1286944 玖、發明說明 * (發明說明應敘明：發明所屬之技術領域、先前技術、內容、實施方式及圖式簡單說明） (一） [發明所屬之技術領域] 本發明爲有關於鼻腔用粉末藥劑施藥裝置，係適於將粉 狀藥劑施藥於鼻腔內者。 (二） [先前技術] 一般帶有鼻炎或鼻過敏性等疾病的患者，將粉狀藥劑施 藥於鼻腔的治療方法爲眾所周知。此種治療方法係使用專 用之施藥裝置，充塡在膠囊內的粉狀藥劑施藥於鼻腔。作 爲使用於此治療方法的施藥裝置，從先前就硏究出有揭示 在日本國特開昭5 9 - 3 4 2 6 7號公報（以下，稱先前技術）者。 於此先前技術的裝置，係設泵部於圓筒構件之空氣流入 側’此圓筒構件之空氣流出側形成用來插入膠囊的凹形狀 部’並由於嵌合前端部在此凹形狀部來形成膠囊收容部， 從該膠囊收容部向泵部，形成持有閥機構的空氣導入通路。 又’該泵部之另〜側設置有另一個閥機構，由該閥機構 及空氣導入通路內之閥機構，於按壓泵部時藉由空氣導入 通路供應空氣於膠囊收容部，在泵部之復原時形成從外部 進空氣於泵部內。 再者’具有嵌合於該圓筒構件前端部的帽蓋，在該帽蓋 之內側設延伸軸方向的針，並以嵌合該圓筒構件之凹形狀 部及具開□部的前端部狀態嵌上帽蓋，形成實行開孔於膠 囊軸方向兩側的構成。 如此所構成的先前技術，首先對於膠囊之開孔係將充塡 1286944 Μ 分狀藥劑的膠囊插入圓筒構件之凹形狀部後，嵌合前端部 插裝膠囊在膠囊收谷部，並由於嵌入帽蓋於硬樹脂做成的 前端部，由設於帽蓋之內側其前端部所導引的針，用來開 孔膠囊之軸方向兩側。 其次谷人投與樂齊u，係從圓筒構件取下帽蓋由使用者將 前端部插入一側之鼻腔，由於按壓泵部從泵部之空氣就藉 由空氣導入通路流入膠囊內，送達膠囊內之藥劑於使用者 之鼻腔施藥，又由於反覆進行插入兩鼻腔以下之動作實行 向兩鼻腔的施藥。 依上所述先則技術的裝置，係首先插入膠囊在圓筒構件 後嵌合硓夠裝卸的前端部於圓筒構件，其次裝置能夠裝卸 的盍在圓商構件來實G，但該等之施藥準備動作煩雜， 亦有發生使用者忘記動作的問題，再於遺失前端部或帽蓋 時，有不硓作爲施藥裝置使用的問題。 其次，從開孔後至施藥動作過程之動作，從膠囊發生粉 狀藥通過該空氣導入通路內之閥機構自泵部落下，在此狀 況膠囊內之藥劑變少、，變成不能施藥使用者所需要量的藥 y 同有必要貫行淸掃落下在泵部內的劑之問題。 再者，施藥時係使用者將前端部插入使用者之鼻腔來實 fr施藥，但由於前端部係以硬樹脂做成，於插入鼻腔之際 有傷到鼻腔之慮，而且由於不能仿照使用者之鼻腔形狀而 不適口拜腔形狀，故妨礙了對鼻腔的施藥，有不能實行有 效率的施藥之問題。 本發明係爲解決如此的問題點者。 1286944 (三）[發明內容] 爲了解決如上所述課題之請求範圍第1項記載之本發明 ，係構成爲具備：膠囊收容保持部，用於收容保持充塡有 粉狀藥劑的膠囊；泵部，爲了供應施藥用之空氣於膠囊收 容保持部，連接設置在膠囊收容保持部；藥劑施藥噴霧部 ，從泵部藉由設在膠囊收容保持部的空氣流通路所供應空 氣，用來送達、施藥膠囊收容保持部之膠囊內藥劑於使用 者之鼻腔，設在膠囊收容保持部設置前端分岐爲1個或2 個；膠囊出入部，爲了在膠囊之出入及膠囊之軸方向兩側 開孔，對膠囊之軸方向以能夠移動於橫方向在膠囊收容保 持部設成抽出式；及刀刃具，爲了在膠囊之軸方向兩側開 孔，於膠囊收容保持部對膠囊之軸方向設在橫方向。 又本發明請求範圍第2項之記載，係構成爲設置：藥劑 捕捉捕集部，具有用來捕捉、捕集在該空氣流動路開孔後 自膠囊落下、逆流來的粉狀藥劑，爲了不逆流於泵部、及 由泵部之作動具有能施藥所捕捉、捕集的粉狀藥劑之空氣 流通路形狀；及由彈簧規定開閥壓力設置單向閥。 又於本發明請求範圍第3項之記載係使用者欲施藥粉狀 藥劑於鼻腔時，仿照使用者之鼻腔爲了插入、施藥該藥劑 施藥噴霧部之噴嘴，以持有可撓性的管構成者。 依本發明提供的請求範圍第1項之粉狀藥劑施藥裝置， 更具體言之，係放置膠囊於膠囊收容保持部對膠囊之軸方 向以如移動於橫方向，設成抽出式的膠囊出入部，而由收 容該膠囊出入部在膠囊收容保持部的動作，於膠囊收容保 1286944 Λ ， 持部對膠囊之軸方向設在橫方向的刀刃具，對膠囊之軸方 向兩側開孔。 _ 又，於施藥時，從泵部供應空氣，該空氣就流入已開有 孔的膠囊，將膠囊內之藥劑藉由藥劑施藥噴霧部之藥劑通 路，從噴嘴送達、施藥於使用者之鼻腔。 . 再者，依具體的請求範圍第2項之發明，由於在膠囊收 容保持部及泵部之間的空氣流通路，由藥劑捕捉捕集部及 彈簧設置規定開閥壓力的單向閥，在膠囊之開孔時加以捕 捉、捕集從膠囊落下、逆流在泵部的藥劑，得以防止落下 ® 、逆流於泵部。 又，施藥時，由自泵部之空氣壓力及流入開閥單向閥， 將捕捉、捕集的藥劑同時與膠囊內之藥劑藉由膠囊收容保 持部或藥劑噴霧部，形成從噴嘴送達、施藥於使用者之鼻 腔。 再於更具體的請求範圍第3項記載之發明，係使用者欲 施藥於鼻腔時，雖將藥劑施藥噴霧部之噴嘴插入鼻腔，但 $ 該噴嘴係由具可撓性管作成，故能沿著使用者之鼻腔插入 者。 (四）[實施方式] 以下，按照圖面的實施例說明本發明。 按照第1圖至第7圖說明本發明之一實施例。 . 第1圖係對本發明之鼻腔用粉狀藥劑施藥裝置，表示按 ^ 照其一實施例的側視圖，第2圖係本實施例所示鼻腔用粉 狀藥劑施藥裝置側視圖之剖面圖。 1286944 圖中，鼻腔用粉狀藥劑施藥裝置1 〇，大略由與藥劑施藥 噴霧部2 0 —起收容保持膠囊Κ的膠囊收容保持部3 0 ;以 抽出式設在膠囊收容保持部3 0的膠囊出入部40 ;設位於 膠囊收容保持部3 0之空氣流入側向膠囊Κ供應空氣的泵 部5 0 ;及位於該膠囊收容保持部3 0膠囊出入部4 0之膠囊 Κ軸方向兩側，由膠囊出入部4 0之出入動作用來開孔於膠 囊Κ軸方向兩側的刀刃具6 0 A、6 0 Β所構成。 在此狀況，於藥劑施藥噴霧部2 0、膠囊收容保持部3 0 之膠囊K軸方向上側（空氣流出側）設有藥劑通路2 1，藥劑 通路2 1之前端部形成以由可撓性之管作成的噴嘴2 2 A及 22B。 膠囊收容保持部3 〇之膠囊K軸方向下側（空氣流入側） 之空氣流通路31，設置用來捕捉、捕集自膠囊K落下、逆 流來的粉狀藥劑之藥劑捕捉捕集部3 2 ;及伺樣設置用來防 止自膠囊K之粉狀藥劑落下、逆流於泵部5 0的單向閥3 3 ，該單向閥33形成爲由彈簧34，當來自泵部50之空氣壓 力成規定壓力以上時開關；又泵部5 0之空氣壓力低於規定 壓力時則閉住空氣流通入口 3 5來防止空氣之逆流。 膠囊出入部40在裝卸膠囊K的位置持有膠囊裝卸用凹 部4 1，形成爲向膠囊收容保持部3 0對膠囊K之軸方向以 抽出式能出入於橫方向，並由於膠囊出入部4 0之引出端部 44頂接設在膠囊收容保持部3 0的凸部3 7，形成予以限制 抽出開端的構成。 又，放進膠囊出入部4 0於膠囊收容保持部3 0時，係膠 -10- 1286944 l 囊出入部4 0之出入部凸部4 5的頂接膠囊收容保持部3 Ο 之頂接面3 6，就予以限制放進端。 泵部5 0，由橡膠彈性材料形成爲安裝部5 1、底部5 2及 周面成爲按壓部5 3的有底圓筒狀，安裝部5 1係氣密地裝 設在膠囊收容保持部3 0之膠囊收容保持部下剖3 8的圓筒 狀外周面，在底部5 2之中央部安裝有空氣取入閥5 4。 空氣取入閥5 4係以橡膠彈性材料形成，由空氣取入孔 5 5及取入閥體5 6所構成，於按壓泵部5 0時閉閥，泵部5 0 在按壓後復原時開閥從外部供應空氣於泵部5 0。 依本實施例的鼻腔用粉狀藥劑施藥裝置1 〇，係構成爲如 上所述者。 其次按照第3圖至第5圖，說明膠囊開孔時之動作。 首先如第3圖所示，放置膠囊Κ於膠囊出入部40之膠 囊裝卸用凹部4 1，按壓膠囊出入部4 0之膠囊出入部端面 4 6，使膠囊出入部4 0進入膠囊收容保持部3 0。 然後如第4圖，隨著放置在膠囊出入部40之膠囊裝卸用 凹部4 1的膠囊Κ，進入膠囊收容保持部3 0，就由於膠囊 收容保持部3 0對膠囊Κ之軸方向，以橫方向位置在膠囊Κ 軸方向兩側所說的刀刃具6 0 A、6 Ο Β，切斷膠囊Κ之軸方 向兩側端部KA、KB，在膠囊K之軸方向兩側開孔。 再者，按壓膠囊出入部40之膠囊出入部端面46，而由 於出入部凸部4 5的頂接於膠囊收容保持部3 0之頂接面3 6 ，已經在軸方向兩側開有孔的膠囊K，係與藥劑施藥噴霧 部2 0之藥劑通路2 1及膠囊收容保持部3 0之空氣流通路 -11- 1 1286944 31連通，完成施藥之準備。 此時如第5圖，在軸方向兩側已開孔的膠囊K內之藥劑 ，雖會向空氣流通路3 1落下，但由於關閉單向閥3 3，以 藥劑捕捉捕集部3 2捕捉、捕集藥劑。 如此依本實施例，於開孔鼻腔用粉狀藥劑施藥裝置時， 僅以收容膠囊K在鼻腔用粉狀藥劑施藥裝置1 0的動作， 容易地在膠囊K軸方向兩側開孔，同時確實地能捕捉由單 向閥3 3及藥劑捕捉捕集部3 2在開孔後落下、逆流的藥劑。 其次，按照第6圖說明實行膠囊K的開孔後施藥於使用 者的施藥時之作動。 首先，插入藥劑施藥噴霧部20之噴嘴22A、22B於使用 者之鼻腔，如第6圖所示，由於以箭頭示P方向按壓泵部 5 〇之按壓部，在單向閥3 3所負載的空氣壓力增高，達到 規定之壓力時開啓單向閥3 3，從泵部5 0通過單向閥3 3、 藥劑捕捉捕集部3 2及空氣流通路3 1向膠囊K供應空氣。 並由此，從泵部5 0之空氣係自膠囊K內藉由藥劑通路 2 1及噴嘴2 2 A、2 2 B流入使用者鼻腔。 此時，由流動在膠囊K內的空氣，攪拌膠囊K之藥劑與 空氣一起送達、施藥於使用者之鼻腔。 再者，在開孔時，於藥劑捕捉捕集部3 2所捕捉、捕集， 在藥劑捕捉捕集部3 2及空氣流通路3 1的藥劑，係從泵部 50之空氣送出，與膠囊K內之藥劑一起送達、施藥於使用 者之鼻腔。結果，充塡在膠囊K內的規定量之藥劑能確實 地送達、施藥於使用者之鼻腔。 -12- 1286944 羹 又，將要結束按壓泵部5 0之前，負載於單向閥3 3的空 氣壓力變弱而變成低於單向閥3 3開閥的規定壓力時，單向 閥3 3會閉閥，但至將要閉閥單向閥3 3之前從泵部5 0向膠 囊Κ流動有空氣。並由此膠囊Κ內或空氣流通路3 1及藥 劑捕捉捕集部3 2之藥劑，不會向泵部5 0落下、逆流能確 實地防止藥劑之落下、逆流於泵部5 0。 再者，結束泵部5 0之按壓而解除按壓時，橡膠彈性的泵 部5 0之按壓部5 3回到箭頭示R方向，由於在泵部5 0內 產生負壓使空氣取入閥54之取入閥體56，由外部之空氣 壓力開啓藉由空氣取入孔5 5自外部流入空氣於泵部5 0內 ，將泵部5 0之按壓部以二點鏈線所示恢復至原來狀態。 於依本實施例的鼻腔用粉狀藥劑施藥裝置1 〇，係放置膠 囊Κ在膠囊出入部40之膠囊裝卸用凹部41，隨著放進膠 囊出入部4 0於膠囊收容保持部3 0，於膠囊收容保持部3 0 對膠囊Κ之軸方向於橫方向位於膠囊Κ軸方向兩側所設刀 刃具60Α、60Β，由於切斷膠囊Κ軸方向兩側端部ΚΑ、ΚΒ 在膠囊Κ之軸方向兩側開孔。亦即，將膠囊Κ僅以收容在 鼻腔用粉狀藥劑施藥裝置1 0之動作，就能以極少的動作收 容膠囊Κ及開孔。而且不會有遺失如先前技術成爲另外的 開孔用帽蓋或前端部之慮，又對施藥並不會忘記了開孔動 作而失敗，能確實地開孔膠囊Κ來準備施藥。 又在膠囊收容保持部3 0於空氣流通路3 1設置有：捕捉 、捕集從膠囊Κ落下、逆流來的粉狀藥劑之藥劑捕捉捕集 部3 2 ;及同樣予以防止從膠囊Κ向粉狀藥劑之泵部5 0落 -13- 1286944 下、逆流的單向閥3 3。該單向閥3 3係自泵部5 0之空氣壓 力成規定壓力以上時開閥，又自泵部5 0之空氣壓力低於規 定壓力時，由彈簧3 4閉住空氣流通入口 3 5，作成爲確實 地防止或藥劑之逆流。因而，開孔時捕捉、捕集於藥劑捕 捉捕集部3 2在藥劑捕捉捕集部3 2及空氣流通路3 1的藥劑 ’由按壓泵部50使泵部50內之空氣壓力高至規定壓力以 上’單向閥3 0於開閥同時與膠囊κ內之藥劑能送達、施 藥於使用者之鼻腔。所以能解消如先前技術從開孔後的膨 囊落下藥劑於泵部，使其變成不能施藥必要量之藥劑問題 · 、或亦能解消需要實行淸掃泵部之問題，故充塡在膠囊Κ 內的規定量之藥劑能確實地送達、施藥於使用者之鼻腔。 再者，於藥劑施藥噴霧部2 0，設置藥劑通路2 1，藥劑通 路2 1前端部係形成由可撓性管做成的噴嘴2 2 A、2 2 Β，於 施藥時能仿照使用者之鼻腔插入、施藥。此結果，並不會 如先前技術以硬樹脂作成的前端部插入鼻腔而有傷到使用 者鼻腔之慮，或由於不適合使用者之鼻腔形狀而妨礙了對 鼻腔的施藥變成不能有效率的施藥，能安全地且有效率的 ® 施藥於適合使用者之鼻腔形狀。 又，第7圖係依本發明之其他一實施例表示鼻腔用粉狀 藥劑施藥裝置之剖面圖（圖中之符號係具有與前實施例同 樣之意義）。於本實施例係在藥劑噴霧部2 0，藥劑通路2 1 之前端部以由可撓性管做成的噴嘴2 2，與上所述實施例不 同僅以1條噴嘴構成的點不同，膠囊K開孔時之作動，以 及實行開孔後施藥於使用者的施藥時之作動係與前實施例 -14- 1286944 完全相同。 [產業上之利用可能性] 如以上本發明請求範圍第1項記載之發明，由於放置膠 囊在膠囊出入部之膠囊裝卸用凹部，隨著放進膠囊出入部 於膠囊收容保持部，於膠囊收容保持部對膠囊之軸方向在 橫方向位於膠囊軸方向兩側所設刀刃具，切斷膠囊之軸方 向兩側端部，能在膠囊之軸方向兩側開孔。作成此後從泵 部供應空氣於膠囊收容保持部之膠囊，將膠囊內之藥劑同 時與空氣從施藥噴霧部之藥劑通路藉由噴嘴施藥於使用者 鼻腔的構成，所以僅收容膠囊在鼻腔用粉狀藥劑施藥裝置 的動作，就能對膠囊實行至開孔。依本發明，省略容易忘 記的開孔動作，無遺失設置開孔針的帽蓋或前端部等，另 外物件之慮，以極少的動作確實地能對膠囊實行開孔。 又，請求範圍第2項記載之發明，係於膠囊收容保持部 及泵部之間，由於爲了捕捉、捕集開孔後從膠囊落下、逆 流來的藥劑，使其不落下於泵部內，及能將所捕捉、捕集 的藥劑由泵部之作動與膠囊內之藥劑一起施藥，具有通路 形狀的空氣流通路或藥劑捕捉捕集部及彈簧，設置規定開 閥壓力的單向閥，將開孔時落下、逆流的藥劑在施藥時由 來自泵部之空氣，藉由膠囊收容保持部、藥劑施藥噴霧部 與膠囊內之藥劑一起送達、施藥於使用者之鼻腔，將充塡 在膠囊內的規定量之藥劑能確實地送達、施藥於使用者之 鼻腔。再於藥劑完全不落下於泵部，故能省去淸掃泵部。 再者，請求範圍第3項記載之發明，係將藥劑施藥噴霧 -15- 1286944 部之噴嘴形成爲持有可撓性管，所以施藥時使用者插入噴 嘴於鼻腔之際，仿照使用者之鼻腔形狀能合適地插入，安 全地且以適合使用者之鼻腔形狀能有效率的施藥。 (五）[圖式簡單說明] 第1圖係表示本發明粉狀藥劑施藥裝置之一實施例側面 圖。 第2圖係表示本發明粉狀藥劑施藥裝置之一實施例剖面 圖。 第3圖係於第2圖，表示軸出膠囊出入部放置膠囊狀態 圖。 第4圖係於第2圖，將放置膠囊的膠囊出入部放進膠囊 收容保持部中途狀態，表示刀刃具將要切斷膠囊端部狀態 剖面圖。 第5圖係於第2圖，表示由刀刃具切斷膠囊端部，完成 開孔而膠囊內之藥劑落下、逆流於泵部方向狀態剖面圖。 第6圖係由於按壓泵部表示送達、施藥膠囊內之藥劑狀 態剖面圖。 第7圖係表示本發明粉狀藥劑施藥裝置之其他實施例剖 面圖。 [主要部分之代表符號說明] 10 鼻腔用粉狀藥劑施藥裝置 20 藥劑施藥噴霧部 2 1 藥劑通路 22、22A、22B 噴嘴 1286944 3 0 膠 囊 收 容 保 持 部 3 1 空 氣 流 通 路 32 藥 劑 捕 捉 捕 集 部 3 3 單 向 閥 34 彈 簧 3 5 空 氣 流 通 入 □ 3 6 頂 接 面 3 7 凸 部 3 8 膠 囊 收 容 保 持 部下部 40 膠 囊 出 入 部 4 1 膠 囊 裝 卸 用 凹 部 42 A、 42B 膠 囊 切 端 排 出 部 44 引 出 端 部 45 出 入 部 凸 部 46 膠 囊 出 入 部 端 面 5 0 泵 部 5 1 安 裝 部 52 底 部 5 3 按 壓 部 54 空 氣 取 入 閥 5 5 空 氣 取 入 孔 5 6 取 入 閥 體 60A、 60B 刀 刃 具 K 膠 囊 KA、 KB 膠 囊 端 部1286944 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明The pharmaceutical application device is suitable for applying a powdered medicament to the nasal cavity. (2) [Prior Art] A treatment method in which a powdered medicament is administered to the nasal cavity is generally known in patients with diseases such as rhinitis or nasal allergies. In this treatment, a special administration device is used, and the powdered medicament filled in the capsule is applied to the nasal cavity. As a dispensing device using this method of treatment, it has been disclosed in the Japanese Patent Publication No. 5 9 - 3 4 2 6 7 (hereinafter referred to as the prior art). In the prior art device, the pump portion is formed on the air inflow side of the cylindrical member. The air outflow side of the cylindrical member forms a concave shaped portion for inserting the capsule and the fitting front end portion is in the concave shape portion. A capsule accommodating portion is formed, and an air introduction path that holds the valve mechanism is formed from the capsule accommodating portion to the pump portion. Further, another valve mechanism is provided on the other side of the pump unit, and the valve mechanism and the valve mechanism in the air introduction passage supply air to the capsule accommodating portion through the air introduction passage when the pump portion is pressed, and the pump portion When returning, air is introduced from the outside into the pump unit. Further, 'there is a cap fitted to the front end portion of the cylindrical member, and a needle extending in the axial direction is provided inside the cap, and the concave portion of the cylindrical member and the front end portion having the opening portion are fitted The cap is fitted in a state to form a configuration in which the opening is formed on both sides in the direction of the capsule axis. In the prior art configured as described above, first, a capsule filled with 1,286,944 Μ split-shaped medicine is inserted into a concave-shaped portion of a cylindrical member for the opening of the capsule, and the fitting distal end portion is inserted into the capsule receiving portion, and is embedded by the capsule. The cap is formed on the front end portion of the hard resin, and the needle is guided by the front end portion provided on the inner side of the cap to open the axial direction of the capsule. Next, the Gu Ren casts the Le Qi u, and removes the cap from the cylindrical member. The user inserts the front end into the nasal cavity on one side, and the air from the pump portion is pushed into the capsule through the air introduction passage. The medicament in the capsule is applied to the nasal cavity of the user, and the application to the two nasal cavities is carried out by repeatedly inserting the action below the two nasal cavities. According to the above-mentioned prior art device, the first end of the capsule is inserted into the cylindrical member and the front end portion of the cylindrical member is fitted and detached, and the second device is detachable from the round member, but the The application preparation operation is troublesome, and there is a problem that the user forgets to move the operation, and when the front end portion or the cap is lost, there is a problem that it is used as a medicine application device. Next, from the operation after the opening of the hole to the action of the application operation, the valve body from the capsule passes through the valve mechanism in the air introduction passage from the pumping tribe, and in this case, the amount of the medicine in the capsule becomes small, and the application becomes impossible. The amount of medicine required by the person y is also necessary to circumvent the problem of the agent falling in the pump. Furthermore, when applying the medicine, the user inserts the front end into the nasal cavity of the user to apply the fr, but since the front end portion is made of hard resin, the nasal cavity is injured when the nasal cavity is inserted, and since the nasal cavity cannot be imitated The shape of the nasal cavity of the user is not suitable for the shape of the cavity, so that the application of the nasal cavity is hindered, and the problem of efficient administration cannot be performed. The present invention is directed to solving such problems. In the first aspect of the invention, the present invention provides a capsule storage holding unit for accommodating a capsule filled with a powdery drug, and a pump unit. In order to supply the medicinal air to the capsule accommodating and holding portion, the capsule accommodating and holding portion is connected to the medicinal application spraying portion, and the air is supplied from the pump portion through the air flow path provided in the capsule accommodating portion for delivery. The capsule in the capsule holding and holding portion is placed in the nasal cavity of the user, and the front end of the capsule receiving and holding portion is provided with one or two branches; the capsule entrance and exit portion is opened on both sides of the capsule in the axial direction of the capsule. The hole is provided in a pull-out type in the axial direction of the capsule so as to be movable in the lateral direction, and the blade holder is provided in the axial direction of the capsule in order to open the hole in the axial direction of the capsule. Horizontal direction. Further, in the second aspect of the present invention, it is provided that the medicine capturing and collecting unit has a powder medicine for capturing and trapping the pores of the air flow path and then falling back from the capsule, in order to prevent The shape of the air flow path of the powdered medicine that can be captured and collected by the application of the pump is reversed by the pump unit, and the check valve is provided with a check valve. Further, in the third item of the scope of the present invention, when the user wants to apply the powdered medicament to the nasal cavity, the user's nasal cavity is modeled to insert and apply the nozzle of the pharmaceutical application spray portion to hold the flexible portion. Pipe builder. According to the powdery medicament application device of the first aspect of the present invention, in particular, the capsule is placed in the capsule housing and holding portion in the axial direction of the capsule, such as moving in the lateral direction, and is provided as a withdrawal type capsule. In the capsule accommodating portion, the capsule accommodating portion is placed in the capsule accommodating portion, and the holder is placed in the horizontal direction of the capsule in the axial direction of the capsule, and the hole is opened on both sides in the axial direction of the capsule. _ Further, at the time of application, air is supplied from the pump unit, and the air flows into the capsule having the hole, and the medicine in the capsule is delivered from the nozzle and applied to the user through the drug passage of the medicine application spray unit. Nasal cavity. Further, according to the invention of the second aspect of the invention, in the air flow path between the capsule accommodating portion and the pump portion, the check valve and the spring are provided with a check valve having a predetermined valve opening pressure. When the capsule is opened, it captures and traps the medicine that falls from the capsule and flows back in the pump to prevent falling and backflow to the pump. In addition, at the time of application, the trapped and trapped drug is simultaneously supplied to the drug in the capsule from the capsule storage holding portion or the drug spray portion by the air pressure from the pump portion and the inflow valve check valve. Apply to the nasal cavity of the user. Further, in the invention described in the third aspect of the present invention, when the user wants to apply the medicine to the nasal cavity, the nozzle of the pharmaceutical application spray portion is inserted into the nasal cavity, but the nozzle is made of a flexible tube. Can be inserted along the user's nasal cavity. (4) [Embodiment] Hereinafter, the present invention will be described in accordance with an embodiment of the drawings. An embodiment of the present invention will be described in accordance with Figs. 1 through 7. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a side view of a powdery medicament application device for nasal cavity according to the present invention, and Fig. 2 is a side view of a side view of a powder medicament application device for nasal cavity of the present embodiment. Figure. 1286944 In the figure, the nasal powder application device 1 is used to receive and hold the capsule holding and holding unit 30 together with the medicine application spraying unit 20; and to provide the capsule housing and holding unit 3 in a withdrawable manner. a capsule inlet portion 40; a pump portion 50 that supplies air to the capsule enthalpy in the air inflow side of the capsule accommodating portion 30; and a capsule portion of the capsule accommodating portion 40 of the capsule accommodating portion 30 The opening and exiting operation of the capsule access portion 40 is used to open the cutting edges 6 0 A and 60 0 两侧 on both sides of the capsule axis. In this case, the drug supply path 2 is provided on the upper side (air outflow side) in the K-axis direction of the capsule application holding portion 30 and the capsule storage holding portion 30, and the front end portion of the drug passage 2 1 is formed to be flexible. The nozzles 2 2 A and 22B are made of tubes. The air flow path 31 of the lower side (air inflow side) of the capsule in the K-axis direction of the capsule storage holding portion 3 is provided with a medicine capturing and collecting unit for capturing and collecting the powdered medicine dropped from the capsule K and flowing backward. And a check valve 3 3 for preventing the powdery agent from the capsule K from falling down and flowing back to the pump portion 50, the check valve 33 being formed by the spring 34 when the air pressure from the pump portion 50 is When the pressure is higher than the predetermined pressure, when the air pressure of the pump unit 50 is lower than the predetermined pressure, the air flow inlet 35 is closed to prevent the air from flowing backward. The capsule accessing portion 40 is provided with the capsule attaching and detaching recessed portion 4 1 at the position where the capsule K is attached or detached, so that the capsule accommodating portion 30 can be inserted into the lateral direction in the axial direction of the capsule K in the axial direction, and the capsule accessing portion 40 The lead end portion 44 is connected to the convex portion 37 of the capsule housing holding portion 30 to form a configuration for restricting the extraction end. Further, when the capsule accessing portion 40 is placed in the capsule accommodating portion 30, the accommodating portion of the capsule accommodating portion 3 Ο of the accommodating portion of the accommodating portion 40 of the capsule accommodating portion 40 is attached. 3 6, it is restricted to the end. The pump portion 50 is formed of a rubber elastic material as a mounting portion 5 1 , a bottom portion 5 2 , and a bottomed cylindrical shape in which the circumferential surface is the pressing portion 5 3 , and the mounting portion 51 is airtightly attached to the capsule housing and holding portion 3 . The capsule of the 0 is accommodated in the cylindrical outer peripheral surface of the lower portion 38, and the air intake valve 504 is attached to the central portion of the bottom portion 52. The air intake valve 54 is formed of a rubber elastic material, and is composed of an air intake hole 55 and a valve body 56. When the pump unit 50 is pressed, the valve is closed, and the pump unit 50 is opened when pressed. The valve supplies air from the outside to the pump portion 50. The nasal medicament application device 1 for nasal cavity according to the present embodiment is constructed as described above. Next, the action of the capsule opening will be described in accordance with Figs. 3 to 5. First, as shown in Fig. 3, the capsule loading/unloading recessed portion 41 is placed in the capsule inlet and outlet portion 40, and the capsule inlet and outlet portion end surface 4, 6 is pressed, and the capsule inlet and outlet portion 40 enters the capsule housing and holding portion 3. 0. Then, as shown in Fig. 4, the capsule accommodating portion 30 is placed in the capsule accommodating portion 30 of the capsule accommodating portion 40, and the capsule accommodating portion 30 is oriented in the axial direction of the capsule ridge. The direction of the blade is 6 0 A, 6 Ο 所说 on both sides in the direction of the axis of the capsule, and the ends KA and KB on both sides in the axial direction of the capsule are cut, and holes are formed on both sides in the axial direction of the capsule K. Further, the capsule access portion end surface 46 of the capsule access portion 40 is pressed, and the entrance and exit convex portion 45 is attached to the top surface 36 of the capsule housing holding portion 30, and holes are formed on both sides in the axial direction. The capsule K is in communication with the drug passage 2 1 of the drug application spray unit 20 and the air flow path -11-1 1286944 31 of the capsule storage holding unit 30 to complete preparation for administration. At this time, as shown in Fig. 5, the medicine in the capsule K which has been opened on both sides in the axial direction falls into the air flow path 31, but the check valve 3 is closed, and the medicine catching and collecting unit 3 2 is caught. Collecting medicines. According to the present embodiment, in the case of the powder medicine application device for the open-mouth nasal cavity, only the action of the capsule-like powder application device 10 for the nasal cavity is used, and the holes are easily opened in the K-axis direction of the capsule. At the same time, it is possible to surely capture the medicine which is dropped by the check valve 3 3 and the medicine catching and collecting portion 32 after the opening and backflow. Next, according to Fig. 6, the operation of applying the capsule K after the opening of the capsule is applied to the user's application. First, the nozzles 22A and 22B of the drug application spray unit 20 are inserted into the nasal cavity of the user. As shown in Fig. 6, the pressing portion of the pump unit 5 is pressed in the direction of the arrow P, and the check valve 3 is loaded. When the air pressure is increased, the check valve 3 is opened when the predetermined pressure is reached, and the air is supplied from the pump unit 50 to the capsule K through the check valve 3 3, the medicine catching and collecting unit 3 2 and the air flow path 3 1 . Thereby, the air from the pump unit 50 flows into the user's nasal cavity from the capsule K through the drug passage 2 1 and the nozzles 2 2 A and 2 2 B. At this time, the agent that agitates the capsule K is delivered together with the air flowing in the capsule K and applied to the nasal cavity of the user. Further, at the time of opening the hole, the medicine catching and collecting unit 32 captures and collects the medicine, and the medicine in the medicine catching and collecting unit 32 and the air flow path 31 is sent out from the air of the pump unit 50, and the capsule The agent in K is delivered together and applied to the nasal cavity of the user. As a result, a predetermined amount of the drug filled in the capsule K can be surely delivered and applied to the nasal cavity of the user. -12- 1286944 In addition, the check valve 3 3 will be closed when the air pressure applied to the check valve 3 3 becomes weaker and becomes lower than the predetermined pressure at which the check valve 3 3 opens before the pump unit 50 is pressed. The valve is closed, but air is supplied from the pump portion 50 to the capsule 之前 before the valve check valve 3 is to be closed. Further, the medicine in the capsule or the air flow path 31 and the medicine catching and collecting unit 32 does not fall into the pump unit 50, and the backflow can surely prevent the medicine from falling and flowing back to the pump unit 50. When the pressing of the pump unit 50 is completed and the pressing is released, the pressing portion 53 of the rubber-elastic pump portion 50 returns to the direction of the arrow R, and the air is taken into the valve 54 by the negative pressure generated in the pump portion 50. The valve body 56 is taken in, and the external air pressure is opened, and air is introduced into the pump unit 50 from the outside through the air intake hole 5 5 , and the pressing portion of the pump unit 50 is restored to the original position by the two-dot chain line. status. In the nasal powder application device 1 of the present embodiment, the capsule accommodating recess 41 is placed in the capsule accommodating portion 40, and is placed in the capsule accommodating portion 30 in the capsule accommodating portion 40. In the capsule accommodating and holding portion 30, the knives are placed 60 Α and 60 两侧 on both sides of the capsule Κ axis direction in the axial direction of the capsule Β, and the ends of the capsule Κ, ΚΒ are in the axis of the capsule Open holes on both sides of the direction. In other words, the capsule can be accommodated in the nasal powder application device 10, and the capsule and the opening can be accommodated with little movement. Moreover, there is no loss of the prior art as a separate cap or front end opening, and the application does not forget the opening operation and fails, and the capsule can be surely opened for preparation. Further, in the capsule storage holding portion 30, the air flow path 3 1 is provided with a medicine capturing and collecting unit 3 2 that captures and collects the powdered medicine that falls from the capsule and flows back; and also prevents the powder from being smashed from the capsule to the powder. The pump portion of the medicament is 10 0 - 13 - 1286944, and the check valve 3 3 is countercurrent. The check valve 33 opens when the air pressure of the pump unit 50 is equal to or higher than a predetermined pressure, and when the air pressure from the pump unit 50 is lower than a predetermined pressure, the air flow inlet 35 is closed by the spring 34. It is done to prevent or counteract the pharmacy. Therefore, the medicine "trapped in the medicine catching and collecting unit 32 and the air flow path 31 in the medicine catching and collecting unit 32 at the time of opening the air pressure in the pump unit 50 by the pressing pump unit 50 is as high as the predetermined Above the pressure, the check valve 30 can be delivered to the nasal cavity of the user while the valve is opened. Therefore, it can solve the problem that the prior art drops the medicine from the sac of the opening hole to the pump part, so that it becomes a medicine that cannot be applied a necessary amount, or can solve the problem that the pump part needs to be performed, so it is filled in the capsule. The prescribed amount of the drug in the 能 can be reliably delivered and applied to the nasal cavity of the user. Further, in the medicine application spraying unit 20, the medicine passage 2 is provided, and the nozzles 2 2 A and 2 2 做成 made of a flexible tube are formed at the distal end portion of the medicine passage 2 1 , and can be used as they are at the time of application. The nasal cavity is inserted and applied. As a result, the front end portion made of a hard resin is not inserted into the nasal cavity as in the prior art, which may cause injury to the user's nasal cavity, or the application to the nasal cavity of the user may hinder the application of the nasal cavity to become inefficient. The drug can be applied safely and efficiently to the shape of the nose suitable for the user. Further, Fig. 7 is a cross-sectional view showing a powder application device for nasal cavity according to another embodiment of the present invention (the symbols in the drawings have the same meaning as in the previous embodiment). In the present embodiment, in the drug spraying unit 20, the nozzle 2 made of a flexible tube at the end of the drug passage 2 1 is different from the above-described embodiment, and the capsule is formed by only one nozzle. The actuation of the K opening and the actuation of the application after the opening is applied to the user are identical to the previous embodiment-14-1286944. [Industrial Applicability] According to the invention of the first aspect of the present invention, the capsule loading and unloading recessed portion of the capsule insertion portion is placed in the capsule receiving and holding portion in the capsule receiving and holding portion. The holding portion is provided with a blade provided on both sides in the axial direction of the capsule in the axial direction of the capsule, and cuts both end portions in the axial direction of the capsule, and can be opened at both sides in the axial direction of the capsule. After that, the capsule is supplied from the pump portion to the capsule storage holding portion, and the medicine in the capsule is simultaneously applied to the nasal cavity of the user by the nozzle from the drug passage of the application spray portion. Therefore, only the capsule is contained in the nasal cavity. The action of the powdered drug application device allows the capsule to be opened to the opening. According to the present invention, the opening operation which is easy to forget can be omitted, and the cap or the front end portion of the opening needle can be provided without any loss, and the capsule can be surely opened with a small amount of movement. Further, the invention according to the second aspect of the present invention is provided between the capsule storage holding portion and the pump portion, and the medicine that has been dropped from the capsule and is returned to the inside of the pump is not trapped in the pump portion, and The trapped and trapped drug can be applied by the pump unit together with the drug in the capsule, and has a passage-shaped air flow path, a drug trapping and collecting portion, and a spring, and a check valve that defines a valve opening pressure is provided. When the medicine is dropped, the medicine that falls and flows back is applied by the air from the pump portion at the time of application, and is supplied to the nasal cavity of the user by the capsule storage holding portion and the medicine application spray portion together with the medicine in the capsule, and is filled with the medicine. A predetermined amount of the drug in the capsule can be reliably delivered to the nasal cavity of the user. Further, the medicine does not fall to the pump portion at all, so that the pump portion can be omitted. Further, in the invention described in the third aspect of the invention, the nozzle of the pharmaceutical application spray -15-1286944 is formed to hold the flexible tube, so that when the user inserts the nozzle into the nasal cavity during the application, the user is modeled The shape of the nasal cavity can be properly inserted, and can be applied safely and in a shape suitable for the nasal cavity of the user. (5) [Simplified description of the drawings] Fig. 1 is a side view showing an embodiment of the powdery drug application device of the present invention. Fig. 2 is a cross-sectional view showing an embodiment of the powdery drug application device of the present invention. Fig. 3 is a view showing a state in which the capsule is placed in the capsule inlet and outlet portion in Fig. 2; Fig. 4 is a cross-sectional view showing the state in which the capsule end portion of the capsule is placed in the middle of the capsule accommodating portion in the state in which the capsule insertion portion of the capsule is placed in the second embodiment. Fig. 5 is a cross-sectional view showing the state in which the end of the capsule is cut by the blade and the medicine in the capsule is dropped and reversed in the direction of the pump portion. Fig. 6 is a cross-sectional view showing the state of the drug in the delivery and administration capsules by pressing the pump portion. Fig. 7 is a cross-sectional view showing another embodiment of the powdery pharmaceutical application device of the present invention. [Description of representative symbols of main parts] 10 Powder medicine application device for nasal cavity 20 Drug application spray unit 2 1 Drug path 22, 22A, 22B Nozzle 1284944 3 0 Capsule accommodation holding unit 3 1 Air flow path 32 Drug capture and collection Part 3 3 check valve 34 spring 3 5 air flow in □ 3 6 top surface 3 7 convex portion 3 8 capsule storage holding portion lower portion 40 capsule access portion 4 1 capsule loading and unloading recess portion 42 A, 42B capsule cut end discharge portion 44 End portion 45 Access portion convex portion 46 Capsule access portion end surface 5 0 Pump portion 5 1 Mounting portion 52 Bottom portion 5 3 Pressing portion 54 Air intake valve 5 5 Air intake hole 5 6 Take in valve body 60A, 60B Knife edge K capsule KA, KB capsule end
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