JP2003304847A - Liquid drinking composition containing coenzyme q10 - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a homogeneous ubiquinone-containing liquid drinking composition having excellent storage stability. <P>SOLUTION: This stabilized liquid drinking composition is characterized by containing coenzyme Q10 and a glycerol fatty acid ester or/and a sucrose fatty acid ester. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to coenzyme Q1.
It relates to a drinking composition containing 0. Coenzyme Q10
Is a physiological substance that exists in cells as a component of the mitochondrial respiratory chain. Coenzyme Q10 produces energy through metabolic pathways, especially aerobic pathways (A
It directly acts on the oxidative phosphorylation pathway for TP generation). Requirement for coenzyme Q10 is increased in normal individuals experiencing severe physical exertion, or in cardiovascular and debilitating chronic diseases (patients with chronic debilitating illness, or individuals receiving chronic medication) In particular, deficiency has been reported in ischemic heart failure, senile myocardial sclerosis, and hypertensive heart failure (Elsevier / North-Holland).
Biomedical Press Vol.3 / 79,1981, ibidem Vol. 3,6
7). In such pathological findings, the external supply of coenzyme Q10 has included striking improvements and important therapeutic consequences (Elsevier / North-Holland B
iomedical Press Vol.2,333,1980). Coenzyme Q1
If 0 can be used on a daily basis as a liquid drinking composition that is convenient and easy to take, there is a great contribution to maintaining health.

[0002]

2. Description of the Related Art Coenzyme Q10 is a lipophilic substance having a low melting point and is practically insoluble in water. This property limits the scope of application to solid formulations, and has hindered its application to liquid drinking compositions that are convenient and easy to take. Conventional formulations containing coenzyme Q10 in solid form (tablets,
When administered as a capsule, a freshly prepared suspension), its ability to dissolve in gastrointestinal fluid is limited.

[0003]

DISCLOSURE OF THE INVENTION The present invention uses a safe substance which is approved for use in foods and uses coenzyme Q.
Allows the production of 10 stable liquid drinking compositions.
And enables high bioavailability. That is the purpose of the present invention. As an improvement on this point, US Pat. No. 3,11
No. 3,073 and Belgian Patent No. 906034 disclose aqueous formulations solubilized by polyethoxylated castor oil and N, N-dimethylacetamide. However, this amide has embryotoxicity and teratogenicity, and as a matter of course, its use in food is not permitted.

Also, the Italian patent No. 59216572
No. 7 discloses a medical preparation in the form of an oral aqueous solution of coenzyme Q10 using polyethoxylated 40 hydrogenated castor oil. Polyethoxylated 40 hydrogenated castor oil is a substance used only for pharmaceuticals and is used in foods in Japan. Is not recognized. It may be possible to emulsify and disperse coenzyme Q10 using a harmful surfactant such as a nonionic surfactant, but it has problems such as hemolytic property, mucous membrane irritation, and mucosal defect, and therefore hesitated to use. There are many.

[0005]

[Means for Solving the Problems] The preparation according to the present invention uses one or several kinds of polyglycerin fatty acid ester and / or sucrose fatty acid ester, which are safe glycerin fatty acid esters that can be used as foods, and coenzyme Q10. The present invention was completed by discovering that a liquid drinking composition can be easily obtained by solubilizing.

That is, the present invention provides (1) coenzyme Q
10 and glycerin fatty acid ester or / and sucrose fatty acid ester, stabilized liquid drinking composition, (2) glycerin fatty acid ester has n value 6
The liquid drinking composition according to (1) above, which is 10 or less polyglycerin fatty acid ester, and (3) the liquid drink according to (1) above, wherein the sucrose fatty acid ester is HLB6 or more and 20 or less sucrose fatty acid ester. Composition, (4) The liquid drinking composition according to the above (2) or (3), wherein the use amount of coenzyme Q10 and glycerin fatty acid ester or / and sucrose fatty acid ester is 1: 5 or more by weight ratio, ( 5) It further contains one or more components other than coenzyme Q10 selected from the group consisting of preservatives, sweeteners, vitamins, cerebral blood flow improving agents, amino acids, peptides, oligosaccharides, acidulants, and crude drugs. (6) The stabilized liquid drinking composition according to any one of (1) to (4) above, (6) after storage at 40 ° C for 4 months, no oil separation is visually observed. The stabilized liquid drinking composition according to any one of the items (1) to (5), (7) Coenzyme Q10 is dissolved in glycerin fatty acid ester or / and sucrose fatty acid ester, and this and (5) above. A method for producing a stabilized liquid drinking composition, which comprises mixing with an aqueous solution containing one or more components other than the coenzyme Q10 described in 1., stirring, and suspending or clarifying, 8) Use of glycerin fatty acid ester or / and sucrose fatty acid ester for producing a stabilized liquid drinking composition containing coenzyme Q10.

As the polyglycerin fatty acid ester used in the present invention, stearic acid having an n value of 6 or more and 10 or less, and the type of fatty acid is saturated or unsaturated,
Oleic acid, lauric acid, ricinoleic acid, myristic acid, linoleic acid and the like are preferable, and the number of carbon atoms is preferably 12 to 18, and examples thereof include decagulin 1-50VS (manufactured by Nikko Chemicals).

The sucrose fatty acid ester is preferably HLB 6 or more and 20 or less, and the type of fatty acid is saturated or unsaturated stearic acid, palmitic acid, oleic acid, lauric acid, myristic acid, etc., having 12 carbon atoms.
-18, and examples thereof include DK ester SS (manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd.).

In the present invention, the dissolution temperature of coenzyme Q10 is not particularly limited as long as it is within the range of 60 ° C. to 80 ° C., and is a temperature at which it can be mixed and dissolved with polyglycerin fatty acid ester and / or sucrose fatty acid ester. Good.

In the liquid drinking composition of the present invention, the ratio of each component can be selected depending on the taste and the ease of drinking. The amount of polyglycerin fatty acid ester or / and sucrose fatty acid ester is, for example, 1 to 200 parts by weight, preferably 5 to 100 parts by weight, relative to 101 parts by weight of coenzyme Q.
More preferably, it is about 10 to 50 parts by weight.

In the present invention, in addition to glycerin fatty acid esters and / or sucrose fatty acid esters, glycerin fatty acid esters, sorbitan fatty acid esters and lecithins which are surfactants as auxiliary agents for assisting the effect of these solubilizers. Etc. can be blended.

In the present invention, sweeteners include fructose-glucose liquid sugar, sucrose, fructose, glucose, honey, oligosaccharides (isomalto-oligosaccharide, galactooligosaccharide, fructooligosaccharide, xylooligosaccharide, soybean oligosaccharide, etc.), sugar alcohol ( Sorbitol, erythritol, maltitol, mannitol, xylitol, etc.) can be added as necessary. Further, high-intensity sweeteners such as aspartame, stevia, sucralose, acesulfame potassium, thaumatin and the like can be added.

In the present invention, it is preferable to add an inorganic acid or an organic acid from the viewpoint of flavor, for example, citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, succinic acid, acetic acid, gluconic acid, glutamic acid, hydrochloric acid, Polyphosphoric acid and the like and salts thereof can be blended.

In the liquid composition of the present invention, in addition to the above-mentioned components, components that can be usually used in liquid preparations, such as amino acids (aspartic acid and glutamic acid), glycine, arginine, lysine, threonine, valine, histidine,
Leucine, isoleucine, protein, peptide, various vitamins (vitamin B1, vitamin B2, vitamin B6,
Vitamin B12, niacin, vitamin C, vitamin D, vitamin A, vitamin E, vitamin K, vitamin P
Etc.) and their derivatives, minerals (calcium, magnesium, sodium, iron, zinc, copper, phosphorus), various herbal medicine extracts (Ginkgo biloba, Ganoderma lucidum, mulberry leaf, Dokudami, Kuma bamboo, Yamabushitake, rosemary, Hops, chrysanthemums, agaricus, armatures, turmeric, echinacea, eleuthero, zedoary, carrots, guarana, karin, garcinia, licorice, kyokyou, kidachialoe, gymnema sylvestre, cat's claw, kumquat, guava, kuko,
Gardenia, cinnamon, hawthorn, perilla, mandarin orange, tencha, capsicum, caterpillar, Eucommia, jujube, narcoli, garlic, mint, pearl barley, banaba, hub tea,
Propolis, safflower, peppermint, maitake, maca, pit viper, thistle, mexum linden, burmesa cob, yam, mugwort, lakanka, longan,
Lemon balm, royal jelly, quinoa, blueberries, etc.), γ-aminobutyric acid, phosphatidylserine, tea extract, collagen, chondroitin, isoflavones, preservatives (sodium benzoate, butyl paraoxybenzoate, etc.), manufacturing aids (sodium hydroxide, Calcium hydroxide, etc.) and the like can be added. The above components in order to prevent oil separation in the liquid drinking composition of the present invention,
A hydrophilic component is preferred. For the same reason as above, the liquid drinking composition of the present invention preferably does not contain fats and oils such as edible oils such as soybean oil, rapeseed oil and coconut oil.

The coenzyme Q1 obtained by the present invention
The liquid drinking composition of No. 0 stably maintained the emulsified and solubilized state even under the condition of warm storage, and its practicality was proved.

[0016]

The present invention will be described in more detail by the following examples.

Example 1 Coenzyme Q10 5 mg Polyglycerin fatty acid ester 200 mg (trade name: decagulin 1-50VS) Fructose glucose syrup 5000 mg citric acid 150 mg sodium benzoate 30 mg Water appropriate amount (total amount 50 ml) Polyglycerin fatty acid ester at about 60 ° C. The mixture is heated to dissolve and coenzyme Q10 is added to dissolve. Separately, fructose-glucose liquid sugar to sodium benzoate are dissolved in an appropriate amount of water. To this solution, add the Coenzyme Q10
And a solution of polyglycerin fatty acid ester are added and mixed and dissolved. After that, water is added to bring the total volume to 50 ml.

Example 2 Coenzyme Q10 5 mg Sucrose fatty acid ester (trade name: DK ester SS) 200 mg Fructose dextrose liquid sugar 5000 mg Citric acid 150 mg Sodium benzoate 30 mg Water suitable amount (total amount 50 ml) Sucrose fatty acid ester at about 60 ° C. Dissolve by heating and mix with Coenzyme Q10. Separately, fructose-glucose liquid sugar to sodium benzoate are dissolved in an appropriate amount of water. To this solution, the above-mentioned dissolved product of coenzyme Q10 and sucrose fatty acid ester is added and mixed and dissolved. After that, water is added to bring the total volume to 50 ml.

Example 3 Coenzyme Q10 5 mg Polyglycerin fatty acid ester 200 mg (trade name: decagulin 1-50VS) γ-aminobutyric acid 10 mg Phosphatidylserine-containing phospholipid 10 mg (trade name: Nichiyu PS20, manufactured by NOF Corporation) Tea extract 50 mg Vitamin C 500 mg Vitamin B2 5 mg Vitamin B6 20 mg Nicotinamide 15 mg Vitamin E emulsion 200 mg Vitamin P 3 mg Calcium gluconate 600 mg Ginkgo biloba extract 120 mg Rosemary extract 40 mg Yamabushi extract 100 mg Ganoderma lucidum extract 100 mg Hop extract 35 mg Chrysanthemum extract Peptide 100 mg Fructose glucose liquid sugar 5000 mg Isomaltooligosaccharide 6000 mg L-glutamic acid sodium 100 mg Sodium aspartate 125 mg Citric acid 100 mg Sodium benzoate 30 mg Butyl paraoxybenzoate 6 mg Acesulfame potassium 23 mg Sodium hydroxide 0.6 mg Perfume Trace water Appropriate amount (total amount 50 ml) Polyglycerin fatty acid ester is dissolved by heating to about 60 ° C. Add Coenzyme Q10 and mix to dissolve. Separately, γ-aminobutyric acid and up to the perfume are dissolved in an appropriate amount of water and filtered. The coenzyme Q10 and the polyglycerol fatty acid ester dissolved product are added to this filtrate and mixed and dissolved. After that, water is added to bring the total volume to 50 ml.

Example 4 Coenzyme Q10 5 mg Sucrose fatty acid ester (trade name: DK ester SS) 200 mg γ-aminobutyric acid 10 mg Phosphatidylserine-containing phospholipid 10 mg (trade name: Nichiyu PS20) Tea extract 50 mg Vitamin C 500 mg Vitamin B2 5 mg Vitamin B6 20 mg Nicotinamide 15 mg Vitamin E emulsion 200 mg Vitamin P 3 mg Calcium gluconate 600 mg Ginkgo biloba extract 120 mg Rosemary extract 40 mg Yamabushitake extract 100 mg Ganoderma lucidum extract 100 mg Hop extract 35 mg Chrysanthemum extract 40 mg Silk peptide 100 mg fructose glucose Isomaltooligosaccharide 6000 mg L-sodium glutamate 100 mg Sodium aspartate 125 mg Citric acid 100 mg Sodium benzoate 30 mg Butyl paraoxybenzoate 6 mg Acesulfame potassium 23 mg Sodium hydroxide 0.6 mg Fragrance A small amount of water (50 ml in total) Sucrose fatty acid ester is heated to about 60 ° C to dissolve it, and coenzyme Q10 is added. Mix and dissolve. Separately, γ-aminobutyric acid and up to the perfume are dissolved in an appropriate amount of water and filtered. To the filtrate, the above-mentioned dissolved product of coenzyme Q10 and sucrose fatty acid ester is added and mixed and dissolved. After that, water is added to bring the total volume to 50 ml.

Comparative Example 1 Coenzyme Q10 5 mg γ-aminobutyric acid 10 mg Phosphatidylserine-containing phospholipid 10 mg (trade name: Nichiyu PS20) Tea extract 50 mg Vitamin C 500 mg Vitamin B2 5 mg Vitamin B6 20 mg Nicotinic acid amide 15 mg Vitamin E emulsion 200 mg Vitamin P 3 mg Calcium gluconate 600 mg Ginkgo biloba extract 120 mg Rosemary extract 40 mg Yamabushitake extract 100 mg Ganoderma lucidum extract 100 mg Hop extract 35 mg Chrysanthemum extract 40 mg Silk peptide 100 mg Fructose dextrose syrup 5000 mg Isomaltooligosaccharide 6000 mg L-Glutamate sodium 100 mg sodium formate Citric acid 100 mg Sodium benzoate 30 mg Butyl paraoxybenzoate 6 mg Acesulfame potassium 23 mg Sodium hydroxide 0.6 mg Perfume Trace purified water Appropriate amount (total amount 50 ml) γ-Aminobutyric acid The following perfumes are dissolved in an appropriate amount of water and filtered. Coenzyme Q10 is added to this filtrate and mixed. After that, water is added to bring the total volume to 50 ml.

Stability Test Results Each of the prototypes of Examples 1 to 4 and Comparative Example 1 was stored in a thermostat at 40 ° C. for 4 months, and the turbidity of the prototype and the separation of coenzyme Q10 were visually observed. The results are shown in Table 1.

[0023]

[Table 1]

[0024]

EFFECTS OF THE INVENTION As described above, coenzyme Q10 is difficult to dissolve in water, and conventionally the preparation has been substantially limited to a solid dosage form. According to the present invention, a uniform and stable liquid preparation can be produced, and such a liquid preparation does not show oil separation even after storage at 40 ° C for 4 months, that is, formation of cream on the upper part of the liquid.

Continued front page    (72) Inventor Toshihito Akiyama             50 Nishiterada, Gosho City, Nara Tamura Pharmaceutical Co., Ltd.             In the company F-term (reference) 4B017 LC03 LK06 LL06

Claims (8)

[Claims] 1. A stabilized liquid drinking composition containing coenzyme Q10 and glycerin fatty acid ester and / or sucrose fatty acid ester. 2. A glycerin fatty acid ester having an n value of 6 or more 1
2. A polyglycerin fatty acid ester having 0 or less.
The liquid drinking composition according to. 3. A sucrose fatty acid ester having an HLB of 6 or more 20
The liquid drinking composition according to claim 1, which is the following sucrose fatty acid ester. 4. The liquid drinking composition according to claim 2 or 3, wherein the amount of coenzyme Q10 and glycerin fatty acid ester or / and sucrose fatty acid ester used is 1: 5 or more by weight. 5. One other than coenzyme Q10 selected from the group consisting of preservatives, sweeteners, vitamins, cerebral blood flow improving agents, amino acids, peptides, oligosaccharides, acidulants, and crude drugs.
Alternatively, the stabilized liquid drinking composition according to any one of claims 1 to 4, which contains two or more components. 6. The stabilized liquid drinking composition according to any one of claims 1 to 5, wherein no oil separation is visually observed after storage at 40 ° C for 4 months. 7. Coenzyme Q10 is dissolved in glycerin fatty acid ester and / or sucrose fatty acid ester, and 1 or 2 other than coenzyme Q10 according to claim 5 is dissolved.
A method for producing a stabilized liquid drinking composition, which comprises mixing with an aqueous solution containing the above components, stirring, and suspending or clarifying. 8. Use of a glycerin fatty acid ester or / and a sucrose fatty acid ester for producing a stabilized liquid drinking composition containing coenzyme Q10.