JP2003501022A - イオンチャネルコンダクタンスを測定するための方法およびその組成物 - Google Patents

イオンチャネルコンダクタンスを測定するための方法およびその組成物

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Publication number
JP2003501022A
JP2003501022A JP2001500744A JP2001500744A JP2003501022A JP 2003501022 A JP2003501022 A JP 2003501022A JP 2001500744 A JP2001500744 A JP 2001500744A JP 2001500744 A JP2001500744 A JP 2001500744A JP 2003501022 A JP2003501022 A JP 2003501022A
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JP
Japan
Prior art keywords
channel
seq
amino acid
nucleic acid
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001500744A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003501022A5 (enExample
Inventor
ビンセント・イー・グロッピ
マーク・エル・ウルフ
ミッチェル・ビー・バーケンパス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
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Pharmacia and Upjohn Co
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Filing date
Publication date
Application filed by Pharmacia and Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of JP2003501022A publication Critical patent/JP2003501022A/ja
Publication of JP2003501022A5 publication Critical patent/JP2003501022A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Thin Film Transistor (AREA)
JP2001500744A 1999-05-27 2000-05-25 イオンチャネルコンダクタンスを測定するための方法およびその組成物 Withdrawn JP2003501022A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13617499P 1999-05-27 1999-05-27
US60/136,174 1999-05-27
PCT/US2000/011862 WO2000073431A2 (en) 1999-05-27 2000-05-25 Methods and compositions for measuring ion channel conductance

Publications (2)

Publication Number Publication Date
JP2003501022A true JP2003501022A (ja) 2003-01-14
JP2003501022A5 JP2003501022A5 (enExample) 2007-07-12

Family

ID=22471672

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001500744A Withdrawn JP2003501022A (ja) 1999-05-27 2000-05-25 イオンチャネルコンダクタンスを測定するための方法およびその組成物

Country Status (5)

Country Link
US (1) US20070238168A1 (enExample)
EP (1) EP1180142A2 (enExample)
JP (1) JP2003501022A (enExample)
AU (1) AU4980200A (enExample)
WO (1) WO2000073431A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008516604A (ja) * 2004-10-15 2008-05-22 モネル ケミカル センシズ センター 哺乳動物の味覚細胞の培養方法
JP2009186183A (ja) * 2008-02-01 2009-08-20 Seikagaku Kogyo Co Ltd 関節痛の評価方法
JP2012504966A (ja) * 2008-10-09 2012-03-01 ハワード ヒューズ メディカル インスティチュート 新規なキメラリガンド開口型イオンチャネルおよびその使用方法

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214686B2 (en) 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
AU784644B2 (en) * 1999-12-14 2006-05-18 Pharmacia & Upjohn Company Human ion channels
GB0003069D0 (en) * 2000-02-11 2000-03-29 Cambridge Drug Discovery Ltd Improved assay
DE10006309A1 (de) 2000-02-12 2001-08-23 Aventis Pharma Gmbh Verfahren zur Identifizierung von Substanzen, die die Aktivität von hyperpolarisationsaktivierten Kationen-kanälen modulieren
AU2001282874A1 (en) 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002015662A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
WO2002017358A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
WO2002061074A1 (fr) * 2001-01-30 2002-08-08 Takeda Chemical Industries, Ltd. Nouvelle proteine et adn la comprenant
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
BR0212101A (pt) 2001-08-24 2004-08-24 Pharmacia & Up John Company 7-aza [2.2.1] biciclo-heptanos substituìdos com heteroarila para o tratamento de doenças
CZ2004408A3 (cs) 2001-10-02 2005-03-16 Pharmacia & Upjohn Company Azabicyklicky substituované kondenzované heteroarylsloučeniny
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
WO2003040147A1 (en) 2001-11-08 2003-05-15 Pharmacia & Upjohn Company Azabicyclic-substituted-heteroaryl compounds for the treatment of disease__________________________________________________________________________________________________________________________
JP2005510523A (ja) 2001-11-09 2005-04-21 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー アザ二環式フェニル縮合複素環式化合物、及びα７ＮＡＣＨＲリガンドとしての当該化合物の使用
US6852716B2 (en) 2002-02-15 2005-02-08 Pfizer Inc Substituted-aryl compounds for treatment of disease
CA2476624A1 (en) 2002-02-19 2003-08-28 Pharmacia & Upjohn Company Azabicyclic compounds for the treatment of disease
JP2005523288A (ja) 2002-02-19 2005-08-04 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 疾病治療用の縮合した二環式−ｎ−架橋−複素環式芳香族カルボキサミド
MXPA04007083A (es) 2002-02-20 2004-10-29 Upjohn Co Compuestos azabiciclicos para el tratamiento de enfermedades.
AU2003267174A1 (en) 2002-05-09 2003-11-11 Memory Pharmaceuticals Corporation Qm-7 and qt-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells
WO2004013137A1 (en) 2002-08-01 2004-02-12 Pharmacia & Upjohn Company Llc 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
US7270949B2 (en) * 2003-01-07 2007-09-18 Neuromed Pharmaceuticals Ltd. Fluorescence based T-type channel assay
US7732607B2 (en) 2005-08-22 2010-06-08 Anatoly Mazurov Heteroaryl-substituted diazatricycloalkanes and methods of use thereof
EP2296640A1 (en) 2008-05-12 2011-03-23 Targacept Inc. Methods for preventing the development of retinopathy by the oral administration of nnr ligands
AU2011246503B2 (en) 2010-04-26 2013-09-26 Novartis Ag Improved cell culture medium
IL274702B2 (en) 2017-11-27 2026-04-01 Coda Biotherapeutics Inc Compounds and methods for neurological diseases
CN111378025A (zh) * 2020-03-26 2020-07-07 集美大学 河豚毒素结合蛋白tfPSTBP2、核苷酸序列、其多克隆抗体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
JP3628691B2 (ja) 1993-03-08 2005-03-16 メルク エンド カンパニー インコーポレーテッド ヒト神経細胞性ニコチン性アセチルコリン受容体組成物およびそれらの使用方法
US6323000B2 (en) * 1996-12-20 2001-11-27 Clark A. Briggs Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
WO1999018438A1 (en) * 1997-10-02 1999-04-15 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008516604A (ja) * 2004-10-15 2008-05-22 モネル ケミカル センシズ センター 哺乳動物の味覚細胞の培養方法
JP2009186183A (ja) * 2008-02-01 2009-08-20 Seikagaku Kogyo Co Ltd 関節痛の評価方法
JP2012504966A (ja) * 2008-10-09 2012-03-01 ハワード ヒューズ メディカル インスティチュート 新規なキメラリガンド開口型イオンチャネルおよびその使用方法

Also Published As

Publication number Publication date
WO2000073431A3 (en) 2001-05-03
WO2000073431A2 (en) 2000-12-07
WO2000073431B1 (en) 2001-07-19
AU4980200A (en) 2000-12-18
US20070238168A1 (en) 2007-10-11
EP1180142A2 (en) 2002-02-20

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