JP2003277286A - In vivo collagen synthesis accelerator - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a collagen synthesis accelerator. <P>SOLUTION: This collagen synthesis accelerator contains a powder or an extract, as it is or roughly purified or purified, of at least one plant selected from among plants of the genera Pfaffia and Ajuga as the effective component. The accelerator accelerates the in vivo biosynthesis of collagen, can restore the tissue synthesis function, can improve the fatigue of tissue and the lowering of functions accompanying to the change by aging, and brings about the effects on various dermal wounds (e.g. bedsores), osteoporosis, etc. Since the accelerator contains a crude drug-derived component as the effective one, it does not cause side effects and can be administered over a long time. <P>COPYRIGHT: (C)2004,JPO

Description

Description: BACKGROUND OF THE INVENTION [0001] 1. Field of the Invention [0002] The present invention relates to a collagen synthesis promoter which activates the metabolism of living tissue by enhancing the ability of the body to promote collagen synthesis. . [0002] Collagen is a main structural protein of the biological skeleton occupying about 30% of the biological protein, and plays an important role in maintaining the structure as a supporting tissue of the living body. It protects cells and plays an important physiological role, such as cell binding, as an intercellular factor. In this way, collagen, which plays an important role in the living body, also decreases with the decrease of metabolism due to aging, and it is thought to cause various diseases associated with aging, such as progress of aging, delay in recovery of diseases and chronic diseases. Therefore, countermeasures to improve the metabolic decline are desired. In particular, aging of the skin is easy to progress, and signs of aging are easily observed. Wrinkles and tarmi, which symbolize skin aging, are caused by a decrease in the elasticity and flexibility of the skin, and such skin aging is based on a decrease in collagen. [0003] When a tissue is injured, a repair reaction occurs in the living body, and the skin ulcer causes a granulation, and a bone fracture results in a remodeling of the callus. These remodeling is also degraded in a state of reduced metabolism, and by activating the metabolism in the body and enhancing the remodeling process of tissues, it is possible to treat intractable skin ulcers such as pressure sores, diabetic vascular ulcers and elderly people. Healing of osteoporotic fractures and bone defects. [0004] Furthermore, collagen is also important as a component of bone together with calcium, and it has been recognized that active collagen synthesis is required to form strong bone, and is also important for prevention of osteoporosis. is there. [0005] In recent years, a patent relating to the promotion of skin metabolism by oral ingestion of Tochu and ginseng (Japanese Patent Laid-Open No. 9-67262)
No.) has also been released, and health foods mainly for beauty are sold, but there are still few examples that have verified the effects of oral ingestion. [0006] It is an object of the present invention to provide a biocollagen synthesis promoter which can dramatically enhance the ability of collagen in vivo to promote collagen synthesis. Means for Solving the Problems [0007] The present invention has been accomplished by the inventors of the present invention to solve the above-mentioned problems by ingesting a specific useful plant part or an extract thereof.
It has been found that biosynthesis of living collagen is promoted.
That is, the present invention provides at least one member selected from the group consisting of plants belonging to the genus Paphia and plants belonging to the genus Kylansou.
It is an object of the present invention to provide a biocollagen synthesis promoter comprising a plant powder, an extract of a species, or a roughly purified or purified extract thereof as an active ingredient. Hereinafter, the present invention will be described in detail. BEST MODE FOR CARRYING OUT THE INVENTION The biocollagen synthesizing agent of the present invention is, as described above, a group consisting of a plant belonging to the genus Paphia (hereinafter sometimes simply referred to as “pafia”) and a plant belonging to the genus Kylansou. And at least one plant powder or extract selected from the above, or a crude or purified product of the extract as an active ingredient. [Paffia] The plant belonging to the genus Pafia may be of any kind as long as it contains an active ingredient that promotes biocollagen synthesis, such as Pfaffia glomerate and Paffia glomerate. P. iresinoides, P. paniculata, P. jubata, P. pulverrenta (P. pul)
verulenta), Paffia spicata, P. actifolia, P. aphylla, P. cinerea (P. c)
inerea, P. denudata, P. elata, P. equisetiformis, P. eriantha, P. glabrat
a), P. glabratoides,
P. gnaphaloides, P. helicrysoides, P. hirtula, P. lanata, P. reticulata (P. retic)
ulata), P. stenophyla,
One or more species such as P. tuberosa and P. velutina can be used, among which P. glomerate and P. iremerinoides
sinoides) are preferably used. The plant belonging to the genus Kirancho may be of any type as long as it contains an active ingredient that promotes biocollagen synthesis.
For example, giraffe (Ajuga decumbens), oja quail (Ajaponica), periwinkle (A. shikotanensis),
Himekiranso (A. pygmaea), Hirakisou (A. inc.)
isa), Kaijindo (A. ciliata), Western goromo (A. yezoensis), Juenihitoe (A. nipponensis)
And one or two such as A. reptans
More than seeds can be used, especially Kiranso (A.d.
ecumbens). [0011] Powdering and extraction of the plant may be performed by a conventional method. The extraction can be performed, for example, by drying and chopping or powdering one or more of the above-mentioned plants, adding an extraction solvent, and immersing or heating. As the extraction solvent, use one or a mixture of two or more of water, alcohols, ethers, esters, ketones, nitriles, aromatic hydrocarbons, halogenated aliphatic hydrocarbons, and the like. Can be done. The extract in the present invention means any of an extract, a diluent or concentrate of the extract, a dried product obtained by drying the extract, and an extract. . Crude purification and purification of the above extract may be performed by a conventional method, and for example, adsorption and elution with an adsorbent, chromatography and the like can be carried out in an appropriate combination. [0013] One or more of the above-obtained plant powders, extracts, crudely purified products and purified products of the above-mentioned extracts can be obtained from in vivo organisms as will be apparent from the examples described below. Since it has a collagen synthesis promoting action, it can be used as an active ingredient of a biological collagen synthesis promoter. Since the biocollagen synthesis promoter of the present invention is derived from a crude drug as an active ingredient, it is considered that it has relatively few side effects and can be administered for a long period of time. The biocollagen synthesizing agent of the present invention can be in a form that can be orally ingested, for example, a powder, powder, granules, tablets, capsules and the like. Foods of various use forms, such as adding to confectionery, soft drinks, and staple foods, can be obtained. Foods to which the biocollagen synthesis promoter of the present invention is added include, in addition to the active ingredient as the above-mentioned promoter, royal jelly, animal extracts such as mucopolysaccharides, amino acids such as glycine and proline, and antioxidant vitamins , Unsaturated fatty acids, nucleic acids, and other components having a conventionally known effect of preventing aging change may be simultaneously added, and if necessary, excipients, bulking agents, sweeteners, flavoring agents, colorings that are ordinarily used in foods. Additives such as agents can be appropriately compounded within a range that does not impair the effects of the present invention. Furthermore, the biocollagen synthesis promoter of the present invention can be added to ointments and cosmetics as an external preparation without any problem. Hereinafter, the present invention will be described more specifically with reference to examples, but the scope of the present invention is not limited to these examples. "%" Is% by weight unless otherwise specified.
Means [Example] Tissue synthesis ability recovery experiment The present invention uses a formalin filter paper method (FFP method: A. Tanaka).
1960 (4), 357-364) et al, Endocrinol, Japan. The present invention has been reported by Rao et al. (Rao et al, Lea).
Based on ther Science, Vol. 33 (1), 1986, 1-7), the effect of the biocollagen synthesizing agent of the present invention on rats whose metabolism has been significantly reduced by long-term feeding on a low protein diet is examined. It was done. (1) Experimental animals After pre-breeding 5-week-old male Wistar rats for 1 week,
Each group consisted of 5 animals. (2) Feed Each group was allowed to freely take the feed and drinking water shown in Table 1. The sample solution was forcibly administered orally once a day using a gastric tube until the end of the experiment. [Table 1] The mixed vitamins and minerals shown in Table 1 are mixtures having the compositions shown in Tables 2 and 3, respectively. [Table 2] [Table 3] (3) Preparation of a sample solution 1000 ml of 70% ethanol was added to 100 g of paffia or kalanchoe, and the mixture was extracted by heating for 1 hour. The extract was filtered, and the filtrate was concentrated to obtain a paffia extract and a kalanchoe extract, respectively. . In addition, 15
A solution prepared to be 00 mg / kg was used as a sample solution. (4) Evaluation of FFP Method Three weeks after the start of the experiment, 20 μl of 7% formalin was impregnated with ether under anesthesia with an ether of 6 mm in diameter and 8 mg in weight.
Filter paper (TOTO filter paper No. 126) was implanted at four subcutaneous sites on the back of the rat. From the same day, given feed, drinking water, and sample solution, the animals were reared for 5 days, killed with ether, and immediately removed the granulation tissue surrounding the filter paper, wet weight of granuloma and content of hydroxyproline (Hyp) in the tissue. Was measured and used as an index of collagen synthesis ability and rat tissue repair ability. Table 4 shows the results of the above experiment. The granuloma wet weight and Hyp content of Group 1 in Table 4 were set to 100%. * And ** show a significant difference from Group 1 (6% protein diet, ion-exchanged water) when statistically processed by Dunnett test (significance level * p <0.05, ** p <0.01). Show things. [Table 4] According to Table 4, the promotion of granulation formation and the increase in the amount of Hyp were clearly observed by the ingestion of the Paffia extract and the Chinese lantern extract. The biological collagen synthesis promoter of the present invention comprises:
It is possible to promote collagen biosynthesis in the living body and to restore the tissue synthesis ability.
It is able to improve the decrease in function and further exerts effects on various skin wounds such as pressure sores, osteoporosis and the like. And because the active ingredient is derived from crude drugs,
It has relatively few side effects and can be administered for a long time.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 19/10 A61P 19/10 43/00 111 43/00 111 // A23L 1/30 A23L 1/30 B (72) Inventor Yukitaka Fukaya 3-2-2, Marunouchi, Naka-ku, Nagoya-shi, Aichi Prefecture Inside Matsuura Pharmaceutical Co., Ltd. Company F term (reference) 4B018 LB01 LB08 LE03 MD48 MD54 ME14 MF01 MF07 4C088 AB38 AC01 BA10 BA11 MA35 MA37 MA41 MA43 MA52 NA14 ZA36 ZA89 ZA96 ZA97 ZC21

Claims (1)

Claims 1. A powder, extract, or a crude or purified extract of at least one plant selected from the group consisting of a plant belonging to the genus Pafia and a plant belonging to the genus Kylansou. Biological collagen synthesis promoter characterized by containing as an active ingredient