JP2003505350A - 免疫関連疾患の治療のための組成物と方法 - Google Patents
免疫関連疾患の治療のための組成物と方法Info
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- JP2003505350A JP2003505350A JP2001511185A JP2001511185A JP2003505350A JP 2003505350 A JP2003505350 A JP 2003505350A JP 2001511185 A JP2001511185 A JP 2001511185A JP 2001511185 A JP2001511185 A JP 2001511185A JP 2003505350 A JP2003505350 A JP 2003505350A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Diabetes (AREA)
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- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
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- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US14475899P | 1999-07-20 | 1999-07-20 | |
| US60/144,758 | 1999-07-20 | ||
| PCT/US2000/006884 WO2001005972A1 (en) | 1999-07-20 | 2000-03-15 | Compositions and methods for the treatment of immune related diseases |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| JP2002270825A Division JP2003180381A (ja) | 1999-07-20 | 2002-09-17 | 免疫関連疾患の治療のための組成物と方法 |
| JP2002270824A Division JP2003189880A (ja) | 1999-07-20 | 2002-09-17 | 免疫関連疾患の治療のための組成物と方法 |
Publications (2)
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| JP2003505350A true JP2003505350A (ja) | 2003-02-12 |
| JP2003505350A5 JP2003505350A5 (enExample) | 2007-05-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2001511185A Pending JP2003505350A (ja) | 1999-07-20 | 2000-03-15 | 免疫関連疾患の治療のための組成物と方法 |
| JP2002270824A Pending JP2003189880A (ja) | 1999-07-20 | 2002-09-17 | 免疫関連疾患の治療のための組成物と方法 |
| JP2002270825A Pending JP2003180381A (ja) | 1999-07-20 | 2002-09-17 | 免疫関連疾患の治療のための組成物と方法 |
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| JP2002270824A Pending JP2003189880A (ja) | 1999-07-20 | 2002-09-17 | 免疫関連疾患の治療のための組成物と方法 |
| JP2002270825A Pending JP2003180381A (ja) | 1999-07-20 | 2002-09-17 | 免疫関連疾患の治療のための組成物と方法 |
Country Status (8)
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| JP (3) | JP2003505350A (enExample) |
| AT (1) | ATE368110T1 (enExample) |
| AU (1) | AU4011300A (enExample) |
| CA (1) | CA2375458A1 (enExample) |
| DE (1) | DE60035693T2 (enExample) |
| ES (1) | ES2291198T3 (enExample) |
| WO (1) | WO2001005972A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007536931A (ja) * | 2004-05-12 | 2007-12-20 | ジェネンテック・インコーポレーテッド | 新規の遺伝子破壊、組成物およびそれらに関連する方法 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689607B2 (en) | 1997-10-21 | 2004-02-10 | Human Genome Sciences, Inc. | Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| US6503184B1 (en) | 1997-10-21 | 2003-01-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| US20030119113A1 (en) | 1999-07-20 | 2003-06-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| HUP0203408A3 (en) * | 1999-12-09 | 2005-01-28 | Sankyo Co | Method of testing remedy or preventive for hyperlipemia |
| US6800604B2 (en) | 2000-02-11 | 2004-10-05 | Genentech, Inc. | Polypeptides that inhibit human serum-induced cleavage of hepatocyte growth factor |
| WO2003009865A1 (en) * | 2001-07-25 | 2003-02-06 | Genset S.A. | Agonists and antagonists of energen for use in the treatment of metabolic disorders |
| WO2003049758A1 (en) * | 2001-12-13 | 2003-06-19 | Genset S.A. | Emergen agonists and antagonists for use in the treatment of metabolic disorders |
| AU2003270439B2 (en) | 2002-09-11 | 2009-09-24 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
| JP5770624B2 (ja) * | 2008-04-09 | 2015-08-26 | ジェネンテック， インコーポレイテッド | 免疫関連疾患の治療のための新規組成物と方法 |
| BR112012000914B8 (pt) | 2009-07-14 | 2021-05-25 | Irm Llc | uso de polipeptídeo com atividade condrogênica, método in vitro de indução da diferenciação de células-tronco mesenquimais em condrócitos, e composição farmacêutica para aplicação intra-articular |
| MA38369B1 (fr) | 2013-03-08 | 2018-10-31 | Novartis Ag | Peptides et compositions pour le traitement d'une lesion de l'articulation |
| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
| SG11201600310QA (en) | 2013-07-16 | 2016-02-26 | Genentech Inc | Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors |
| KR20230125094A (ko) | 2015-09-25 | 2023-08-28 | 제넨테크, 인크. | 항-tigit 항체 및 이의 이용 방법 |
| AR116566A1 (es) | 2018-10-03 | 2021-05-19 | Novartis Ag | Administración sostenida de polipéptidos similares a la angiopoyetina 3 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999055869A1 (en) * | 1998-04-27 | 1999-11-04 | Zymogenetics, Inc. | Novel polypeptide growth factors and materials and methods for making them |
| EP0962466A1 (en) * | 1998-06-02 | 1999-12-08 | Eli Lilly And Company | Angiopoietin related gene sequence scarface 3 |
| WO1999067382A2 (en) * | 1998-06-24 | 1999-12-29 | Compugen Ltd. | Angiopoietin-like growth factor sequences |
| JP2000325087A (ja) * | 1999-05-21 | 2000-11-28 | Otsuka Pharmaceut Co Ltd | Ｔｓａ２３０６遺伝子 |
| JP2002533058A (ja) * | 1998-05-12 | 2002-10-08 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ９７個のヒト分泌タンパク質 |
| JP2003524385A (ja) * | 1998-12-01 | 2003-08-19 | ジェネンテック・インコーポレーテッド | 血管形成及び心臓血管新生の促進又は阻害 |
| JP2003529317A (ja) * | 1998-12-22 | 2003-10-07 | ジェネンテック・インコーポレーテッド | 腫瘍性細胞成長阻害のための組成物及び方法 |
| JP2005176848A (ja) * | 1997-09-19 | 2005-07-07 | Genentech Inc | Ｔｉｅレセプターチロシンキナーゼリガンドホモログ |
| JP2007222001A (ja) * | 1998-11-17 | 2007-09-06 | Sagami Chem Res Center | 疎水性ドメインを有するヒトタンパク質及びそれをコードするｄｎａ |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6066322A (en) * | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| EP0759467B1 (en) * | 1995-07-24 | 2004-02-11 | Mitsubishi Chemical Corporation | Hepatocyte growth factor activator inhibitor |
| US5874230A (en) * | 1996-07-10 | 1999-02-23 | Tularik, Inc. | Assays using TRAF2-associated protein kinase polypeptides |
| AU4268097A (en) * | 1996-09-12 | 1998-04-02 | Human Genome Sciences, Inc. | Chemokine alpha-4 |
| WO1998024908A1 (en) * | 1996-12-05 | 1998-06-11 | Human Genome Sciences, Inc. | Human chemokine beta-13 |
| JP2001505783A (ja) * | 1996-12-11 | 2001-05-08 | カイロン コーポレイション | 分泌ヒトタンパク質 |
| US6057435A (en) * | 1997-09-19 | 2000-05-02 | Genentech, Inc. | Tie ligand homologues |
| US6171790B1 (en) * | 1998-05-01 | 2001-01-09 | Incyte Pharmaceuticals, Inc. | Human protease associated proteins |
| EP1161536A1 (en) * | 1998-11-17 | 2001-12-12 | Sagami Chemical Research Center | Human proteins having hydrophobic domains and dnas encoding these proteins |
-
2000
- 2000-03-15 ES ES00919420T patent/ES2291198T3/es not_active Expired - Lifetime
- 2000-03-15 WO PCT/US2000/006884 patent/WO2001005972A1/en not_active Ceased
- 2000-03-15 CA CA002375458A patent/CA2375458A1/en not_active Abandoned
- 2000-03-15 JP JP2001511185A patent/JP2003505350A/ja active Pending
- 2000-03-15 DE DE60035693T patent/DE60035693T2/de not_active Expired - Lifetime
- 2000-03-15 EP EP00919420A patent/EP1198568B1/en not_active Expired - Lifetime
- 2000-03-15 AU AU40113/00A patent/AU4011300A/en not_active Abandoned
- 2000-03-15 AT AT00919420T patent/ATE368110T1/de not_active IP Right Cessation
-
2002
- 2002-09-17 JP JP2002270824A patent/JP2003189880A/ja active Pending
- 2002-09-17 JP JP2002270825A patent/JP2003180381A/ja active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005176848A (ja) * | 1997-09-19 | 2005-07-07 | Genentech Inc | Ｔｉｅレセプターチロシンキナーゼリガンドホモログ |
| WO1999055869A1 (en) * | 1998-04-27 | 1999-11-04 | Zymogenetics, Inc. | Novel polypeptide growth factors and materials and methods for making them |
| JP2002533058A (ja) * | 1998-05-12 | 2002-10-08 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ９７個のヒト分泌タンパク質 |
| EP0962466A1 (en) * | 1998-06-02 | 1999-12-08 | Eli Lilly And Company | Angiopoietin related gene sequence scarface 3 |
| WO1999067382A2 (en) * | 1998-06-24 | 1999-12-29 | Compugen Ltd. | Angiopoietin-like growth factor sequences |
| JP2007222001A (ja) * | 1998-11-17 | 2007-09-06 | Sagami Chem Res Center | 疎水性ドメインを有するヒトタンパク質及びそれをコードするｄｎａ |
| JP2003524385A (ja) * | 1998-12-01 | 2003-08-19 | ジェネンテック・インコーポレーテッド | 血管形成及び心臓血管新生の促進又は阻害 |
| JP2003529317A (ja) * | 1998-12-22 | 2003-10-07 | ジェネンテック・インコーポレーテッド | 腫瘍性細胞成長阻害のための組成物及び方法 |
| JP2000325087A (ja) * | 1999-05-21 | 2000-11-28 | Otsuka Pharmaceut Co Ltd | Ｔｓａ２３０６遺伝子 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007536931A (ja) * | 2004-05-12 | 2007-12-20 | ジェネンテック・インコーポレーテッド | 新規の遺伝子破壊、組成物およびそれらに関連する方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1198568B1 (en) | 2007-07-25 |
| AU4011300A (en) | 2001-02-05 |
| WO2001005972A1 (en) | 2001-01-25 |
| JP2003180381A (ja) | 2003-07-02 |
| EP1198568A1 (en) | 2002-04-24 |
| ATE368110T1 (de) | 2007-08-15 |
| ES2291198T3 (es) | 2008-03-01 |
| DE60035693D1 (de) | 2007-09-06 |
| DE60035693T2 (de) | 2008-05-15 |
| JP2003189880A (ja) | 2003-07-08 |
| CA2375458A1 (en) | 2001-01-25 |
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