JP2003183146A - Skin care preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation for external use possessing an excellent skin inflammation-preventing effect and whitening effect. <P>SOLUTION: This skin care preparation for external use contains extracts obtained from Saint John's wort (Hypericum erectum Thunb.) and olive (Olea europaea Linne) foliage. The skin care preparation for external use further contains at least one or more than two kinds selected from the group consisting of glycyrrhizinic acid and its derivatives, glycyrrhetinic acid and its derivatives and allantoin. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin having an excellent effect of preventing skin inflammation and a whitening effect.

[0002]

2. Description of the Related Art Conventionally, agents having an anti-inflammatory effect such as calamine have been used to suppress skin inflammation due to sunburn, and whitening effects such as ascorbic acid and glutathione have been used to suppress pigmentation after sunburn. Drugs have been used as a component of topical skin preparations.

[0003]

However, external preparations for skin containing these agents have weak anti-inflammatory effects and whitening effects, and have not been sufficiently satisfactory.

[0004]

In view of the above-mentioned circumstances, the present inventors have conducted diligent research, and as a result, by combining an extract obtained from Hypericum perforatum and an extract obtained from the branches and leaves of olives, It was found that a skin external preparation having the above-mentioned problems solved and synergistically improved in the effect of suppressing skin inflammation due to sunburn and pigmentation after sunburn is obtained,
The present invention has been completed.

That is, claim 1 of the present invention is a skin external preparation characterized by containing an extract obtained from Hypericum perforatum and an extract obtained from the branches and leaves of olives.

Further, claim 2 of the present invention further comprises one or two selected from the group consisting of glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, and allantoin.
The external preparation for skin according to claim 1, which contains one or more kinds.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described in detail below.

"Hypericum perforatum" used in the present invention means
Hypericumaceae (Guttiferae), Hypericum (Hype
ricum) plant: Hypericum erectum Thu
nb.), Hypericum perforatum (Hypericum perforatum)
L.), Hypericum perforatum L.
var angustifoliom DC), and in the present invention,
The whole plant and / or flowers are used.

The term "olive" used in the present invention means a plant of the family Oleaceae or genus Olea: olive.
(Olea europaea Linne), and its branches and / or leaves are used in the present invention. Also other congeners,
For example, O.welwitschi
i), Olea paniculata, etc. can also be used.

The method for preparing the extract obtained from Hypericum perforatum used in the present invention and the extract obtained from the branches and leaves of olives are not particularly limited. For example, extraction is carried out at room temperature to under heating with various suitable solvents. To be done. Examples of the extraction solvent include water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol; lower alkyl esters such as ethyl acetate; benzene and hexane. Hydrocarbons; one or more ethers such as diethyl ether can be used,
Particularly, water, ethyl alcohol, glycerin, and a mixed solvent of one or more kinds of 1,3-butylene glycol are preferable. The extraction conditions are 1 to 1000 times the volume of the branches and leaves of Hypericum and olives, especially 5 to 10 times.
It is preferable to use 0 times the amount of the solvent, and to carry out at a temperature of 4 ° C. or higher, particularly 15 to 30 ° C., for 1 hour or longer, particularly 1 to 3 days.

The extract obtained from the branches and leaves of St. John's wort and olives obtained under the above conditions may be used as the extracted solution as it is, but if necessary, it may be subjected to treatment such as concentration and filtration. Can be used.

The amount of the extract obtained from Hypericum perforatum used in the present invention and the amount of the extract obtained from the branches and leaves of olives are 0.0001-converted to dry solids based on the total amount of the external preparation for skin. 10% by mass (hereinafter, simply "%"
Is preferable, and the range of 0.001 to 5% is particularly preferable. If the content is less than 0.0001%, the effect of the present invention may not be sufficiently exhibited, and if the content exceeds 10%, the effect may not be further increased.

In the present invention, by further containing one or more selected from the group consisting of glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, and allantoin, a more effective external preparation for skin is obtained. be able to.

Examples of glycyrrhizic acid and its derivative used in the present invention include glycyrrhizic acid, its salt, and its ester. Specific examples thereof include glycyrrhizic acid, dipotassium glycyrrhizinate, and monoammonium glycyrrhizinate. . The blending amount thereof is preferably 0.001 to 5%, and particularly preferably 0.01 to 1%, based on the total amount of the skin external preparation.

Examples of the glycyrrhetinic acid and its derivative used in the present invention include glycyrrhetinic acid, its salt, and its ester. Specific examples thereof include glycyrrhetinic acid and glycyrrhetinic acid stearate. The blending amount is 0.00 based on the total amount of the skin external preparation.
1 to 5% is preferable, and 0.01 to 1% is particularly preferable.

The amount of allantoin used in the present invention is 0.001 to 8% based on the total amount of the external preparation for skin.
Is preferable, and 0.1 to 5% is particularly preferable.

Further, the external preparation for skin of the present invention contains, in addition to the above-mentioned essential components, aqueous components, powders, surfactants, oils, moisturizers, which are used in ordinary external preparations for skin, as long as the effects of the present invention are not impaired. Agents, alcohols, pH adjusters, antiseptics, pigments, antioxidants, ultraviolet absorbers, thickeners, fragrances, cosmetic ingredients and the like can be appropriately added as necessary.

The external preparation for skin of the present invention can be produced according to a conventional method by mixing an extract obtained from Hypericum perforatum, which is an essential component, and an extract obtained from the branches and leaves of olives. In addition to emulsions, creams, lotions, beauty essences, cleansing, packs, foundations, detergents, etc., they can be prepared into pharmaceuticals such as dispersion liquids, ointments and granules, quasi-drugs or cosmetics.

[0019]

EXAMPLES The present invention will be described in more detail with reference to test examples and examples, but the present invention is not limited thereto.

An extract obtained from Hypericum perforatum,
The following extracts were used as the extracts obtained from the branches and leaves of olives. Hypericum perforatum extract: A product obtained by heating and extracting with 30 vol% ethyl alcohol, filtering and concentrating under reduced pressure, and leaving it in a cool place. Dry solid content: approx. 3% Olive leaf extract: Extracted by refluxing with 50 vol% ethyl alcohol, filtered, concentrated under reduced pressure and left in a cool place. Dry solid content about 2%

The test methods used for evaluation are as follows.

(1) Test Method for Anti-Inflammatory Effect A sample was applied to the back of a colored guinea pig and its effect on inflammation and pigmentation due to sunburn was examined.

[Test Method] Colored guinea pigs (10 for each group)
The back of each animal was shaved and irradiated with ultraviolet rays under anesthesia. UV irradiation is the FL20S / BLB lamp and FL20 manufactured by Toshiba
Three S / E30 lamps were simultaneously irradiated, and the amount of ultraviolet rays was 4.8 × 10 ⁻¹ J / cm ² . UV irradiation 24
Before the time, immediately after the irradiation, and 12 hours after the irradiation, and 24 hours after the irradiation, 0.2 mL of the sample was rubbed into each of four places on the back of the guinea pig. However, the application site was thoroughly washed with warm water before irradiation. The degree of inflammation was observed 24 hours after the irradiation, and after 7 days, the degree of pigmentation was observed and judged according to the following criteria.

[Criteria] Criteria for inflammation (anti-inflammatory effect) 0: No inflammation is observed 1: Very slight inflammation is observed 2: Inflammation is observed, but the boundary with the non-irradiated area is unclear 3: Inflammation was observed, and the boundary with the non-irradiated area was clear

Criteria for pigmentation (whitening effect) 0: No pigmentation is observed 1: Very slight pigmentation is observed 2: Pigmentation is observed

(2) Skin color lightness recovery test method Minimize UV rays in the UV-B region on the back skin of 20 subjects
Irradiate twice the amount of erythema and set the sample application area and non-application area
Then, the standard lightness (V₀Value, V₀’Value)
It was Subsequently, the sample was applied to the application site twice a day for 15 weeks.
After continuous application for 3,6,9,12,15 weeks
Lightness of skin (V and V) _nValue, V_n'value)
And evaluate the recovery of skin color according to the criteria in Table 1.
did. The brightness of the skin (V value of Munsell color system) is high
Calculated from the X, Y, Z values obtained by measuring with a light colorimeter
It was In addition, the evaluation was made for 20 subjects and the evaluation points after 6 weeks
The average value of

[0027]

[Table 1]

(3) Sensory test Twenty test subjects evaluated the characteristics of the sample after continuously using the sample for 10 days. The evaluation is shown by the number of respondents who answered "a whitening effect was felt" in the whitening effect questionnaire item.

Examples 1 to 5 and Comparative Examples 1 to 4 (Anti-inflammatory test) A lotion containing the Hypericum perforatum extract and the olive leaf extract was prepared according to the conventional method based on the composition shown in Table 2, and the above test ( 1) was carried out. The results are also shown in Table 2. The lotions of Examples 1 to 5 of the present invention showed good results in anti-inflammatory effect and whitening effect. On the other hand, the lotions of Comparative Examples 1 to 4 were inferior to the examples of the present invention, because no sufficient effect was observed.

[0030]

[Table 2]

Examples 6 to 9 and Comparative Examples 5 to 8 Skin creams containing Hypericum perforatum extract and olive leaf extract were prepared by a conventional method based on the compositions shown in Tables 3 and 4. The above tests (2) and (3) using these as samples
Was carried out. The results are also shown in Table 4.

[0032]

[Table 3]

[0033]

[Table 4]

The skin creams of Examples 6 to 9 of the present invention showed good results in the above tests. On the other hand, the skin creams of Comparative Examples 5 to 8 were inferior to those of the examples of the present invention because sufficient effects were not recognized.

Example 10 (skin lotion) A skin lotion having the following composition was prepared by a conventional method.
The fragrance used had the composition shown in Table 5.

[0036] Blending ingredients Blending amount (mass%) Ethanol 8.0 Polyoxyethylene sorbitan monolaurate (20EO) 0.4 Methylparaben 0.1 Fragrance 0.01 1,3-butylene glycol 3.0 Polyethylene glycol 1000 0.3 Hypericum extract 0.5 Olive leaf extract 0.5 Purified water 87.19

The skin lotion of this Example 10 showed good results in the above tests.

Example 11 (day essence) A day essence (daytime beauty essence) having the following composition was prepared by a conventional method. The fragrance used had the composition shown in Table 5.

[0039] Blending ingredients Blending amount (mass%) (A) component Stearic acid 0.5 Lipophilic type glyceryl monostearate 1.0 Methylphenyl polysiloxane 3.0 Parasol MCX * 5.0 Parasol 1789 ** 2.0 Liquid paraffin 2.0 Fragrance 0.05 (B) component N-stearoyl-L-glutamate sodium 0.5 Glycerin 5.0 Hypericum extract 0.3 Olive leaf extract 0.5 Allantoin 0.5 Xanthan gum 0.15 Titanium dioxide 5.0 Purified water 74.5 *, **: Made by Givaudan

The deessence of Example 11 showed good results in the above-mentioned tests.

[0041]

[Table 5]

It should be noted that, when the compositions of any of the Examples are used, the skin does not exhibit inflammation or other symptoms considered to be side effects, and it is clear that the external preparation for skin according to the present invention is excellent in safety. Met.

[0043]

EFFECTS OF THE INVENTION As described above, it is apparent that the present invention provides a skin external preparation having excellent skin inflammation prevention and whitening effects.

Front page continuation (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/00 A61K 7/00 W A61P 17/00 A61P 17/00 (72) Inventor Keito Takahashi Hisashi Odawara, Kanagawa Prefecture 5-3-28, Machi Kanebo Ltd., Institute of Basic Science (72) Inventor Ayumi Kusaka 5-3-28, Kotobukicho, Odawara-shi, Kanagawa F-Term, Kanebo Ltd., Institute of Basic Science (reference) 4C083 AA111 AA112 AB242 AC022 AC102 AC112 AC122 AC172 AC242 AC262 AC392 AC442 AC482 AC662 AC851 AC852 AD042 AD092 AD152 AD172 AD352 AD492 AD531 AD532 EE10 EE16

Claims (2)

[Claims] 1. An external preparation for skin, comprising an extract obtained from Hypericum perforatum and an extract obtained from the branches and leaves of olives. 2. Glycyrrhizic acid and its derivatives,
The external preparation for skin according to claim 1, which contains one or more selected from the group consisting of glycyrrhetinic acid and its derivatives and allantoin.