JP2003290351A - Syringe also serving as vessel - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a syringe also serving as a vessel with a simple structure capable of being manufactured at low cost in a small number of production processes. <P>SOLUTION: This syringe is the syringe also serving as the vessel having the structure wherein an inner vessel 3 is housed in bellows-shaped outer vessel 2, and a medical solution is sealed inside the inner vessel 3 to use as the syringe. A vessel body 1 is formed by covering the outside of the inner vessel 3 to be filled with the medical solution with the outer vessel 2, and a stopper member 4 is fitted into a port part 7 of the vessel body 1 to seal the port part 7. A needle installation part 44 for installing a needle is formed on the stopper member 4. The outer vessel 2 of the vessel body 1 is bored with ventholes 23 for introducing outside air into between the inner vessel 3 and the outer vessel 2. When the inside of the outer vessel 2 becomes a negative pressure, the ventholes 23 open to introduce the outside air. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a container-combined syringe that includes a container for containing a drug solution and can be used as a syringe for injecting the drug solution in the container.

[0002]

2. Description of the Related Art In recent years, for the purpose of preventing erroneous operation when sucking a drug solution from a container such as an ampoule into a syringe and preventing contamination by contamination of foreign substances, a container for containing a drug solution such as a prefilled syringe has been provided in recent years. Various types of container-use syringes that can be used as syringes for injecting the above medicinal solution have been developed and used in medical institutions (for example, Japanese Patent Laid-Open No. 11-192).
No. 12, etc.).

[0003]

The conventional container / syringe of this type generally uses a glass injection cylinder, and the drug solution is filled in the injection cylinder. However, the glass injection cylinder has a size. Since the accuracy is relatively low and the inner diameter and other variations are large, a rubber seal material is used to seal the inside of the cylinder and to seal the rubber stopper and plunger. Generally, rubber materials may cause impurities to elute into the chemical liquid, and the active ingredients in the chemical liquid may adhere to the rubber material to alter the chemical liquid. The process of attaching the film is performed.

Therefore, the conventional container-combined syringe using the glass syringe barrel and the rubber stopper has a problem that the structure is complicated and the number of manufacturing processes is increased. Further, silicone oil is applied to the rubber seal material fitted to the plunger for the sliding seal, but there is a problem that the silicone oil is eluted into the chemical solution. Furthermore, when sterilizing a container-combined syringe provided with a rubber stopper, the chemical resistance film on the surface of the rubber stopper may deteriorate depending on the method such as normal heat treatment or gas sterilization, and impurities may be removed from the rubber stopper. There is a risk of elution, and for this reason, the container / syringe using a rubber stopper requires a special sterilization treatment, which causes a problem of increasing the manufacturing cost.

The present invention has been made in view of the above points,
It is an object of the present invention to provide a container / syringe which has a simple structure and can be manufactured at a low cost with relatively few manufacturing steps.

[0006]

In order to achieve the above object, the container-combined syringe of the present invention is a container-combined syringe in which a drug solution for a syringe is sealed and used as a syringe.
A container body having a shape in which the outer side of an inner container filled with a chemical solution is covered with a bellows-type outer container, a stopper member fitted into the mouth portion of the container body to seal the mouth portion, and a needle provided on the stopper member. Mounting part,
And a vent hole for introducing outside air is bored between the inner container and the outer container in the bellows-type outer container of the container body.

Here, if the thickness of the body of the inner container is made thin so that it can contract due to the decrease in the pressure inside the container body, and the thickness of the vicinity of the mouth of the inner container is made thicker than the thickness of the body. Good. Further, the vent hole may be formed in the vicinity of the mouth portion of the container body, and the vent hole may be closed by the close contact of the inner container, and the close contact may be released by the contraction of the inner container to open the vent hole.

Further, the stopper member is provided with a seal portion for sealing the mouth portion when the stopper member is fitted in an intermediate position of the mouth portion of the container body, and the stopper member is pushed into the mouth portion at the time of use to seal. The seal of the portion may be released, and the chemical liquid in the container body may be introduced into the chemical liquid passage of the stopper member.

Further, the cap member and the mouth portion of the container body may be covered so that the cap can be pushed in, and the cap member can be pushed into the mouth portion to release the seal of the seal portion. it can. Further, the needle mounting portion on the stopper member is provided with a communication hole communicating with the chemical liquid passage,
The injection needle can be used by being fitted into the needle mounting portion.

Furthermore, the bellows-type outer container can be provided with a bellows portion on the distal end side, a cylindrical portion on the tip end side, and the inner container can be disposed within the cylindrical portion. In addition, the bellows-type outer container may be provided with a bellows portion as a whole, and the inner container may be disposed over the entire bellows portion.

[0011]

In the container-combined syringe having the above structure, the inner container of the container body having the bellows-type outer container and the inner container is filled with the drug solution,
A plug member is fitted into the mouth of the container body to seal the mouth. Then, the cap and the mouth of the container body are covered with a cap. When covering the cap with the injection needle fitted to the needle attachment part of the stopper member, cover the cap with a long length so that the injection needle can be accommodated, and when making the product without the injection needle fitted, Put on a small cap with a short length.

When the syringe is used, the sealing position of the sealing portion of the stopper member is displaced by further pushing the cap of the container body. As a result, the seal of the seal portion is removed, and the chemical liquid in the inner container of the container body can be introduced into the chemical liquid passage of the stopper member. Then, the cap is removed from the mouth of the container body, and when the injection needle is not attached, the injection needle is attached to the needle attachment portion on the stopper member.

When injecting the drug solution, the rear end of the bellows type outer container of the container body is pushed. At this time, the inner container in the container body is pushed by the outer container or contracts due to a pressure increase in the outer container, and the drug solution in the inner container is injected through the injection needle. The bellows-type outer container has spring elasticity, and when the force pushing the rear end part is loosened, the bellows-type outer container has a force to return to its original shape, but at this time, the vent hole of the bellows-type outer container opens. Since the outside air enters between the outer container and the inner container, no negative pressure is applied to the outer container or the inner container, and the chemical solution does not flow backward. Further, if the rear end of the bellows type outer container is pushed again, a force for contracting the inner container is generated, and the chemical solution can be easily pushed out.

The present container-combined syringe can be easily molded entirely of plastic and can be formed without using a rubber stopper as in the prior art. Further, since the bellows type outer container is used and the plunger is not used, it can be formed without using the rubber seal material for the plunger. For this reason, the chemical-resistant film-adhering treatment on the surface of the rubber stopper or the like, which has been performed on the conventional syringe using the rubber stopper, is unnecessary, and the silicone oil applied to the rubber seal material is not affected. Furthermore, since no rubber material is used, the choice of treatment methods when sterilizing the instrument is expanded, and a simpler sterilization treatment can be performed to reduce the manufacturing cost.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION An embodiment of the present invention will be described below with reference to the drawings. FIG. 1 is a front view of the container / syringe, FIG. 2 is an exploded view thereof, and FIG. 3 is a sectional view thereof. This container-combined syringe is a container body 1 having a shape in which an outer side of an inner container 3 filled with a drug solution is covered with a bellows-type outer container 2.
A plug member 4 that is fitted into the mouth portion 7 of the container body 1 to seal the mouth portion 7, and a needle mounting portion 44 provided on the stopper member 4.
A cap 6 covering the stopper member 4 and the mouth portion 7,
It is configured with.

The bellows-type outer container 2 of the container body 1 is formed in a bellows shape at the terminal half of the body portion as a bellows portion 20, and is formed as a cylindrical portion 24 at the tip side of the body portion.
The body can be contracted along its length by pushing on the distal end. The mouth portion 7 of the bellows-type outer container 2 is formed to be thicker than the body portion, and a ventilation hole 23 for introducing outside air is provided between the inner container 3 and the outer container 2 slightly below the mouth portion 7. A flange 25 is formed below the ventilation hole 23. The flange 25 is used as a grip portion on the container side when performing an injection.

The inner container 3 is formed so as to cover the inside of the cylindrical portion 24 in such a bellows-type outer container 2, and in particular, the mouth portion of the inner container 3 is formed thicker than the body portion, Furthermore, an annular protrusion 31 is formed on the inner peripheral surface of the mouth of the inner container 3, and the mouth of the outer container 2 is in close contact with the outside of the mouth of the inner container 3. Although the vent hole 23 is closed by the mouth portion of the inner container 3 being in close contact with the inside of the air hole 23, when the inner container 3 is contracted, the close contact of the inner container 3 is eliminated, and the outer container 2 and the inner container 3 are closed. Outside air is introduced through the ventilation hole 23 during the period.

As shown in FIG. 4, the stopper member 4 which is fitted into the mouth portion 7 of the container body 1 and seals the mouth portion 7 has a disc-shaped base portion 4.
0, a needle mounting portion 44 is provided so as to project, a circular guide portion 42 is horizontally provided below the disc-shaped base portion 40 via a support portion, and a disc-shaped seal portion 41 is provided below the annular guide portion 42 via the support portion. Is provided. A chemical liquid passage 45 is provided in a cylindrical support portion vertically provided in the center of the disc-shaped base portion 40, and an opening portion 45 is provided in the support portion between the annular guide portion 42 and the disc-shaped seal portion 41.
a is provided. A concave stripe is formed on the outer peripheral surface of the annular guide portion 42, and can be fitted to a convex stripe provided on the inner peripheral surface of the mouth portion 7.

As shown in FIG. 3, the stopper member 4 is a container body 1.
At this time, the concave strips of the annular guide portion 42 and the convex strips on the inner peripheral surface of the mouth are fitted to each other, so that the plug member 4 is fitted in a fixed position and the disc member Shaped seal portion 41
Is abutted against the annular projection 31 at the mouth of the inner container 3 and is fitted in a position for sealing the gap therebetween. At this time, the disc-shaped base 40
A gap is created between the upper surface of the container body and the upper surface of the container body, and the cap member 4 is further pushed into the mouth portion 7 of the container body 1 by the pushing operation of the cap 6, and the upper surface of the mouth portion 7 is formed by the lower surface of the disk-shaped base portion 40. It is possible to seal. A seal surface is formed on the lower surface of the disk-shaped base portion 40, and a seal surface is also formed on the outer peripheral surface of the annular guide portion 42, which also functions as a seal portion that contacts the inner peripheral surface of the mouth portion of the inner container 3.

The stopper member 4 is used for the container body 1 when the liquid medicine is filled.
3 is inserted into the mouth portion 7 of the outer container 2 so as to be pushed to the position shown in FIG. 3, and at that time, since the pushing jig performs positioning when grasping the vicinity of the mouth portion of the container body 1, The step portion 22 is formed on the ventilation hole 23. Further, when the stopper member 4 is pushed into the mouth portion 7, the outer peripheral surface of the annular guide portion 42 is accurately positioned at the uppermost portion of the inner peripheral surface of the mouth portion of the inner container 3 so as to stop, and the outer peripheral surface and the inner peripheral portion thereof are stopped. An uneven portion is formed on the surface. When the stopper member 4 is pushed in to a fixed position, the disc-shaped seal portion 41 has the annular protrusion 3 in the mouth portion of the inner container 3.
Stops in contact with 1 and seals the mouth.

As shown in FIG. 3, a cap 6 is placed on the opening 7 of the container body 1 in which the plug member 4 is fitted so as to cover the plug member 4 and the opening 7, and the lower inner peripheral surface of the cap 6 is covered. Is welded to the outer surface of the outer container 2 at the welded portion 61. As the welding, heat welding or ultrasonic welding can be used. Further, as shown in FIG. 3, an annular pressing portion 62 is provided inside the cap 6, and when the cap 6 is pushed when the chemical liquid is used, the stopper member 4 is pushed in and the opening portion of the container is opened. 62 can evenly press the upper surface of the disk-shaped base portion 40 of the plug member 4.

Although not shown, the cap 6 is pushed to a predetermined position when it is used, and as shown in FIG.
When the plug member 4 is pushed deep into the mouth portion 7, a concave portion or a convex portion may be provided on the inner peripheral surface so that the pushing end can be easily recognized by the user by a click feeling.

The container body 1 is molded by a molding method such as an injection molding blow molding method or a direct blow molding method.
The inner container 3 and the bellows-type outer container 2 can be molded. In addition, for example, the inner layer preform of the inner container and the outer layer preform of the outer container may be separately molded, and the parison in which the inner layer parison is inserted inside the outer layer parison may be blow-molded to mold the container body 1. In this case, the container body 1 has a mouth portion and a cylindrical portion following the mouth portion formed from the inner container 3 and the outer container 2, and the mouth portion is made thicker than the body portion so as to have rigidity, and the inner container 3 By forming the body of the film into a film shape, it can be easily contracted. The cylindrical portion 24 of the bellows-type outer container 2 is formed with a shape-retaining property that is not easily deformed, and the bellows portion 20 contracts in the longitudinal direction when its rear end is pressed, and when the pressing force is released, It is molded so as to restore its original shape with an appropriate elastic force.

The inner container 3 is laminated in the cylindrical portion of the bellows-type outer container 2 so that it can be easily peeled off. The upper end of the mouth of the inner container 3 is locked to the upper end of the mouth of the outer container 2. Be worn.
It is also possible to prevent the inner container 3 from shifting in the circumferential direction by providing knurls in the axial direction on the inner peripheral surface of the mouth of the outer container 2.

As a material for the inner container 3 of the container body 1, a polyolefin resin such as polyethylene or polypropylene can be used. As the material of the bellows type outer container 2, a saturated polyester resin such as polyethylene terephthalate or polyethylene naphthalate, or EVOH (ethylene-vinyl alcohol copolymer) can be used. Further, as the material of the container main body 1, a material having high transparency, excellent gas barrier property, and low water permeability is selected. However, since the inner container 3 is in direct contact with the chemical liquid, it has chemical resistance. It is preferable to use high materials such as polyethylene. Further, both the outer container and the inner container can be made of polyolefin resin, the outer container can be made of polyethylene, and the inner container can be made of polypropylene.

When the bellows type outer container 2 is polyethylene terephthalate and the inner container 3 is polyethylene, the container body 1
Can perform good EO (ethylene oxide) sterilization. The biggest problem in EO sterilization of containers is EO
The point that gas remains in the molding resin and the chemical reaction with elution of EO gas into the chemical solution are polyethylene and polyethylene terephthalate, because EO gas remains little and is released quickly, so EO is dissolved into the chemical solution. And the concentration of the component can be prevented by preventing evaporation of the chemical liquid. The plug member 4 can be integrally formed of polyethylene, for example.

As described above, a material having a high chemical resistance is selected as the inner container 3, while the bellows-type outer container 2 has a high releasability from the inner container, a high shape-retaining property, and a small water permeability. It is possible to construct a highly functional container-combined syringe by using materials having different physical properties for the inner layer and the outer layer.

When actually injecting a chemical solution into the container body 1 and fitting the plug member 4 into the mouth to seal the container body, first, the container body 1 and the plug member 4 are subjected to EO sterilization treatment, and then the container body. A chemical solution is injected into the inner container 3 of No. 1 and the mouth member 7 is sealed by fitting the stopper member 4. At this time, as shown in FIG. 3, the plug member 4 is fitted in a position where the disk-shaped seal portion 41 of the plug member 4 abuts and seals the annular projection 31 of the inner container 3.

The container body 1 is formed by molding the bellows type outer container 2 with a hard synthetic resin such as polyethylene terephthalate. Polyethylene terephthalate is a material having high elastic strength, good transparency, and low water permeability, and thus is suitable as the bellows-type outer container 2, and is suitable for transportation and handling of the container / syringe. Even if an external force is applied, it will not be damaged. Also,
By molding the inner container 3 and the plug member 4 with a material such as polyethylene having a high chemical resistance and a small amount of residue and elution of the EO sterilization treatment, the chemical solution can be favorably stored in the container body 1.

In the case of using the container-combined syringe having the above structure, first, as shown in FIG.
Then, the liquid medicine is introduced into the liquid medicine passage 45 of the stopper member 4. Break the welded portion 61 of the cap 6 into the mouth portion 7
On the other hand, when the plug member 4 is pushed to the pushing end, the plug member 4 is pushed into the mouth portion 7, and the disc-shaped seal portion 41 of the plug member 4 is pushed.
Is removed from the annular protrusion 31 in the mouth of the inner container 3,
The chemical liquid inside passes through between them, and the chemical liquid passage 45 in the stopper member 4
Flow into. Even in this state, the disk-shaped base portion 40 of the plug member 4
Contacts the upper surface of the mouth portion 7 and seals the surface thereof, and the annular guide portion 42 contacts the inner peripheral surface of the mouth portion of the inner container and seals the surface thereof. Securely retained.

Next, the cap 6 is removed, and the injection needle 5 is fitted into the needle mounting portion 44 as shown in FIG. Then, the end portion of the bellows type outer container 2 is pushed while gripping the flange 25 to inject the drug solution in the inner container 3. At this time, as shown in FIG. 6, when the end of the bellows portion 20 of the bellows-type outer container 2 is pushed, the volume inside the outer container 2 decreases and its internal pressure rises. Then, the liquid medicine in the inner container 3 is contracted, passes through the liquid medicine passage 45 in the stopper member 4 from the opening 45a, is sent from the needle attachment portion 44 to the injection needle 5, and is injected.

When the pushing force of the bellows portion 20 is released, the bellows portion 2 is released.
0 returns to its original shape due to its spring elasticity, and the inside of the outer container 2 has a negative pressure. At this time, the vent hole 2 at the mouth of the outer container 2
3 is opened by peeling inside the inner container 3 and the outside air enters the outer container 2, so that it immediately becomes atmospheric pressure, which causes a negative pressure in the inner container 3, or the inner container 3 has a shape before contraction. Never return to. Therefore, when the force for pressing the bellows portion 20 is loosened, the injection of the chemical solution is stopped, the outside air does not enter the inside of the inner container 3 and the chemical solution passage 45, and the backflow of the chemical solution does not occur. Injection can be performed.

In the above embodiment, the injection needle is not attached to the syringe, and when the user uses the injection needle, the injection needle 5 purchased separately is attached to the needle mounting portion 44 of the stopper member 4 of the syringe which also serves as a container. As shown in FIG. 7, it is also possible to use a container-combined syringe in which the injection needle 5 is mounted in advance. In this case, the mouth portion 7 and the plug member 4 may be covered with a cap 26 long enough to cover the injection needle 5. This long cap 2
Similarly to the above, 6 is provided with an annular pressing portion 62 so that the upper surface of the disk-shaped base portion 40 of the plug member 4 can be pressed uniformly, and the lower end inner peripheral surface of the cap 26 is welded to the outer container 2. It

Further, FIG. 8 shows another embodiment of the container / syringe, in which the stopper member 34 is fitted or welded to the mouth portion 7 of the container to be fixed. As shown in FIG. 9, this plug member 34 is formed by arranging a threaded threaded portion 37 on a cylindrical base portion 35 upright and providing a needle mounting portion 38 on the threaded portion 37. It A drug solution passage 39 that communicates with the threaded portion 37 to the needle mounting portion 38 is formed, and the drug solution passage 39 communicates with the inside of the inner container 3 through a hole.

An annular recess 35a which fits into the mouth 7 of the container body is provided below the cylindrical base 35, and the mouth 7 is tightly fitted in the annular recess 35a. A cap 36 is put on the stopper member 34 and screwed. An annular pressing portion 36a is provided inside the cap 36, and the annular pressing portion 36a can evenly press the upper surface of the plug member 34.

In the container-combined syringe having such a structure, the inner container 3 is filled with the drug solution, and the annular recess 35a of the lower cylindrical base portion 35 of the stopper member 34 is fitted into the mouth portion 7 of the inner container 3 and the joint portion is joined. Heat welding or ultrasonic welding. When using this container-combined syringe, similarly to the above, the cap 36 is removed, the injection needle is attached to the needle mounting portion 38, and the rear end of the bellows portion 20 of the bellows-type outer container 2 is pushed to perform injection.

At this time, similarly to the above, the bellows type outer container 2
When the end of the bellows portion 20 is pushed, the volume inside the outer container 2 decreases and its internal pressure rises, and the inner container 3 is pushed and contracted due to the rise of the inner pressure, and the chemical liquid in the inner container 3 is closed. It is sent to the injection needle 5 from the needle mounting portion 38 through the drug solution passage 39 in the inside,
Be injected. In this container / syringe as well, when the force pushing the bellows portion 20 is relaxed, the injection of the drug solution is stopped, and the outside air enters the inner container 3 or the drug solution passage 45, or the backflow of the drug solution occurs. In addition, the injection can be performed safely and hygienically.

10 to 13 show a container / syringe injector according to still another embodiment. In this example, almost the entire container body 51 is formed in a bellows shape. The plug member 4 and the cap 6 have the same structure as in the above embodiment. That is, the bellows-type outer container 52 of the container body 51 has a bellows-shaped whole body portion, and the body portion can be contracted in the longitudinal direction by pushing the end portion. The mouth portion of the bellows-type outer container 52 is formed thicker than the body portion in the same manner as described above, and a ventilation hole 58 for introducing outside air is provided below the mouth portion between the inner container 53 and the outer container 52. The flange 56 is drilled and formed below the flange 56. Further, an annular protrusion 57 is provided inside the mouth. The flange 56 is used as a grip portion of the container when performing injection.

The inner container 53 is such a bellows-type outer container 5.
Although formed along the inner side of 2, the mouth portion of the inner container 53 is formed thicker than the body portion and is in close contact with the mouth portion of the outer container 52. Further, an annular convex portion is formed inside the mouth of the inner container 53. The vent 58 is closed by the mouth portion of the inner container 53 being in close contact with the inside of the vent 58, but when the inner container 53 contracts, the inner container 53 peels from the outer container 52, and the contents of the outer container 52 Outside air is introduced between the containers 53 through the ventilation holes 58. Similarly to the above, the cap 6 covers the mouth of the outer container so as to cover the plug member 4, and is welded to the inner peripheral surface of the lower end thereof.

Similar to the above, as shown in FIG. 12, the plug member 4
Is fitted into the mouth of the container body 51 to a predetermined position,
At this time, the disc-shaped seal portion 41 abuts on the annular protruding portion 57 of the mouth portion of the inner container 3 and is fitted in a position for sealing the gap therebetween. At this time, a gap is created between the disc-shaped base 40 and the upper surface of the container body opening, and the stopper member 4 is further pushed into the opening of the container body 51 by pushing the cap 6 and the upper surface of the opening is disc-shaped. The lower surface of the base 40 is sealed. A sealing surface is formed on the lower surface of the disc-shaped base portion 40, and the annular guide portion 42
A sealing surface is also formed on the outer peripheral surface of the inner container 53 and functions as a seal portion that abuts on the inner peripheral surface of the mouth portion of the inner container 53.

In the case of actually injecting a chemical solution into the container body 51 and fitting the plug member 4 into the mouth portion to seal it, first, similarly to the above, the container body 51 and the plug member 4 are EO sterilized. After that, the chemical solution is injected into the inner container 53 of the container body 51,
The plug member 4 is fitted and the mouth thereof is sealed. At this time,
As shown in FIG. 2, the plug member 4 is fitted in a position where the disk-shaped seal portion 41 of the plug member 4 contacts and seals with the annular projection 57 of the inner container 53.

When the container-combined syringe having the above-mentioned configuration is used, the cap 6 is pushed into the container main body 51 to introduce the drug solution into the drug solution passage 45 of the stopper member 4 in the same manner as described above.
When the cap 6 is ruptured against the mouth portion of the welded portion 61 and pushed to the pushing end, the stopper member 4 is pushed into the mouth portion as shown in FIG. 13, and the disc-shaped seal portion of the stopper member 4 is pushed. Four
1 disengages from the annular projection 58 in the mouth of the inner container 53, and the chemical liquid in the inner container 3 passes through the space and flows into the chemical liquid passage 45 in the plug member 4. In this state, the disk-shaped base 4 of the plug member 4
0 contacts the upper surface of the mouth portion to seal the surface, and the annular guide portion 42 contacts the inner peripheral surface of the inner container mouth portion to seal the surface, so that the mouth portion of the container body 1 is securely sealed. Held in.

Next, the cap 6 is removed, and the injection needle 5 is fitted into the needle mounting portion 44 as shown in FIG. Then, the end portion of the bellows-type outer container 52 is pushed while gripping the flange 56 to inject the drug solution in the inner container 53. At this time, when the end of the bellows-type outer container 52 is pushed, the inner container 53 is pushed and contracted by being pushed by the end portion or by the increase in the inner pressure thereof, and the drug solution in the inner container 53 is discharged from the opening 45a. It passes through the drug solution passage 45 in the stopper member 4 and is sent from the needle mounting portion 44 to the injection needle 5 for injection.

Also in this container / syringe, when the force for pushing the bellows-type outer container 52 is relaxed, the injection of the drug solution is stopped, and the outside air enters the inner container 53 and the drug solution passage 45 as in the above embodiment. , Does not cause backflow of the drug solution,
Injection can be performed safely and hygienically.

Also in the embodiment of FIGS. 10 to 13, the plug member can be welded and fixed to the mouth of the container body 51 as in the example of FIG. Similar to the above, this plug member is formed by arranging a threaded portion having a thread formed on a cylindrical base portion and providing a needle attachment portion on the threaded portion. A drug solution passage that communicates from the threaded portion to the needle mounting portion is formed,
The chemical liquid passage communicates with the inner container through the hole. An annular recess that fits into the mouth of the container body is provided on the lower side of the cylindrical base, and the mouth of the container body 51 is tightly fitted in the annular recess and the joint is welded (for example, by heat welding or Ultrasonic welding). Further, as in the embodiment of FIG. 7, instead of the cap 6, a long-length cap 26 is used.
1 is screwed into the mouth, and the injection needle 5 is cap 2
It can also be configured to be housed within 6.

FIG. 14 shows a container-combined syringe according to still another embodiment. In this example, the inner container 3 is provided at the mouth of the container body.
With the drug solution filled in the inside, a thin container lid 75 having a substantially container shape is fitted to the peripheral edge of the mouth portion and seal-welded by heat welding or the like. Above the thin film lid 75 at the mouth of the container body, a plug member 70 having a sharpened portion 73 at the bottom is mounted. The stopper member 70 includes a needle mounting portion 74 on the disc-shaped base portion 71.
And an annular guide portion 72 is horizontally provided below the disc-shaped base portion 71 via a support portion, and a sharp portion 73 is provided in a sharp shape in a downward direction at the center of the bottom portion of the annular guide portion 72. .

The outer peripheral portion of the annular guide portion 72 and the thin film lid 75
An uneven portion is provided on the inner peripheral surface of, and the annular guide portion 72 is fitted to the upper inner side of the container-shaped thin film lid body 75 in an unused initial state. A chemical liquid passage is provided in the central longitudinal direction of the stopper member 70 from the needle mounting portion 74 to the lower end of the sharpened portion 3, and the stopper member 70 is pushed in so that the sharpened portion 73 becomes the thin film lid 7.
When 5 is broken, the drug solution is sent from the needle attachment portion 74 to the injection needle through the drug solution passage from the hole opened in the sharpened portion 73.

Similarly to the above, a vent hole 23 is formed below the mouth portion of the outer container 2, and a flange 25 is formed below the vent hole. Further, the cap 6 having the same structure as that described above is put on the stopper member 70 and the mouth portion, and the inner peripheral surface of the lower end portion thereof and the outer peripheral surface of the outer container 2 are welded by thermal welding or the like to be mounted.

When using this container-combined syringe, first, the cap 6 is pushed into the container body, and the stopper member 70 is inserted.
The sharp portion 73 at the bottom of the container is pierced into the thin film lid body 75, the thin film lid body 75 that seals the mouth is broken, and the sharp portion 73 having the opening of the chemical liquid passage is inserted into the inner container 3 of the container body.
At this time, the lower end of the cap 6 is pushed to the vicinity of the flange 25, the annular guide portion 72 of the stopper member 70 enters the recess of the thin film lid body 75 to the lower portion, and the disc-shaped base portion 71 hits the mouth portion of the container body. Stop. As a result, the chemical liquid in the inner container 3 flows into the chemical liquid passage in the stopper member 70.

Next, the cap 6 is removed, and the same as above.
The injection needle is fitted into the needle mounting portion 74, the end portion of the bellows type outer container 2 is pushed, and the drug solution in the inner container 3 is injected. At this time, if the end of the bellows part of the bellows type outer container 2 is pushed, the outer container 2
The inner volume decreases and its inner pressure rises, and the inner container 3 is pushed and contracted by the rise of the inner pressure, and the drug solution in the inner container 3 passes through the drug solution passage in the stopper member 70 and is injected from the needle mounting portion 74. It is sent to a needle and injected.

[0051]

As described above, according to the container / syringe of the present invention, since the plunger used in the conventional syringe is unnecessary, the syringe having a simple structure and a small number of parts can be obtained. . In addition, since the whole can be easily formed of plastic without using rubber stoppers or rubber sealing materials as in the past, the chemical resistant film on the surface of rubber stoppers, etc. Further, the treatment becomes unnecessary, and further, the choice of treatment methods when sterilizing the instrument is expanded, and a simpler sterilization treatment can be adopted to reduce the manufacturing cost.

[Brief description of drawings]

FIG. 1 is a front view of a container / syringe according to an embodiment of the present invention.

FIG. 2 is an exploded view of the container-combined syringe.

FIG. 3 is a longitudinal cross-sectional view of the container-combined syringe.

FIG. 4 is a perspective view of a plug member 4.

FIG. 5 is a vertical cross-sectional view during use.

FIG. 6 is a vertical cross-sectional view showing a state where a bellows portion is pushed.

FIG. 7 is a vertical cross-sectional view of a container / syringe of another embodiment.

FIG. 8 is a vertical cross-sectional view of a container / syringe injector according to still another embodiment.

FIG. 9 is a perspective view of a stopper member 34 of the syringe.

FIG. 10 is a front view of a container / syringe according to still another embodiment.

FIG. 11 is an exploded view of the container-combined syringe.

FIG. 12 is a cross-sectional view of the container-combined syringe.

FIG. 13 is a cross-sectional view of the same syringe as the container in use.

FIG. 14 is a sectional view of a container / syringe according to still another embodiment.

[Explanation of symbols]

1-container body 2- bellows type outer container 3-inner container 4-plug member 5-injection needle 6-cap 7-mouth 23-vent 44-needle mount

Claims (8)

[Claims] 1. A container-combined syringe for enclosing a drug solution for a syringe and used as a syringe, comprising: a container body in which an outer side of an inner container filled with the drug solution is covered with a bellows-type outer container.
The container body is provided with a stopper member which is fitted into the mouth portion of the container body and seals the mouth portion, and a needle attachment portion which is provided on the stopper member. A container / syringe characterized in that a vent hole for introducing outside air is provided between the container and the outer container. 2. The thickness of the body of the inner container is formed so as to be contractible by the decrease of the pressure in the body of the container, and the thickness of the inner container near the mouth is thicker than the thickness of the body. The syringe which also serves as a container according to claim 1. 3. The vent hole is formed in the vicinity of the mouth portion of the container body, the vent hole is closed by the close contact of the inner container, and the close contact is released by the contraction of the inner container to open the vent hole. The container-combined syringe according to claim 2. 4. The plug member is provided with a seal portion for sealing the plug member when the plug member is fitted in an intermediate position of the mouth portion of the container body, and the plug member is provided in the mouth portion during use. 2. The container-combined syringe according to claim 1, wherein the syringe is configured to release the seal of the seal portion to introduce the drug solution in the container body into the drug solution passage of the stopper member by pushing. 5. A cap is pushably covered so as to cover the stopper member and the mouth portion of the container body, and the stopper member is pushed into the mouth portion by pushing the cap, and the seal of the seal portion is released. The container-combined syringe according to claim 4. 6. The container-combined syringe according to claim 4, wherein the needle mounting portion on the stopper member is provided with a communication hole communicating with the drug solution passage, and an injection needle is fitted therein. 7. The container according to claim 1, wherein the bellows-type outer container is provided with a bellows portion on a terminal side thereof, a cylindrical portion is provided on a tip side thereof, and the inner container is arranged within the cylindrical portion. Dual-purpose syringe. 8. The container-combined syringe according to claim 1, wherein the bellows-type outer container is entirely provided with a bellows portion, and the bellows-type outer container is entirely provided with the inner container.