JP2003113103A - Ameliorant for renal function - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an ameliorant for renal functions daily and tastily ingestible in the same manner as that of usual tea. SOLUTION: This ameliorant for the renal functions is obtained by mixing the tea material with liquors and an acid fermented milk, aging the resultant mixture and extracting the aged tea material with an aqueous solvent as an active ingredient. The resultant ameliorant for the renal functions is capable of maintaining the renal functions normal even when, e.g. a meal with a high fat content is ingested. The tea material is preferably one or more kinds selected from green teas, Chinese teas, black teas and barley teas. The liquors are preferably one or more kinds selected from Sake, wines, whiskeys, brandies, Shaoxing and Shochu (Japanese distilled spirit). Furthermore, the acid fermented milk is preferably yogurts, acid milk beverages or lactic acid bacteria beverages.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an agent for improving renal function, which has an effect of keeping a normal renal function even when a high-fat diet is ingested, using an extract component of tea material as a raw material.

[0002]

2. Description of the Related Art Blood from the heart is poured directly into the kidney through a renal artery of about 200 ml per minute. One kidney is made up of about 1 million nephrons, each of which is a unit of kidney function. Nephrons are made up of glomeruli and their connected tubules, which are cage-like networks of blood vessels that branch from renal arteries and connect to narrowed renal arterioles. When blood passes under pressure here, urine is pumped out, just like when making tofu. The strained urine is collected by Bowman's capsule, which is a bag that wraps the glomerulus, and is poured into the tubules.

The function of the kidney is examined by the amount of glomerular filtration (examined by the creatinine clearance test). The urine excreted by this glomerulus is called raw urine and is 120
L (about 100 times the normal urine volume) is also made. Up to 99% of this raw urine is reabsorbed while returning to the blood while passing through the renal tubule. In this way, the kidneys prevent the body from becoming dry (called dehydration) or swelling (called overflow). In this way, each urine made of nephron is collected in the funnel-shaped part called renal pelvis, and is poured into the bladder through the ureter.

In addition, the renal tubules activate vitamin D,
It makes a hormone called erythropoietin that makes red blood cells, regulates minerals (sodium, potassium, calcium, phosphorus, magnesium, etc.), excretes waste products made by the body, and makes acids made by the body (acids are produced when cells work). )
Plays an important role in excreting urine from urine.

When renal failure occurs, many of these functions are lost, resulting in a condition called uremia (also called end stage renal failure). There are also diseases in which some parts of the tubules are damaged rather than renal failure, and only some of these functions are lost.

[0006] Kidney disease is caused by many causes such as chronic glomerulonephritis, diabetes, and acute glomerulonephritis, but until now, treatment with chemicals has been the mainstream. However, since chemicals often have side effects, it is dangerous to continuously use them for a long period of time.

In view of such a problem, for example, Japanese Patent Laid-Open No. 6-
No. 122626 proposes an agent for improving renal function, which contains tea polyphenols extracted from tea as an active ingredient, which suppresses the progression of glomerulonephritis and diabetic nephropathy due to proliferation of mesangial cells and is effective for improving renal function. Has been done.

On the other hand, the applicant of the present invention has filed a patent No. 3148167.
As disclosed in the publication, a method for producing an aged tea material is already proposed, which comprises mixing alcoholic beverages and acid-fermented milk into a tea material for beverage, swelling the tea material for beverage, and then aging. ing.

[0009]

However, in the invention described in JP-A-6-122626, the effect is confirmed by taking out polyphenols which are a specific component in the tea material and feeding them to animals as feed. However, there is no description about whether or not the extract itself obtained by adding water or hot water to the tea material has such an effect.

The aged tea material described in Japanese Patent No. 3148167 is mixed with alcohol and acid-fermented milk in the tea material for swelling and aging, so that its components are different from those of a normal tea material. Therefore, it was unclear whether or not it contained the components that contribute to the improvement of renal function as described in the above-mentioned prior art.

Therefore, it is an object of the present invention to provide a renal function improving agent which can be ingested on a daily basis with a delicious taste like ordinary tea.

[0012]

[Means for Solving the Problems] To achieve the above object, the present invention provides a tea material mixed with liquor and acid-fermented milk and aged tea material obtained by aging. The present invention provides a renal function improving agent as an active ingredient.

In the present invention, the tea material is green tea,
It is preferably one or more selected from Chinese tea, black tea and barley tea.

Further, the liquor is preferably one or more selected from sake, wine, whiskey, brandy, vodka, Shaoxing liquor and shochu.

Further, it is preferable that the acid-fermented milk is yogurt, sour milk drink, or lactic acid bacterium drink.

According to the present invention, as with ordinary tea materials, it can be eaten with good flavor and taste, and can maintain its normal renal function even if a meal with a high fat content is taken. A renal function improving agent can be provided.

[0017]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in more detail below.

The tea material used in the present invention is not particularly limited, but for example, green teas such as matcha, gyokuro, sencha, kiln roasted tea, bancha, houjicha, oolong tea, iron Kannon tea, puuaru tea, huashan tea, Examples include Chinese teas such as Longines tea and Paochun tea, teas such as Darjeeling tea and Assam tea, and barley tea, herb tea, jasmine tea and the like. Further, two or more kinds of these tea materials can be mixed and used. In that case, among the tea materials for beverages mentioned above, gyokuro, sencha, bancha, oolong tea, iron kannon tea, darjeeling tea, assam tea, Barley tea and the like are particularly preferable.

The liquors used in the present invention include sake, wine, whiskey, brandy, vodka, Shaoxing liquor, shochu and the like.

Further, the acid-fermented milk used in the present invention means a fermented milk which is a semi-gelled or liquid dairy product fermented with lactic acid bacteria, which is produced only by lactic acid fermentation.
Examples include yogurt, sour milk drink, lactic acid bacteria drink and the like. Among these, lactic acid bacteria beverages include lactic acid beverages for dairy products (non-fat milk solids content of 3.0 to 8.0% according to the component specifications in the Ordinance of the Ministry of Health and Welfare) and non-dairy lactic acid beverages (non-fat according to the component specifications in the Ordinance of the Health and Welfare Milk solid content is 3.0% or less), and the lactic acid beverages for dairy products further include live lactic acid bacterium beverages and sterilized lactic acid bacterium beverages. Examples of live lactic acid bacterium beverages include "Yakult" (trade name,
Yakult Honsha Co., Ltd., etc. are known, and as a sterilized lactic acid bacterium beverage, for example, “Calpis” (trade name,
Calpis Food Industry Co., Ltd.) and the like are known.

The aqueous solvent used in the present invention is not particularly limited as long as it is a solvent capable of extracting a water-soluble component from an aged tea material, and examples thereof include water, boiling water, hydrous alcohol, alcohol and the like, and boiling water is particularly preferable. .

The method for producing the renal function-improving agent of the present invention will be described. First, one or more selected from the above tea materials are put into a container, preferably a plastic or stainless steel sealable container. To take. This is to prevent the alcohol in the alcoholic beverage from volatilizing and impairing the aging effect of the alcohol.

Next, 1 or 2 or more kinds selected from the above as alcoholic beverages and 1 or 2 or more kinds selected from the above as acid fermented milk are added to the weight of the tea material 1. By ratio, liquor is 0.3 to 2, preferably 0.5 to 1,
Acid fermented milk 0.05-0.5, preferably 0.05-0.
It is added at a ratio of 2 and mixed to swell the tea material. In this case, liquor and acid-fermented milk mean the weight as a water-containing material. In addition, it is preferable that the tea material is not soaked in the liquid material of the alcoholic beverage and the acid-fermented milk in the container, but is in a state of moistening the tea material.

After swelling, the hermetically sealed container is capped and placed in, for example, a constant temperature oven and aged at a constant temperature of 0 to 100 ° C., preferably 30 to 70 ° C., preferably for 4 hours to 7 days. However, if the aging temperature is around 5 ° C, the aging time is 30
It may take ~ 40 days. However, the aging time is 4
If it exceeds 0 days, an odor will be aged, and if it is shorter than 4 hours, the flavor of the finished aged tea material will be different and uncoordinated, which is not preferable.

After the aging is completed in this way, the aged tea material of the present invention in a wet state can be obtained by taking it out from the sealed container. The aged tea material can be aseptically packaged as it is to be commercialized, or can be refrigerated or frozen, and can be dried and stored like normal tea leaves.

In the present invention, the above-mentioned aqueous solvent, preferably boiling water, is added to the aged tea material obtained as described above to extract the water-soluble components contained in the aged tea material. The extract thus obtained can be concentrated or diluted as needed, and can be sterilized and filled into containers such as PET bottles, cans, bottles, etc. to be commercialized as beverages with good flavor. In addition, the extract may be concentrated as required, dried and powdered, and granulated as required to produce a powder, granules, tablets or the like.

A tea beverage extracted by adding hot water to aged tea material is commercially available, for example, as "fermented tea" (trade name, manufactured by Nagasaki Beverage Co., Ltd.). Beverages can also be used.

The effective dose of the renal function-improving agent of the present invention is, for example, when it is commercialized as an aqueous extract having a concentration of Brix 0.15 to 2.4, it is ingested in an amount of 100 to 1000 ml / day per person. Preferably.

Further, the renal function improving agent of the present invention is already marketed as "fermented tea" (trade name, manufactured by Nagasaki Beverage Co., Ltd.) and is eaten and eaten by people. Needless to say that there is no problem with.

[0030]

EXAMPLES Example A mixture of 100 g of sencha, 100 g of oolong tea, 100 g of barley tea, 100 g of black tea, 150 g of whiskey, 50 g of white wine, 50 g of Ginjo sake, and 120 g of calpis was placed in a stainless steel hermetically sealed container and kept at a temperature of 80 ° C. After aging for 72 hours, sencha was taken out from the sealed container, and 50 L of hot water at 85 ° C. was added to the sencha to extract water-soluble components to obtain a water extract.

Test Example Rats were divided into 3 groups of 6 animals, and rats in each group were fed with commercially available normal feed and normal water as drinking water for 6 weeks.

Then, one group was fed with the above-mentioned normal feed and normal water as drinking water, and further raised for 9 weeks (15 weeks in total). This is a control group.

The other group was fed with a soybean oil-containing feed prepared by adding 10% by mass of soybean oil to the above-mentioned ordinary feed and ordinary water as drinking water, and further raised for 9 weeks (15 weeks in total). This serves as a control group.

In yet another group, the above-mentioned soybean oil-added feed and "fermented tea" (trade name, manufactured by Nagasaki Beverage Co., Ltd.), which is a drink produced by the same method as in the above-mentioned example, was used as drinking water. They were fed and further raised for 9 weeks (15 weeks in total). This is an example group.

Urine was collected from each group of rats after breeding for 9 weeks (15 weeks in total), and the total amount of protein in urine, urea nitrogen, creatinine, creatine,
Uric acid, Na, Cl, K and hippuric acid were measured. The results are shown in Table 1. The numerical values in Table 1 are average values of the rats in each group.

[0036]

[Table 1]

From the results shown in Table 1, the measured values of the Example group fed with the soybean oil-added feed and "fermented tea" were almost the same as those of the control group fed with the normal feed, and the renal function was normal. You can see that it is maintained. On the contrary,
In the control group fed with the soybean oil-added feed and water, urea nitrogen, creatinine, creatine, uric acid, Na, Cl, K, and hippuric acid were all significantly increased, and renal function was decreased. Recognize.

[0038]

As described above, according to the present invention,
Like ordinary tea, it has a good flavor and can be consumed deliciously, for example, even if you eat a meal with a high fat content,
It is possible to provide a renal function improving agent that can keep the renal function normal.

Claims (4)

[Claims] 1. A renal function improving agent comprising, as an active ingredient, an ingredient extracted from an aged tea material obtained by mixing sake and acid fermented milk with a tea material and aging. 2. The tea material is one or more selected from green tea, Chinese tea, black tea and barley tea.
The described renal function improving agent. 3. The renal function improving agent according to claim 1, wherein the liquor is one or more selected from sake, wine, whiskey, brandy, vodka, Shaoxing liquor, and shochu. 4. The renal function improving agent according to claim 1, wherein the acid-fermented milk is yogurt, a sour milk drink, or a lactic acid bacterium drink.