostimulator for improving blood flow |
| US10105540B2 (en) | 2015-11-09 | 2018-10-23 | Bluewind Medical Ltd. | Optimization of application of current |
| US9713707B2 (en) | 2015-11-12 | 2017-07-25 | Bluewind Medical Ltd. | Inhibition of implant migration |
| US10124178B2 (en) | 2016-11-23 | 2018-11-13 | Bluewind Medical Ltd. | Implant and delivery tool therefor |
| US20180353764A1 (en) | 2017-06-13 | 2018-12-13 | Bluewind Medical Ltd. | Antenna configuration |
| EP3542799A1 (en) * | 2018-03-22 | 2019-09-25 | Helsinn Healthcare SA | New centrally-active ghrelin agonist and medical uses thereof |
| US11400299B1 (en) | 2021-09-14 | 2022-08-02 | Rainbow Medical Ltd. | Flexible antenna for stimulator |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2489319A1 (fr) * | 1980-08-27 | 1982-03-05 | Clin Midy | Derives de l'acide amino-4 butyrique et les medicaments, actifs notamment sur le systeme nerveux central, en contenant |
| IT1137492B (it) * | 1981-05-26 | 1986-09-10 | Maria Curti | Composti ad attivita' gaba simile,procedimento per prepararli e composizioni farmaceutiche che li comprendono |
| US5871472A (en) * | 1987-11-17 | 1999-02-16 | Brown University Research Foundation | Planting devices for the focal release of neuroinhibitory compounds |
| US5711316A (en) * | 1996-04-30 | 1998-01-27 | Medtronic, Inc. | Method of treating movement disorders by brain infusion |
| US7354954B1 (en) * | 2000-08-10 | 2008-04-08 | Meythaler Jay M | Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy |
| US7074775B2 (en) * | 2004-09-14 | 2006-07-11 | Miller Landon C G | Aminobutyramide conjugate and a pharmaceutical composition for treatment of neuronal disorders |
| CN101056629B (zh) * | 2004-09-16 | 2012-01-11 | 詹森药业有限公司 | 2-苯基-1,2-乙二醇-(二)氨基甲酸酯在制备治疗癫痫发生的药物中的用途 |
-
2000
- 2000-08-10 IL IL14805200A patent/IL148052A0/xx unknown
- 2000-08-10 CA CA002378955A patent/CA2378955A1/en not_active Abandoned
- 2000-08-10 NZ NZ517407A patent/NZ517407A/en unknown
- 2000-08-10 WO PCT/US2000/021886 patent/WO2001010432A1/en not_active Ceased
- 2000-08-10 AU AU67645/00A patent/AU771115B2/en not_active Ceased
- 2000-08-10 EP EP00955436A patent/EP1202720A4/en not_active Withdrawn
- 2000-08-10 JP JP2001514950A patent/JP2003506407A/ja active Pending
-
2006
- 2006-01-06 US US11/327,137 patent/US20060142396A1/en not_active Abandoned
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