JP3308418B2 - Nasal administration device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a nasal administration device suitable for intranasally administering a powdered drug.

[0002]

2. Description of the Related Art In general, a method of treating a patient suffering from nasal allergy or asthma by administering a powdery drug through a nasal cavity is employed. Further, in this treatment method, a powdery drug filled in a capsule is administered into the nasal cavity using a dedicated device (a nasal administration device).

Further, as an apparatus used for this treatment, there is known an apparatus disclosed in JP-A-59-34267 (hereinafter referred to as "prior art").

In the prior art apparatus, a pump portion is provided on the air inflow side of the cylindrical member, and a concave portion into which a capsule is inserted is formed on the air outflow side of the cylindrical member. A capsule housing portion is formed by fitting the distal end portion, and an air introduction passage is formed from the capsule housing portion to the pump portion. Further, a valve mechanism is provided on the other side of the pump section, and the valve mechanism supplies air to the capsule housing section via an air introduction passage when the pump section is pressed, and supplies air from outside when the pump section returns. It is designed to be sucked into the pump section. Furthermore, a state in which a cap fitted to the cylindrical member and a distal end portion is provided, and a pin extending in an axial direction is provided in the cap, and a concave portion of the cylindrical member and a distal end portion having an opening portion are fitted. The capsule is pierced by fitting a cap with the.

In the prior art constructed as described above, first, a capsule filled with a powdered drug is inserted into a concave portion of a cylindrical member, and then a tip portion is fitted into a hole of the capsule in preparation for administration. Then, the capsule is inserted into the capsule receiving portion, and the cap is mounted so that the pin is inserted into the opening at the tip portion, whereby holes are formed on both sides in the axial direction of the capsule by the pins provided in the cap. .

Next, to administer the medicine, the cap is removed from the cylindrical member, and the tip is inserted into one of the nasal cavities of the patient.
By pressing the pump unit, air from the pump unit flows through the air introduction passage into the capsule, transports the medicine in the capsule into the patient's nasal cavity through the opening, and inserts the drug into the nasal cavity. By alternately exchanging the operation and repeating the operation, the medicine is administered to the patient.

Further, in the prior art, since the medication into the nasal cavity is performed alternately on the left and right nasal cavities, a gap is provided between the capsule receiving portion and the capsule, and the pump portion is pressed only once. The medicine in the capsule is not administered at all by the operation, and the medicine in the capsule is administered by only about one operation of the nasal cavity about four times.

[0008]

In the above-described prior art apparatus, since the nasal cavity is dosed one nose at a time, the pump is repeatedly pumped so as to uniformly supply the left and right nasal cavities. Pressing of the part and insertion of the cylindrical member into the nasal cavity must be repeated, which makes the dispensing operation cumbersome.

[0009] In addition, when the capsule is pierced, a detachable cap is attached to the cylindrical member, so that if the cap is lost, it cannot be used as a prescription device.

[0010] Further, at the time of drilling, the powdery medicine in the capsule falls into the pump section. In this case, the medicine in the capsule drops below the specified amount, and the specified amount of the medicine required for the patient is reduced. There is a problem that it becomes impossible to administer the medicine, and it is necessary to frequently clean the medicine dropped in the pump section.

The present invention has been made in view of the above-mentioned various problems of the prior art, and an object of the present invention is to provide a nasal administration device capable of administering a medicine by a simple administration operation.

[0012]

In order to solve the above-mentioned problems, a nasal administration device according to the first aspect of the present invention comprises a capsule holding section for holding a capsule filled with a powdery medicine, for supplying air toward the said capsule holding part, a pump part provided on the air inlet side of the capsule holding part, a medicine in the capsule <br/> Le Ri by the air supplied from the pump section A medicine spraying section provided on the air outflow side of the capsule holding section so as to be branched into two medicine passages, and the tip of each medicine spraying section is provided as a separate spraying port, for spraying into the left and right nasal cavities of the patient; Located between the two chemical passages;
A single pin is provided in the chemical spraying section so as to be movable in the axial direction , and the cap is moved by moving the pin in the axial direction.
Penetrates the capsule held in the cell holder in the axial direction
And a drilled that drilling instrument with two through holes, said capsule
Of the two through holes provided on the pump portion side
The through hole is smaller in diameter than the through hole located on the chemical spraying part side
And so that the pin of the drilling tool is you are configured to form a tapered shape <br/> distally relative to the proximal end side.

[0013] inventions of claims 2, inside the medicine spraying section
Forming a piercing tool mounting hole located between the two chemical passages,
The drilling tool is axially movable within the drilling tool mounting hole.
Protruding toward the outside of the chemical spraying unit,
A pusher having a protrusion, and the pusher provided on the pusher.
Said pin extending towards the capsule in the capsule holding part
Provided between the drilling hole and the pusher.
Turn the pusher away from the capsule
It is constituted by a spring biasing.

[0014] Claim 3Ming is, The tip side of the pinsmall
A large rod orFormed into a rectangular bodyConfiguration
You.

[0015]

[Action] In the inventions of claims 1, at the time of drilling, after holding the capsule in the capsule holder, the pins of the drilling tool is moved to the capsule side, through holes in the capsule by the tip of the pin. In addition, at the time of medication, air is supplied from the pump unit, and this air flows through the two through-holes in the capsule, and flows from the capsule together with the drug through the respective drug passages of the drug spraying unit to the left. , From the right spray to the left and right nasal cavity of the patient. The through-hole two through holes pin in the axial direction of the capsule by forming the tip end side tapered, reduce the through-holes located on the air inlet side of the capsule, located on the air outflow side Can be increased, and the amount of chemicals falling to the pump section side when drilling can be reduced.

According to the second aspect of the present invention , the inside of the chemical spraying section is provided.
Formed between two chemical passages with a hole
And move the drilling tool axially into the drilling tool mounting hole.
A movable pusher and a cap in the capsule holder
A pin that extends toward the cell and this pin
A spring for biasing the pusher in a direction away from the
Can be configured .

According to a third aspect of the present invention, the tip of the pin is
By forming the rod into a small-diameter rod or rectangular body, the through hole formed on the air inflow side of the capsule is made circular or rectangular, and the through hole on the air inflow side of the capsule is penetrated on the outflow side.
The diameter can be smaller than the hole. Also,
In the case where the through hole of the capsule is formed in a rectangular shape, the amount of the chemical falling to the pump section side can be reduced by the circular through hole at the time of drilling.

[0018]

DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described below with reference to FIGS.

First, a first embodiment of a nasal administration device according to the present invention will be described with reference to FIGS.

In the drawing, reference numeral 1 denotes a nasal administration device according to the present embodiment. The nasal administration device 1 is located at the center in the axial direction, and serves as a capsule holding unit for holding a capsule K together with a medicine spraying unit 15 as described later. A holder 2, a pump unit 11 provided on the air inlet side of the capsule holder 2 and supplying air to the capsule holder 2, and a pump unit 11 provided on the air outlet side of the capsule holder 2; A medicine spraying part 15 for forming a capsule holding part together with the capsule holder 2 in the part and spraying medicine to the left and right nasal cavities of the patient;
A drilling tool 25 is provided in the chemical spraying section 15 and drills a capsule K housed in the capsule holder 2. Note that the capsule holder 2 is integrated with the pump unit 11, and the capsule holder 2 is detachable from the chemical spraying unit 15.

Reference numeral 2 denotes a capsule holder constituting a capsule holding portion. The capsule holder 2 is formed of a resin material into a small-diameter cylindrical shape, and the other side in the axial direction (air outflow side) of the capsule holder 2 has A screw portion 3 is formed on the outer peripheral surface, and a one-side capsule hole 4 opening on the end surface is formed on the inner periphery. The capsule accommodation hole 5 is formed by being integrated. On one axial side (air inflow side) of the one-side capsule hole 4, an air supply passage 6 for supplying air from the pump unit 11 and an air supply passage 6
A large-diameter supply valve chamber 7 communicating with the supply valve chamber 7 and a small-diameter capsule inflow-side passage 8 opening from the supply valve chamber 7 to the capsule hole 4 are formed. 29 are formed.

Reference numeral 9 denotes a supply valve. The supply valve 9 comprises a valve element 10 provided in the supply valve chamber 7. The valve element 10 opens when air is supplied from a pump section 11, and At the time of suction, the seat is seated to close the air supply passage 6.

Reference numeral 11 denotes a pump provided on the air inflow side of the capsule holder 2. The pump 11 has an opening 11A, a bottom 11B and a peripheral surface made of a rubber material.
1C is formed in a cylindrical shape with a bottom and its opening 11A
One side outer peripheral surface of the capsule holder 2 is hermetically mounted, and a suction valve 12, which will be described later, is attached to the center of the bottom 11B.

Reference numeral 12 denotes a suction valve. The suction valve 12 is formed at the bottom 11B of the pump section 11, and has a suction passage 13 located at the center and a valve element 14 for opening and closing the suction passage 13.
The valve element 14 closes when air is supplied from the pump section 11, opens when suction is performed, and sucks air from outside into the pump section 11.

Reference numeral 15 denotes a chemical spraying portion provided on the air outflow side of the capsule holder 2. The chemical spraying portion 15 has a small diameter portion 15A having the same diameter as that of the capsule holder 2 on one side in the axial direction due to the resin material, and on the other side. The large-diameter portion 15B is formed in a cylindrical shape, and the large-diameter portion 15B has a pair of nasal cavity insertion portions 1.
6, 16 are formed to project. The small-diameter portion 15A has a female thread 17 which is screwed to the external thread 3 of the capsule holder 2 on the inner peripheral side thereof. 5 is formed, and the other-side capsule hole 1 is formed.
A capsule outlet side passage 19 communicating with the other-side capsule hole 18 and two chemical passages 20, 20 branching from the capsule outlet side passage 19 and extending in a substantially U-shape are formed in the inner part of the inside 8. The tip side of each of the drug passages 20 is located at the nasal cavity insertion portion 16.
And are independent spray ports 21 and 21.

Further, a pair of radially positioned and axially extending holes is provided at the radially intermediate portion of each of the chemical passages 20 extending in the chemical spraying section 15 in the axial direction so as to incorporate a drilling tool 25 in the axial direction. A drilling tool mounting hole 22 having long holes 22A, 22A (see FIG. 3) is formed. A pin insertion hole 23 through which a pin 27 to be described later is inserted, and a pin insertion hole 23 between the pin insertion hole 23 and each of the medicine passages 20 at a position near the capsule outlet side passage 19 in the drilling tool mounting hole 22, The seal mounting step 24 for mounting the seal rubber 31 is formed coaxially.

Here, as shown in FIG. 2, by screwing the external thread 3 of the capsule holder 2 and the internal thread 17 of the chemical spraying section 15, the one capsule hole 4 and the other capsule hole 18 are screwed. Cooperate with each other to form a capsule receiving hole 5. At this time, the axial dimension L0 of the capsule receiving hole 5 is slightly shorter than the axial dimension LK of the capsule K, so that the capsule K is It is fixed firmly in the direction.

Reference numeral 25 denotes a hole for mounting a piercing tool of the chemical spraying section 15.
2 shows a piercing tool provided in 2, wherein the piercing tool 25 comprises:
A disk portion 26A and a pair of protrusions 26B, 26 protruding radially from the disk portion 26A and fitted into the elongated holes 22A, 22A.
B and a pusher 26 (see FIG. 3) integrally formed therefrom;
A pin 27 having a proximal end fixed to the center of the disc portion 26A of the pusher 26 and a distal end extending toward one axial side;
A spring 28 is provided in the hole 22 so as to press the pusher 26 to one side in the axial direction, and urges the disk portion 26A of the pusher 26 in the extending direction. As shown in FIG. 3, the protruding portions 26B of the pusher 26 have elongated holes 22A, 22A.
It protrudes so that it can be displaced in the axial direction.

As shown in FIG. 5, the pin 27 has a large-diameter portion 27A at the base end and a taper at the distal end from the large-diameter portion 27A via the tapered step 27B. A small-diameter portion 27C in the shape of a rod is formed.
The tip of 7C becomes a perforated portion 27D which is a cut needle with an inclination. In addition, the pin 27 is inserted into the pin insertion hole 23, and the perforated portion 27 </ b> D at the tip is located in the seal rubber 31.

Here, in the drilling tool 25, a pusher 26 is used.
6 is displaced along the elongated hole 22A in the direction indicated by the arrow A in FIG. 6 so that the perforated portion 27D of the pin 27 passes through the capsule K in the capsule receiving hole 5 in the axial direction. 8 and 9, the through hole H1 on the air inflow side and the through hole H2 on the air outflow side can be easily formed.
reference). The through-hole H1 has a minimum diameter required for air to flow in, and the through-hole H2 has a large diameter, so that the flow velocity coefficient is large and air can easily escape.

Numeral 29 denotes a medicine trapping portion formed in the supply valve chamber 7 of the capsule holder 2 so as to face the supply valve 9 and project in a small cylindrical shape. Capture passage 3 for communicating passage 8 with supply valve chamber 7
0 is formed. The medicine trapping section 29 catches the medicine falling to the supply valve 9 side when the perforated portion 27D of the pin 27 penetrates the capsule K at the time of drilling.

Reference numeral 31 denotes a seal rubber attached to the seal attachment step 24 of the chemical spraying section 15. The seal rubber 31 is formed of an elastic material, and surrounds the periphery of the perforated section 27 D of the pin 27 to form a capsule. The powder flowing through the outflow side passage 19 and each of the medicine passages 20 is powder-tight and slidable with respect to the pin 27, so that the medicine can enter the piercing hole 22 through the pin insertion hole 23. Preventing.

The dispenser for nasal cavity 1 according to the present embodiment is constructed as described above. Next, the operation when the capsule is pierced will be described with reference to FIGS.

First, as shown in FIG. 6, the capsule K is inserted into the capsule hole 4 on one side of the capsule holder 2, and the external thread 3 of the capsule holder 2 and the screw 17 of the chemical spraying section 15 are screwed into the capsule. The capsule K is accommodated in a capsule accommodation hole 5 formed by one capsule hole 4 of the holder 2 and another capsule hole 18 of the chemical spraying section 15 as shown in FIG.

Then, as shown in FIG. 8, each projection 26B of the pusher 26 constituting the drilling tool 25 is manually displaced downward (in the direction of arrow A in FIG. 6).
The perforated portion 27D of the pin 27 escapes from the axial direction of the capsule K via the capsule outflow passage 19, and forms through holes H1 and H2 on both axial sides of the capsule K.

At this time, the base end of the pin 27 is a large diameter portion 27A.
Since the tip side is formed as a tapered rod-shaped small diameter portion 27C (a perforated portion 27D) via a step portion 27B,
As shown only by the capsule K and the pin 27 in FIG. 9, the through hole H1 on the air inflow side of the capsule K has a small diameter circular shape,
The through hole H2 on the air outflow side has a large diameter circular shape. Further, the number of chemicals falling from the inside of the capsule K toward the capsule inflow side passage 8 at the time of drilling can be reduced because the through hole H1 has a small diameter, and the dropped chemicals can be reduced by the chemical trapping unit 2.
Nine capturing passages 30 are captured.

Further, after the perforation, the pusher 26 is automatically returned by the spring 28. As shown in FIG. 11, the through-holes H1 and H2 are formed on both sides of the capsule K in the axial direction. And each chemical passage 20 can be communicated. Further, the perforated portion 27D of the pin 27 is held powder-tight by the seal rubber 31. Further, as described above, the medicine falling from the capsule K generated at the time of piercing by the pin 27 is captured by the medicine capturing section 29, thereby preventing the medicine from dropping to the supply valve 9 and the pump section 11 side.

As described above, when the nasal administration device 1 according to the present embodiment is pierced, the through holes H1 and H2 are easily pierced by the piercing tool 25 in the axial direction of the capsule K, and the through hole H1 on the air inflow side. Is reduced in diameter to reduce the drop of the chemical to the pump section 11 side, and the chemical dropping from the through hole H1 is captured by the chemical capturing section 29.

Next, the operation at the time of medication will be described with reference to FIG.

First, the left and right nasal cavity insertion sections 16 of the chemical spraying section 15 are inserted into the left and right nasal cavities of the patient, respectively, and the pressing section 11C of the pump section 11 is pressed in the direction of arrow P to supply the medicine. The valve element 10 of the valve 9 opens, and supplies air from the pump unit 11 to the capsule holder 2.

Thus, the air from the pump section 11
Each medicine passage 20, the left and right spray ports 21 from inside the capsule K
Through the patient's nasal cavity. At this time, the medicine in the capsule K is stirred by the air flowing into the capsule K, and the medicine is sent to the nasal cavity of the patient together with the air.

Further, the medicine spraying section 15 is formed with medicine passages 20, 20 for branching the capsule outflow passage 19 into two, and the distal end of each of the medicine passages 20, 20 is connected to the left and right nasal cavity of the patient. The inserted nasal cavity insertion portions 16, 16 (spray ports 21,
Since 21) is formed, the medicine to be sent together with the air can be evenly divided in each medicine passage 20 and simultaneously administered to the left and right nasal cavities of the patient.

Also, by forming the axial dimension L0 of the capsule receiving hole 5 according to the present embodiment to be slightly shorter than the axial dimension LK of the capsule K, the play in the receiving hole 5 of the capsule K is reduced. In addition, the through hole H1 on the air inflow side of the capsule K and the capsule inflow side passage 8 and the through hole H2 on the air outflow side of the capsule K and the capsule outflow side passage 19 are provided.
And all the air from the pump section 11 is encapsulated in a capsule K.
In order to guide the medicine from the through hole H2 of the capsule K to the capsule outflow passage 19, the amount of the medicine ejected from each spray port 21 is stabilized, and the pump unit 11 is operated three times. By pressing, most of the medicine in the capsule K can be administered to the left and right nasal cavities of the patient. As a result, it is possible to eliminate troublesomeness when the patient administers the medication.

Further, the medicine trapped in the trapping passage 30 of the medicine trapping part 29 at the time of drilling is sent out by the air while spraying the air and the medicine, and together with the medicine in the capsule K, the left side of the patient, Can be supplied to the right nasal cavity. As a result, the amount of medicine remaining in the nasal administration device 1 can be reduced, the prescribed amount of the medicine filled in the capsule K can be reliably administered to the patient, and the frequency of cleaning the nasal administration device 1 can be improved. Can be reduced.

On the other hand, when the pump section 11 returns, the supply valve 9 is closed, the valve element 14 of the suction valve 12 is opened, and air is sucked into the pump section 11 from outside via the suction passage 13.
The pressing portion 11C of the pump portion 11 is returned in the direction of the arrow R indicated by the two-dot chain line.

However, in the nasal administration device 1 according to the present embodiment, the medicine spraying section 15 includes the capsule outflow passage 1.
9, two drug passages 20, 20 separated from the left of the patient,
Nasal cavity insertion parts 16, 16 (spray port 2) inserted into the right nasal cavity
1, 21), the capsule K is firmly fixed by making the axial dimension L0 of the capsule receiving hole 5 slightly shorter than the axial dimension LK of the capsule K, and air inflow of the capsule K is performed. The through-hole H1 on the side of the capsule and the capsule inflow side passage 8 and the through-hole H2 on the air outflow side of the capsule K and the capsule outflow side passage 19 are brought into close contact with each other.
All of the air from 1 can flow into the capsule K, and the medicine can be guided from the through hole H2 of the capsule K to the capsule outflow passage 19, so that the medicine can be administered to the nasal cavity of the patient with a small amount of administration operation at the time of administration. Can be administered. As a result, as in the related art, the dispenser is inserted into each of the nasal cavities of the patient, and the pump unit 11 is pressed about three times without repeatedly and repeatedly administering the medication to the left and right nasal cavities. Thereby, the medicine can be administered to the patient, and the administration operation can be simplified.

Further, since the drilling tool 25 is incorporated in the chemical spraying section 15, after the capsule K is accommodated in the capsule accommodation hole 5, the pusher 26 is displaced in the axial direction only, The through holes H1 and H2 can be easily formed. Further, since the drilling tool 25 is incorporated in the chemical spraying section 15, there is no risk of loss as compared with a conventional technique in which a pin is provided on a cap, and handling is safe.

The shape of the pin 27 of the drilling tool 25 is such that the base end is a large-diameter portion 27A, the distal end side is a tapered small-diameter portion 27C via a step 27B, and the distal end of the small-diameter portion 27C is a perforated portion 27D. As a result, the diameter of the through hole H1 on the air inflow side and the diameter of the through hole H2 on the air outflow side of the through holes H1 and H2 formed in the capsule K can be reduced. Through the pump unit 11
The amount of chemicals falling to the side can be reduced. As a result, it is possible to eliminate the variation in the dosage at the time of medication, and to administer the prescribed amount of medicine to the patient every time.

In addition, the medicine trapping part 29 formed in the capsule holder 2 captures the medicine falling when the capsule K is pierced, and the captured medicine is administered to the patient together with the air. Therefore, the amount of medicine remaining in the nasal administration device 1 can be almost eliminated, and the medicine filled in the capsule K can be reliably administered to the patient. Thereby, the variation at the time of administration can be eliminated, and the number of times of cleaning the nasal administration device 1 can be reduced as compared with the related art.

Further, a seal rubber 31 formed of an elastic material is provided on the seal mounting step 24 of the chemical spraying section 15, and the perforated section 27 of the pin 27 is formed by the seal rubber 31.
Since the surroundings of the perimeter D are surrounded, it is possible to separate the medicine passages 20 and the piercing tool mounting holes 22 in a powder-tight manner, and the medicine in the air flowing through each of the medicine passages 20 is used for the piercing tool mounting holes 2.
2 can be prevented from entering.

Next, FIG. 12 shows a second embodiment. The feature of this embodiment is that the shape of a pin 41 used in place of the pin 27 of the drilling tool 25 described above is different from that of FIG. The large-diameter portion 41A is formed as a rectangular portion 41C whose tip side is tapered from the large-diameter portion 41A through the step portion 41B from the large-diameter portion 41A, and the distal end of the rectangular portion 41C has a knife-edge-shaped perforated portion. 41D. In this embodiment, the same components as those in the above-described first embodiment are denoted by the same reference numerals, and description thereof will be omitted.

In the nasal administration device of the present embodiment configured as described above, the medicine is sprayed by making a hole in the capsule K by using the pin 41 as described above.
In addition to obtaining the same operation and effect as the embodiment,
Since the pin 41 of this embodiment has a tapered shape as the rectangular portion 41C, the hole shape of the through hole H1 on the air inflow side among the through holes formed in the capsule K can be made rectangular, so that the side of the pump portion 11 at the time of drilling is formed. It is possible to further reduce the amount of chemicals falling to the surface.

FIG. 13 shows a third embodiment of the present invention. The shape of the pin 51 according to this embodiment is such that the large diameter portion 51A is formed at the base end and the large diameter portion 51A is formed at the tip end. A conical portion 51B and a perforated portion 51C serving as a cut needle inclined at the tip of the conical portion 51B.

With the nasal administration device of the present embodiment configured as described above, the same operation and effect as those of the first embodiment can be obtained.

Next, FIG. 14 shows a fourth embodiment. The feature of the present embodiment is that the feature of the present embodiment is that the medicine spraying section 61 is provided between the nasal cavity insertion sections 16 and 16 of the patient. That is, the abutting portion 52 forming an arc surface is formed so as to contact between the nasal cavities.
In this embodiment, the same components as those in the above-described first embodiment are denoted by the same reference numerals, and description thereof will be omitted.

In the present embodiment thus constructed, not only the same operation and effect as in the first embodiment described above can be obtained, but also the provision of the contact portion 52 between the nasal cavities of the patient allows the nasal cavity to be applied. The variation in the insertion dimension of the nasal cavity insertion section 16 can be eliminated, and a constant medication can be always performed.

[0057]

As has been described above in detail, originating in claim 1
According to Ming, after accommodating the capsule in a capsule holder, a single pin of the drilling tool is moved to the capsule side, opened two through holes on both sides in the axial direction of the capsule by the tip of the pin, after this Is configured such that air is supplied into the capsule from the pump unit, and the medicine in the capsule is supplied together with air to the left and right nasal cavities of the patient from each of the medicine passages of the medicine spraying unit through the spray ports. Medicine can be simultaneously and uniformly administered to the left and right nasal cavities, eliminating the hassle of separately administering the left and right nasal cavities, increasing the nebulization efficiency and simplifying the patient's medication operation. You. Moreover , chemical injection
A shaft is located between the two chemical passages of the mist section and within the chemical spray section.
Simply sliding the drilling tool provided in the moving movable in a direction, the hole
Can drilling into capsules by the pins of the opened tool, and without fear that the pin is lost, and handling doctor it is safe.
The through hole by forming a distal end side of the through holes pin in the axial direction of the capsule tapered shape, the through holes located on the air inlet side of the capsule, located in air outflow side
Since the diameter can be made smaller than that, it is possible to reduce the amount of chemicals that drop to the pump section side through the through hole on the air inflow side at the time of drilling, and to prevent variation in the dosage at the time of medication.

According to the second aspect of the present invention, between the two chemical passages
In the drilling tool mounting hole that is located and formed in the chemical spraying section,
A drilling tool pusher is provided to be movable in the axial direction.
The protrusion that protrudes toward the outside of the chemical spray section
Part from the outside of the chemical spraying part
By displacing the pusher projection, the capsule
The pin can be moved toward the capsule in the holding section,
Pin and the air flow in the axial direction of the capsule
Rukoto open the through-hole of the exit side is possible.

According to the third aspect of the present invention, the tip end of the pin has a small diameter.
Capsule by forming into a simple rod or rectangular body
Make the through hole formed in the circular or rectangular shape, capsule
The diameter of the through hole on the air inflow side is larger than the diameter of the through hole on the outflow side.
The size of the air inlet can be reduced when drilling.
Reducing the amount of chemicals that drop through the through hole to the pump
Wear. Also, make the through hole on the air inflow side of the capsule rectangular.
When it is formed , the amount of chemicals that drop to the pump section side at the time of drilling can be reduced more than the circular through hole.

[Brief description of the drawings]

FIG. 1 is a side view showing a nasal administration device according to a first embodiment.

FIG. 2 is a longitudinal sectional view showing a nasal administration device according to the first embodiment.

FIG. 3 is a transverse sectional view as seen from the direction of arrows III-III in FIG. 2;

FIG. 4 is an enlarged longitudinal sectional view showing a main part in FIG. 2 in an enlarged manner.

FIG. 5 is a perspective view showing a pin used in the first embodiment.

FIG. 6 is an exploded perspective view showing a state before a capsule is accommodated in a nasal administration device.

FIG. 7 is a longitudinal sectional view showing a state in which a capsule is accommodated in a nasal administration device.

FIG. 8 is a longitudinal sectional view showing a state in which a through hole is made in the axial direction of the capsule by moving a pin of the hole making tool.

FIG. 9 is an enlarged sectional view showing a state in which a hole is formed in the capsule with a pin.

FIG. 10 is a longitudinal sectional view showing a state where the pin is returned to an original position after a through hole has been made in the capsule with a pin of a drilling tool.

FIG. 11 is a longitudinal sectional view showing a state in which a medicine in a capsule is sprayed by pressing a pump unit.

FIG. 12 is a perspective view showing a pin used in a second embodiment of the present invention.

FIG. 13 is a perspective view showing a pin used in a third embodiment of the present invention.

FIG. 14 is a longitudinal sectional view of a nasal administration device according to a fourth embodiment of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Nasal cavity administration device 2 Capsule holder (capsule holding part) 4 One-side capsule hole 5 Capsule accommodation hole 11 Pump part 15, 61 Chemical spray part 18 Other capsule hole 20 Chemical passage 21 Spray port 25 Drilling tool 27, 41, 51 Pin 27A, 41A, 51A Large diameter portion 27B, 41B Step 27C Small diameter portion 27D, 41D, 51C Perforated portion 41C Rectangular portion 51B Conical portion K Capsule H1, H2 Through hole

──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Kazunori Ishiseki 1370 Onna, Atsugi-shi, Kanagawa Prefecture Inside Unisia Gex Co., Ltd. (72) Inventor Akira Yanagawa 5-3 Fujimigaoka, Tsuzuki-ku, Yokohama-shi, Kanagawa Prefecture (56) References Special JP-A 50-48782 (JP, A) JP-A 56-33939 (JP, U) JP 5-36436 (JP, Y2) US Patent 3066669 (US, A) (58) Fields investigated (Int. . ^7, DB name) A61M 11 / 00,15 / 08

Claims (3)

(57) [Claims] 1. A and the capsule holding portion powdery chemicals to hold the capsules filled therein, for supplying air toward the said capsule holding part, a pump provided on the air inflow side of the capsule holding portion parts and left the patient chemicals in by Ri the capsule to the air supplied from the pump unit, for spraying toward the right in the nasal cavity, branched into two medicine passages to the air outlet side of the capsule holding portion and provided, chromatic and medicine spraying section tip becomes each separate spray outlet, the single pin provided on the two medicine passages movement movable and the on drug product spraying section axially located between the And replace the pin
Holds in the capsule holder by moving in the axial direction
Has been a two drilled through-holes <br/> Ru drilling tool that penetrates in the axial direction of the capsule, the pump portion of the two through holes provided in the capsule
Penetrating hole located on the chemical spraying part side
The pin of the drilling tool should be at the proximal end so that it has a smaller diameter than the hole.
Medicine administering device comprising a structure forming the tapered tip end compared to the side. 2. The method according to claim 2, wherein the medicine spraying section is provided between two medicine passages.
Forming a piercing tool mounting hole, wherein the piercing tool is
The drilling tool mounting hole is provided movably in the axial direction in the mounting hole.
A pusher with a protrusion protruding toward the outside of the chemical sprayer
And a pusher, provided in the pusher, in the capsule holding portion.
Said pin extending towards a capsule and said piercing device
The pusher is provided between the fitting hole and the pusher, and the pusher is
Spring biasing the capsule away from the capsule.
Ri構 form medicine administering device according to claim 1, wherein comprising. 3. The nasal administration device according to claim 1, wherein the distal end side of the pin is formed into a small-diameter rod-like body or a rectangular body.