JP2003245346A - Blood processing device of hollow fiber membrane type and manufacturing method therefor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a blood processing device which shows an excellent residual blood performance by suppressing activation of blood at the time of the flow and by reducing the amount of residual blood after use, and a manufacturing method therefor. <P>SOLUTION: A bundle of cellulosic hollow fiber membranes formed with a resin embedding part by embedding and securing the end part of the bundle of the hollow fiber membranes with a resin is contained in the blood processing device. The hollow fiber membranes are opened by cutting at least one end of the resin embedding part, and the cross section of the resin embedding part of the hollow fiber membranes is treated with a urea organic solvent solution and is impregnated with urea. Urea is fixed to the cross-section by an irradiation treatment. Preferably, the hollow fiber membrane of a regenerated cellulose should be used, and the ratio of the internal diameter of the opening part of the hollow fiber membrane at the cross-section of the resin embedding part in a dry condition to the internal diameter in a wet condition should be set as 'Dw/Dd=1.0-1.1'. (Dw stands for the inner diameter of the hollow fiber at the cross-section of the resin embedding part in a wet condition with water. Dd stands for the inner diameter of the hollow fiber in a dry condition before being wet with water.) The manufacturing method is to perform the irradiation treatment of the cross-section of the resin embedding part of the hollow fiber membranes after it is impregnated with urea by treating it with the organic solvent urea solution. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hollow fiber membrane type blood treatment apparatus and a method for manufacturing the same. INDUSTRIAL APPLICABILITY The hollow fiber membrane blood processing apparatus of the present invention can be suitably used in a medical field or the like for a blood purifier with less residual blood.

[0002]

2. Description of the Related Art Hollow fiber membrane blood treatment equipment is used for hemodialysis,
It is used for separation of specific components in blood such as blood filtration and plasma separation. In the hollow fiber membrane blood processing device, the flow of blood in the header part and the hollow fiber part is smoothly performed,
Moreover, it is desirable that the activation of the blood component does not occur due to the contact between the blood and the member. In such a blood purifier with good fluidity of blood, the amount of blood remaining in the blood purifier after use, that is, the amount of residual blood can be reduced.

For example, as a technique for improving the flow state of blood, Japanese Patent Application Laid-Open No. 57-86362 discloses that the inner diameter of the hollow fiber membrane at the cut surface of the resin fixing portion of the hollow fiber membrane blood processing apparatus is enlarged to introduce blood. There is disclosed a hollow fiber membrane-type blood treatment device with less residual blood, in which the flow resistance of blood is improved by increasing the opening degree of the blood discharge part and the blood discharge part. However, when a synthetic membrane is used, this device can exert its effect because swelling of the hollow fiber membrane due to wetting is not substantially observed, but it swells with blood or water like regenerated cellulose. In the case of a raw material, the narrowing of the opening due to the swelling of the film thickness portion of the hollow fiber membrane is remarkable. Therefore, when using a cellulosic hollow fiber membrane, it is difficult to maintain the inner diameter size of the hollow fiber membrane in the resin-embedded portion in the same state as in the dry state or in a state where the hollow fiber membrane is further expanded, and a sufficient opening degree and Not effective in reducing residual blood. As a means of increasing the opening degree, it is possible to use a hollow fiber membrane having a large inner diameter in a dry state in order to prevent a decrease in the opening degree due to swelling. There are problems such as deterioration in performance and hollow fiber productivity, and their size is limited.

The problems of the above-mentioned conventional cellulose-based hollow fiber membranes for blood processing apparatuses will be described with reference to the drawings. FIG. 1 is an explanatory view (schematic diagram) of a conventionally used cellulose-based hollow fiber membrane for a blood processing apparatus and a resin for embedding and fixing the hollow-fiber membrane, and FIG. 2 is for the same blood processing apparatus. FIG. 3 is an explanatory diagram (schematic diagram) of the cellulosic hollow fiber membrane and its embedded fixing resin in a wet state. 1 and 2, 1 is a resin for embedding and fixing a hollow fiber membrane, 2 is a resin-embedded portion of the hollow fiber membrane, 3 is a non-resin-embedded portion of the hollow fiber membrane, 4 is a cut surface of the resin, 5 Is a cut surface of the resin-embedded portion of the hollow fiber membrane. Comparing FIG. 1 and FIG. 2, in the hollow fiber membrane in the wet state (FIG. 2), the hollow fiber membrane swells and the thickness becomes larger than that in the dry state (FIG. 1). In the resin-embedded portion 2, since the swelling in the radial direction is restricted by the resin 1 that embeds and fixes the resin-embedded portion 2, the inner diameter dimension of the cut surface 5 of the hollow fiber membrane is reduced, while the non-resin-embedded portion It can be understood that the thickness and the inner diameter of the portion 3 are greatly expanded because the swelling is not regulated.

Therefore, in the form of such a hollow fiber membrane in the resin-embedded portion, a rapid reduction of the flow occurs at the time of introducing blood into the hollow fiber membrane, and a sharp flow of the flow occurs at the time of drawing blood. Expansion occurs. As a result, blood disorder is likely to occur, causing activation of blood components. This is one of the factors that deteriorate the residual blood property of the cellulosic hollow fiber membrane blood treatment apparatus.

[0006]

SUMMARY OF THE INVENTION In view of the above situation, the present invention provides a blood introducing portion of a hollow fiber membrane of a blood processing apparatus incorporating a cellulosic hollow fiber membrane, which has not been sufficiently achieved in the prior art. Suppressing the inner diameter reduction due to the wetting of the hollow fiber membrane on the cut surface and the blood discharge portion cut surface, and improving the blood flow resistance by imparting a tapered shape to the cut surface opening of the hollow fiber membrane, and blood Hollow fiber membrane blood treatment apparatus having excellent residual blood characteristics, which suppresses the activation of blood during activation and reduces the amount of blood remaining in the blood treatment apparatus after use, that is, residual blood volume, and a method for producing the same The challenge is to provide.

[0007]

In order to solve the above-mentioned problems, the inventors of the present invention treated the cut surface of the hollow fiber membrane-embedded portion in contact with blood with a solution of urea in an organic solvent to form urea. By impregnating the cut surface and then irradiating the cut surface, it was found that expansion of the inner diameter of the hollow fiber membrane at the cut surface and swelling of the film thickness portion due to water or blood impregnation were suppressed, and the present invention was reached.

That is, the invention according to claim 1 of the present invention has a built-in cellulosic hollow fiber membrane bundle in which an end portion of the hollow fiber membrane bundle is embedded and fixed in a resin to form a resin-embedded portion. Then
At least one end of the resin-embedded portion is cut to open the hollow fiber membrane, and the cut surface of the resin-embedded portion of the hollow fiber membrane is treated with an organic solvent solution of urea to impregnate it with urea. The hollow fiber membrane-type blood treatment apparatus is characterized in that it has been subjected to irradiation treatment.

The second aspect of the present invention is the apparatus according to the first aspect, wherein the material of the cellulosic hollow fiber membrane bundle is a regenerated cellulose. . The invention according to claim 3 is the device according to claim 1 or 2, wherein the resin for embedding and fixing the hollow fiber is a polyurethane resin.

A fourth aspect of the present invention is the apparatus according to any one of the first to third aspects, wherein the opening of the hollow fiber membrane on the cut surface of the resin-embedded portion is dried. The hollow fiber membrane-type blood processing device has an inner diameter ratio in the following range when wet. Dw / Dd = 1.0 to 1.1 Here, Dw is the inner diameter of the hollow fiber membrane in the water-wet state on the cut surface of the resin-embedded portion, and Dd is the hollow fiber membrane in the dry state before the water-wet state. Indicates the inner diameter of.

According to a fifth aspect of the present invention, the cellulosic hollow fiber membrane bundle in which the end portion of the hollow fiber membrane bundle is embedded and fixed in a resin to form a resin-embedded portion is incorporated, After cutting at least one end of the resin-embedded portion to open the hollow fiber membrane, after treating the cut surface of the resin-embedded portion of the hollow fiber membrane with an organic solvent solution of urea to impregnate urea The method for manufacturing a hollow fiber membrane-type blood treatment device is characterized in that irradiation treatment is performed.

The invention according to claim 6 of the present invention is the method for manufacturing the device according to claim 5, wherein the organic solvent solution of urea is a methanol solution. Is the way.

The invention according to claim 7 of the present invention is the method for manufacturing the device according to claim 5 or 6, wherein the concentration of the urea solution is 1 to 20% by weight. It is a manufacturing method of a processing apparatus.

The invention according to claim 8 of the present invention is the method for manufacturing the device according to any one of claims 5 to 7, wherein the irradiation is carried out by ultraviolet ray irradiation. It is a manufacturing method of a blood processing apparatus.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be specifically described below. In the present invention, the “hollow fiber membrane” is a hollow fiber thin tube having a membrane function. In addition, in the present invention, “%” is a weight ratio unless otherwise specified.

After storing the cellulosic hollow fiber membrane bundle in the main body case of the blood processing apparatus, both ends of the hollow fiber membrane bundle are embedded in the main body case with resin and fixed. This embedded fixation method is
Any known method may be used. The material of the hollow fiber membrane used in the present invention is not particularly limited as long as it is a material capable of suppressing swelling when wet by the fixing method of the present invention, but swells by wetness with blood in a conventional method such as regenerated cellulose. It is preferable to actively use the material. Polyurethane resin is generally used as the embedding resin.

As described above, the end portion of the hollow fiber membrane bundle contained in the main body case is cut to open at least one end of the hollow fiber membrane. Then, the opened cut surface is impregnated with urea. As a method for impregnating urea, there are a method of immersing the cut surface in an organic solvent solution of urea, a method of spraying an organic solvent solution of urea, and the like, but the spraying method is preferable in view of simplicity of the treatment process. At this time, the solvent that dissolves urea must be one that does not dissolve the resin, has an affinity for the material of the hollow fiber membrane, and can be easily impregnated into the hollow fiber membrane.
Further, a solvent that easily volatilizes or a solvent that can be easily removed by washing with water is preferable. Examples of the organic solvent that satisfies such conditions include methanol and ethanol. However, the present invention is not limited to these.

Since the concentration of the urea solution varies depending on the material of the hollow fiber membrane, it is preferable to optimize it according to these materials. For example, when a hollow fiber membrane of regenerated cellulose is used, it is preferably in the range of 1 to 20% when using a methanol solution of urea. When the concentration is lower than 1%, a sufficient amount of adhesion cannot be obtained by only one dipping, and the adhesion effect cannot be improved. Further, when the concentration is lower than 1%, it is necessary to repeat spraying in order to obtain a sufficient impregnation amount by the spraying method, but when spraying repeatedly, the amount of the urea solution penetrating into the resin increases, and Solvent removal becomes complicated. On the other hand, 2
When the concentration is 0% or more, urea is deposited on the cut surface of the hollow fiber membrane after the urea solution treatment, the energy absorption efficiency at the time of the subsequent irradiation treatment is deteriorated, and irradiation takes a long time. Occurs.

After the treatment with the organic solvent solution of urea, irradiation for fixing the impregnated urea to the cellulose is performed in order to suppress the reduction of the inner diameter of the hollow fiber membrane due to wetting. Far infrared rays, gamma rays, ultraviolet rays, laser beams and the like can be used for this irradiation treatment, but ultraviolet irradiation is preferable from the viewpoint of handleability and ease of fixing treatment. When irradiating and fixing with ultraviolet rays, the wavelength of ultraviolet rays is not particularly limited as long as it is around 170 nm obtained using an excimer lamp to 370 nm, but the ultraviolet absorption characteristics of the hollow fiber membrane material and the embedding resin are taken into consideration. It is preferable to make the above decision. For example, in the case of a combination of regenerated cellulose and a polyurethane resin, it is preferable that the wavelength is 253.7 nm or more, which is used for sterilization, considering that it is for medical use. It is preferable to determine appropriate irradiation conditions depending on the irradiation intensity and irradiation amount of ultraviolet rays, the wavelength of ultraviolet rays to be irradiated, the irradiation distance, the type of ultraviolet ray generating light source, the type of fixing resin, and the like.
For example, in the case of a blood processing apparatus in which a hollow fiber membrane bundle of regenerated cellulose is used and fixed with a polyurethane resin, the irradiation intensity may be in the range of 1 to 29 nmW / cm ² for about 5 to 90 minutes. If the irradiation intensity is weaker than 1 mW / cm ² , it takes a long time to process. Moreover, a sufficient swelling suppressing effect cannot be obtained. If the strength is higher than 20 mW / cm ² , chemical deterioration is likely to occur on the surface of the polyurethane resin, which may cause undesirable effects. Further, in the case of irradiating and fixing with a laser beam, a carbon dioxide gas laser is preferable and its wavelength is 10.6 μm. The irradiation conditions can be optimized in a wide range by changing the laser output, the irradiation distance, the irradiation atmosphere or the irradiation speed, etc., but it is preferably determined in consideration of the laser beam resistance property of the hollow fiber membrane material.
For example, in the case of cellulose, the laser output is 10 to 10
The 0 watt range is preferred. Further, the irradiation distance needs to be optimized depending on the output and irradiation atmosphere conditions, but for example, in the case of 50 watts, a distance of 20 to 50 cm is preferable. Further, the irradiation atmosphere is preferably irradiation while flowing an inert gas such as nitrogen gas in order to prevent oxidation and deterioration of the hollow fiber membrane and the hollow fiber fixing resin. However, since these conditions act complementarily, the scope of the present invention is
It is not limited to these condition ranges. Further, if the irradiation energy is too large, the fixing resin is likely to melt, deform, etc., and the blood activity suppressing effect cannot be obtained.

The amount of urea with which the hollow fiber membrane is impregnated is defined by the amount of urea that has penetrated into the hollow fiber membrane and the resin that embeds it. When a polyurethane resin is used, the resin and the hollow fiber are used. The urea solution having the above concentration may be impregnated over a range of 0.1 cm or more from the cut surface of the membrane. Further, the time from the treatment with the organic solvent solution of urea to the irradiation treatment is not particularly limited, but when stored at room temperature, a sufficient effect of suppressing the inner diameter reduction is recognized within 2 weeks immediately after the treatment with the organic solvent solution.

After the treatment of the organic solvent with urea and the irradiation treatment, it is preferable to provide a removing step for removing the residual solvent and free urea. As the removing method, for example, a washing and removing method using water can be applied.

In the blood processing apparatus according to the present invention, the cut surface of the resin-embedded portion including the cut surface of the hollow fiber membrane is an organic solvent solution of urea,
For example, the following two mechanisms can be inferred for the effect of suppressing the reduction of the inner diameter due to the wetting of the hollow fiber membrane, which is achieved by irradiating after treating with a methanol solution of urea to impregnate urea. . (1) By impregnating the cut surface of the resin containing the hollow fiber membrane with an organic solvent such as methanol, the resin, particularly the resin in the vicinity of the hollow fiber membrane, becomes flexible, and the organic material such as methanol Swelling of the inner diameter and the membrane portion of the hollow fiber membrane due to the solvent occurs. At this time, with an organic solvent such as methanol, the swelling of the film thickness portion is small, so that the inner diameter increases. Due to the expansion of the inner diameter due to the swelling of the hollow fiber membrane, the softened resin in the opening of the cut surface is spread and the inner diameter of the hollow fiber membrane is expanded in a tapered shape. (2) By subjecting the hollow fiber membrane in the swollen state to irradiation treatment, a chemical reaction occurs between the hollow fiber membrane and the urea impregnated in the hollow fiber membrane, so that the swelling of cellulose in the hollow fiber membrane due to wetting is suppressed. It is estimated to change.

It is presumed that the present invention suppresses the swelling of the cellulosic hollow fiber membrane due to the wetting by the above two mechanisms. Therefore, the swelling state when wet changes depending on the progress of the reaction. There is a method in which an organic solvent solution of urea is supplied to the surface of a roller or the like on which the previous hollow fiber membrane is running to bring it into contact with the hollow fiber membrane. However, when measured with an infrared spectrophotometer, a change in the absorption pattern is observed in the wavelength range of 5.0 to 6.0 μm, but since it does not have a specific absorption wavelength, the bonding group produced is not clear. There is no.

In the blood treatment apparatus of the present invention, the cut surface of the resin-embedded portion of the embedding resin and the hollow fiber membrane is treated with an organic solvent solution of urea, and the organic solvent and urea are treated with the embedding resin and the hollow fiber membrane. By impregnating the resin-embedded portion, the inner diameter of the hollow fiber membrane is increased, and the subsequent irradiation treatment suppresses the inner diameter reduction due to the swelling of the membrane portion, but the inner diameter reduction suppression effect is Dw / D.
In the range of d = 1.0 to 1.1, the effect of improving the residual blood property was recognized. However, Dw represents the inner diameter of the hollow surface of the resin-embedded portion in the water-wet state, and Dd represents the inner diameter of the resin-embedded portion in the dry state before wetting. When Dw / Dd was smaller than 1.0, the effect was insufficient. On the other hand, although it seems that the larger the upper limit is, the more preferable, but in the production method of the present invention, values up to 1.1 could be confirmed.

The wet state of the hollow fiber membrane of the present invention will be described with reference to the drawings. FIG. 3 is an explanatory diagram (schematic diagram) in a wet state of a cellulosic hollow fiber membrane for a blood processing apparatus according to the present invention and a resin for embedding and fixing the same. Reference numerals used in FIG. 3 are the same as those in FIGS. 1 and 2, 1 is a resin for embedding and fixing the hollow fiber membrane, 2 is a resin embedding portion of the hollow fiber membrane, and 3 is a non-resin embedding of the hollow fiber membrane. Reference numeral 4 denotes a cut surface of the resin, and 5 denotes a cut surface of the resin-embedded portion of the hollow fiber membrane. Comparing FIG. 1 and FIG. 2 (conventional hollow fiber membrane) with FIG. 3 (hollow fiber membrane of the present invention), the resin-embedded portion 2 of the hollow fiber membrane of FIG. 2 does not swell like the resin-embedded portion 2 of the hollow fiber membrane, and the cut surface 5 of the hollow fiber membrane of FIG. 3 is in a state of being enlarged in a tapered shape from the cut surface 5 of the hollow fiber membrane of FIG. Has become. The cut surface 5 of the hollow fiber membrane shown in FIG. 3 is almost the same as the cut surface 5 of the hollow fiber membrane shown in FIG. 1 (when dried by the conventional method). The reason for this is that when the cut surface 4 of the embedding resin 1 and the cut surface 5 of the resin-embedded portion 2 of the hollow fiber membrane are treated with an organic solvent solution of urea, the resin 1 is caused by the action of the organic solvent that has penetrated into the resin 1.
Is softened, and at the same time, the inner diameter of the cut surface 5 of the hollow fiber membrane is enlarged by the swelling action of the organic solvent that has penetrated into the film-thickness portion of the resin-embedded portion 2 of the hollow fiber membrane. The expanded state is maintained by the action of urea. On this occasion,
It is considered that the swelling of the film thickness part by the organic solvent hardly occurs. Subsequent irradiation treatment causes a reaction between urea and the hollow fiber membrane to form a structure in which the swelling of the thickness of the hollow fiber membrane due to wetting is suppressed, and after wetting, the inner diameter expanded to a tapered shape. It is considered that the shape is realized.

The present invention will be further described with reference to Examples and Comparative Examples. In addition, various numerical values described in Examples and Comparative Examples were measured according to the following procedures.

<Measurement of Inner Diameter of Hollow Fiber Membrane at Cut Surface of Polyurethane Resin Embedding Section> After housing the hollow fiber membrane bundle in the main body case, and embedding both ends of the hollow fiber membrane bundle in the main body case with polyurethane resin, The end of the case was cut to open at least one end of the hollow fiber membrane. The hollow fiber membrane inner diameter on the cut surface was observed and measured with a digital HD microscope VH7000 (manufactured by Keyence Corporation) before and after the urea treatment and after the irradiation treatment. <Evaluation of residual blood property> The hollow fiber membrane blood treatment apparatus was comparatively evaluated for its residual blood property under the following conditions. Each blood processing device is 1.
After washing with 5 L of physiological saline, fresh blood of bovine (hematocrit 45%, total protein concentration 9.0 g / dL, hevalin added amount 3000 IU / L) was applied, and the transmembrane pressure difference was 100 mmHg.
The blood was circulated for 3 hours at a flow rate of 200 mL / min. 1.5 L of blood was used for each blood processing apparatus.
Then, the blood return operation was performed with 200 mL of physiological saline.
After the blood returning operation, from the appearance, the number of residual blood hollow fibers and the state of the cut surface of the hollow fiber-fixed resin were visually observed.

[0028]

[Example 1] A regenerated cellulose hollow fiber membrane bundle for hemodialysis having an inner diameter of 180 µm was housed in a main body case, embedded and fixed in a case with a polyurethane resin, and then the polyurethane surface was cut with a knife to cut the cut surface. Both ends of the hollow fiber membrane were opened. Both sides of the cut surface were immersed in 10 mL of 15% urea methanol solution placed in a petri dish to impregnate the membrane part of the hollow fiber membrane with the urea methanol solution. After shaking the adhering solution by hand to drain it, UV lamp EUV200GS-
5 cm below the surface of 4 (Sen Special Light Source Co., Ltd.)
The above impregnated surface was fixed at a distance of, and irradiation was performed for 30 minutes. Then, the same irradiation treatment was performed on the other end. After that, a header for introducing blood and a header for extracting blood were attached to the main body case, residual solvents, free urea, etc. were washed away with clean running water, and distilled water for injection containing an antioxidant was filled, followed by sterilization with gamma rays. A hollow fiber membrane-type blood treatment device having an effective membrane area of 1.5 m ² was prepared by the treatment, and the residual blood property was evaluated.
The evaluation results are shown in Table 1. The ultraviolet irradiation intensity at the same distance as the irradiation surface was 7.6 mW / cm ² . In addition, as a result of measuring the inner diameter of the hollow fiber membrane opening on the cut surface of the polyurethane after the sterilization treatment, Dw / Dd was 1.05, and it was confirmed that the reduction of the inner diameter was suppressed.

[0029]

Example 2 Hollow fiber membrane inner diameter 200 μm, urea concentration 1
A cellulosic hollow fiber membrane blood treatment apparatus was prepared and the residual blood property was evaluated by the same method as in Example 1 except that the UV irradiation time was changed to 0% and the irradiation time with ultraviolet rays was changed to 15 minutes. Moreover, as a result of measuring the inner diameter of the hollow fiber membrane opening, Dw / Dd is 1.0
It was 2 and it was confirmed that the reduction of the inner diameter was suppressed. The evaluation results are shown in Table 1.

[0030]

Comparative Example 1 A blood treatment apparatus using a regenerated cellulose hollow fiber membrane bundle was assembled in the same manner as in Example 1 without the urea solution treatment and the irradiation immobilization treatment, and washed and sterilized under the same conditions as in Example 1. After processing, effective membrane area 1.5m ²
A blood processing apparatus for comparison was prepared. The evaluation results are shown in Table 1.
Shown in.

[0031]

[Comparative Example 2] A blood treatment apparatus using a cellulose hollow fiber membrane bundle was prepared under the same conditions as in Comparative Example 1 except that only the impregnation treatment with a urea solution was performed. The evaluation results are shown in Table 1.

[0032]

Example 3 A urea solution of each concentration was treated under the same conditions as in Example 1 except that 1, 5, 10 and 20% urea methanol solutions were used, followed by irradiation treatment. , Created a blood processing device. Table 2 shows the evaluation results of the residual blood property and the Dw / Dd of the hollow fiber membrane.

[0033]

Comparative Example 4 A blood processing apparatus was prepared under the same conditions as the method shown in Example 1 except that a 0.1% methanol solution of urea was used. Its residual blood property and Dw / Dd of hollow fiber membrane
The evaluation results of are shown in Table 2.

[0034]

[Table 1] ────────────────────────────────────   Blood treatment Hollow fiber membrane Residual blood hollow Observation result of cut surface   Material of the device Number of fiber membranes (both cut surfaces)                                 (Book) Dw / Dd ratio ──────────────────────────────────── Device of Example 1 Regeneration cell 6 Micro blood aggregation 1.05                   There are several loins ──────────────────────────────────── Device of Example 2 Regeneration cell 8 Micro blood aggregation 1.02                   There are several loins ──────────────────────────────────── Apparatus of Comparative Example 1 Regeneration cell Approximately 100 Blood clots are numerous 0.9                   There is loin ──────────────────────────────────── Apparatus of Comparative Example 2 Regeneration cell Approximately 100 Blood clots are numerous 0.92                   There is loin ──────────────────────────────────── Apparatus of Comparative Example 3 Regeneration cell Approximately 100 Blood clots are numerous 0.91                   There is loin ────────────────────────────────────

[0035]

[Table 2] ────────────────────────────────────   Urea solution Hollow fiber membrane Residual blood hollow Observation result of cut surface   Concentration material Number of fiber membranes (both cut surfaces)                                 (Book) Dw / Dd ratio ────────────────────────────────────   0.1% Regeneration cell About 80 Many blood clots 0.93 (Comparative Example 4) With loin ────────────────────────────────────     1% Regeneration cell 10 Micro blood aggregation 1.02 (Example 3) Loin There are several lumps ────────────────────────────────────     5% Regeneration cell 5 Micro blood coagulation 1.03 (Example 3) Loin There are several lumps ────────────────────────────────────   10% Regeneration cell 5 Micro blood aggregation 1.05 (Example 3) Loin There are several lumps ────────────────────────────────────   20% Regeneration cell 10 Micro blood coagulation 1.02 (Example 3) There are several loins ────────────────────────────────────

<Observation of Results of Each Example> From Table 1,
A blood treatment device that incorporates a hollow fiber membrane bundle that has been treated with a urea solution on the cut surface of the resin-embedded portion of the hollow fiber membrane to impregnate it with urea and then fixed by irradiation is a hollow fiber made of the same regenerated cellulose material. It can be understood that the residual blood characteristics are significantly improved even when the membrane is used, or when compared with a device that has undergone only urea treatment or a device that has only undergone irradiation treatment. From Table 2,
The blood treatment device incorporating the hollow fiber membrane bundle, which is obtained by treating the cut surface of the resin-embedded portion of the hollow fiber membrane with a urea solution having a concentration of 1 to 20% to impregnate urea, and then further performing irradiation fixing treatment, has the same regeneration. It can be understood that even with a hollow fiber membrane made of a cellulose material, the residual blood characteristics are significantly improved as compared with a device for treating a 0.1% concentration urea solution.

[0037]

As described above in detail, according to the present invention, the inner diameter of the hollow fiber membrane of the blood treatment apparatus comprising the cellulosic hollow fiber membrane is wetted by the wetting of the hollow fiber membrane at the cut surface of the blood introducing section and the blood introducing section of the hollow fiber membrane. Since the reduction can be suppressed, the blood flow resistance of the blood processing apparatus can be greatly improved.
Therefore, the hollow fiber membrane-based blood processing apparatus of the present invention suppresses activation during blood flow and reduces the amount of blood remaining in the blood processing apparatus after use, that is, the amount of residual blood. A blood processing apparatus having blood characteristics. Therefore,
INDUSTRIAL APPLICABILITY The present invention can provide a hollow fiber membrane-type blood treatment apparatus and a method for producing the same, which has less residual blood and can be suitably used for hemodialysis, hemofiltration, hemodiafiltration, and the like.

[Brief description of drawings]

FIG. 1 is an explanatory view of a cut surface of a conventional hollow fiber membrane for a blood processing apparatus and a resin for embedding and fixing the hollow fiber membrane in a dry state.

FIG. 2 is an explanatory view of a cut surface in a wet state of a conventional hollow fiber membrane for a blood processing apparatus and a resin for embedding and fixing the hollow fiber membrane.

FIG. 3 is an explanatory view of a cut surface of a hollow fiber membrane for a blood processing apparatus of the present invention and a resin for embedding and fixing the hollow fiber membrane in a wet state.

[Explanation of symbols]

1: Resin for embedding and fixing hollow fiber membranes 2: Resin embedding part of hollow fiber membrane 3: Non-resin embedded part of hollow fiber membrane 4: Cut surface of embedded fixing resin 5: Cut surface of the resin-embedded portion of the hollow fiber membrane

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Claims (8)

[Claims] 1. A cellulosic hollow fiber membrane bundle in which an end portion of a hollow fiber membrane bundle is embedded and fixed in a resin to form a resin-embedded portion, and at least one end portion of the resin-embedded portion is provided. The hollow fiber membrane is cut to open the hollow fiber membrane, the cut surface of the resin-embedded portion of the hollow fiber membrane is treated with an organic solvent solution of urea to be impregnated with urea, and irradiation treatment is performed. A hollow fiber membrane-type blood treatment device characterized by the above. 2. The hollow fiber membrane-type blood treatment apparatus according to claim 1, wherein the material of the cellulosic hollow fiber membrane bundle is regenerated cellulose. 3. The hollow fiber membrane-type blood treatment device according to claim 1, wherein the resin for embedding and fixing the hollow fiber is a polyurethane resin. 4. The hollow fiber membrane blood according to claim 1, wherein an inner diameter ratio of the opening of the hollow fiber membrane on the cut surface of the resin-embedded portion when the opening is dry and when the opening is wet is within the following range. Processing equipment. Dw / Dd = 1.0 to 1.1 Here, Dw is the inner diameter of the hollow fiber membrane in the water-wet state on the cut surface of the resin-embedded portion, and Dd is the hollow fiber membrane in the dry state before the water-wet state. Indicates the inner diameter of. 5. A cellulosic hollow fiber membrane bundle in which an end portion of a hollow fiber membrane bundle is embedded and fixed with a resin to form a resin embedding portion is built in, and at least one end portion of the resin embedding portion is provided. A hollow fiber which is cut to open the hollow fiber membrane, and the cut surface of the resin-embedded portion of the hollow fiber membrane is treated with an organic solvent solution of urea to impregnate urea and then subjected to irradiation treatment. Membrane-type blood processing apparatus manufacturing method. 6. The method for producing a hollow fiber membrane blood treatment apparatus according to claim 5, wherein the organic solvent solution of urea is a methanol solution. 7. The method for producing a hollow fiber membrane-based blood treatment device according to claim 5, wherein the urea solution has a concentration of 1 to 20% by weight. 8. The method for manufacturing a hollow fiber membrane-type blood treatment device according to claim 5, wherein the irradiation treatment is irradiation with ultraviolet rays.