JP2003505336A5 - - Google Patents
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- Publication number
- JP2003505336A5 JP2003505336A5 JP2000549261A JP2000549261A JP2003505336A5 JP 2003505336 A5 JP2003505336 A5 JP 2003505336A5 JP 2000549261 A JP2000549261 A JP 2000549261A JP 2000549261 A JP2000549261 A JP 2000549261A JP 2003505336 A5 JP2003505336 A5 JP 2003505336A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- receptor antagonist
- glucocorticoid receptor
- dementia
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940126013 glucocorticoid receptor antagonist Drugs 0.000 description 16
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 description 16
- 239000000203 mixture Substances 0.000 description 16
- 206010012289 Dementia Diseases 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 230000037396 body weight Effects 0.000 description 6
- 208000024827 Alzheimer disease Diseases 0.000 description 4
- 108010060159 Apolipoprotein E4 Proteins 0.000 description 3
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 description 3
- 229960003248 mifepristone Drugs 0.000 description 3
- 108700028369 Alleles Proteins 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 150000003431 steroids Chemical group 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 230000006999 cognitive decline Effects 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- -1 dimethylaminophenyl moiety Chemical group 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000006996 mental state Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8570398P | 1998-05-15 | 1998-05-15 | |
| US60/085,703 | 1998-05-15 | ||
| PCT/US1998/020908 WO1999059596A1 (en) | 1998-05-15 | 1998-10-05 | Glucocorticoid receptor antagonists for the treatment of dementia |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008294967A Division JP2009051864A (ja) | 1998-05-15 | 2008-11-18 | 痴呆の処置のためのグルココルチコイドレセプターアンタゴニスト |
| JP2009124741A Division JP2009185067A (ja) | 1998-05-15 | 2009-05-22 | 痴呆の処置のためのグルココルチコイドレセプターアンタゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003505336A JP2003505336A (ja) | 2003-02-12 |
| JP2003505336A5 true JP2003505336A5 (https=) | 2006-01-05 |
Family
ID=22193399
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000549261A Pending JP2003505336A (ja) | 1998-05-15 | 1998-10-05 | 痴呆の処置のためのグルココルチコイドレセプターアンタゴニスト |
| JP2008294967A Pending JP2009051864A (ja) | 1998-05-15 | 2008-11-18 | 痴呆の処置のためのグルココルチコイドレセプターアンタゴニスト |
| JP2009124741A Pending JP2009185067A (ja) | 1998-05-15 | 2009-05-22 | 痴呆の処置のためのグルココルチコイドレセプターアンタゴニスト |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008294967A Pending JP2009051864A (ja) | 1998-05-15 | 2008-11-18 | 痴呆の処置のためのグルココルチコイドレセプターアンタゴニスト |
| JP2009124741A Pending JP2009185067A (ja) | 1998-05-15 | 2009-05-22 | 痴呆の処置のためのグルココルチコイドレセプターアンタゴニスト |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6369046B1 (https=) |
| EP (1) | EP1076562B1 (https=) |
| JP (3) | JP2003505336A (https=) |
| KR (1) | KR20010043630A (https=) |
| CN (1) | CN1130200C (https=) |
| AT (1) | ATE317699T1 (https=) |
| AU (1) | AU756818B2 (https=) |
| CA (1) | CA2328411C (https=) |
| DE (1) | DE69833502T2 (https=) |
| IL (1) | IL139672A (https=) |
| NZ (1) | NZ507449A (https=) |
| WO (1) | WO1999059596A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620802B1 (en) | 1999-11-23 | 2003-09-16 | Corcept Therapeutics, Inc. | Methods of treating mild cognitive impairment using a glucocorticoid-specific receptor antagonist |
| WO2001039664A1 (en) * | 1999-12-02 | 2001-06-07 | The General Hospital Corporation | Method and apparatus for measuring indices of brain activity |
| US20010046470A1 (en) * | 2000-05-10 | 2001-11-29 | Kieko Morita | Diagnoses and treatment of disorders using an alternative glucose pathway |
| WO2002096433A1 (en) * | 2001-05-04 | 2002-12-05 | Corcept Therapeutics, Inc. | Methods for treating delirium using glucocorticoid receptor-specific antagonists |
| US7163934B2 (en) | 2001-05-04 | 2007-01-16 | Corcept Therapeutics, Inc. | Methods for treating delirium glucocorticoid receptor-specific antagonists |
| CA2454339C (en) | 2001-07-23 | 2012-01-10 | Corcept Therapeutics, Inc. | Methods for preventing antipsychotic-induced weight gain |
| NZ531477A (en) * | 2001-08-31 | 2006-10-27 | Corcept Therapeutics Inc | Use of a glucocorticoid receptor antagonist comprising a steroidal skeleton with at least one phenyl-containing moiety in the 11-beta position of the steroidal skeleton to decrease cognitive deterioration in adults with Down's syndrome |
| US7326697B2 (en) * | 2002-04-29 | 2008-02-05 | Corcept Therapeutics, Inc. | Methods for increasing the therapeutic response to electroconvulsive therapy |
| JP2005535664A (ja) * | 2002-07-02 | 2005-11-24 | コーセプト セラピューティクス， インコーポレイテッド | インターフェロン−α治療に関連した精神病を処置するための方法 |
| FR2850022B1 (fr) * | 2003-01-22 | 2006-09-08 | Centre Nat Rech Scient | Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications |
| US7473903B2 (en) * | 2003-02-12 | 2009-01-06 | General Electric Company | Method and apparatus for deposited hermetic cover for digital X-ray panel |
| US8778979B2 (en) * | 2005-04-05 | 2014-07-15 | Yale University | Glutamate agents in the treatment of mental disorders |
| WO2008080083A2 (en) * | 2006-12-22 | 2008-07-03 | Washington University | High performance imaging system for diffuse optical tomography and associated method of use |
| US9480425B2 (en) * | 2008-04-17 | 2016-11-01 | Washington University | Task-less optical mapping of dynamic brain function using resting state functional connectivity |
| WO2011063453A1 (en) * | 2009-11-24 | 2011-06-03 | Commonweath Scientific And Industrial Research Organisation | Methods, kits and reagents for diagnosing, aiding diagnosis and/or monitoring progression of a neurological disorder |
| WO2011150209A1 (en) * | 2010-05-26 | 2011-12-01 | Corcept Therapeutics, Inc. | Treatment of muscular dystrophy |
| US10500216B2 (en) | 2011-11-18 | 2019-12-10 | Corcept Therapeutics, Inc. | Optimizing mifepristone absorption |
| WO2015187988A1 (en) * | 2014-06-04 | 2015-12-10 | Intellimedix | Composition and methods of treating epilepsy and/or epilepsy-related disorders |
| US9943526B2 (en) | 2015-04-21 | 2018-04-17 | Corcept Therapeutics, Inc. | Optimizing mifepristone levels for cushing's patients |
| US10261310B2 (en) | 2016-06-27 | 2019-04-16 | Amazon Technologies, Inc. | Amorphous silicon layer as optical filter for thin film transistor channel |
| JP7569492B2 (ja) | 2019-12-11 | 2024-10-18 | コーセプト セラピューティクス， インコーポレイテッド | 抗精神病薬誘発性体重増加のミリコリラントによる治療方法 |
| US12194036B2 (en) * | 2022-07-07 | 2025-01-14 | Antecip Bioventures Ii Llc | Combination of dextromethorphan and bupropion for treating depression |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
| US5348729A (en) | 1988-11-30 | 1994-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Evaluative means for detecting inflammatory reactivity |
| FR2696934B1 (fr) | 1992-10-20 | 1995-06-02 | Conservatoire Nal Arts Metiers | Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir. |
| IL110309A0 (en) * | 1993-07-15 | 1994-10-21 | Univ Kentucky Res Found | A method of protecting against neuron loss |
| IL118974A (en) | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| EP0954317B1 (en) | 1996-04-09 | 2007-06-06 | The University Of Edinburgh | Use of 7 apha-substituted steroids to treat neuropsychiatric disorders |
-
1998
- 1998-10-05 IL IL13967298A patent/IL139672A/xx not_active IP Right Cessation
- 1998-10-05 EP EP98950912A patent/EP1076562B1/en not_active Expired - Lifetime
- 1998-10-05 CA CA002328411A patent/CA2328411C/en not_active Expired - Fee Related
- 1998-10-05 JP JP2000549261A patent/JP2003505336A/ja active Pending
- 1998-10-05 WO PCT/US1998/020908 patent/WO1999059596A1/en not_active Ceased
- 1998-10-05 KR KR1020007012796A patent/KR20010043630A/ko not_active Withdrawn
- 1998-10-05 AU AU96833/98A patent/AU756818B2/en not_active Ceased
- 1998-10-05 DE DE69833502T patent/DE69833502T2/de not_active Expired - Lifetime
- 1998-10-05 NZ NZ507449A patent/NZ507449A/en not_active IP Right Cessation
- 1998-10-05 CN CN98814043A patent/CN1130200C/zh not_active Expired - Fee Related
- 1998-10-05 AT AT98950912T patent/ATE317699T1/de not_active IP Right Cessation
-
1999
- 1999-02-04 US US09/246,780 patent/US6369046B1/en not_active Expired - Lifetime
-
2008
- 2008-11-18 JP JP2008294967A patent/JP2009051864A/ja active Pending
-
2009
- 2009-05-22 JP JP2009124741A patent/JP2009185067A/ja active Pending
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