JP2003505518A5 - - Google Patents
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- Publication number
- JP2003505518A5 JP2003505518A5 JP2001513438A JP2001513438A JP2003505518A5 JP 2003505518 A5 JP2003505518 A5 JP 2003505518A5 JP 2001513438 A JP2001513438 A JP 2001513438A JP 2001513438 A JP2001513438 A JP 2001513438A JP 2003505518 A5 JP2003505518 A5 JP 2003505518A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmacological agent
- pharmacological
- ligand
- secr
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002831 pharmacologic agent Substances 0.000 description 53
- 238000000034 method Methods 0.000 description 47
- 108010005584 serpin-enzyme complex receptor Proteins 0.000 description 41
- 239000003446 ligand Substances 0.000 description 38
- 102000039446 nucleic acids Human genes 0.000 description 23
- 108020004707 nucleic acids Proteins 0.000 description 23
- 150000007523 nucleic acids Chemical class 0.000 description 23
- 230000000144 pharmacologic effect Effects 0.000 description 22
- 239000000203 mixture Substances 0.000 description 19
- 210000000981 epithelium Anatomy 0.000 description 18
- 210000004556 brain Anatomy 0.000 description 17
- 238000002347 injection Methods 0.000 description 16
- 239000007924 injection Substances 0.000 description 16
- 238000002360 preparation method Methods 0.000 description 16
- 241000124008 Mammalia Species 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 241000700605 Viruses Species 0.000 description 5
- 239000003981 vehicle Substances 0.000 description 4
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 210000005013 brain tissue Anatomy 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 201000003883 Cystic fibrosis Diseases 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 102000015728 Mucins Human genes 0.000 description 2
- 108010063954 Mucins Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 description 2
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 description 2
- 229940024142 alpha 1-antitrypsin Drugs 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
- 229920000656 polylysine Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000003087 receptor blocking agent Substances 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- OBKXEAXTFZPCHS-UHFFFAOYSA-M 4-phenylbutyrate Chemical group [O-]C(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-M 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 206010006417 Bronchial carcinoma Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004559 Interleukin-13 Receptors Human genes 0.000 description 1
- 108010017511 Interleukin-13 Receptors Proteins 0.000 description 1
- 102000010787 Interleukin-4 Receptors Human genes 0.000 description 1
- 108010038486 Interleukin-4 Receptors Proteins 0.000 description 1
- 241000713666 Lentivirus Species 0.000 description 1
- 208000005119 Necrotizing Pneumonia Diseases 0.000 description 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 102000008847 Serpin Human genes 0.000 description 1
- 108050000761 Serpin Proteins 0.000 description 1
- 208000006682 alpha 1-Antitrypsin Deficiency Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000003362 bronchogenic carcinoma Diseases 0.000 description 1
- 239000000430 cytokine receptor antagonist Substances 0.000 description 1
- OBKXEAXTFZPCHS-UHFFFAOYSA-N gamma-phenylbutyric acid Natural products OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000005171 mammalian brain Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000003001 serine protease inhibitor Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14597099P | 1999-07-29 | 1999-07-29 | |
| US60/145,970 | 1999-07-29 | ||
| PCT/US2000/020545 WO2001008708A2 (en) | 1999-07-29 | 2000-07-28 | Enhanced delivery via serpin enzyme complex receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003505518A JP2003505518A (ja) | 2003-02-12 |
| JP2003505518A5 true JP2003505518A5 (https=) | 2007-08-30 |
Family
ID=22515370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001513438A Withdrawn JP2003505518A (ja) | 1999-07-29 | 2000-07-28 | セルピン酵素複合体受容体を介する増強された送達 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20040152653A1 (https=) |
| EP (1) | EP1200616A2 (https=) |
| JP (1) | JP2003505518A (https=) |
| AU (1) | AU782051B2 (https=) |
| CA (1) | CA2391348A1 (https=) |
| WO (1) | WO2001008708A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4813720B2 (ja) | 1999-11-08 | 2011-11-09 | イーペーエフ ファルマシューティカルス ゲゼルシャフト ミット ベシュレンクテル ハフツング | ヒト循環ウイルス阻害ペプチド（ｖｉｒｉｐ）及びその使用 |
| DE60127175T2 (de) | 2000-12-21 | 2007-11-08 | Nektar Therapeutics, San Carlos | Lagerstabile pulverzusammensetzungen mit interleukin-4 rezeptor |
| GB0106315D0 (en) | 2001-03-14 | 2001-05-02 | Ich Productions Ltd | Transfection complexes |
| CA2509423A1 (en) | 2002-12-19 | 2004-07-08 | Ipf Pharmaceuticals Gmbh | Peptides and their use for the treatment of hiv infections |
| CN101959429B (zh) | 2008-01-08 | 2014-09-10 | 阿克塞利亚制药公司 | 抗微生物肽系统的激动剂 |
| US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| EP2667857A4 (en) * | 2010-11-26 | 2015-11-25 | Univ Witwatersrand Jhb | ACTIVE RELEASE DEVICE |
| JP2015111050A (ja) * | 2012-03-28 | 2015-06-18 | 国立大学法人九州大学 | Ｋａｌｌｉｓｔａｔｉｎ蛋白質による脳梗塞検査方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3482840D1 (de) * | 1983-01-21 | 1990-09-06 | Transgene Sa | Expressionsvektoren und deren verwendung zur herstellung eines proteins mit menschlicher alpha-antitrypsin-aktivitaet. |
| US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| WO1992018141A1 (en) * | 1991-04-18 | 1992-10-29 | The Uab Research Foundation | Compositions and methods for inhibiting elastase |
| FR2711523B1 (fr) * | 1993-10-26 | 1996-02-16 | Transgene Sa | Procédé de préparation d'un aérosol viral. |
| US5972901A (en) * | 1994-03-23 | 1999-10-26 | Case Western Reserve University | Serpin enzyme complex receptor--mediated gene transfer |
| WO1997024453A1 (en) * | 1995-12-28 | 1997-07-10 | Chiron Corporation | Receptor specific chimeric viral surface polypeptides for viral and particle incorporation and internalization in target cells |
| US6287857B1 (en) * | 1998-02-09 | 2001-09-11 | Genzyme Corporation | Nucleic acid delivery vehicles |
-
2000
- 2000-07-28 JP JP2001513438A patent/JP2003505518A/ja not_active Withdrawn
- 2000-07-28 EP EP00948981A patent/EP1200616A2/en not_active Withdrawn
- 2000-07-28 WO PCT/US2000/020545 patent/WO2001008708A2/en not_active Ceased
- 2000-07-28 AU AU62397/00A patent/AU782051B2/en not_active Ceased
- 2000-07-28 CA CA002391348A patent/CA2391348A1/en not_active Abandoned
-
2003
- 2003-11-07 US US10/703,206 patent/US20040152653A1/en not_active Abandoned
-
2006
- 2006-06-20 US US11/455,791 patent/US20060228407A1/en not_active Abandoned
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