JP2002544243A5 - - Google Patents
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- JP2002544243A5 JP2002544243A5 JP2000617933A JP2000617933A JP2002544243A5 JP 2002544243 A5 JP2002544243 A5 JP 2002544243A5 JP 2000617933 A JP2000617933 A JP 2000617933A JP 2000617933 A JP2000617933 A JP 2000617933A JP 2002544243 A5 JP2002544243 A5 JP 2002544243A5
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- JP
- Japan
- Prior art keywords
- molecule
- group
- molecule according
- agent
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002738 chelating agent Substances 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 210000005005 sentinel lymph node Anatomy 0.000 description 5
- 230000002285 radioactive effect Effects 0.000 description 4
- ZQXIMYREBUZLPM-UHFFFAOYSA-N 1-aminoethanethiol Chemical compound CC(N)S ZQXIMYREBUZLPM-UHFFFAOYSA-N 0.000 description 2
- RXACEEPNTRHYBQ-UHFFFAOYSA-N 2-[[2-[[2-[(2-sulfanylacetyl)amino]acetyl]amino]acetyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)CNC(=O)CNC(=O)CS RXACEEPNTRHYBQ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
- 125000003636 chemical group Chemical group 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000005298 paramagnetic effect Effects 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 229940124553 radioprotectant Drugs 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 1
- 229910052688 Gadolinium Inorganic materials 0.000 description 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
- 229910052769 Ytterbium Inorganic materials 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000002534 radiation-sensitizing agent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13432999P | 1999-05-14 | 1999-05-14 | |
| US60/134,329 | 1999-05-14 | ||
| PCT/US2000/013300 WO2000069473A2 (en) | 1999-05-14 | 2000-05-12 | Macromolecular carrier for drug and diagnostic agent delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007175770A Division JP2007332380A (ja) | 1999-05-14 | 2007-07-04 | 薬剤および診断薬の送達のための高分子担体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002544243A JP2002544243A (ja) | 2002-12-24 |
| JP2002544243A5 true JP2002544243A5 (https=) | 2006-01-05 |
| JP4056701B2 JP4056701B2 (ja) | 2008-03-05 |
Family
ID=22462862
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617933A Expired - Lifetime JP4056701B2 (ja) | 1999-05-14 | 2000-05-12 | 薬剤および診断薬の送達のための高分子担体 |
| JP2007175770A Pending JP2007332380A (ja) | 1999-05-14 | 2007-07-04 | 薬剤および診断薬の送達のための高分子担体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007175770A Pending JP2007332380A (ja) | 1999-05-14 | 2007-07-04 | 薬剤および診断薬の送達のための高分子担体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6409990B1 (https=) |
| EP (1) | EP1178838B1 (https=) |
| JP (2) | JP4056701B2 (https=) |
| AT (1) | ATE277642T1 (https=) |
| AU (1) | AU5270500A (https=) |
| DE (1) | DE60014359T2 (https=) |
| ES (1) | ES2228536T3 (https=) |
| FR (1) | FR15C0033I2 (https=) |
| NL (1) | NL300736I2 (https=) |
| WO (1) | WO2000069473A2 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| EP1032430A2 (en) | 1997-11-17 | 2000-09-06 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| EP1178838B1 (en) * | 1999-05-14 | 2004-09-29 | The Regents of the University of California | Macromolecular carrier based on dextran for drug and diagnostic agent delivery |
| US20040146463A1 (en) * | 2000-05-04 | 2004-07-29 | Meade Thomas J. | Functional MRI agents for cancer imaging |
| US6673333B1 (en) * | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| CN100406065C (zh) | 2000-12-01 | 2008-07-30 | 细胞工厂治疗公司 | 糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法 |
| US20030004236A1 (en) * | 2001-04-20 | 2003-01-02 | Meade Thomas J. | Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances |
| WO2002087632A1 (en) * | 2001-05-02 | 2002-11-07 | Metaprobe, Inc. | High throughput screening methods using magnetic resonance imaging agents |
| AU2002364607A1 (en) * | 2001-12-28 | 2003-07-24 | The Burnham Institute | Novel ligand involved in the transmigration of leukocytes . |
| US20030198597A1 (en) * | 2002-04-22 | 2003-10-23 | Meade Thomas J. | Novel macrocyclic activatible magnetic resonance imaging contrast agents |
| US7651689B2 (en) * | 2002-11-15 | 2010-01-26 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of applying ionization radiation for therapy of infections |
| EP1590440A4 (en) * | 2003-02-03 | 2009-03-18 | Palo Alto Inst Of Molecular Me | CELL-KILLING MOLECULES AND METHODS FOR THEIR USE |
| US7727969B2 (en) * | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| US20050171424A1 (en) * | 2004-01-13 | 2005-08-04 | The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services | Methods for imaging the lymphatic system using dendrimer-based contrast agents |
| US20050186642A1 (en) | 2004-02-24 | 2005-08-25 | Biocare Medical, Inc. | Immunoassay reagents and methods of use thereof |
| US20070232904A1 (en) * | 2004-06-03 | 2007-10-04 | Oakley, Inc. | Application of Hyaluronic Acid to Sentinel Lymph Node Identification |
| US7381400B2 (en) * | 2004-07-13 | 2008-06-03 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Injection of a radioactive dye for sentinel lymph node identification |
| US20060204443A1 (en) * | 2005-03-11 | 2006-09-14 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for tumor treatment using dendrimer conjugates |
| DE102005018330B4 (de) | 2005-04-20 | 2007-04-19 | Siemens Ag | System zur Erzeugung von CT-Bilddatensätzen und zur Bestrahlung eines Tumor-Patienten |
| JP4934802B2 (ja) * | 2005-05-30 | 2012-05-23 | 国立大学法人信州大学 | リンパ系の細胞接着物質、リンパ系薬物輸送材およびそれを含有する薬剤 |
| US20070031512A1 (en) * | 2005-08-03 | 2007-02-08 | Amcol International Corporation | Virus-interacting layered phyllosilicates and methods of inactivating viruses |
| US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
| US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
| WO2008022263A2 (en) * | 2006-08-17 | 2008-02-21 | Epix Pharmaceuticals, Inc. | Methods for lymph system imaging |
| US20100196272A1 (en) * | 2009-01-30 | 2010-08-05 | Neoprobe Corporation | Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran |
| US11077212B2 (en) | 2010-08-24 | 2021-08-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Molecular imaging of cancer cells in vivo |
| US8852592B2 (en) | 2011-05-10 | 2014-10-07 | Biocare Medical, Llc | Systems and methods for anti-PAX8 antibodies |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| EP2900265B1 (en) | 2012-09-27 | 2018-05-30 | Biocare Medical, LLC | Anti-uroplakin ii antibodies systems and methods |
| US10429390B2 (en) | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| DK2962113T3 (da) | 2013-02-28 | 2019-07-01 | Biocare Medical Llc | Systemer og fremgangsmåder med anti-p40-antistoffer |
| JP6163698B2 (ja) * | 2013-03-21 | 2017-07-19 | 国立大学法人 千葉大学 | マクロファージマンノース受容体を認識する新規多糖金属錯体化合物、及び、その医薬組成物 |
| CN114377143A (zh) * | 2013-07-22 | 2022-04-22 | 康德乐健康414有限责任公司 | 用于诊断和治疗与表达cd206的细胞相关的病症的组合物、方法和药盒 |
| CN104511030A (zh) * | 2013-09-29 | 2015-04-15 | 复旦大学 | 基于葡聚糖的双模态纳米影像药物-Dex-Rho-99mTc |
| US9816997B2 (en) | 2013-10-03 | 2017-11-14 | Biocare Medical, Llc | Anti-SOX10 antibody systems and methods |
| EP3154587B1 (en) | 2014-06-13 | 2020-01-15 | Tenboron OY | Conjugates comprising an anti-egfr1 antibody |
| WO2016011419A1 (en) * | 2014-07-17 | 2016-01-21 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other cd206 high expressing cells and methods of treating and diagnosis |
| CA2955438C (en) * | 2014-07-17 | 2024-07-02 | Ohio State Innovation Foundation | DEXTRANE CONJUGATES TO TARGET MACROPHAGES AND OTHER CELLS EXPRESSING THE D-MANBOSE BINDING TYPE C LECTIN RECEPTOR |
| US10806803B2 (en) * | 2014-07-17 | 2020-10-20 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis |
| WO2016118188A1 (en) * | 2015-01-21 | 2016-07-28 | Navidea Biopharmaceuticals, Inc. | Compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells |
| CN106317237B (zh) * | 2015-07-03 | 2019-07-19 | 华中科技大学 | 一种用于spect成像的当归多糖衍生物及其合成方法 |
| CN108348619A (zh) | 2015-09-25 | 2018-07-31 | 瑟日尼有限责任公司 | Sn-117m标记的甘露糖偶联的葡聚糖胺 |
| EP3359202A1 (en) | 2015-10-05 | 2018-08-15 | Serene, LLC | Hyaluronan sn-117m colloid for radiosynoviorthersis and symptomatic therapy related applications |
| WO2018067751A1 (en) * | 2016-10-04 | 2018-04-12 | Navidea Biopharmaceuticals, Inc. | Compositions and methods for diagnosing and treating macrophage-related disorders using carbohydrate-based macromolecular carrier |
| MX2019004029A (es) | 2016-10-07 | 2019-09-27 | Navidea Biopharmaceuticals Inc | Compuestos y metodos para diagnosis y tratamiento de infecciones virales. |
| JP6329302B2 (ja) * | 2017-05-10 | 2018-05-23 | 国立大学法人千葉大学 | マクロファージマンノース受容体を認識する新規多糖金属錯体化合物、及び、その医薬組成物 |
| US20210052639A1 (en) * | 2019-08-19 | 2021-02-25 | Navidea Biopharmaceuticals, Inc. | Compositions and related methods for the ablation of m2 macrophages and myeloid derived suppressor cells |
| US20210145989A1 (en) * | 2019-09-30 | 2021-05-20 | Navidea Biopharmaceuticals, Inc. | Compositions and related methods for blocking off-target localization of mannosylated dextrans and other cd206 ligands |
| US11497763B1 (en) | 2020-07-01 | 2022-11-15 | Physis International LLC | Compounds and methods for treating and diagnosing RNA virus infections |
| US12070504B1 (en) | 2020-07-01 | 2024-08-27 | Physis International LLC | Compounds and methods for altering cyto-states of cells that express c-type lectin receptors |
| EP4076540A4 (en) | 2020-07-08 | 2024-02-21 | Navidea Biopharmaceuticals, Inc. | Synthesis of uniformly defined molecular weight mannosylated dextrans and derivatives thereof |
| CA3192041A1 (en) * | 2020-08-21 | 2022-02-24 | Resolute Science, Inc. | Compositions and methods for targeting tumor-associated macrophages |
| EP4472643A1 (en) * | 2022-02-04 | 2024-12-11 | Navidea Biopharmaceuticals, Inc. | Altering net charge on mannosylated dextrans to maximize target tissue uptake and off target competitive blocking |
| US20230302041A1 (en) * | 2022-03-25 | 2023-09-28 | Navidea Biopharmaceuticals, Inc. | Competitive Self-Blocking with Unlabeled Manocept Imaging Agents |
| WO2024076988A2 (en) * | 2022-10-03 | 2024-04-11 | Navidea Biopharmaceuticals, Inc. | Amide linkages of sugar moieties to amine terminated leashes attached to carbohydrate polymers |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE286598C (https=) | ||||
| US4707440A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
| US5175269A (en) * | 1984-01-30 | 1992-12-29 | Enzo Diagnostics, Inc. | Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group |
| SE465907B (sv) * | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
| US5336762A (en) * | 1985-11-18 | 1994-08-09 | Access Pharmaceuticals, Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
| US5490991A (en) * | 1986-07-03 | 1996-02-13 | Advanced Magnetics, Inc. | Directed delivery of radioprotectants using a receptor specific carrier |
| US4822594A (en) * | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
| CS263561B1 (en) * | 1987-09-18 | 1989-04-14 | Kery Vladimir | Process for preparing water soluble allylderivatives of oligo and polysaccharides |
| DD286598A5 (de) * | 1989-06-29 | 1991-01-31 | Adw Der Ddr,Zi F. Mulekularbiologie,De | Verfahren zur einfuehrung von primaeren aminogruppen in wasserloesliche polymere |
| US5789578A (en) * | 1996-01-11 | 1998-08-04 | Massey University | Methods for the preparation of resins with ligands attached thereto through a linking group comprising sulfide, sulfoxide or sulfone functionality |
| ES2206689T3 (es) * | 1996-10-28 | 2004-05-16 | Amersham Health As | Agentes de contraste. |
| WO1998023293A1 (en) * | 1996-11-28 | 1998-06-04 | Nihon Schering K.K. | Contrast compound, contrast medium for mri, and method for mri |
| EP1178838B1 (en) * | 1999-05-14 | 2004-09-29 | The Regents of the University of California | Macromolecular carrier based on dextran for drug and diagnostic agent delivery |
-
2000
- 2000-05-12 EP EP00937555A patent/EP1178838B1/en not_active Expired - Lifetime
- 2000-05-12 US US09/569,466 patent/US6409990B1/en not_active Expired - Lifetime
- 2000-05-12 WO PCT/US2000/013300 patent/WO2000069473A2/en not_active Ceased
- 2000-05-12 DE DE60014359T patent/DE60014359T2/de not_active Expired - Lifetime
- 2000-05-12 AT AT00937555T patent/ATE277642T1/de not_active IP Right Cessation
- 2000-05-12 JP JP2000617933A patent/JP4056701B2/ja not_active Expired - Lifetime
- 2000-05-12 ES ES00937555T patent/ES2228536T3/es not_active Expired - Lifetime
- 2000-05-12 AU AU52705/00A patent/AU5270500A/en not_active Abandoned
-
2007
- 2007-07-04 JP JP2007175770A patent/JP2007332380A/ja active Pending
-
2015
- 2015-04-23 FR FR15C0033C patent/FR15C0033I2/fr active Active
- 2015-04-29 NL NL300736C patent/NL300736I2/nl unknown
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