JP2003154006A - Powdery medicine dispensing device for nasal cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve a device for dispensing a powdery medicine into the nasal cavity. SOLUTION: A drawer type capsule inlet and outlet part 40 is provided to a capsule housing and holding part 30 and edge tools 60A and 60B for cutting both end parts in the axial direction of a capsule and boring the capsule are arranged to both sides holding the capsule draw-out part 40 of the capsule housing and holding part 30. A medicine collecting and capturing part 32 and a one-way valve 33 are provided to the lower part 38 of the capsule housing and holding part 30 and a pump part 50 having an air intake valve 54 is provided on an air inflow side. A medicine dispensing and spraying part 20 is provided on the air outflow side of the capsule housing and holding part 30 and a nozzle 22 is arranged thereto and the medicine in the capsule can be dispensed to the nasal cavity of a user by pressing the pump part 50.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a powdery drug administration device for the nasal cavity, which is suitable for administering a powdery drug into the nasal cavity.

[0002]

2. Description of the Related Art Generally, there is known a method of treating a patient having a disease such as rhinitis or nasal allergy by applying a powdered drug to the nasal cavity. In this treatment method, a powdery drug filled in a capsule is applied to the nasal cavity using a dedicated drug delivery device. As a drug delivery device used for this treatment method, a device shown in Japanese Patent Application Laid-Open No. 59-34267 (hereinafter referred to as a prior art) has been conventionally devised.

In this conventional apparatus, a pump portion is provided on the air inlet side of the cylindrical member, and a concave portion into which a capsule is inserted is formed on the air outlet side of the cylindrical member. A capsule housing portion is formed by fitting the tip end portion, and an air introduction passage having a valve mechanism is formed from the capsule housing portion toward the pump portion.

Further, another valve mechanism is provided on the other side of the pump portion, and by this valve mechanism and the valve mechanism in the air introducing passage, when the pump portion is pressed, it is passed through the air introducing passage to the capsule housing portion. Air is supplied, and when the pump unit returns, air is sucked into the pump unit from the outside.

Further, there is provided a cap which is fitted to the tip of the cylindrical member, a needle extending in the axial direction is provided inside the cap, and the tip of the cylindrical member having the concave portion and the opening is fitted. By inserting the caps in the combined state, holes are formed on both sides in the axial direction of the capsule.

According to the prior art thus constructed, first, a capsule filled with a powdered medicine is inserted into the concave portion of the cylindrical member to make a hole in the capsule, and then the tip portion is fitted to the capsule storage portion. Then, the cap is fitted to the tip made of a hard resin, and holes are formed in both ends in the axial direction of the capsule by the needles provided inside the cap guided by the tip.

Next, in order to administer the drug, the cap is removed from the cylindrical member, the user inserts the tip into one of the nasal cavities, and the pump is pressed to allow air from the pump to pass through the air introduction passage. The drug in the capsule is delivered to the nasal cavity of the user to administer the drug, and the drug is applied to both nasal cavities by repeating the operation of insertion into both nasal cavities and thereafter.

[0008]

In the above-mentioned prior art device, the capsule is first inserted into the cylindrical member, then the removable tip portion is fitted to the cylindrical member, and then the removable cap is attached to the cylindrical member. However, there is a problem that the drug preparation operation is complicated and the user forgets to perform the operation. Further, when the tip or the cap is lost, there is a problem that the drug cannot be used as a drug administration device. .

Next, the powdered medicine from the capsule passes through the valve mechanism in the air introducing passage and falls from the pump portion due to the operation in the process from the drilling to the medicine applying operation. There is a problem that the amount of medicine is reduced, the user cannot administer a necessary amount of medicine, and it is necessary to clean the medicine dropped in the pump unit.

Furthermore, when applying the drug, the user inserts the tip into the nasal cavity of the user to administer the drug, but since the tip is made of a hard resin, there is a risk of damaging the nasal cavity during insertion into the nasal cavity. In addition, since it does not conform to the shape of the nasal cavity because it does not follow the shape of the user's nasal cavity, there is a problem that the administration to the nasal cavity is hindered and efficient administration cannot be performed.

[0011]

In order to solve the above-mentioned problems, the present invention according to claim 1 provides a capsule housing holding part for housing and holding a capsule filled with a powdered medicine, and a capsule housing holding part. In order to supply air for medication to the capsule, the capsule portion is connected to the capsule housing holding portion, and the air is supplied from the pump portion through the air flow passage provided in the capsule housing holding portion. In order to deliver and administer the drug in the capsule of the accommodating / holding part to the nasal cavity of the user, the drug drug spraying part provided in the capsule accommodating / holding part and having the tip branched into one or two; In order to make holes on both sides of the capsule in the axial direction, the capsule storage part is provided in the capsule housing and holding part so that it can move laterally with respect to the axial direction of the capsule. Provided transversely to the axial direction of the capsule holding part, in that a structure with a cutting tool for drilling in the axial direction on both sides of the capsule.

According to the second aspect of the present invention, the powdered drug falling and flowing back from the capsule after making holes in the air flow passage is trapped and collected, and is prevented from flowing back to the pump portion. A drug capturing and collecting unit having an air flow passage shape capable of delivering the powdered drug by the action of the pump unit,
It is configured by providing a one-way valve whose opening pressure is regulated by a spring.

According to the third aspect of the present invention, when the user administers the powdered medicine to the nasal cavity, the nozzle of the medicine-medication spraying section is flexible so as to be inserted and administrated following the nasal cavity of the user. It consists of a flexible tube.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION According to the invention of a powdered medicine dispensing device according to claim 1 provided by the present invention, the powdery medicine dispensing device is provided in the capsule housing and holding part in a pull-out manner so as to move laterally with respect to the axial direction of the capsule. By placing the capsule in the capsule loading / unloading section and putting the capsule loading / unloading section into the capsule housing / holding section, a blade provided laterally to the capsule housing / holding section in the axial direction of the capsule creates holes on both sides in the axial direction of the capsule. Open

Further, at the time of drug administration, air is supplied from the pump part, and this air flows into the capsule having holes and the drug in the capsule is passed through the drug passage of the drug drug spraying part from the nozzle to the nasal cavity of the user. Delivered to and administered to.

According to the second aspect of the present invention, the one-way valve whose valve opening pressure is regulated by the spring is provided in the air flow passage between the capsule accommodating and holding portion and the pump portion. It is possible to prevent a drug that falls from the capsule to the pump portion when the hole is punched and collects and collects a drug that flows backward, and to drop the drug to the pump portion and backflow.

Further, at the time of drug administration, the one-way valve is opened and captured by the pressure and inflow of air from the pump unit, and the collected drug is taken together with the drug in the capsule from the nozzle via the capsule holding unit and the drug spraying unit. It will be delivered and administered to the user's nasal cavity.

According to the third aspect of the invention, when the user administers the drug to the nasal cavity, the nozzle of the drug application spraying section is inserted into the nasal cavity. Since the nozzle is made of a flexible tube, the user's It can be inserted following the nasal cavity.

[0019]

Embodiments of the present invention will be described below with reference to FIGS.

FIG. 1 is a side view of the powdery drug delivery device for nasal cavity according to this embodiment, and FIG. 2 is a sectional view of the side view of the powdery drug delivery device for nasal cavity according to this embodiment. The powdery drug administration device 10 for the nasal cavity includes the capsule K together with the drug application sprayer 20.
Capsule storage / holding section 30 for storing and holding capsules, and capsule loading / unloading section 4 provided in the capsule storage / holding section 30 in a retractable manner.
0, and a pump unit 5 which is provided on the air inflow side of the capsule storing and holding unit 30 and supplies air toward the capsule K.
0, and the capsule loading / unloading section 4 of the capsule storage / holding section 30.
It is roughly composed of blades 60A and 60B which are located on both sides of the capsule K in the axial direction of 0 and are used for making holes on both sides of the capsule K in the axial direction by the inserting / extracting operation of the capsule inserting / extracting portion 40.

In the medicine applying / spraying section 20, the capsule accommodating / holding section 30 is axially above the capsule K (air outflow side).
Is provided with a drug passage 21, and a tip end of the drug passage 21 is made of a flexible tube having nozzles 22A and 2A.
2B is formed.

In the air flow passage 31 on the axially lower side (air inflow side) of the capsule K of the capsule accommodating / holding portion 30, the powder drug falling and flowing back from the capsule K is captured and collected. Similarly to the part 32, the one-way valve 3 for preventing the powdered drug from the capsule K from falling and flowing back to the pump part 50.
3 is provided so that the one-way valve 33 is opened by the spring 34 when the air pressure from the pump unit 50 becomes equal to or higher than the specified pressure, and when the air pressure of the pump unit 50 is lower than the specified pressure. The air circulation inlet 35 is closed to prevent backflow of air.

The capsule loading / unloading section 40 has a capsule loading / unloading recess 41 at a position where the capsule K is loaded / unloaded, and can be loaded / unloaded into / from the capsule accommodating / holding section 30 laterally with respect to the axial direction of the capsule K. The capsule loading / unloading portion 40 is provided on the convex portion 37 provided on the capsule housing / holding portion 30.
The open end of the drawer is regulated by the contact of the draw-out end 44 of the.

When the capsule loading / unloading portion 40 is loaded into the capsule housing / holding portion 30, the loading / unloading portion convex portion 45 of the capsule loading / unloading portion 40 causes the contact surface 36 of the capsule housing / holding portion 30.
The insertion end is regulated by abutting against.

The pump portion 50 is formed of a material having rubber elasticity into a bottomed cylindrical shape having a mounting portion 51, a bottom portion 52 and a pressing portion 53 on the peripheral surface. An air intake valve 54 is attached to the central portion of the bottom portion 52, which is airtightly attached to the cylindrical outer peripheral surface of the lower portion 38 of the holding portion.

The air intake valve 54 is made of a material having rubber elasticity and is composed of an air intake hole 55 and an intake valve body 56. When the pump portion 50 is pressed, the air intake valve 54 is closed and the pump portion 50 is pressed. When is returned after being pressed, the valve is opened and air is supplied to the pump unit 50 from the outside.

Powdery drug administration device 1 for nasal cavity according to the present embodiment
0 is configured as described above, and next, the operation at the time of punching the capsule will be described based on FIGS. 3 to 5.

First, as shown in FIG. 3, the capsule K is placed in the capsule attaching / detaching recess 41 of the capsule loading / unloading section 40, and the capsule loading / unloading section end face 46 of the capsule loading / unloading section 40 is pushed so that the capsule loading / unloading section 40 is held in the capsule housing / holding section. Try to get into 30.

Then, as shown in FIG. 4, the capsule inlet / outlet portion 4
As the capsules K, which are placed in the capsule attachment / detachment recess 41 of 0, enter the capsule housing / holding portion 30, the capsule housing / holding portions 30 are positioned on both sides in the axial direction of the capsule K in the lateral direction with respect to the axial direction of the capsule K. Provided with a cutting tool 60
A and 60B cut both axial end portions KA and KB of the capsule K, whereby holes are formed on both axial sides of the capsule K.

Further, by pushing the end surface 46 of the capsule inlet / outlet portion 40 of the capsule inlet / outlet portion 40 and bringing the inlet / outlet portion convex portion 45 into contact with the contact surface 36 of the capsule accommodating / holding portion 30, holes are already formed on both sides in the axial direction. The capsule K communicates with the medicine passage 21 of the medicine medicine spraying section 20 and the air flow passage 31 of the capsule housing / holding section 30, and preparation for medicine preparation is possible.

At this time, as shown in FIG. 5, the drug in the capsule K having holes on both sides in the axial direction drops toward the air flow passage 31, but the one-way valve 33 is closed, The drug capturing / collecting unit 32 captures and collects the drug.

As described above, according to the present embodiment, at the time of drilling the powdery drug administration device 10 for nasal cavity, only the operation of storing the capsule K in the powdery drug administration device 10 for nasal cavity is performed on both sides in the axial direction of the capsule K. A hole can be easily drilled, and the one-way valve 33 and the drug capturing / collecting unit 32 can reliably capture the drug that drops and flows backward after the hole is drilled.

Next, the operation at the time of drug delivery to the user after punching the capsule K will be described with reference to FIG.

First, the nozzle 22 of the medicine applying spraying section 20.
By inserting A and 22B into the nasal cavity of the user and pressing the pressing part 53 of the pump part 50 in the P direction shown by the arrow as shown in FIG. 6, the pressure of the air loaded on the one-way valve 33 increases, When the prescribed pressure is reached, the one-way valve 33 is opened, and air is supplied from the pump unit 50 toward the capsule K through the one-way valve 33, the drug capturing / collecting unit 32 and the air flow passage 31.

As a result, the air from the pump section 50 flows from the inside of the capsule K into the medicine passage 21 and the nozzles 22A, 22.
It flows into the nasal cavity of the user via B.

At this time, the drug in the capsule K is agitated by the air flowing in the capsule K and is delivered and administered to the nasal cavity of the user together with the air.

Further, at the time of drilling, the drug capturing / collecting unit 32 is captured and collected by the drug capturing / collecting unit 32 and the air flow passage 31.
The drug present in is delivered by the air from the pump unit 50 and is delivered and administered to the user's nasal cavity together with the drug in the capsule K. As a result, it is possible to reliably deliver and administer the prescribed amount of the drug filled in the capsule K to the nasal cavity of the user.

Immediately before the pressing of the pump portion 50 is finished, if the pressure of the air loaded on the one-way valve 33 becomes weaker and becomes lower than the specified pressure at which the one-way valve 33 opens, the one-way valve 33 is opened. Although the valve is closed, the air is flowing from the pump unit 50 toward the capsule K until just before the one-way valve 33 is closed. As a result, the drug in the capsule K, the air flow passage 31, and the drug capturing / collecting unit 32 can be reliably prevented from falling or backflowing into the pump unit 50 without dropping or backflowing.

Further, when the pressing of the pump section 50 is completed and the pressing is released, the pressing section 5 of the pump section 50 having rubber elasticity is provided.
3 returns in the direction of the arrow R to generate a negative pressure in the pump portion 50, whereby the intake valve body 56 of the air intake valve 54 is opened by the pressure of the external air, and the air is introduced from the outside via the air intake hole 55. When air flows into the pump unit 50, the pump unit 50
The pressing portion of is returned to the original state as shown by the chain double-dashed line.

Powdery drug delivery device 1 for nasal cavity according to the present embodiment
In No. 0, the capsule K is placed in the capsule attaching / detaching recess 41 of the capsule loading / unloading section 40, and as the capsule loading / unloading section 40 is loaded into the capsule housing / holding section 30, the capsule housing / holding section 30 moves laterally with respect to the axial direction of the capsule K. Blades 60A, 6 provided on both sides of the capsule K in the axial direction.
OB cuts both end portions KA, KB of the capsule K in the axial direction, whereby holes are formed in both sides of the capsule K in the axial direction. That is, the capsule K is applied to the nasal powder drug administration device 1
Capsule K with very few movements of accommodating 0
It can accommodate and drill holes. Moreover, unlike the prior art, there is no risk of losing the cap for drilling and the tip part which are separate from each other, and without failing to forget the drilling operation and failing to administer the drug, surely make a hole in the capsule K to prepare for drug administration. You can

Further, in the capsule accommodating / holding section 30, a drug capturing / collecting section 32 for capturing and collecting the powdery drug falling from the capsule K in the air flow passage 31 and flowing back, and the powdery powder from the capsule K as well. A one-way valve 33 is provided to prevent the drug from falling into the pump unit 50 and backflowing. This one-way valve 3
No. 3 opens when the air pressure from the pump unit 50 becomes equal to or higher than the specified pressure, and when the air pressure from the pump unit 50 is lower than the specified pressure, the air circulation inlet 35 is closed by the spring 34, It is designed to prevent the backflow of medicines and drugs. Therefore, when the drug is trapped and collected by the drug capturing / collecting unit 32 at the time of punching and the drug in the drug capturing / collecting unit 32 and the air flow passage 31 is pressed by the pump unit 50, the air pressure in the pump unit 50 is equal to the specified pressure. As described above, the one-way valve 33 opens to allow the drug in the capsule K to be delivered and administered to the nasal cavity of the user. As in the prior art, it is possible to solve the problem that the required amount of the drug cannot be dispensed by dropping the drug from the capsule after punching into the pump part and the problem that the pump part needs to be cleaned. It is possible to reliably deliver and administer the prescribed amount of the drug filled inside into the nasal cavity of the user.

Further, in the medicine applying / spraying section 20, a medicine passage 21 is provided, and nozzles 22A and 22B made of flexible tubes are formed at the tip of the medicine passage 21 so as to follow the user's nasal cavity during medicine application. Can be inserted and medication can be administered. As a result, as in the prior art, inserting the tip made of a hard resin into the nasal cavity may damage the user's nasal cavity, or because it does not conform to the shape of the user's nasal cavity, drug delivery to the nasal cavity is hindered and efficiency is reduced. It is possible to safely and efficiently administer a drug that conforms to the shape of the nasal cavity of the user without stopping the effective drug administration.

FIG. 7 is a sectional view of a powdery drug delivery device for nasal cavity according to another embodiment of the present invention (reference numerals in the figure indicate
It has the same meaning as in the previous example). In the present embodiment, in the medicine spraying section 20, the nozzle 22 made of a flexible tube at the tip of the medicine passage 21 is different from the above-mentioned embodiments in that it is composed of one nozzle. Only, the operation at the time of making a hole in the capsule K and the operation at the time of applying a medicine to the user after making the hole are exactly the same as in the previous embodiment.

[0044]

As described above, according to the first aspect of the invention, the capsule is placed in the capsule attaching / detaching recess of the capsule loading / unloading section, and the capsule loading / unloading section is inserted into the capsule housing / holding section.
Cutting tools that are provided on the capsule accommodating / holding section laterally with respect to the axial direction of the capsule on both sides in the axial direction of the capsule cut the both axial end portions of the capsule to form holes on both axial sides of the capsule. You can open After that, air is supplied from the pump unit to the capsule of the capsule housing and holding unit, and the drug in the capsule is applied to the nasal cavity of the user through the nozzle from the drug passage of the drug spray unit together with the air. The capsule can be punched only by the operation of storing it in the powdery drug delivery device for nasal cavity.
According to the present invention, it is possible to omit the puncturing operation that is easy to forget, and to pierce the capsule reliably with extremely few operations without fear of losing a separate object such as the cap or the tip portion provided with the piercing needle.

According to the second aspect of the present invention, between the capsule accommodating / holding portion and the pump portion, the medicine that falls from the capsule after perforation and flows back is trapped and collected so as not to drop into the pump. Due to the provision of a one-way valve that regulates the valve opening pressure by an air flow passage with a passage shape that allows the collected drug to be dispensed together with the drug in the capsule by the operation of the pump unit, the drug trapping unit, and a spring. The drug that has fallen or flows backward during drilling is delivered to the nasal cavity of the user together with the drug in the capsule through the capsule holding part and the drug drug spraying part by the air from the pump part when the drug is applied, and the drug is filled into the capsule. The specified amount of drug can be reliably delivered and administered to the user's nasal cavity. Further, since the medicine does not drop into the pump portion at all, cleaning of the pump portion can be omitted.

Further, according to the invention of claim 3, since the nozzle of the drug spraying portion is formed of a flexible tube,
When the user inserts the nozzle into the nasal cavity at the time of drug administration, the nozzle can be easily inserted following the shape of the nasal cavity of the user, and the drug can be safely and efficiently administered in conformity with the nasal cavity of the user.

[Brief description of drawings]

FIG. 1 is a side view showing an embodiment of the present invention.

FIG. 2 is a sectional view showing an embodiment of the present invention.

FIG. 3 is a view showing a state where a capsule is put in and out and a capsule is placed.

FIG. 4 is a cross-sectional view showing a state in which the blade is cutting the end of the capsule while the capsule loading / unloading part with the capsule placed therein is being inserted into the capsule housing / holding part.

FIG. 5 is a cross-sectional view showing a state in which the end of the capsule is cut by a cutting tool, the perforation is completed, and the drug in the capsule drops toward the pump unit and flows backward.

FIG. 6 is a cross-sectional view showing a state in which the drug in the capsule is delivered and administered by pressing the pump unit.

FIG. 7 is a cross-sectional view showing another embodiment of the present invention.

[Explanation of symbols]

10 ... Powdery drug delivery device for nasal cavity 20 ... Medication spraying section 21 ... Drug passage 22, 22A, 22B ... Nozzle 30: Capsule accommodating and holding section 31 ... Air flow passage 32 ... Drug capture and collection unit 33 ... One-way valve 34 ... Spring 35 ... Air circulation inlet 36 ... Contact surface 37 ... convex part 38 ... Lower part of the capsule housing / holding unit 40 ... Capsule entrance / exit 41 ... Recess for detaching capsule 42A, 42B ... Capsule end discharge part 44 ... Draw-out end 45 ... Inlet / outlet convex portion 46 ... Capsule entry / exit end face 50 ... Pump section 51 ... Mounting part 52 ... bottom 53 ... Pressing part 54 ... Air intake valve 55 ... Air intake hole 56 ... Intake valve body 60A, 60B ... Cutting tool K ... Capsules KA, KB ... End of capsule

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) B67B 7/92 A61J 1/08 A

Claims (4)

[Claims] 1. A capsule accommodating / holding section for accommodating and holding a capsule filled with a powdered medicine, and a pump provided in connection with the capsule accommodating / holding section for supplying air for medication to the capsule accommodating / holding section. Section and the air supplied from the pump section through the air flow passage provided in the capsule housing and holding section to deliver and administer the drug in the capsule of the capsule housing and holding section to the nasal cavity of the user. And a drug spraying section provided at the end of the capsule with one or two branches diverging, and a capsule accommodating and holding section in the axial direction of the capsule for opening and closing the capsule and making holes on both sides in the axial direction of the capsule. The capsule loading / unloading part is provided so that the capsule can be moved laterally, and the capsule housing / holding part is provided laterally with respect to the axial direction of the capsule. Powdery drug administration device for nasal cavity, which is provided with a blade for making a hole in the nasal cavity. 2. The air medicine is trapped in the air flow passage so as not to flow back to the pump portion by trapping and collecting the powdered medicine which has fallen from the capsule after being punched and flows backward. The drug delivery device according to claim 1, further comprising: a drug capturing / collecting part having an air flow passage shape capable of delivering a drug by the action of the part, and a one-way valve in which a valve opening pressure is regulated by a spring. 3. When the user administers a powdered drug to the nasal cavity, the nozzle of the drug application spraying part is composed of a flexible tube so that it can be inserted and dispensed following the nasal cavity of the user. The drug administration device according to claim 1, wherein 4. The drug application device according to claim 1, wherein the drug application spray unit is a drug application spray unit provided with a tip branched into two.