JP2003245057A - Favorite food additive - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a favorite food additive which enables the simultaneous intake of the crude medicine action-having ingredients of a Salasia plant (Salasia reticulata, Salasia oblonga, or Salasia prinoides) on the eating or drinking of a daily favorite food and can reasonably prevent diabetes and obesity due to the excessive intake of carbohydrates. <P>SOLUTION: This favorite food additive is obtained by formulating the extract of the Salasia plant into powdery or milky milk or its substitute. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to improvement of powdered or milky milk added to coffee and tea, which are favorite products, or a substitute thereof. Contains a crude drug extract known to have an obesity effect, a diet effect, etc.,
The present invention relates to a luxury food additive improved so that the absorption of saccharides into the human body can be exhibited without impairing the original flavor.

[0002]

2. Description of the Related Art It is well known that some plants of the genus Salacia contain a component having an antidiabetic effect. This is, for example, a book in Sri Lanka called "SINHALES
E MATERIA MEDICA "(JOHN ATTYGALLE, LAKEHOUSE
BOOKSHOP published in 1917), it is believed that it was actually used as a crude drug in the field long before the publication of the book.

The present inventor has been conducting research for some time in order to scientifically elucidate the medicinal efficacy of modern herbal medicines, their active ingredients, their function and toxicity. As part of this research, the genus Salacia (Salasia reticulata; Salasia oblonga; Sal
asia oblonga, and Salacia purinoides; Salas
ia prinoides plants (Euaceae) actually have a diabetes-preventing action and an obesity-suppressing action. To find out that it is exerted by showing an inhibitory effect on α-glucosidase, which is a glycolytic enzyme that controls the transfer of glucose as an energy source into blood, and further to identify its active ingredient compound. It succeeded and obtained the patent No. 303008 first.

The plants of the genus Salacia are Indian,
Since it is abundantly grown in Sri Lanka, Thailand, Vietnam, southern China, etc., currently, wild species of these are being collected and processed and researched as crude drugs.Recently, research on their cultivation techniques is also advanced. Has been.

On the other hand, the eating habits in Japan have become richer than the Japanese people have ever experienced, and rapid technological innovation and changes in lifestyles have led to a lack of exercise by humans as represented by the car society. There is a tendency to promote more and more. In Japan, combined with such abundant eating habits and lack of exercise, the number of people with diabetes mellitus is now increasing to what is called the national illness, and various solutions are being taken by the national and local governments. The reality is that the effectiveness has not improved so much.

In addition to the above situation, one of the causes of increase in the number of people with diabetes mellitus in Japan is carbohydrate-based diet. That is, most of the staple foods in Japan are carbohydrates (grains such as rice), and since the carbohydrates are polysaccharides, a large amount of sugars are produced by digestion in the body and are absorbed in the body.

[0007] In addition, as another cause of the significant increase in the number of people with diabetes mellitus, it is added as a sweetener to favorite beverages typified by coffee and tea, or confectioneries typified by cakes and ice creams. The excess intake of sugar from the sugar used cannot be underestimated.

[0008]

SUMMARY OF THE INVENTION The present invention has been made by paying attention to the above circumstances, and its purpose is not only carbohydrate, which is the main body of eating habits, but also that it is almost indispensable for cultural life in modern times. It is possible to prevent diabetes and obesity caused by it from being absorbed daily by suppressing excessive absorption into the body of sugars that are ingested daily as sugar along with coffee and tea, which are popular items that can be said, and confectioneries. Another object of the present invention is to provide an additive for luxury products that can be effectively prevented by ingestion from various luxury products.

[0009]

[Means for Solving the Problems] The additive for luxury goods according to the present invention, which has been able to solve the above problems, is a genus Salacia (Salasia reticulat).
a, Salacia oblonga; Salasia oblonga, and Salacia prinoides; Eucalyptus family) plant extract is mixed with powdered or milky milk or its substitute.

In the present invention, the above plant extract is
In the powdered or milky milk or its substitute,
Preferably, it is contained in an amount of 0.05 to 5% by mass on a dry basis, and is added to coffee or tea that is used as a favorite beverage, or in fresh cream or whipped cake that is used as a dessert after eating. If added, by eating or drinking these during or after meals, α
-The above-mentioned extract which inhibits the action of glucosidase as a glycolytic enzyme can be naturally taken, and the action can be effectively utilized.

Therefore, as a preferred use form of the present invention, powdered milk or condensed milk to be added to favorite beverages such as coffee and tea that are commonly used as a favorite product, or condensed milk, or
Examples include a form in which the cream is added to fresh cream or whipped to be used for producing cakes and the like.

[0012]

Under the above-mentioned problems, the inventors of the present invention have an activity inhibiting action on α-glucosidase possessed by a component contained in a plant of the genus Salacia, and a diabetes preventive action and an obesity inhibiting action by the action. We have been studying from a variety of angles in order to efficiently and effectively demonstrate such things in a normal diet without feeling a sense of duty or compulsion.

As a result, as described above, powdered or milky milk or a substitute thereof is mixed with an appropriate amount of the extract of the plant having a herbal medicine activity, and this is used for daily use such as coffee and tea. If added to and taken
Based on the idea that the herbal medicine extract can be taken very naturally, the present invention has been made based on such an idea.

As described above, the plant extract which is the active ingredient of the additive according to the present invention is derived from a plant of the genus Salacia (Salasia reticulata; Salasia oblonga; Salasia oblonga and Salasia prinoides; It is known that the extract (hereinafter sometimes referred to as an extract), which has been extracted, has a diabetes suppressing action and an obesity suppressing action, and further has a diet promoting action.

The present invention basically enables the action of such an extract to be ingested extremely naturally in daily life without any drug sensation. The method of extracting valuable components from the plant or the plant is a method previously disclosed by the present inventors, for example, the above-mentioned Japanese Patent No. 3030008 (Japanese Patent Laid-Open No. 11-29472) and Japanese Patent Laid-Open No. 11-116496. The method disclosed in 1 above can be applied substantially as it is, or can be implemented with appropriate modifications if necessary.

[0016] By the way, obtaining a crude drug action by taking the above crude drug extract or decocting and drinking a dried product of a plant which is the source of the crude drug as health tea is not limited to the above publications and the like. There is.

However, since the mode of ingestion of these crude drug components does not give the feeling of ingestion as a drug, it gives the user a feeling of compulsion and obligation to take the drug, and in some cases neglects to take them regularly. I often forget. Therefore, it is desirable to allow natural and long-term continuous use of crude drugs whose effects are more effectively exerted by regular and long-term continuous administration in daily life habits. .

In order to meet such demands, the present invention mixes the above-mentioned herbal medicine components into milk or the like, and allows ingestion with coffee or tea with a taste sensation. As far as the applicant of the present invention knows, such a dosage form is adopted. Up to now, such an idea has not existed at all, and, of course, products that enable ingestion in such a form have not been offered. That is, in the present invention, as a means for allowing daily ingestion with a taste sensation, the maximum point is "to include a crude drug component extract in an additive for a luxury item" that no one has tried so far as a blind spot. It has the characteristics of

Therefore, there is no restriction on the kind of plant used as the source of the herbal medicine ingredient used in the present invention, the extraction method of the valuable ingredient, and the food to which the valuable ingredient is added has particular limitation. do not do.

However, in the present invention, in order to more effectively exert the action of the above-mentioned plant of the genus Salacia particularly in preventing diabetes and obesity, coffee or tea often consumed during or after meals is added. It is stipulated to be added to milk and cream (including powder and milk) which are general additives of, and their substitutes. It should be noted that cream and its substitutes, such as whipped, are widely used for frozen desserts such as cakes and ice cream, and cakes are often eaten and desserts after meals. A mode in which the crude drug extract is mixed with the above is also included.

The amount of the crude drug extract added to milk or the like is not particularly limited, but the dose for more effectively exhibiting its action as a crude drug is 25 to 50 mg per human dose, as will be made clear in the Examples below. The amount seems to be appropriate, and in order to secure such a dose, milk or the like should contain 0.05 to 5% by mass, more preferably 0.5 to 1% by mass of the crude drug extract on a dry basis. Recommended However, the added amount can be appropriately increased or decreased according to the degree of obesity of the recipient, and it is also effective to rank the content according to the required degree.

In any case, the additive for luxury products to which the herbal medicine extract of the present invention is added is taken by adding it to a favorite beverage such as coffee or tea which is used during meals or after meals, or cakes or the like. Since it is taken in the state of being contained in the cream, it is used as a source of excess energy as well as the sugar contained in these luxury products, as well as the decomposition of carbohydrates derived from carbohydrates such as rice and bread that are ingested as staple foods. The action of α-glucosidase that promotes glucose transfer into blood is inhibited, which effectively acts to prevent diabetes and the like, and also prevents obesity, or effectively promotes a diet for obese persons, who is also called a diabetic reserve army. To work.

[0023]

EXAMPLES The present invention will be described in more detail with reference to the following experimental examples. However, the present invention is not limited by the following experimental examples, and may be appropriately applied within the scope of the above and the following points. Modifications can be made, and all of them are included in the technical scope of the present invention.

Example Salacia reticulata of the genus Salacia (from Sri Lanka and India), Salacia oblonga (from India), Salacia purinoides (from Thailand and Vietnam,
(Produced in Guangdong, China) was collected, sufficiently dried locally, and purchased commercially, and 1 kg of each was roughly cut and used as a raw material.

In the extraction method, each crude cut product was added to 20 liters of water and extracted at 90 to 95 ° C. for 3 hours, and then the filtrate was concentrated under reduced pressure at 45 ° C. or lower to completely remove the solvent. The extract yield of the obtained concentrate is shown in Table 1 below. In addition, the concentrate was stored in a desiccator for one day and night, and then the α-glucosidase inhibitory activity was examined by the following method, and the results are also shown in Table 1.

[Method for measuring α-glucosidase inhibitory activity]
Accurately weigh 37 mM of sucrose and add 20 m of each of the above concentrates.
g and further add water so that the total amount becomes 1000 mL, and dissolve to make a sample solution. On the other hand, α-glycosidase (α-glucosidase for biochemistry manufactured by Wako Pure Chemical Industries, origin: Saccharomyses sp, activity; 120 units / mg) 10 mg
Is precisely weighed and dissolved in 100 mL of water to prepare an enzyme solution.

The sample solution and the enzyme solution obtained above were each added to 0.7
mM Weigh precisely and mix well, incubate at 37 ° C for 30 minutes, then add 0.8 mL of water, then 90-100 ° C
The mixture is heated for 2 minutes, and the IC ₅₀ value of each of the obtained reaction solutions is measured using a glucose measurement kit (in-vitro diagnostic drug “Glucose CII-Test Wako” manufactured by Wako Pure Chemical Industries, Ltd.).

[0028]

[Table 1]

As is clear from Table 1, the α-glucosidase inhibitory activity of the extract extracted from the plant of the genus Salacia in a yield of 5.6 to 8.0% by mass is 20.1 to 5%.
It can be confirmed that it falls within the range of 0.3 μg / ml.

Next, using each of the extracts obtained above, the inhibitory effect on the increase in blood glucose level due to sugar intake was examined by the following animal experiment.

That is, each of the above-obtained extracts was suspended in a 5% gum arabic solution in a male dd-y mouse (body weight: 28 to 30 g) after fasting for 20 to 24 hours, and 50 mg / kg to the mouse.
Oral administration is performed, and 30 minutes later, 1 g / kg of sucrose is orally administered. After a further 30 minutes, blood was collected from each mouse to obtain a blood glucose level, thereby quantitatively evaluating the inhibitory effect on the blood glucose increase. The results are shown in Table 2.

[0032]

[Table 2]

As is clear from Table 2, each of the extracts extracted from the plants of the genus Salacia has an action of suppressing an increase in blood glucose level due to ingestion of sucrose, that is, a sugar of α-glucosidase. It can be seen that it inhibits the action as a degrading enzyme. In particular, the extract having an IC ₅₀ value of 35 μg / ml or higher was 6% compared to the control group in the sucrose-loaded group.
The inhibition rate is 0% or more.

From these results, the extract from the plant of the genus Salacia has the function of obviously suppressing the increase in blood glucose level due to the decomposition of sugars in the body, and is effective in preventing diabetes.
Alternatively, it is considered that it can effectively act on suppression of obesity due to excessive intake of sugar.

Next, using the extract extracted from the root of "Salacia reticulata", which was confirmed to have the effect of suppressing the elevation of blood glucose level, the relationship between the dose and the inhibitory activity was examined. The experiment was 25 mg / kg, 50 m
The procedure was the same as that described above except that g / kg, 75 mg / kg and 100 mg / kg were used.

The results are shown in Table 3, and the extract extracted from the root of "Salacia reticulata" was added to 50
Oral administration of more than about mg / kg can suppress the increase in blood glucose level due to ingestion of sucrose by about 90% or more.
It can be seen that almost 100% inhibition is achieved by oral administration over a certain level.

[0037]

[Table 3]

Next, the dry extract powder extracted from the above-mentioned "Salacia reticulata (root)" was added to liquid milk so that the content ratio was 10% by mass, and sufficiently mixed and dispersed in a mortar to obtain an extract. A milk containing was produced. And 0.25 ml / kg (containing 5 mg / kg as Salacia reticulata extract) and 0.5 ml twice that
/ kg (10 mg / kg as Salacia reticulata extract
Was orally administered to mice in the same manner as described above, and the inhibitory effect on blood glucose level was examined. In all cases, 90% or more was obtained as the inhibition rate of blood glucose elevation.

That is, the above-mentioned dried extract has no adverse effect on the enzyme activity-inhibiting action of α-glucosidase even when added to milk and taken. The dose is usually determined by the dose based on the body weight, and since the average human body weight is 60 kg, it seems that the dose to human needs to be increased by about 60 times that in the case of mouse. However, in the case of usual new drug development tests, 100 mg /
If about kg is effective, the dose for humans is 100 mg once.
Therefore, the above extract having a dose of 25 to 50 mg / kg for suppressing the blood glucose level has a sufficient blood glucose level suppressing effect on humans at a dose of about 25 to 50 mg once. Is expected to be demonstrated.

Further, it has been confirmed that the amount of the extracted extract added to milk to the extent adopted in the above experiment does not adversely affect the flavor and appearance of coffee or tea.

[0041]

The present invention is configured as described above,
Since the extract extract of the Salacia plant which has been confirmed to have a diabetes preventive action and an obesity preventive action is contained in the additive for a luxury item, the effect in a normal diet along with the luxury item is effective. It is possible to take the ingredients as naturally as possible on a daily, regular, and long-term basis without difficulty and to take full advantage of the action of the herbal medicine ingredients.

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Claims (3)

[Claims] 1. A genus of Salacia (Salasia reticulata; Salicia oblonga; Sal
asia oblonga, and Salacia purinoides; Salas
ia prinoides (Euaceae) plant extract is mixed with powdered or milky milk or its substitute, which is an additive for luxury items. 2. The extract of the plant is added to the powdered or milky milk or its substitute on a dry basis of 0.0
The additive according to claim 1, which is contained in an amount of 5 to 5% by mass. 3. The additive according to claim 1, wherein the favorite product is a favorite beverage such as coffee or tea.