JP2003501022A - イオンチャネルコンダクタンスを測定するための方法およびその組成物 - Google Patents
イオンチャネルコンダクタンスを測定するための方法およびその組成物Info
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- JP2003501022A JP2003501022A JP2001500744A JP2001500744A JP2003501022A JP 2003501022 A JP2003501022 A JP 2003501022A JP 2001500744 A JP2001500744 A JP 2001500744A JP 2001500744 A JP2001500744 A JP 2001500744A JP 2003501022 A JP2003501022 A JP 2003501022A
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- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
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- 238000012163 sequencing technique Methods 0.000 description 1
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- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229940063675 spermine Drugs 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
- 210000000331 sympathetic ganglia Anatomy 0.000 description 1
- CFMYXEVWODSLAX-QOZOJKKESA-N tetrodotoxin Chemical compound O([C@@]([C@H]1O)(O)O[C@H]2[C@@]3(O)CO)[C@H]3[C@@H](O)[C@]11[C@H]2[C@@H](O)N=C(N)N1 CFMYXEVWODSLAX-QOZOJKKESA-N 0.000 description 1
- 229950010357 tetrodotoxin Drugs 0.000 description 1
- CFMYXEVWODSLAX-UHFFFAOYSA-N tetrodotoxin Natural products C12C(O)NC(=N)NC2(C2O)C(O)C3C(CO)(O)C1OC2(O)O3 CFMYXEVWODSLAX-UHFFFAOYSA-N 0.000 description 1
- 108010093171 tetrodotoxin-binding protein Proteins 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Thin Film Transistor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13617499P | 1999-05-27 | 1999-05-27 | |
| US60/136,174 | 1999-05-27 | ||
| PCT/US2000/011862 WO2000073431A2 (en) | 1999-05-27 | 2000-05-25 | Methods and compositions for measuring ion channel conductance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003501022A true JP2003501022A (ja) | 2003-01-14 |
| JP2003501022A5 JP2003501022A5 (enExample) | 2007-07-12 |
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| JP2001500744A Withdrawn JP2003501022A (ja) | 1999-05-27 | 2000-05-25 | イオンチャネルコンダクタンスを測定するための方法およびその組成物 |
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| Country | Link |
|---|---|
| US (1) | US20070238168A1 (enExample) |
| EP (1) | EP1180142A2 (enExample) |
| JP (1) | JP2003501022A (enExample) |
| AU (1) | AU4980200A (enExample) |
| WO (1) | WO2000073431A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008516604A (ja) * | 2004-10-15 | 2008-05-22 | モネル ケミカル センシズ センター | 哺乳動物の味覚細胞の培養方法 |
| JP2009186183A (ja) * | 2008-02-01 | 2009-08-20 | Seikagaku Kogyo Co Ltd | 関節痛の評価方法 |
| JP2012504966A (ja) * | 2008-10-09 | 2012-03-01 | ハワード ヒューズ メディカル インスティチュート | 新規なキメラリガンド開口型イオンチャネルおよびその使用方法 |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214686B2 (en) | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
| CA2393538A1 (en) * | 1999-12-14 | 2001-06-21 | Pharmacia & Upjohn Company | Human ion channels |
| GB0003069D0 (en) * | 2000-02-11 | 2000-03-29 | Cambridge Drug Discovery Ltd | Improved assay |
| DE10006309A1 (de) * | 2000-02-12 | 2001-08-23 | Aventis Pharma Gmbh | Verfahren zur Identifizierung von Substanzen, die die Aktivität von hyperpolarisationsaktivierten Kationen-kanälen modulieren |
| WO2002016357A2 (en) | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
| US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| US6479510B2 (en) | 2000-08-18 | 2002-11-12 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
| US6599916B2 (en) | 2000-08-21 | 2003-07-29 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| AU2001282875A1 (en) | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| WO2002061074A1 (fr) * | 2001-01-30 | 2002-08-08 | Takeda Chemical Industries, Ltd. | Nouvelle proteine et adn la comprenant |
| PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
| AR036041A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
| AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
| CA2458375A1 (en) | 2001-08-24 | 2003-03-06 | Pharmacia & Upjohn Company | Substituted-heteroaryl-7-aza¬2.2.1|bicycloheptanes for the treatment of disease |
| CA2462453C (en) | 2001-10-02 | 2009-07-28 | Pharmacia & Upjohn Company | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease |
| US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
| CA2466375A1 (en) | 2001-11-08 | 2003-05-15 | Pharmacia & Upjohn Company | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease |
| MXPA04004373A (es) | 2001-11-09 | 2004-08-11 | Upjohn Co | Compuestos heterociclicos condensados con fenilo azabiciclo para el tratamiento de enfermedades. |
| EP1480977A2 (en) | 2002-02-15 | 2004-12-01 | PHARMACIA & UPJOHN COMPANY | Substituted aryl compounds for treatment of disease |
| CA2476624A1 (en) | 2002-02-19 | 2003-08-28 | Pharmacia & Upjohn Company | Azabicyclic compounds for the treatment of disease |
| CA2476681A1 (en) | 2002-02-19 | 2003-08-28 | Bruce N. Rogers | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
| WO2003072578A1 (en) * | 2002-02-20 | 2003-09-04 | Pharmacia & Upjohn Company | Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity |
| US7358057B2 (en) | 2002-05-09 | 2008-04-15 | Memory Pharmaceuticals Corporation | QM-7 and QT-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells |
| US7176198B2 (en) | 2002-08-01 | 2007-02-13 | Pfizer Inc. | 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease |
| EP1581558A2 (en) * | 2003-01-07 | 2005-10-05 | Neuromed Technologies, Inc. | Fluorescence based t-type channel assay |
| US7732607B2 (en) | 2005-08-22 | 2010-06-08 | Anatoly Mazurov | Heteroaryl-substituted diazatricycloalkanes and methods of use thereof |
| US20110098312A1 (en) | 2008-05-12 | 2011-04-28 | Targacept ,Inc | Methods for preventing the development of retinopathy by the oral administration of nnr ligands |
| CA2797356C (en) | 2010-04-26 | 2020-12-29 | Novartis Ag | Improved cell culture medium |
| US10538571B2 (en) | 2017-11-27 | 2020-01-21 | Coda Biotherapeutics, Inc. | Compositions and methods for neurological diseases |
| CN111378025A (zh) * | 2020-03-26 | 2020-07-07 | 集美大学 | 河豚毒素结合蛋白tfPSTBP2、核苷酸序列、其多克隆抗体及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670113A (en) * | 1991-12-20 | 1997-09-23 | Sibia Neurosciences, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
| DE69434067T2 (de) | 1993-03-08 | 2006-03-02 | Merck & Co., Inc. | Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes |
| US6323000B2 (en) * | 1996-12-20 | 2001-11-27 | Clark A. Briggs | Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof |
| AU9673198A (en) * | 1997-10-02 | 1999-04-27 | Aclara Biosciences, Inc. | Capillary assays involving separation of free and bound species |
-
2000
- 2000-05-25 AU AU49802/00A patent/AU4980200A/en not_active Abandoned
- 2000-05-25 EP EP00932007A patent/EP1180142A2/en not_active Withdrawn
- 2000-05-25 WO PCT/US2000/011862 patent/WO2000073431A2/en not_active Ceased
- 2000-05-25 JP JP2001500744A patent/JP2003501022A/ja not_active Withdrawn
-
2007
- 2007-02-12 US US11/705,209 patent/US20070238168A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008516604A (ja) * | 2004-10-15 | 2008-05-22 | モネル ケミカル センシズ センター | 哺乳動物の味覚細胞の培養方法 |
| JP2009186183A (ja) * | 2008-02-01 | 2009-08-20 | Seikagaku Kogyo Co Ltd | 関節痛の評価方法 |
| JP2012504966A (ja) * | 2008-10-09 | 2012-03-01 | ハワード ヒューズ メディカル インスティチュート | 新規なキメラリガンド開口型イオンチャネルおよびその使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070238168A1 (en) | 2007-10-11 |
| AU4980200A (en) | 2000-12-18 |
| WO2000073431A3 (en) | 2001-05-03 |
| WO2000073431A2 (en) | 2000-12-07 |
| WO2000073431B1 (en) | 2001-07-19 |
| EP1180142A2 (en) | 2002-02-20 |
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